• Radiation Oncology Journal
• /
• v.9 no.1
• /
• pp.7-15
• /
• 1991

Pentoxifylline (PENTO) has been known to improve RBC fluidity, and thus improve the flux of RBC through narrow capillaries. Additionally, PENTO also decreases the $O_2$ affinity of hemoglobin by increasing 2,3-DPG levels, thereby increasing the $O_2$ release from RBC. Nicotinamide (NA) has been reported to decrease the number of acutely hypoxic cells in tumors by temporarily increasing tumor blood flow. Therefore, the purpose of this study was to examine whether the combination of PENTO and NA (PENTO+NA) would reduce the radioresistance of the Fsall murine fibrosarcoma by oxygenating the hypoxic cells. We obsewed a significantly enhanced radiation-induced growth delay of the FSaII tumors by PENTO+NA. Thus the enhancement ratio was between 2.5 and 2.8 in growth delay assay. The $TCD_{50}$ of control tumors was about 57 Gy, but that of PENTO+NA treated tumors was about 32Gy. Thus $TCD_{50}$ was modified by a factor of 1.8. We also observed that PENTO+NA exerted no effect on the radiation-induced skin damage after the legs without bearing tumors were exposed to X-irradiation. In order to clarify radiosensitizing effects of PENTO+ NA, changes in tumor blood flow and intratumor pOf were measured using laser Doppler flowmetry and $O_2$ microelectrode methods. The tumor blood flow significantly increased at 10 min. after injection of PENTO+ NA. Furthermore, we also found that PENTO+ NA significantly increased intratumor $pO_2$ from 8 to 19 mmHg. We concluded that PENTO+MA was far more effective than NA alone or PENTO alone. The increase in the response of tumors in vivo to X-irradiation appeared to be due mainly to an increase in the tumor oxygenation. Further studies using various concentrations of PENTO alone and in combination with NA to obtain better sequencing and maximal radiosensitization are warranted.

• Science of Emotion and Sensibility
• /
• v.21 no.1
• /
• pp.177-186
• /
• 2018

The mechanism of emotion is complex and influenced by a variety of factors, so that it is crucial to analyze emotion in broad and diversified perspectives. In this study, we classified neutral and negative emotions(sadness, fear, surprise) using arousal evaluation, which is one of the psychological evaluation scales, as well as physiological signals. We have not only revealed the difference between physiological signals coupled to the emotions, but also assessed how accurate these emotions can be classified by our emotional recognizer based on neural network algorithm. A total of 146 participants(mean age $20.1{\pm}4.0$, male 41%) were emotionally stimulated while their physiological signals of the electrocardiogram, blood flow, and dermal activity were recorded. In addition, the participants evaluated their psychological states on the emotional rating scale in response to the emotional stimuli. Heart rate(HR), standard deviation(SDNN), blood flow(BVP), pulse wave transmission time(PTT), skin conduction level(SCL) and skin conduction response(SCR) were calculated before and after the emotional stimulation. As a result, the difference between physiological responses was verified corresponding to the emotions, and the highest emotion classification performance of 86.9% was obtained using the combined analysis of arousal and physiological features. This study suggests that negative emotion can be categorized by psychological and physiological evaluation along with the application of machine learning algorithm, which can contribute to the science and technology of detecting human emotion.

• Korean Journal of Acupuncture
• /
• v.40 no.4
• /
• pp.141-148
• /
• 2023

Objectives : The purpose of this study is to investigate on the application of the yttrium aluminum garnet (YAG) lasers for acupoints irradiation. Methods : We conducted a systematic search for peer-reviewed studies published from inception to November 2023, in the following electronic databases: PubMed, Scopus, and Web of Science in English, Science ON, Oriental Medicine Advanced Searching Integrated System (OASIS) and Research Information Sharing Service (RISS) in Korean, and China National Knowledge Infrastructure (CNKI) and Wanfang in Chinese, and Japan Science Technology Information Aggregator, Electronic (J-STAGE) and Citation Information by NII (CiNii) in Japanese. Inclusion criteria were original articles including clinical and experimental studies related with YAG lasers for acupoints including Ashi or meridian sinews. Results : Among the 8 selected studies, there were 7 studies on human subjects and 1 study on animals, 7 studies on Nd:YAG (1,064 nm) laser, and 1 study on Er:YAG (2,940 nm) laser. A total of 16 acupoints were used, 15 of which were in the face and 1 of which was located in the foot. In addition, there were two studies using Ashi. 4 studies looked at the effect of pain relief, 2 studies looked at safety, 1 study looked at changes in blood flow, and 1 study looked at the effect of skin care. There were no reported adverse events, and the YAG laser was confirmed to be safe and effective in pain relief, beautifying the skin, and increasing blood flow. Conclusions : We suggest that high intensity YAG lasers can be applied to laser acupuncture or laser moxibustion. YAG lasers are considered to be worth using for various clinical indications of Korean medicine because of photobiomodulation effects, analgesic action, and deep penetration depth. Further scientific research and clinical evidences should be warranted.

