• Title/Summary/Keyword: size concerns

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Ultrasound Imaging in Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer

  • Sangeet Ghai;David P Goldstein;Anna M Sawka
    • Korean Journal of Radiology
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    • v.25 no.8
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    • pp.749-755
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    • 2024
  • The recent surge in the incidence of small papillary thyroid cancers (PTCs) has been linked to the widespread use of ultrasonography, thereby prompting concerns regarding overdiagnosis. Active surveillance (AS) has emerged as a less invasive alternative management strategy for low-risk PTCs, especially for PTCs measuring ≤1 cm in maximal diameter. Recent studies report low disease progression rates of low-risk PTCs ≤1 cm under AS. Ongoing research is currently exploring the feasibility of AS for larger PTCs (<20 mm). AS protocols include meticulous ultrasound assessment, emphasis on standardized techniques, and a multidisciplinary approach; they involve monitoring the nodules for size, growth, potential extrathyroidal extension, proximity to the trachea and recurrent laryngeal nerve, and potential cervical nodal metastases. The criteria for progression, often defined as an increase in the maximum diameter of the PTC, warrant a review of precision and ongoing examinations. Challenges exist regarding the reliability of volume measurements for defining PTC disease progression. Although ultrasonography plays a pivotal role, challenges in assessing progression and minor extrathyroidal extension underscore the importance of a multidisciplinary approach in disease management. This comprehensive overview highlights the evolving landscape of AS for PTCs, emphasizing the need for standardized protocols, meticulous assessments, and ongoing research to inform decision-making.

The Framework of Research Network and Performance Evaluation on Personal Information Security: Social Network Analysis Perspective (개인정보보호 분야의 연구자 네트워크와 성과 평가 프레임워크: 소셜 네트워크 분석을 중심으로)

  • Kim, Minsu;Choi, Jaewon;Kim, Hyun Jin
    • Journal of Intelligence and Information Systems
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    • v.20 no.1
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    • pp.177-193
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    • 2014
  • Over the past decade, there has been a rapid diffusion of electronic commerce and a rising number of interconnected networks, resulting in an escalation of security threats and privacy concerns. Electronic commerce has a built-in trade-off between the necessity of providing at least some personal information to consummate an online transaction, and the risk of negative consequences from providing such information. More recently, the frequent disclosure of private information has raised concerns about privacy and its impacts. This has motivated researchers in various fields to explore information privacy issues to address these concerns. Accordingly, the necessity for information privacy policies and technologies for collecting and storing data, and information privacy research in various fields such as medicine, computer science, business, and statistics has increased. The occurrence of various information security accidents have made finding experts in the information security field an important issue. Objective measures for finding such experts are required, as it is currently rather subjective. Based on social network analysis, this paper focused on a framework to evaluate the process of finding experts in the information security field. We collected data from the National Discovery for Science Leaders (NDSL) database, initially collecting about 2000 papers covering the period between 2005 and 2013. Outliers and the data of irrelevant papers were dropped, leaving 784 papers to test the suggested hypotheses. The co-authorship network data for co-author relationship, publisher, affiliation, and so on were analyzed using social network measures including centrality and structural hole. The results of our model estimation are as follows. With the exception of Hypothesis 3, which deals with the relationship between eigenvector centrality and performance, all of our hypotheses were supported. In line with our hypothesis, degree centrality (H1) was supported with its positive influence on the researchers' publishing performance (p<0.001). This finding indicates that as the degree of cooperation increased, the more the publishing performance of researchers increased. In addition, closeness centrality (H2) was also positively associated with researchers' publishing performance (p<0.001), suggesting that, as the efficiency of information acquisition increased, the more the researchers' publishing performance increased. This paper identified the difference in publishing performance among researchers. The analysis can be used to identify core experts and evaluate their performance in the information privacy research field. The co-authorship network for information privacy can aid in understanding the deep relationships among researchers. In addition, extracting characteristics of publishers and affiliations, this paper suggested an understanding of the social network measures and their potential for finding experts in the information privacy field. Social concerns about securing the objectivity of experts have increased, because experts in the information privacy field frequently participate in political consultation, and business education support and evaluation. In terms of practical implications, this research suggests an objective framework for experts in the information privacy field, and is useful for people who are in charge of managing research human resources. This study has some limitations, providing opportunities and suggestions for future research. Presenting the difference in information diffusion according to media and proximity presents difficulties for the generalization of the theory due to the small sample size. Therefore, further studies could consider an increased sample size and media diversity, the difference in information diffusion according to the media type, and information proximity could be explored in more detail. Moreover, previous network research has commonly observed a causal relationship between the independent and dependent variable (Kadushin, 2012). In this study, degree centrality as an independent variable might have causal relationship with performance as a dependent variable. However, in the case of network analysis research, network indices could be computed after the network relationship is created. An annual analysis could help mitigate this limitation.

