• 한국체육학회지인문사회과학편
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• 제54권2호
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• pp.431-439
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• 2015

본 연구의 목적은 sarcopenic obese 흰쥐를 대상으로 사다리 등반 운동 또는 고단백식이 처치가 골격근의 단백질 합성과 인슐린 저항성에 미치는 영향을 규명하는 것이다. 50주령 SD계 수컷 흰쥐를 이용하여 6주간 고지방식이로 sarcopenic obese 쥐를 유도한 다음 4집단(Chow, HP, Ex, HPEx)으로 무선 배정하였다. 연구결과 8주간의 사다리 등반 운동은 sarcopenic obese 흰쥐의 인슐린 저항성과 체지방량을 감소시키고, mTOR 활성도를 유의하게 증가시켰다. 그러나 하지 근육양은 유의한 변화가 나타나지 않았고, 고지방식과 운동을 병행 처치한 경우 체지방과 인슐린 저항성이 개선되지 않았으며, 오히려 운동의 효과가 저해되는 것으로 나타났다. 이러한 결과를 통해 노화에 따른 sarcopenic obesity 개선을 위한 고단백식이는 그 양과 조성에 있어서 보다 면밀한 연구가 이루어져야 한다.

• 대한지역사회영양학회지
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• 제29권3호
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• pp.212-221
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• 2024

Objectives: Metabolic disease is strongly associated with future insulin resistance, and its prevalence is increasing worldwide. Thus, identifying early biomarkers of metabolic-related disease based on serum profiling is useful to control future metabolic disease. Our study aimed to assess the association of serum branched chain amino acids (BCAAs) and aromatic amino acids (AAAs) ratio and metabolic disease according to body mass index (BMI) status among Korean adults. Methods: This cross-sectional study included 78 adults aged 20-59 years in Korea. We compared serum amino acid (AA) levels between adults with normal-weight and adults with obesity and investigated biomarkers of metabolic disease. We examined serum AA levels, blood profile, and body composition. We also evaluated the association between serum AAs and metabolic-related disease. Results: The height, weight, BMI, waist circumference, hip circumference, waist-hip-ratio, body fat mass, body fat percent, skeletal muscle mass, systolic blood pressure, and diastolic blood pressure were higher in the group with obesity compared to normal weight group. The group with obesity showed significantly higher levels of BCAA, AAA, and BCAA and AAA ratio. Further, BCAA and AAA ratio were significantly positively correlated with triglyceride, body weight, and skeletal muscle mass. The evaluation of metabolic disease risks revealed an association between the ratios of BCAAs and AAAs, hypertension, and metabolic syndrome. Conclusions: Our study is showed the associations between BCAA and AAA ratio, obesity, and obesity-related diseases using various analytical approaches. The elevated BCAA and AAA ratio could be early biomarkers for predicting future metabolic diseases in Korean population.

• 한국방사선학회논문지
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• 제11권2호
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• pp.145-155
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• 2017