• The Korean Journal of Pharmacology
• /
• v.30 no.2
• /
• pp.227-242
• /
• 1994

The general pharmacological effects of a new anthracycline anticancer agent, DA-125 $[7-0-(2,\;6-dideoxy-2-fluoro-{\alpha}-L-talopyranosyl)-adriamycinone-14-{\beta}-alaninate{\cdot}HCI]$ were investigated in mice, rats, guinea pigs, rabbits and dogs. Intravenous administration of DA-125 presented no significant effects on the central and peripheral nervous systems of ICR mice except a decrease in the numbers of acetic acid-induced writhing response at a dose of 10 mg/kg. In anesthetized rats and dogs, DA-125 produced a transient depression of blood pressure and an increase in heart rate, but did not affect the peripheral blood flow in the isolated ear vessels of rabbits and the mechanical functions of the isolated hearts of guinea pigs. No significant effects were observed on the gastrointestinal functions and the contractilities of smooth muscle preparations obtained from guinea pig trachea, rabbit ileum, pregnant and non-pregnant uterus and vas deferens of rats. DA-125 Increased the contractility of the isolated ileum of guinea pigs in a dose range of $10^{-6}{\sim}10^{-9}g/ml$, and also increased, but weaker than adriamycin, the vascular permeability in rat skin. DA-125 had no effect on the kallikrein-induced increase in permeability and the permeability of the visceral organs. DA-125 did not adversely affect the liver function and the blood coagulation system, and did not induce hemolysis in vitro. It is concluded from the results that the general pharmachological effects of DA-125 are similar to or weaker than those of adriamycin, and that little adverse effects are anticipated with a therapeutic dose range.

• Journal of Broadcast Engineering
• /
• v.20 no.3
• /
• pp.430-439
• /
• 2015

The demand of violence detection techniques using a video analysis to help prevent crimes is increasing recently. Many researchers have studied vision based behavior recognition but, violent behavior analysis techniques usually focus on violent scenes in television and movie content. Many methods previously published usually used both a color(e.g., skin and blood) and motion information for detecting violent scenes because violences usually involve blood scenes in movies. However, color information (e.g., blood scenes) may not be useful cues for violence detection in surveillance videos, because they are rarely taken in real world situations. In this paper, we propose a method of violent behavior detection in surveillance videos using motion vectors such as flow vector magnitudes and changes in direction except the color information. In order to evaluate the proposed algorithm, we test both USI dataset and various real world surveillance videos from YouTube.

• Korean Journal of Acupuncture
• /
• v.21 no.1
• /
• pp.149-173
• /
• 2004

Objective & Methods : In the point of several medical books included 'Internal Classic' and Hyungsang medicine, the writer studied about meridian theory and it's disorders, after adapting to acupuncture and herb medicine. Results : 1. Dr. Jisan explained concretely physiological and pathological meridian appearances with using metaphor about phenomenons of nature and human living. 2. Shapes corresponding to meridian are considered as Yukkyunghyung formed by more or less of vigor and blood, and by tendency of up and down in eyes and nose, and also contained diseases of viscera and characters. 3. The colors connected with meridian are changed according to conditions, and meridian is seen through colors. And then colors is the properties of vital energy and symbol of spirit, that is expressed as aspect of essence, vigor, spirit and blood, as the original color of five viscera, as the colors of four seasons and as the colors of diseases. So the changes of feelings are appeared to meridian flow. 4. The method of examining pulse for meridian disorders is applied to Jisan diagram. Jisan diagram is devised from mutual communication of viscera and connection with inside and outside. It is conjugated widely in clinical examination to be distinguished into Dam-Bangkwang, into diseased part of viscera and into meridian. Also it is conjugated recuperation of diseases. 5. The meridian diseases are appeared all the distributed parts of meridian, especially skin, hair, eyebrow, and the ends of the extremities which are sensitive to stimulus. The causes are the disharmony between vital energy and blood and the discordance of six atmospheric variation. The symptoms are skinny aches, itching and eruption, etc. Conclusions : The acupuncture of Hyungsang medicine which utilizes classification of shapes, examining pulse according to Jisan diagram and demonstration of symptoms, is very effective and required systematical study from now on.

