• Smart Structures and Systems
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• v.30 no.3
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• pp.327-332
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• 2022

In building envelope, transparent components play an important role. The structural glazing systems are the weak element of the casing in terms of mechanical resistance, thermal and acoustic insulation. In the present work, new structural glass panels with granular aerogel in interspace were investigated from different points of view. In particular, the mechanical characterization was carried out in order to assess the resistance to bending of the single glazing pane. To this end, a special instrument system was built to define an alternative configuration of the coaxial double ring test, able to predict the fracture strength of glass large samples (400 × 400 mm) without overpressure. The thermal and lighting performance of an innovative double-glazing façade with granular aerogel was evaluated. An experimental campaign at pilot scale was developed: it is composed of two boxes of about 1.60 × 2 m² and 2 m high together with an external weather station. The rooms, identical in terms of size, construction materials, and orientation, are equipped with a two-wing window in the south wall surface: the first one has a standard glazing solution (double glazing with air in interspace), the second room is equipped with the innovative double-glazing system with aerogel. The indoor mean air temperature and the surface temperature of the glass panes were monitored together with the illuminance data for the lighting characterization. Finally, a brief energy characterization of the performance of the material was carried out by means of dynamic simulation models when the proposed solution is applied to real case studies.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1110-1119
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• 2022

Fe-S clusters are versatile and essential cofactors that participate in multiple and fundamental biological processes. In Escherichia coli, the biogenesis of these cofactors requires either the housekeeping Isc pathway, or the stress-induced Suf pathway which plays a general role under conditions of oxidative stress or iron limitation. In the present work, the Fe-S cluster assembly Isc and Suf systems of acidophilic Bacteria and Archaea, which thrive in highly oxidative environments, were studied. This analysis revealed that acidophilic microorganisms have a complete set of genes encoding for a single system (either Suf or Isc). In acidophilic Proteobacteria and Nitrospirae, a complete set of isc genes (iscRSUAX-hscBA-fdx), but not genes coding for the Suf system, was detected. The activity of the Isc system was studied in Leptospirillum sp. CF-1 (Nitrospirae). RT-PCR experiments showed that eight candidate genes were co-transcribed and conform the isc operon in this strain. Additionally, RT-qPCR assays showed that the expression of the iscS gene was significantly up-regulated in cells exposed to oxidative stress imposed by 260 mM Fe₂(SO₄)₃ for 1 h or iron starvation for 3 h. The activity of cysteine desulfurase (IscS) in CF-1 cell extracts was also upregulated under such conditions. Thus, the Isc system from Leptospirillum sp. CF-1 seems to play an active role in stressful environments. These results contribute to a better understanding of the distribution and role of Fe-S cluster protein biogenesis systems in organisms that thrive in extreme environmental conditions.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.6
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• pp.782-787
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• 2015

The myogenic regulatory factors is a family of transcription factors that play a key role in the development of skeletal muscle fibers, which are the main factors to affect the meat taste and texture. In the present study, we performed candidate gene analysis to identify single-nucleotide polymorphisms in the MyoD, Myf5, MyoG, and Mrf4 genes using polymerase chain reaction-single strand conformation polymorphism in 360 Erlang Mountain Chickens from three different housing systems (cage, pen, and free-range). The general linear model procedure was used to estimate the statistical significance of association between combined genotypes and muscle fiber traits of chickens. Two polymorphisms (g.39928301T>G and g.11579368C>T) were detected in the Mrf4 and MyoD gene, respectively. The diameters of thigh and pectoralis muscle fibers were higher in birds with the combined genotypes of GG-TT and TTCT (p<0.05). Moreover, the interaction between housing system and combined genotypes has no significant effect on the traits of muscle fiber (p>0.05). Our findings suggest that the combined genotypes of TT-CT and GG-TT might be advantageous for muscle fiber traits, and could be the potential genetic markers for breeding program in Erlang Mountain Chickens.

