• 대한의생명과학회지
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• 제25권4호
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• pp.372-380
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• 2019

Mice with specific modified genes are useful means of studying development and disease. The CRISPR/Cas9 system is a very powerful and effective tool for generating genetically modified mice in a simple and fast manner. To generate human IgG light kappa constant knock-in mice, we tested by microinjection of a mixture of Cas9 protein, single-guide RNA and target homologous recombinant donor DNA into zygotes. We found that the injection of 10 ng/μL of Cas9 protein and crRNA/tracrRNA, rather than single guide RNA, induced the production of knock-in mice more effectively. Thus, our study provides valuable information that will help to improve the production of knock-in mice and contribute the successful generation of humanized Ab-producing mice in Korea.

• 제어로봇시스템학회논문지
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• 제15권2호
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• pp.192-197
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• 2009

In this paper, we proposed the obstacle avoidance system using a single camera image and LM(Levenberg-Marquart) neural network fuzzy controller. According to a robot technology adapt to various fields of industry and public, the robot has to move using self-navigation and obstacle avoidance algorithms. When the robot moves to target point, obstacle avoidance is must-have technology. So in this paper, we present the algorithm that avoidance method based on fuzzy controller by sensing data and image information from a camera and using the LM neural network to minimize the moving error. And then to verify the system performance of the simulation test.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 B
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• pp.770-772
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• 2004

This paper presents a new approach regarding thermal characteristics associated with a design of the high efficiency motor. The adjoint variable design sensitivity equations for both electromagnetics with respect to permeability and heat transfer considering conduction and convection terms are derived using the continuum method. For multi-objective topology optimization, FEA is validated in terms of electromagnetics and heat transfer by experiments. The proposed method is applied to a single-phase induction motor of the scroll compressor in order to control the direction of heat flow by maximizing/minimizing the temperature of the target area while maintaining the efficiency.

• 한국국방경영분석학회지
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• 제18권1호
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• pp.61-73
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• 1992

Up to the present, the operating time has been studied on only a single aircraft attacking a single target or multiple targets under enemy threats. This study is to determine optimal operating time and appropriate size of aircrafts attacking multiple targets. Measures of mission effectiveness is defined through derivation of the probability of the various events associated with operating. By using these measures, the expected benefit of operating and the expected cost of operating are generated as a function of time. To formulate operating time determination model, the expected gain of operating is defined as the difference between the expected benefit of operating and the expected cost of operating. The model can be used to determine optimal operating time which maximizes the expected gain of operating, and can be used as the basis for determining the appropriate size of aircrafts.

• 한국재료학회지
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• 제1권3호
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• pp.168-174
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• 1991

Ti-Silicides를 single-Si wafer와 그 위에 oxide를 성장시킨 기판위에 composite target($TiSi_{2.6}$)을 sputtering함으로써 증착시켰다. 증착된 비정질 상태의 Ti-silicide는 급속 열처리(RTA)방법으로 $600^{\circ}C$에서 $850^{\circ}C$가지 20초간 처리하였다. RTA온도가 $800^{\circ}C$가 되어서야 비로소 안정한 $TiSi_2$가 형성되었으며, 그 때의 비저항 값은 $27~29{\mu}\Omega-cm$로 Ti-metal reactive방법에 의한 $TiSi_2$보다 약간 높은 값으로 드러났다. X-ray로 상천이를 조사한 결과 역시 $750^{\circ}C$가지 C49 $TiSi_2$가 형성되고, $800^{\circ}C$가 되어서야 안정한 C54 $TiSi_2$로의 상천이가 일어남을 나타내고 있다. 또한 완전히 형성된 Ti-silicide의 조성비는 x-ray photoelectron spectroscopy(XPS)결과에서 Ti : Si이 1 : 2로 드러났으며, 그 동안 reactive 시켰을 때 $TiSi_2$의 단점으로 지적되어 왔던 형성 완료된 $TiSi_2$의 surface roughness는 $17{\pm}1mm$이내로 매우 우수한 값으로 판명되어, device에 대한 응용 가능성을 높이고 있다.

• 한국전자파학회논문지
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• 제22권3호
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• pp.327-335
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• 2011

본 논문에서는 X-밴드 대역의 SAR(Synthetic Aperture Radar) 영상 분석을 위해 RCS 조절이 가능한 자체 설계/제작된 능동 전파반사기의 RCS 분석 연구 결과를 선보인다. 다양한 SAR 영상 보정 및 분석 연구를 위해 사용되는 능동 전파반사기의 RCS 크기를 실험실 내 측정(lab-test)과 실제 위성 SAR(COSMO-SkyMed) 영상을 통해 비교 분석하여, 정확히 조절 및 예측 가능한 능동 전파반사기의 RCS 특성을 비교 분석하였다. 설계/제작된 능동 전파반사기의 최대 RCS는 약 60 dBsm이며, 실제 실험 환경을 고려해 최대 RCS와 이보다 20 dB 낮은 RCS의 변화된 특성을 STCT(Single Target Calibration Technique) 보정 기법과 2차원 목표물 스캔닝 측정법(2D Target Scanning Technique)을 이용해 능동반사기의 RCS를 측정하였다. 또한, 실제 위성 SAR 영상으로부터 전력적분기법(power-spill integration technique)을 통해 전파반사기의 RCS를 추출하여 측정값과 비교 분석하였다. 능동 전파반사기의 측정 RCS는 59.7 dBsm과 40.2 dBsm이었으며, SAR 영상 내 추출 RCS는 57.3 dBsm과 39.2 dBsm이었다.

• 한국국방경영분석학회지
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• 제5권1호
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• pp.37-72
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• 1979

This paper presents the FORTRAN program for expected damage by surface-to-surface weapons. One of the methods can be used to determine the effectiveness of general purpose (GP) bombs and cluster weapons against single unitary targets, linear targets, area targets, and areas of unitary target elements, The effectiveness index is in terms of fractional damage ($F_D$) or the number of volleys ($N_V$).

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2000년도 추계학술대회 학술발표 논문집
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• pp.274-277
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• 2000

In this paper we propose new algorithms of path planning and obstacle avoidance for an autonomous mobile robot with vision system. Distance variation is included in path planning to approach the target point and avoid obstacles well. The fuzzy rules are also applied to both trajectory planning and obstacle avoidance to improve the autonomy of mobile robot. It is shown by computer simulation that the proposed algorithm is working well.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.205-208
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• 2005

A single span-to-depth ratio function is proposed for control of deflection in one-way concrete construction. The equation can be applied to one-way slabs, beams, and flat plates. Effects of cracking, time-dependent deformation, boundary conditions, applied loading, and target deflection-to-span ratio are taken into account.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 하계종합학술대회 논문집(2)
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• pp.293-296
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• 2001

This paper describes an implementation of 4$^{th}$ order single-loop Butterworth noise shaper for a 16-bit $\Delta$$\Sigma$ DAC with the viewpoint of minimum hardware overhead. we adopt simple bit-shifting scheme and ROM selection technique for the multiplication, and propose a new buffer-and-routing method for the ROM circuits. The behavioral level and timing simulations reveal that our proposal is valid for the target specificationrget specificationn