• Journal of Oral Medicine and Pain
• /
• v.34 no.1
• /
• pp.115-122
• /
• 2009

The following results were obtained, after experimenting on change of masseter muscle and bloodstream epithelium with Transcutaneous Electrical Nerve Stimulator(TENS), among 16 male adults. 1. According to applying TENS, it was observed that bloodstream in muscle increases at 1.5, 3.0 Hz. 2. According to applying TENS, it was observed that concentration of moving blood cells in muscle increase at 1.5, 3.0, 6.0 Hz. 3. According to applying TENS, it was observed that velocity of bloodstream in muscle increases only at 1.5 Hz 4. Through experiment, applying TENS at level of 6.0 and 10.0 Hz, all bloodstream, concentration of moving blood cells, and velocity of bloodstream increasing rates were lower in muscle compared to of them in overlying epithelium; and especially increasing bloodstream and its velocity were most frequent at 6.0 Hz, and bloodstream of 10.0 Hz. From the results above when a physical therapy of TENS is carried out the frequency of 1.5, 3.0 H is effective, and as the frequency increases it is disadvantageous to the muscle.

• Tuberculosis and Respiratory Diseases
• /
• v.39 no.4
• /
• pp.334-342
• /
• 1992

Background: The activated T lymphocyte by inhalaed mycobacterial antigen may evoke cell-mediated immunity in patients with active pulmonary tuberculosis. These activated lymphocyte may influence the response of tuberculin-purified protein derivative (PPD) in skin test. But occasionally, anergy to PPD appear in patients with pulmonary tuberculosis in spite of active stage. Thus we evaluated the effect of change of subtypes of lymphocyte in bronchoalveolar lavage fluid (BAL) and peripheral blood on anergy to PPD in patients with active pulmonary tuberculosis. Method: We performed tuberculin skin test and flow-cytometry analysis of lymphocytes obtained from BAL fluid and peripheral blood in 11 healthy normal volunteers and 20 patients with active pulmonary tuberculosis. Results: 1) The composition of lymphocyte significantly increased in patients with active pulmonary tuberculosis when compared with that in healthy control ($25.2{\pm}4.8$ vs $6.5{\pm}1.3%$, p<0.01), but composition of monocyte significantly decreased ($69.6{\pm}5.7$ vs $89.2{\pm}1.4%$, p<0.05) in analysis of BAL fluid. 2) There were no differences in compositions of cells in BAL fluid between responders and no-responders to PPD. 3) The compositions of CD3 (+), CD4 (+), CD3 (+) IL-2R (+), CD3 (+) HLA-DR (+) significantly increased in BAL fluid when compared with those in peripheral blood in patients with active pulmonary tuberculosis. But the composition of CDS (+), CD4/CDS were not different between BAL fluid and peripheral blood. 4) There were no correlations between response to PPD and compositions of cells and lymphocyte subtypes in BAL fluid and peripheral blood in all patients with tuberculosis, responders, and no-responders, respectively. Conclusion: From these results, we suggest no direct relationship between compositions of inflammatory cells in bronchoalveolar lavage fluid and we could not rule out the possibility of compartmentalization of activated lymphocyte involving in anergy to PPD in skin test in patients with active pulmonary tuberculosis.

• The Korean Journal of Pain
• /
• v.13 no.2
• /
• pp.187-190
• /
• 2000

Background: From our clinical experience, there were some problems in paratracheal stellate ganglion block at 6th cervical level (C 6 SGB), for example, lesser change in blood flow of the upper extremity and more occurrence of hoarseness. This study was undertaken to compare the various effectiveness of C 6 SGB and paratracheal stellate ganglion block at 7th cervical level (C 7 SGB). Methods: Forty patients were equally divided into 2 groups. In the Group I, patients were undertaken C 6 SGB with 0.25% bupivacaine 6 mL and in the Group II, patients were undertaken C 7 SGB with 0.25% bupivacaine 6mL. The skin temperature of index finger was measured before and after SGB and the warm sensation on face and upper extremity, hoarseness and upper extremity paralysis were studied. Results: The skin temperature of index finger was increased significantly from $33.95{\pm}0.89^{\circ}C$ to $34.51{\pm}0.90^{\circ}C$ in the Group I and from $33.94{\pm}0.82^{\circ}C$ to $35.38{\pm}0.66^{\circ}C$ in the Group II (P<0.05) The increase of skin temperature of index finger after procedure was $0.56{\pm}0.09^{\circ}C$ in the Group I and $1.44{\pm}0.02^{\circ}C$ in the Group II. The increase of skin temperature of index finger in the Group II was more statistically significant than Group I (P<0.05). The occurance of hoarseness in the Group II was significantly less than in the Group I. There was no significant difference in warm sensation on face and upper extremity and paralysis of upper extremity in both Groups. Conclusions: C 7 SGB showed better sympathetic block effect on upper extremity than C 6 SGB and hoarseness did not occur in C 7 SGB.