A Study on Selective Adsorption of Phenanthrene Dissolved in Triton X-100 Solution using Activated Carbons (활성탄을 이용한 Triton X-100 용액에서의 phenanthrene의 선택적 흡착에 관한 연구)

  • Ahn, Chi-Kyu;Kim, Young-Mi;Woo, Seung-Han;Park, Jong-Moon
    • Journal of Soil and Groundwater Environment
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    • v.11 no.2
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    • pp.13-21
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    • 2006
  • Polycyclic aromatic hydrocarbons (PAHs) are widespread soil contaminants and major environmental concerns. PAHs have extremely low water solubility and are strongly sorbed to soil. A potential technology for remediation of PAHcontaminated soils is a soil washing with surfactant solutions. While the use of surfactants significantly enhances the performance of soil remediation, operation costs are increased. Selective adsorption of PAHs by activated carbons is proposed to reuse the surfactants in the soil-washing process. The adsorption isotherms of pure chemicals (Triton X-100 and phenanthrene) onto three granular activated carbons were obtained. The selective adsorption of phenanthrene in mixed solution was examined at various concentrations of phenanthrene and Triton X-100. The selectivity results were discussed with pore size distribution of activated carbons and molecular sizes of phenanthrene and the Triton X-100 monomer. The selectivity for phenanthrene was much larger than 1 regardless of the particle size of activated carbons. The selective adsorption using activated carbons with proper pore size distribution would greatly reduce the material cost for the soil washing process by the reuse of the surfactants.

Role of Nuclear Factor-κB in female Breast Cancer: A Study in Indian Patients

  • Jana, Debarshi;Das, Soumen;Sarkar, Diptendra Kumar;Mandal, Syamsundar;Maji, Abhiram;Mukhopadhyay, Madhumita
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5511-5515
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    • 2012
  • Introduction: The nuclear factor ${\kappa}B$ (NF-${\kappa}B$) is a super family of transcription factors which plays important roles in development and progression of cancer. The present investigation concerns NF-${\kappa}B$ /p65 activity in human breast cancers with overexpression of ER, PR, HER-2/neu, as well as the significance of p65 expression with regard to menopausal status, stage, grade, tumor size, nodal status, and NPI of invasive ductal carcinomas in Eastern India. Materials and Methods: In this hospital based study 57 breast cancer patients attending a Breast Clinic of a reputed institute of Eastern India were assessed for p65 protein expression in breast tumor tissue samples by Western blotting. ER, PR and HER-2/neu expression was determined by immunohistochemistry. Results: NF-${\kappa}B$/p65 was significantly associated with advanced stage, large tumor size (${\geq}5$ cm), high grade, negative ER, negative PR, and positive HER-2/neu. High NF-${\kappa}B$/p65 expression was more frequent in patients with a high NPI ($NPI{\geq}5.4$, 84.6%) compared with low NPI (<5.4, 44.4%) and this association was statistically significant (p = 0.002). Conclusion: NF-${\kappa}B$/p65 overexpression was associated with advanced stage, large tumor size, high grade, and high NPI which are poor prognostic factors linked to enhanced aggressiveness of the disease. NF-${\kappa}B$/p65 expression implies aggressive biological behavior of breast cancer and this study validates significant association of NF-${\kappa}B$ /p65 overexpression with negative estrogen and progesterone receptor status and overexpression of HER-2/neu oncoprotein. In our good clinical practice, patients with NF-${\kappa}B$ positive tumors need to be treated aggressively.

A Study on Characterizing the Boundary Shape and Size of Land Use Patches in Mountain Village, South Korea: Cases of Sansu and Ajick Villages in Gimje City, Jeonlabukdo (산촌마을의 토지이용 패취 크기와 경계형태 특성에 관한 연구 - 전북 김제시 금산면 선동리 아직마을과 산수마을을 대상으로 -)

