• Earthquakes and Structures
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• 제13권6호
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• pp.573-588
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• 2017

The earthquake input is required when the soil-structure interaction (SSI) analysis is performed by the direct finite element method. In this paper, the earthquake is considered as the obliquely incident plane body wave arising from the truncated linearly elastic layered half space. An earthquake input method is developed for the time-domain three-dimensional SSI analysis. It consists of a new site response analysis method for free field and the viscous-spring artificial boundary condition for scattered field. The proposed earthquake input method can be implemented in the process of building finite element model of commercial software. It can result in the highly accurate solution by using a relatively small SSI model. The initial condition is considered for the nonlinear SSI analysis. The Daikai subway station is analyzed as an example. The effectiveness of the proposed earthquake input method is verified. The effect of the obliquely incident earthquake is studied.

• Bulletin of the Korean Chemical Society
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• 제27권3호
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• pp.407-412
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• 2006

Bioluminescence single-site immunometric assay for methamphetamine (MA) using the native aequorin, a photoprotein, as a signal generator was developed for the first time. MA is a potent sympathomimetic amine with stimulant effects on the central nervous system. MA abuse induces hallucinations and, thus, may cause a serious social problem. The single-site immunometric MA assay was optimized and its dose-response behavior was examined. The dose-response curve shows that the detection limit is 1.1 ${\times}$ $10^{-10}$ M and a dynamic range is four orders of magnitude with 15 $\mu$g/mL BSA-MA conjugate and 1.0 ${\times}$ $10^{-8}$ M anti-MA antibody-biotin conjugate. In order to evaluate this assay, the structurally similar compounds, amphetamine, ephedrine, norephedrine, benzphetamine and N-4-(aminobutyl)methamphetamine were examined for their crossreactivity. None of these five compounds showed any cross-reactivity. Additionally, an artificial urine solution spiked with MA was analyzed by the MA assay, and the result of the analysis demonstrated the usefulness of the present assay for the determination of MA in urine.

• 한국지반공학회논문집
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• 제36권12호
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• pp.77-86
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• 2020

본 논문에서는 얕은 기반암 심도 및 지진 위험도가 상대적으로 낮은 지역에서 부지의 고유주기와 입력지진파의 평균주기의 영향에 따른 전단강도 보정의 필요성을 평가하였다. 이를 위해 일반적으로 널리 사용되는 Modified Kondner-Zelasko(MKZ) 모델과 함께 미소변형률뿐만 아니라 대변형률 영역에서의 응력-변형률 거동을 모사할 수 있는 General Quadratic/Hyperbolic(GQ/H) 모델을 사용하였다. 6개 부지의 다운홀 시험 자료와 평균주기가 다른 3개의 입력지진파를 사용하여 1차원 부지응답해석을 수행하였다. 그 결과, 입력지진파의 평균주기뿐만 아니라 부지의 고유주기에 따라 전단강도 보정 적용 유무에 따른 해석 결과의 차이가 발생했다. 부지의 고유주기의 영향을 파악하기 위해 유효최대지반가속도, 최대전단변형률 및 증폭계수와의 상관관계를 분석하였다. 분석 결과, 부지의 고유주기가 길고 연약한 지반일수록 그 차이가 더욱 커지는 것을 확인하였다.

• 한국지반공학회논문집
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• 제18권1호
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• pp.101-112
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• 2002