• The Korean Journal of Pharmacology
• /
• v.7 no.1
• /
• pp.53-65
• /
• 1971

It is well known that diabetes mellitus is associated with metabolic derangements, such as hyper-glycemia, ketosis, glycosuria, and also widespread alterations in the blood vessels, kidneys, eyes, peripheral nerves and heart. It is also recognized that healing of skin wound is delayed in diabetics. In bone, according to Aegerter, osteopenia develops in diabetes mellitus and it is chiefly ascribed to overutilization of protein. Shim claims that total blood flow to the entire skeletal system is approximately 4 to 8 percent of resting cardiac output and blood supply to the skeletal system would be decreased on account of secondary arteriosclerotic changes in the diabetics. An adequate blood supply is an essential factor in the healing process of fracture, and disturbed blood flow, either local or systemic, will invariably delay union of the fragments or the fragments from being fused. As the author has encountered several cases of diabetics in whom healing of fracture was delayed or incomplete, this experimental study was undertaken to elucidate the effects of hyperglycemia and diabetes mellitus on the healing process of fracture. In this experiment adult albino rabbits, weighing about 2 kg. were used and divided into 6 groups. The femur of each animal was fractured surgically, and then the healing process of fracture was periodically checked by radiography at an interval of one week for a period of 6 weeks. Thereafter, all the rabbits were killed to obtain tissue preparation of the femur. The experimental groups were as follows; 1) Control group: Six rabbits sustained a surgical fracture to the femur, without being given any other treatment or drug. 2) Alloxan-treated group: For inducing diabetes, alloxan was given intravenously to 17 rabbits in various dose as follows; to 7 of them 40 mg/kg, to 6 rabbits 80 mg/kg and to 4 rabbits 120 mg/kg of body weight, respectively. 3) Insulin-treated group: Protamine-zinc insulin was injected subcutaneously to each of 6 rabbits in a daily dose of 1 unit per kilogram of body weight. 4) Group treated with insulin after alloxan: Four rabbits were given 80 mg of alloxan once and than 1 unit of insulin per kilogram of body weight daily. Another 5 rabbits were injected 1 unit of insulin per kg of body weight daily following administration of alloxan in a dose of 120 mg/kg. 5) Homotransplantation group: Following intravenous injection of alloxan in a dose of 120 mg/kg, 10 rabbits underwent homotransplantation of a short bone segment to the femur. Five of them were subsequently given 1 unit/kg of insulin daily. 6) Sugar-treated group: six rabbits were fed $15{\sim}20$ gm of sugar daily throughout the period of experiment. The results obtained are summarized as follows; 1. Blood sugar level and damage to the pancreatic islet increased proportionately when alloxan was given to the rabbits in various doses. No appreciable change could be observed in the islets when the blood sugar level was altered by either oral administration of sugar or subcutaneous injection of insulin. 2. Comparing with the control group, healing of fracture was delayed in the alloxan-treated group, while callus formation and periosteal reaction were shown to be more prominent in this group and subsequently, the ultimate osseous tissue formed at the fracture site was significantly smaller in amount and less compact. These findings were more marked as the amount of alloxan increased. 3. Administration of insulin prevented the delay in healing process of fracture in the rabbits with alloxan-induced hyperglycemia. In this case, the course and progression of fracture healing were almost similar to those of control group. 4. Union between the host bone and the fragment transplanted from other rabbit of the same species was more delayed in the group treated with alloxan alone than in the group to which insulin was administered after development of alloxan-induced diabetes. In both groups periosteal new bone developed from the ends of the host bone, above and below the transplanted fragment, and directly fused with failure of periosteal callus to bridge the adjacent ends of the host bone and the transplanted fragment. 5. The healing process of fracture was not inhibited by alteration in blood sugar level when the blood sugar was abnormally increased by excessive sugar intake or lowered by administration of insulin alone. The healing of fracture in these groups progressed similarly as in the control group. In brief summary, it appears that the healing process of fracture would be definitely disturbed in diabetic state brought about by damage to the pancreatic islet. As such an inhibition could be overcome with insulin, it seems that insulin plays an important role in healing of fracture, but alteration in blood sugar level alone does not modify healing process of fracture to significant degree.