  • 황보철;이명우
    • The Korean Journal of Ecology
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    • v.26 no.5
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    • pp.237-246
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    • 2003
  • A mountain village is defined as that which is autogenously formed over at least 100 years and supported by agricultural yields and forest products and forest area portion of which is over 70% in Guidelines for the Comprehensive Development Planning of Mountain Village. Recently, concerns about management planning of the Green and Eco-Village causes researches related to the Mountain Village's economics, tourism attractiveness, experience programming and investigation of the ecosystem and environment based on the village area. This kind of eco-village project should be supported by ecological evaluation of its spatial structure. But there is rare research of the village spatial structure studied from the ecological viewpoint originally. The purpose of this study is to interpret the spatial structure of Korean mountain village on the landscape ecological paradigm. The paradigm components are patches, corridors, networks, and matrix which explain the land and spatial structure at landscape scale. For this purpose, we selected two case study areas- Sansu and Ajick villages in Gimje city, Jeonlabukdo. We interpreted and evaluated the spatial structure by three steps: (1) to clarify the existing land mosaic pattern by land use mapping (2) to estimate the pore size as development area in matrix (3) to investigate the funnel effect of patch shape. These landscape ecological steps and frameworks could be applied for the proper methodology as fundamentals of eco-village planning and design.

Establishment of Quality Control System for Angiographic Unit (IVR장치의 성능 평가 기준 개발)

  • Kang, Byung-Sam;Son, Jin-Hyun;Kim, Seung-Chul
    • The Journal of the Korea Contents Association
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    • v.11 no.1
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    • pp.236-244
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    • 2011
  • Recently, the number of interventional procedures has increased dramatically as an alternative of invasive surgical procedure. The need for the quality control program of the angiographic units has also increased, because of concerns about the increased patient dose and the importance of image quality of angiographic units for the successful procedures. The purpose of this study was to propose an optimal guideline for the quality control program of the angiographic units. We reviewed domestic and international standards about medical imaging system and we evaluated the quality of 61 angiographic units in Korea with the use of NEMA 21 phantom. According to the results of our study, we propose a guideline for the quality control program of the angiographic units. Quality control program includes tube voltage test, tube current test, HVL test, image-field geometry test, spatial resolution test, low-contrast iodine detectability test, wire resolution test, phantom entrance dose test. Proposed reference levels are as follows: PAE < $\pm$ 10% in tube voltage test, PAE < $\pm$ 15% in tube current test, minimum 2.3 mmAl at 80 kVp in HVL test, minimum 'acceptable' level at image-field geometry test, 0.8 lp/mm for detector size of 34-40cm, 1.0 lp/mm for detector size of 28-33cm, 1.2 lp/mm for detector size of 22-27cm in spatial resolution test, minimum 200mg/cc in low contrast iodine detectability test, phantom entrance dose should be under 10R/min, 0.012 inch wire should be seen at static wire resolution test, and 0.022 inch wire should be seen at moving wire resolution test.

Seed Quality, Germinability and Initial Growth of Pterocarpus erinaceus (African Rosewood). How Important are Mother Tree Size, Source and Timing of Fruit Harvest?

  • Tiika, Richard J.;Issifu, Hamza;Baatuuwie, Bernard Nuoleyeng;Nasare, Latif Iddrisu;Husseini, Rikiatu
    • Journal of Forest and Environmental Science
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    • v.35 no.2
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    • pp.69-77
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    • 2019
  • Pterocarpus erinaceus is a multipurpose tree species indigenous to semi-arid and Guinean-savanna woodlands of Africa. Natural regeneration on the savanna is being hampered by higher fire frequencies and other land use changes. Simultaneously, demand for timber from the species on the international market is on the rise, raising conservation concerns. To ensure sustainability, good quality seeds, sources of which have not received much research focus, are needed for afforestation. This study investigated how seed quality, germinability and initial seedling growth of P. erinaceus might be influenced by land-use type, mother tree size as well as source and timing of fruit harvest, using both correlational and experimental approaches. The results showed that up to 94.6% of all harvested fruits contained seeds, with no differences found between fruits harvested from cultivated and non-cultivated lands. Percentage of (sound) unblemished seeds was found to be higher for fruits harvested early March (47.3%) than fruits from late April (39.5%). Percentage sound seeds was 41.4% for dispersed fruits (i.e. detached fruits picked from under mother trees) which was not found to differ from undispersed fruits (i.e. fruits harvested while still attached to mother trees) at 45.5%. Also, the influence of fruit harvest time was not found to be different for dispersed and undispersed fruits. Correlations between seed set (proportion of fruits containing seeds) and mother tree size (both tree height and DBH) were found to be very low and non-significant for both dispersed and undispersed fruits. Across mother trees, mean emergence percent was 79.7%, and mean seedling height at three weeks following emergence was 5.32 cm. Both emergence percentage and seedling height were not found to differ among mother trees, but seeds from dispersed fruits had a higher emergence percent (85%) than seeds from undispersed fruits (74%). Implications of findings are discussed.