본 연구는 최근 6개월 이내에 특별한 식이 요법이나 정기적으로 약물을 복용하지 않고 규칙적인 신체활동을 하지 않은 폐경 전 성인여성이 복합운동에 따른 신체조성 및 골밀도의 변화를 비교, 분석하고자 수행되었으며 이 결과는 폐경 전 성인여성의 건강 및 운동실시에 대한 중요성을 인식시킬 수 있을 뿐만 아니라 한번 발생하게 되면 치료나 완치가 어려운 골다공증 예방교육을 조기에 실시하고 관리능력을 배양하는 교육프로그램 개발을 위한 기초자료를 제공하고자 한다. 연구대상자의 30대 평균 연령은 35.44세, 신장은 30대 평균 158.89 cm이고, 40대 평균 연령은 41.89세, 40대 평균 신장은 160.78 cm를 차지했다. 신체 조성에서 근육 량, BMI, 체지방률의 평균은 30대에서 높았고, 골무기질, 제지방량, 골격근량, 체중, 체지방량, 허리둘레의 평균은 40대에서 높았다. 요추골밀도 및 대퇴골밀도는 30대가 40대보다 높았다. 폐경 전 성인여성의 연령별 복합운동에 의한 30대 신체조성은 근육량, 골격근량, 제지방량은 증가하였고, 체지방량, 체중, 체지방률, 허리둘레는 감소하였다. 40대 신체조성 중 근육량은 증가 하였으며, 체중, 체지방량, 체지방률, BMI는 감소하였다. 30대 골밀도 변화는 요추골밀도는 요추 1번, 요추2번, 요추3번, 요추전체, 대퇴골밀도는 대퇴 각 부위에서 증가하였고, 40대 골밀도 변화는 요추골밀도는 요추 각 부위, 대퇴골밀도는 대퇴 각 부위에서 증가하였다. 사후분석 결과에서 신체조성의 변화는 복합운동 후 근육량, 체중, 체지방량, BMI는 감소하여 통계적으로 유의하게 나타났으며, 골밀도의 변화에서 요추골밀도는 요추1번, 요추2번, 요추3번, 요추전체에서 유의하게 증가하였고, 대퇴골밀도는 대퇴삼각과 대퇴전체에서 증가하여 통계적으로 유의한 결과가 나타났다.

• 한방비만학회지
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• 제18권2호
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• pp.152-158
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• 2018

한약을 결합한 감로수 절식요법이 여성의 체성분 변화에 미치는 영향을 알아보기 위해 2018년 8월 17일부터 2018년 10월 24일까지 대전대학교 둔산한방병원 여성의학비만센터 외래로 내원하여 절식요법을 시행한 여성 환자 11명을 대상으로 감식기 시작일, 회복식기 종료일에 시행한 체성분검사 결과를 분석하였다. 분석 결과 절식 후 체중은 $2.52{\pm}0.86kg$, 체지방량은 $1.02{\pm}0.65kg$, 골격근량은 $0.83{\pm}0.62kg$, 세포외수분비는 $0.002{\pm}0.003$, 기초대사량은 $32.91{\pm}23.06kcal$, 복부 둘레는 $1.76{\pm}1.47cm$만큼 유의하게 감소하였다. BMI, 내장지방단면적, 복부지방두께도 절식요법 후 유의한 감소를 나타냈다. 이와 같은 결과로 미루어 한약을 결합한 감로수 절식요법은 외래로 내원하는 여성 비만 환자에게 적용하는 단기 절식 프로그램으로 활용될 수 있을 것이라 생각된다.

• 대한한방부인과학회지
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• 제22권2호
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• pp.140-150
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• 2009

Purpose: We investigated the efficacy of electroacupuncture therapy in obese Korean women in order to make basic guidelines for the use of oriental medicine in treating obesity. Methods: Forty women were divided into two groups and each was treated 12 times: 1) one group was treated using electroacupuncture (EA) involving auricular acupuncture and physical treatment, without exercise (EA group, n=10), and 2) the other group was treated using electroacupuncture and exercise (EA plus exercise group, n=30). The EA was applied to subcutaneous fat tissue manually. Body weight was evaluated every visit and body composition was checked at the $1^{st}$ and $12^{th}$ visits. Statistical comparisons were made using SPSS13.0. We compared the weight loss, body mass index (BMI), and body composition before and after treatment using the pairedt-test. The correlations between weight loss and BMI and age were examined. Results: After the $12^{th}$ treatment, both groups showed significant reductions in body weight, BMI, body fat, and body fat percentage. The weight loss averaged 4.58${\pm}$3.87% in the EA group and 4.69${\pm}$3.10% in the EA plus Exercise group. The reduction in skeletal muscle was significant in the EA group, but not significant in the EA plus Exercise group. The speed of the weight loss was correlated with age using Pearson's correlation coefficient. Based on BMI, normal and obese subjects in the EA plus Exercise group had significant reductions in body weight, BMI, body fat, and body fat percentage; the obese subjects also had a significant reduction in skeletal muscle. Conclusion: Combined EA therapy may be effective for weight reduction. Age and BMI were related to weight loss using EA therapy.

