• Title/Summary/Keyword: site-selective

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Recent progress in selective bioconjugation

  • Subramani Rajkumar;Abhinav Bhise;Kondapa Naidu Bobba;Jeongsoo Yoo
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.6 no.2
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    • pp.146-154
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    • 2020
  • Selective installation of proteins using chemical reagents is important for the development of potential biomaterials for the treatment of human diseases. However, modification in a chemo- and regioselective manner under physiological conditions is a great challenge due to the presence of multiple reactive centers in the protein. Currently, the majority of conjugations are limited to lysine (Lys)- and cysteine (Cys)-selective reagents. Thus, they have been extensively studied. Apart from Lys and Cys, widespread site selectivity has been recently achieved through most of the 20 naturally occurring amino acid-bearing reactive functional groups. Consequently, this review focused on several recent achievements in site-selective modification of the rarest amino acid backbones (e.g., methionine, serine, glutamic acid, and tyrosine).

Fixed Site Carrier Membrane for selective metal ion transport, supported by PET fabric (PET 직물을 매트릭스로 이용한 Fixed Site Carrier Membrane의 금속이온 투과성)

  • Kim, Yong-Yl;Soukil Mah
    • Proceedings of the Korean Fiber Society Conference
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    • 2001.10a
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    • pp.219-222
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    • 2001
  • Membranes which selectively transport specific metals on an industrial scale is much useful in a number of applications, such as aqueous stream purification, catalyst and recycling of the reactants, the applications in metal ion sensing and so forth. Numerous studies have been already made to use liquid, supported liquid and, emulsion liquid membranes (LM) for selective carriers for metal ion transport. (omitted)

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The Potentiometric Performances of the Cation Selective Electrodes based on Tetracycline and Chemically Modified Tetracycline

  • Kang, Sang-Hyuk;Rhee, In-Sook;Paeng, Ki-Jung
    • Journal of Electrochemical Science and Technology
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    • v.2 no.3
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    • pp.143-145
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    • 2011
  • Metal-binding antibiotics are very attractive choices as cation selective ionophores. The ability of tetracycline (TC) antibiotics to bind to metal ions has obtained much attention. TCs exhibit the potentiometric performance changes for various cations dependant on several experiment conditions. In this report, we investigated the potentiometric performance changes of TC as the modification of TC's possible metal binding site. We found that the selectivity alter with the blocking main binding site of ionophores for cations. And, additionally it is possible to control the selectivity of sensors with chemical modification of ionophores.

PET Fabric Supported Fixed Site Carrier Membrane for Selective Metal ion Transport

  • Jin, Long Yi;Mah, Soukil
    • Fibers and Polymers
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    • v.3 no.1
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    • pp.14-17
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    • 2002
  • Development of a novel fixed site carrier membrane (FCM), supported by PET fabric for metal ion separation is reported. The membranes were prepared by dipping PET fabric into the methylene chloride solution of Poly(5-vinyl-m-phe-nylene-m'-phenylene-32-crown-10) (P(VCE)), a polymeric metal ion carrier. It was found that the flux of mono-valent metal ion transported across the membrane is signif=cantly differed from each other and the flux decreases in the order $Cs^+$>$Rb^+$>$K^+$>$Na^+$>$Li^+$ irrespective to the anion except perchlorate anion. It was explained in terms of the stability of the complex, formed by crown ether unit of the P(VCE) and the various metal ions, meanwhile, the lower rate of transport in the presence of perchlorate anion was ascribed to its low hydrophilicity.

Marker Genes for in Vitro Selection of Transgenic Plants

  • Brasileiro, Ana C.M.;Aragao, Francisco J.L.
    • Journal of Plant Biotechnology
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    • v.3 no.3
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    • pp.113-121
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    • 2001
  • The use of a marker gene in a transformation process aims to give a selective advantage to the transformed cells, allowing them to grow faster and better, and to kill the non-transformed cells. In general, the selective gene is introduced into plant genome along with the genes of interest. In some cases, the marker gene can be the gene of interest that will confer an agronomic characteristic, such as herbicide resistance. In this review we list and discuss the use of the most common selective marker genes on plant transformation and the effects of their respective selective agents. These genes could be divided in categories according their mode of action: genes that confer resistance to antibiotics and herbicides; and genes for positive selection. The contention of the marker gene flow through chloroplast transformation is further discussed. Moreover, strategies to recover marker-free transgenic plants, involving multi-auto-transformation (MAT), co-transformation, site specific recombination and intragenomic relocation of transgenes through transposable elements, are also reviewed.

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A Study on dynamic RSS channel generator development to support Selective Dissemination of information Service (SDI 서비스를 위한 동적 RSS 채널 생성기 개발)

  • Hyun, mi-hwan;Lee, sang-gi;Yoo, su-hyeon;Yae, yong-hee
    • Proceedings of the Korea Contents Association Conference
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    • 2009.05a
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    • pp.720-725
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    • 2009
  • SDI(Selective Dissemination of Information) is on demand service to inform to the user applies a service after inputting a search strategy, when new information is obtained. This Paper propose the ways to develope the dynamic RSS channel generator for supporting SDI service. The RSS which is a kind of syndication technology enables a part or the whole of the content which it provides from web site to be able to be used in different service. It is protocol to summarize and share various contents on web site. Also, the users register the channel RSS to the RSS aggregator system and recommend it. It can drive to share of knowledge between researchers.

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A New Carboxylate Selective Anion Receptor Utilizing Amide and Carbamate Hydrogens

  • Lee, Sung-Kyu;Kang, Jong-Min
    • Bulletin of the Korean Chemical Society
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    • v.32 no.9
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    • pp.3215-3218
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    • 2011
  • A new anion receptor utilizing carbamate functionality as hydrogen bonding site has been designed and synthesized. This new receptor 2 has two amide hydrogens and two carbamate hydrogens anchored at 1,8-position of anthracene. These four hydrogens form a concave structure for the anions and the receptor 2 was found to be a selective receptor for acetate among the anions investigated.