• 제목/요약/키워드: site-selective

검색결과 176건 처리시간 0.031초

Recent progress in selective bioconjugation

  • Subramani Rajkumar;Abhinav Bhise;Kondapa Naidu Bobba;Jeongsoo Yoo
    • 대한방사성의약품학회지
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    • 제6권2호
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    • pp.146-154
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    • 2020
  • Selective installation of proteins using chemical reagents is important for the development of potential biomaterials for the treatment of human diseases. However, modification in a chemo- and regioselective manner under physiological conditions is a great challenge due to the presence of multiple reactive centers in the protein. Currently, the majority of conjugations are limited to lysine (Lys)- and cysteine (Cys)-selective reagents. Thus, they have been extensively studied. Apart from Lys and Cys, widespread site selectivity has been recently achieved through most of the 20 naturally occurring amino acid-bearing reactive functional groups. Consequently, this review focused on several recent achievements in site-selective modification of the rarest amino acid backbones (e.g., methionine, serine, glutamic acid, and tyrosine).

PET 직물을 매트릭스로 이용한 Fixed Site Carrier Membrane의 금속이온 투과성 (Fixed Site Carrier Membrane for selective metal ion transport, supported by PET fabric)

  • Kim, Yong-Yl;Soukil Mah
    • 한국섬유공학회:학술대회논문집
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    • 한국섬유공학회 2001년도 가을 학술발표회 논문집
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    • pp.219-222
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    • 2001
  • Membranes which selectively transport specific metals on an industrial scale is much useful in a number of applications, such as aqueous stream purification, catalyst and recycling of the reactants, the applications in metal ion sensing and so forth. Numerous studies have been already made to use liquid, supported liquid and, emulsion liquid membranes (LM) for selective carriers for metal ion transport. (omitted)

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The Potentiometric Performances of the Cation Selective Electrodes based on Tetracycline and Chemically Modified Tetracycline

  • Kang, Sang-Hyuk;Rhee, In-Sook;Paeng, Ki-Jung
    • Journal of Electrochemical Science and Technology
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    • 제2권3호
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    • pp.143-145
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    • 2011
  • Metal-binding antibiotics are very attractive choices as cation selective ionophores. The ability of tetracycline (TC) antibiotics to bind to metal ions has obtained much attention. TCs exhibit the potentiometric performance changes for various cations dependant on several experiment conditions. In this report, we investigated the potentiometric performance changes of TC as the modification of TC's possible metal binding site. We found that the selectivity alter with the blocking main binding site of ionophores for cations. And, additionally it is possible to control the selectivity of sensors with chemical modification of ionophores.

PET Fabric Supported Fixed Site Carrier Membrane for Selective Metal ion Transport

  • Jin, Long Yi;Mah, Soukil
    • Fibers and Polymers
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    • 제3권1호
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    • pp.14-17
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    • 2002
  • Development of a novel fixed site carrier membrane (FCM), supported by PET fabric for metal ion separation is reported. The membranes were prepared by dipping PET fabric into the methylene chloride solution of Poly(5-vinyl-m-phe-nylene-m'-phenylene-32-crown-10) (P(VCE)), a polymeric metal ion carrier. It was found that the flux of mono-valent metal ion transported across the membrane is signif=cantly differed from each other and the flux decreases in the order $Cs^+$>$Rb^+$>$K^+$>$Na^+$>$Li^+$ irrespective to the anion except perchlorate anion. It was explained in terms of the stability of the complex, formed by crown ether unit of the P(VCE) and the various metal ions, meanwhile, the lower rate of transport in the presence of perchlorate anion was ascribed to its low hydrophilicity.

Marker Genes for in Vitro Selection of Transgenic Plants

  • Brasileiro, Ana C.M.;Aragao, Francisco J.L.
    • Journal of Plant Biotechnology
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    • 제3권3호
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    • pp.113-121
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    • 2001
  • The use of a marker gene in a transformation process aims to give a selective advantage to the transformed cells, allowing them to grow faster and better, and to kill the non-transformed cells. In general, the selective gene is introduced into plant genome along with the genes of interest. In some cases, the marker gene can be the gene of interest that will confer an agronomic characteristic, such as herbicide resistance. In this review we list and discuss the use of the most common selective marker genes on plant transformation and the effects of their respective selective agents. These genes could be divided in categories according their mode of action: genes that confer resistance to antibiotics and herbicides; and genes for positive selection. The contention of the marker gene flow through chloroplast transformation is further discussed. Moreover, strategies to recover marker-free transgenic plants, involving multi-auto-transformation (MAT), co-transformation, site specific recombination and intragenomic relocation of transgenes through transposable elements, are also reviewed.

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SDI 서비스를 위한 동적 RSS 채널 생성기 개발 (A Study on dynamic RSS channel generator development to support Selective Dissemination of information Service)

  • 현미환;이상기;유수현;예용희
    • 한국콘텐츠학회:학술대회논문집
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    • 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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    • pp.720-725
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    • 2009
  • 선택적 정보 제공인 SDI(Selective Dissemination of Information) 서비스는 이용자가 탐색 전략을 입력하여 서비스를 신청하면 데이터베이스가 갱신될 때마다 자동으로 이용자에게 공지되는데, 본 연구에서는 이러한 SDI 서비스를 XML 포맷인 RSS로 제공하기 위해 동적 RSS 채널 생성기를 개발하였다. RSS는 웹사이트에 갱신되는 정보를 신속히 전달-교환하게 해주는 도구로서 많은 정보를 갱신과 동시에 받아볼 수 있게 해준다. 이러한 RSS를 활용함으로써 이용자는 미리 신청한 맞춤정보서비스 뿐만 아니라 키워드 검색에 대한 검색결과 간략화면을 XML포맷의 RSS로 받아봄으로써 웹사이트를 방문하지 않고도 실시간으로 재검색 결과를 확인해 볼 수 있다.

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A New Carboxylate Selective Anion Receptor Utilizing Amide and Carbamate Hydrogens

  • Lee, Sung-Kyu;Kang, Jong-Min
    • Bulletin of the Korean Chemical Society
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    • 제32권9호
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    • pp.3215-3218
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    • 2011
  • A new anion receptor utilizing carbamate functionality as hydrogen bonding site has been designed and synthesized. This new receptor 2 has two amide hydrogens and two carbamate hydrogens anchored at 1,8-position of anthracene. These four hydrogens form a concave structure for the anions and the receptor 2 was found to be a selective receptor for acetate among the anions investigated.