본 연구에서는 진동하중을 받는 지반의 교란정도차이를 통해 액상화 거동을 규명하는 교란상태개념에 기초하여 제안된 액상화 평가법의 타당성을 비교실험을 통하여 검증하였다. 제안된 평가법의 타당성 검토를 위해, 실내진동시험을 토대로 소산에너지 개념에 기초한 해석결과와 비교하였다. 또한, 불규칙한 지진의 시간이력 전부를 고려하는 제안된 평가법의 특성을 분석하기 위하여 임의의 해석대상지반에 대해 2가지 형태의 실지진 시간이력을 입력한 지진 응답해석을 토대로 액상화 평가를 수행하였으며 이용된 액상화 평가법은 Seed의 경험적 평가방법(Seed등, 1971)을 국내 실정에 부합되도록 수정보완한 방법(김수일 등, 2000)으로 우리나라 해양수산부 주관으로 편찬된 $\ulcorner$항만 및 어항시설의 내진설계 표준서$\lrcorner$에 인용된 방법이다. 액상화 저항특성에 관한 타당성 검토결과, 제안된 평가법과 소산에너지 개념에 기초한 해석결과가 과잉간극수압의 누적으로 발생되는 액상화 현상을 신뢰성 높게 표현하고 있는 것으로 나타났다. 또한, 액상화 평가예를 통해 제안된 평가법에서의 지진력 고려에 대한 특성을 분석한 결과, 제안된 평가법에서는 실지진 시간이력에 대한 지진응답해석을 통해 최대가속도, 탁월주파수, 진동형태, 지속시간 등으로 표현되는 지진특성을 합리적으로 고려되고 있는 반면, 지진에 의한 등가전단음력 산정시 등가의 최대값을 이용하는 액상화 상세예측의 경우, 지진응답해석의 지반 내 지진증폭현상을 단순히 최대가속도만으로 표현함으로써 불규칙한 가속도가 연속재하되는 지진특성을 충분히 반영하지 못하는 것으로 나타났다. 연구결과, 제안된 평가법은 실내진동시험의 수행 및 실지진 시간이력 전부에 대한 고려를 포함하고 있으므로 이를 기초로 한 액상화 평가가 신뢰성이 높다고 판단된다.

• 자원환경지질
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• 제39권3호
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• pp.269-284
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• 2006

지하수위와 하천수위와의 상호반응과 수리적으로 다른 특성을 가지는 각 층별(실트질 모래층, 자갈모래층, 풍화대층) 반응관계를 알아보기 위하여 시계열 분석에서 많이 사용되어 온 방법인 자기상관분석과 교차상관분석방법을 이용하였다. 만경강 하천부지에 각 층을 대표하는 깊이에서 지하수위를 관측한 결과, 지하수위가 강수량보다는 하천수위변동에 민감하게 반응하고 있었다. 연구지역의 하천수위변동은 만경강 제수문의 조절과 조석의 영향을 받아 주기적인 수위변동이 우세하기 때문에 강수량과의 상관성은 낮다. 다심도 관정에서 각층별 하천수위에 대한 지하수위 반응은 시간지연 없이 서로 같이 변동하는 것으로 나타났으며, 반응시간은 하천과 가까운 관정에서 30-60분 이내로 빠르며 하천에서 거리가 멀어지면서 반응시간은 대체로 늦게 나타났다. 그러나 하천과 멀리 떨어져 있는 관정이더라도 하천수위에 대하여 빠른 반응을 보이는 관정이 있으며, 이는 하천과 대수층과의 높은 수리적 연결성을 나타낸다. 지하수위의 하천에 대한 반응양상이 다르게 나타나는 것은 대수층의 수리적 불균질성에 의한 것으로 사료된다. 연구지역의 하천은 대체로 지하수위가 하천수위보다 높게 관측되고 있기 때문에 지하수가 하천으로 유출되는 이득하천의 성격을 가지고 있다고 판단되나, 하천의 급격한 수위상승에 따라 역으로 하천의 물이 지하수로 공급되는 손실하천의 성격도 보여주었다. 하천수위와 대수층이 연결된 시스템에서 시계열분석으로서의 자기 및 교차상관분석은 수리적 상호관계를 파악하기 위한 유용한 도구로 활용될 수 있다.