• 한방재활의학과학회지
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• 제18권1호
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• pp.47-63
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• 2008

Objectives : Eucommiae cortex is reported that it helps bone and skeletal muscle stronger. In case of bone, many report is presented, but reports related to skeletal muscle are rarely existed. So in order to investigate effects of Eucommiae cortex on the skeletal muscle atrophy following stroke, cerebral infarct was induced by the middle cerebral artery occlusion (MCAO) in the rats. Methods : In order to induce MCAO rats, nylon suture was advanced and then blocked middle cerebral artery(MCA). Water extract of Eucommiae cortex was treated for 15 days, once a day orally, after the MCAO. Effects were evaluated with muscle weights, muscle fiber type composition, cross-sectioned area of muscle fibers in soleus and gastrocnemius of the unaffected and affected hind limbs. And MyoD protein expression in gastrocnemius was demonstrated with immunohistochemistry and western blotting. Results : In the affected hind limb of the MCAO rats, muscle weight loss of gastrocnemius and tibialis anterior muscles were attenuated by Eucommiae cortex treatment. In soleus muscle of the affected hind limb of the MCAO rats, increase of type-I fibers and decrease of type-II fibers were induced by Eucommiae cortex treatment. In soleus muscle of the affected hind limb of the MCAO rats, decrease of cross-sectioned areas of type-I fibers was attenuated by Eucommiae cortex treatment. In gastrocnemius muscle of the affected hind limb of the MCAO rats, increase of type-I fibers and decrease of type-II fibers were induced by Eucommiae cortex treatment. In gastrocnemius muscle of the affected hind limb of the MCAO rats, decreases of cross-sectioned areas of type-I and type-II fibers were attenuated by Eucommiae cortex treatment. In gastrocnemius muscle of the affected and unaffected hind limb of the MCAO rats, MyoD expressions were increased by Eucommiae cortex treatment. Conclusions : These results suggest that Eucommiae cortex has a protective effect against muscle atrophy, through the inhibition of the muscle cell apoptosis, following the central nervous system demage.

• 대한본초학회지
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• 제28권2호
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• pp.39-44
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• 2013

Objectives : Gambigyeongsinhwan 16 (GGEx16), gambigyeongsinhwan 18 (GGEx18) and gambitongseong capsule are shown to be involved in the regulation of obesity. Therefore, the aim of this study was to compare the reporter activity of anti-obesity genes such as peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) and $PPAR{\delta}$ by GGEx16, GGEx18 and gambitongseong capsule. Methods : After NMu2Li liver cells, C2C12 skeletal muscle cells and 3T3-L1 preadipocytes were treated with GGEx16 (1 ${\mu}g/ml$), GGEx18 (1 ${\mu}g/ml$) and different concentrations of gambitongseong capsule, the transactivation of $PPAR{\alpha}$ and $PPAR{\delta}$ was measured by a luciferase reporter gene assay. Results : $PPAR{\alpha}$ reporter gene activity in NMu2Li liver cells and 3T3-L1 preadipocytes was significantly increased by GGEx16, GGEx18 and gambitongseong capsule compared with control, whereas $PPAR{\alpha}$ reporter gene activity in C2C12 skeletal muscle cells was significantly increased by GGEx18 only compared with control. Similarly, $PPAR{\delta}$ reporter gene activity in 3T3-L1 preadipocytes was also significantly increased by GGEx18 compared with control. $PPAR{\delta}$ reporter gene activity in C2C12 skeletal muscle cells was significantly increased by GGEx16 and GGEx18 compared with control although $PPAR{\delta}$ reporter gene activity in NMu2Li liver cells was not changed by these three formulas. Conclusions : These results suggest that all three formulas have the ability to stimulate $PPAR{\alpha}$ and $PPAR{\delta}$ transactivation in animal cell lines with high metabolic rates. In particular, this effects were most prominent in GGEx18-treated cells. In addition, it is likely that GGEx18 may be used as an effective anti-obesity composition.