Analysis of the Effect of Maximum Aggregate, Porosity, and Temperature on Durability of Porous Asphalt Mixtures (최대입경, 공극률, 그리고 온도가 다공성 아스팔트 혼합물의 내구성에 미치는 영향분석)

  • Yoo, In-Kyoon;Lee, Su-Hyung;Park, Ki-Soo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.227-233
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    • 2020
  • The demand for porous asphalt mixtures is increasing because it has a range of functions, such as reducing traffic accidents and traffic noise. On the other hand, its application is delayed due to concerns about durability. This study examined the effects of the maximum aggregate size, temperature, and porosity of an asphalt mixture on the durability. To this end, the durability measure was set to the Cantabro loss rate. Mixtures having the same porosity of 20% and the maximum aggregate diameters of 13 mm, 10 mm, and 8 mm were tested at 20℃ and -20℃. Mixtures containing 20% and 22% voids with the same material having the same diameter were tested. With 20% porosity, there was no significant difference in durability when there was a change in the maximum aggregate size. There was a significant difference between 20℃ and -20℃, but no significant difference in durability when there was a 2% difference between 20% and 22%. The significance of this study is that the durability was presented quantitatively by tests and statistical analysis. This research will help improve the durability of porous asphalt mixtures by evaluating the factors affecting the durability quantitatively.

On-site Inventory Management Plan for Construction Materials Considering Activity Float Time and Size of a Stock Yard (공정별 여유시간과 야적장 규모를 고려한 건설자재의 현장 재고관리 방안 연구)

  • Kim, Yong Hwan;Yoon, Hyeong Seok;Lee, Jae Hee;Kang, Leen Seok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.43 no.1
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    • pp.79-89
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    • 2023
  • The inventory of many materials requires a large storage space, and the longer the storage period, the higher the potential maintenance cost. When materials are stored on a construction site, there are also concerns about safety due to the reduction of room for movement and working. On the other hand, construction sites that do not store materials have insufficient inventory, making it difficult to respond to demands such as sudden design changes. Ordering materials is then subject to delays and extra costs. Although securing an appropriate amount of inventory is important, in many cases, material management on a construction site depends on the experience of the site manager, so a reasonable material inventory management plan that reflects the construction conditions of a site is required. This study proposes an economical material management method by reflecting variables such as the status of the preceding and following activities, site size, material delivery cost, timing of an order, and quantity of orders. To this end, we set the appropriate inventory amount while adjusting related activities in the activity network, using float time for each activity, the size of the yard, and the order quantity as the main variables, and applied a genetic algorithm to this process to suggest the optimal order timing and order quantity. The material delivery cost derived from the results is set as a fitness index and the efficiency of inventory management was verified through a case application.

THERMAL-FLUID ANALYSIS FOR COOLING PERFORMANCE IMPROVEMENT OF 3.3KV(105A) COMPACT RACK TYPE MEDIUM VOLTAGE INVERTER SYSTEM (3.3kV(105A) COMPACT RACK TYPE 고압 인버터 시스템의 방열 성능 향상을 위한 열유동 해석)

  • Kim, S.Y.;Kim, S.D.;Ryoo, S.R.;You, N.K.;Kim, T.B.;Hong, C.O.;Ko, H.S.
    • Journal of computational fluids engineering
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    • v.19 no.3
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    • pp.24-28
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    • 2014
  • With ever rising concerns about saving of fossil fuel resource, there have been an increasing demand for use of energy more efficiently. The electric motor driven inverters can be a great help to improve energy efficiency. They are also used to control the motor speed to the actual need. Therefore the use of them can lead to reduce energy consumption. In particular, the medium voltage(MV) drive systems used for pumps, fans, steel rolling mills and tractions have widespread applications in the industry. They cover power ratings from 0.4MW to 40MW at the MV level of 2.3kV to 13.8kV. The majority of the installed MV drive systems however, are in the 1MW to 4MW range with voltage rating from 3.3kV to 6.6kV. But they are required to reduce size and weight like other power electronic equipments. In this paper, we studied on the 3.3kV(105A) compact rack type inverter system for improving the cooling efficiency. At first, we confirmed the tendency of temperature with computational simulation using ANSYS ICEPAK and actual experimental tests. And then we researched thermal performance improvement designs in order to reduce temperature of the transformer for the safe operation. It can reduce temperature of transformer that using pipe type flow guide in the system. As a result, we found out more efficient solution by thermal-fluid analysis.