• 국제초고층학회논문집
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• 제9권3호
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• pp.273-282
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• 2020

An innovative high-rise timber-concrete hybrid structure was proposed in previous research, which is composed of the concrete frame-tube structure and the prefabricated timber modules as main structure and substructures, respectively. Considering that the timber substructures are built on the concrete floors at a different height, the floor response spectrum is more effective in estimating the seismic response of substructures. In this paper, the floor response spectra of the hybrid structure with different structural parameters were calculated using dynamic time-history analysis. Firstly, one simplified model that can well predict the seismic response of the hybrid structure was proposed and validated. Then the construction site, the mass ratio and the frequency ratio of the main-sub structure, and the damping ratio of the substructures were discussed. The results demonstrate that the peaks of the floor response spectra usually occur near the vibration periods of the whole structure, among which the first two peaks stand out; In most cases, the acceleration amplification effect on substructures tends to be more evident when the construction site is farther from the fault rupture; On the other hand, the acceleration response of substructures can be effectively reduced with an appropriate increase in the mass ratio of the main-sub structure and the damping ratio of the substructures; However, the frequency ratio of the main-sub structure has no discernible effect on the floor response spectra. This study investigates the characteristics of the floor response spectrum of the novel timber-concrete structure, which supports the future applications of such hybrid structure in high-rise buildings.

• Korean Journal of Radiology
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• 제24권3호
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• pp.235-246
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• 2023

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27-82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrast-enhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46-4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01-2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.

• 대한자원환경지질학회:학술대회논문집
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• 대한자원환경지질학회 1999년도 춘계 공동학술발표회
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• pp.116-119
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• 1999

Amplification factor spectrum, using the observed strong ground motions database in the Korean Peninsula, has been obtained and compared with Standard Response Spectrum, which was suggested by United States Nuclear Regulatory Committee. The observed und motions from the Yongwol and the Kyoungju, and the other recent Earthquakes, respectively, which ate supposed to represent domestic seismotectonic characteristics such as seismic source, attenuation of the propagation medium, and site specific effect, are used for the analysis of amplification factor spectrum. The database are slightly different from the those of the second study. Amplification factors hue been calculated by comparing the observed peak ground motions with results from responses to the observed horizontal na vertical ground motions. The comparison have shown that the amplification factors resultant from this study exceeds these of Standard Response Spectrum, The results suggest that the characteristics of seismic strong ground motion, which are supposed to represent the domestic seismotectonic characteristics, differs from those of Standard Response Spectrum, especially at higher frequencies. The results from the 2nd study are similar to those of 1st analysis.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1997년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Fall 1997
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• pp.88-93
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• 1997

Amplication factor spectrum has been obtained and compared with standard Response Spectrum using the observed strong ground motions database. The observed ground motions from the Miramichi, Nahanni, Saguenay and New Madrid Earthquake (vertical component 19. horizontal component 36). which are estimated to represent domestic seismotectonic characteristics such as seismic source, attenuation, and site effect, are used for the analysis of amplication factor spectrum. Amplication factor has been calculated using both observed peak values and results from responses to the observed horizontal and vertical ground motions. The comparison shows that the amplication factors resultant from this study exceeds those of Standard Response Spectrum at relatively higher frequencies. The results implie that the characteristics of the seismic strong ground motion which may represent the domestic seismotectonic characteristics differs from those of Standard Response Spectrum, which are resultant from the strong ground motions observed mainly at the westem United States.

• Geomechanics and Engineering
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• 제30권1호
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• pp.1-10
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• 2022

Seismic ground response evaluation is one of the main issues in geotechnical earthquake engineering. These analyses are subsequently divided into one-, two- and three-dimensional methods, and each of which can perform in time or frequency domain. In this study, a novel approach is proposed to assess the seismic site response using two-dimensional transfer functions in frequency domain analysis. Using the proposed formulation, a program is written in MATLAB environment and then promoted utilizing the equivalent linear approach. The accuracy of the written program is evaluated by comparing the obtained results with those of actual recorded data in the Gilroy region during Loma Prieta (1989) and Coyote Lake (1979) earthquakes. In order to precise comparison, acceleration time histories, Fourier amplitude spectra and acceleration response spectra diagrams of calculated and recorded data are presented. The proposed 2D transfer function diagrams are also obtained using mentioned earthquakes which show the amount of amplification or attenuation of the input motion at different frequencies while passing through the soil layer. The results of the proposed method confirm its accuracy and efficiency to evaluate ground motion during earthquakes using two-dimensional model. Then, studies on irregular topographies are carried out, and diagrams of amplification factors are shown.