• 운동영양학회지
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• 제16권2호
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• pp.65-71
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• 2012

Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

• 대한감각통합치료학회지
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• 제11권1호
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• pp.29-37
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• 2013

목적 : 본 연구는 8주간 복합운동프로그램이 초등학생의 신장, 체성분, 체력에 미치는 효과를 알아보고자 실시하였다. 연구방법 : 경기도에 소재한 성남종합사회복지관의 복합운동프로그램에 지원한 남녀 초등 3 ~ 6학년 학생 11명(남자=6명, 여자=5명)을 대상자로 선정하여 8주 동안 주 2회 50분씩 복합운동프로그램(국민체조, 특허스트레칭, 음악 줄넘기, 탄력밴드운동, 마무리운동)을 적용하였다. 운동 전 후의 신장, 체성분을 알아보기 위하여 Inbody 520, 체력의 변화를 알아보기 위하여 Primus RS, Commander Power Track II, 윗몸일으키기, 체전굴을 사용하여 측정하였으며, 8주 후 재측정을 실시하였다. 결과 : 8주간 복합운동프로그램 적용 후 대상자는 실험 전보다 실험 후 신장, 체성분, 하지근력, 근지구력의 측정값은 유의한 차이를 보였다. 그러나 상지근력과 유연성은 향상되었지만 유의한 차이는 없었다. 결론 : 이러한 연구결과를 토대로 초등학생의 키성장, 체성분과 체력 향상에 복합운동프로그램이 긍정적인 효과가 있는 것으로 나타났다. 향후 연구에서 대조군과 다양한 환경적 요인들을 고려한다면 보다 나은 객관적인 결과를 얻을 것으로 생각된다.

• Nutrition Research and Practice
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• 제10권5호
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• pp.494-500
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• 2016

BACKGROUND/OBJECTIVES: Evidence indicates that berry anthocyanins are anti-atherogenic, antioxidant, and anti-inflammatory. However, berries differ vastly in their anthocyanin composition and thus potentially in their biological and metabolic effects. The present study compared hypolipidemic, antioxidant, and anti-inflammatory properties of blueberry (BB), blackberry (BK), and blackcurrant (BC) in a diet-induced obesity (DIO) mouse model. MATERIALS/METHODS: Male C57BL/6J mice were fed a high fat (HF; 35% fat, w/w) control diet or a HF diet supplemented with freeze-dried 5% BB, 6.3% BK or 5.7% BC for 12 weeks (10 mice/group) to achieve the same total anthocyanin content in each diet. Plasma lipids, antioxidant status and pro-inflammatory cytokines were measured. The expression of genes involved in antioxidant defense, inflammation, and lipid metabolism was determined in the liver, epididymal adipose tissue, proximal intestine, and skeletal muscle. Histological analysis was performed to identify crown-like structure (CLS) in epididymal fat pads to determine macrophage infiltration. RESULTS: No differences were noted between the control and any berry-fed groups in plasma levels of liver enzymes, insulin, glucose, ferric reducing antioxidant power, superoxide dismutase, and tumor necrosis factor ${\alpha}$. However, BK significantly lowered plasma triglyceride compared with the HF control and other berries, whereas BC significantly reduced F4/80 mRNA and the number of CLS in the epididymal fat pad, indicative of less macrophage infiltration. CONCLUSIONS: The present study provides evidence that BB, BK and BC with varying anthocyanin composition differentially affect plasma lipids and adipose macrophage infiltration in DIO mice, but with no differences in their antioxidant capacity and anti-inflammatory potential.