• The Transactions of the Korea Information Processing Society
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• v.7 no.2S
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• pp.721-732
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• 2000

Multimedia communication systems require not only high-performance computer hardwares and high-speed networks, but also a buffer management mechanism to process many data efficiently. Two buffer handling methods, Push and Pull, are commonly used. In the Push method, a server controls the flow of dat to a client, while in the Pull method, a client controls the flow of data from a server. Those buffering schemes can be applied to the data transfer between the packet receiving buffer, which receives media data from a network server, and media playout devices, which play the recived media data. However, the buffer management mechanism in client-sides mainly support either one of the Push or the Pull method. Consequently, they have some limitations to support various media playout devices. Futhermore, even though some of them support both methods, it is difficult to use since they can't provide a unified structure. To resolved these problems, in this paper, we propose an efficient and flexible Push/Pull buffer management mechanism at client-side. The proposed buffer management scheme supports both Push and Pull method to provide various media playout devices and to support buffering function to absorb network jitter. The proposed scheme can support the various media playback devices using a single buffer space which in consequence, saves memory space compared to the case that a client keeps tow types of buffers. Moreover, it facilitates the single buffer as a mechanism for the absorbing network jitter effectively and efficiently. The proposed scheme has been implemented in an existing multimedia communication system, so called ISSA (Integrated Streaming Service Architecture), and it shows a good performance result compared to the conventional buffering methods in multimedia communication environments.

• Proceedings of the Korean Society of Computer Information Conference
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• 2013.01a
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• pp.47-50
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• 2013

본 논문에서는 지속적인 싱글 골프게임 플레이를 위한 네트워크 시스템 설계를 제안한다. 본 설계는 스크린 골프 시뮬레이터와 자료동기화 기술을 접합함으로써, 언제 어디서나 이전에 정지된 게임 플레이 환경을 재현하여 계속적인 플레이 할 수 있도록 하는데 그 목적이 있다. 플레이어가 스크린 골프장에서 게임 플레이하다가 게임이 완전히 끝나기 전에 정지하게 되면, 본 논문에서 제안한 네트워크 시스템이 해당 게임 환경 정보를 서버에 저장한다. 차후 플레이어가 게임 재개를 원할 경우, 종전에 정지한 게임 환경 정보를 그대로 재현할 수 있도록 다운로드하여 사용자에게 제공함으로써, 지속적인 게임 플레이를 가능하게 한다. 본 논문의 시스템은 PC콘솔 클라이언트, 프록시 서버, 사용자 데이터 서버로 구성된다. PC콘솔 클라이언트는 콘솔 기기에 탑재되며, 사용자에게 스크린 골프게임을 제공하고, 게임 환경 정보를 프록시 서버로 전송한다. 프록시 서버는 닫힌 네트워크에 존재하는 사용자 데이터 서버와 PC콘솔 클라이언트를 연결하며, 해당 세션을 관리한다. 사용자 데이터 서버는 실제 플레이어의 인증, 데이터 저장 및 불러오기와 같은 실질적인 서비스를 제공한다.

• Steel and Composite Structures
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• v.26 no.3
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• pp.273-287
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• 2018

Buckling and free vibration analysis of sandwich micro plate (SMP) integrated with piezoelectric layers embedded in orthotropic Pasternak are investigated in this paper. The refined Zigzag theory (RZT) is taken into consideration to model the SMP. Four different types of functionally graded (FG) distribution through the thickness of the SMP core layer which is reinforced with single-wall carbon nanotubes (SWCNTs) are considered. The modified couple stress theory (MCST) is employed to capture the effects of small scale effects. The sandwich structure is exposed to a two dimensional magnetic field and also, piezoelectric layers are subjected to external applied voltages. In order to obtain governing equation, energy method as well as Hamilton's principle is applied. Based on an analytical solution the critical buckling loads and natural frequency are obtained. The effects of volume fraction of carbon nanotubes (CNTs), different distributions of CNTs, foundation stiffness parameters, magnetic and electric fields, small scale parameter and the thickness of piezoelectric layers on the both critical buckling loads and natural frequency of the SMP are examined. The obtained results demonstrate that the effects of volume fraction of CNTs play an important role in analyzing buckling and free vibration behavior of the SMP. Furthermore, the effects of magnetic and electric fields are remarkable on the mechanical responses of the system and cannot be neglected.

• Journal of the Korea Society of Computer and Information
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• v.13 no.6
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• pp.225-232
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• 2008

When a single source of multimedia contents is distributed to multiple reproduction devices, the audio and video contents require synchronous play for multi-channel stereo sound and lip-synchronization. The multimedia system in vehicle, especially, has researched to move to wireless environments from legacy wired environments. This paper proposes the advanced algorithm for providing synchronized services of real-time multimedia traffic in IEEE 802.11 WLANs [1]. For these, we implement the advanced IEEE 1588 Precision Time Protocol [2] and the environments for simulation. Also, we estimate and analysis performance of the algorithm, then we experiment and analysis after the porting of algorithm in wireless LAN devices (Linksys wrt-350n AP network device) to characterize timing synchronization accuracy.

• Archives of Pharmacal Research
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• v.28 no.10
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• pp.1164-1169
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• 2005

Brain microglia are phagocytic cells that are the major inflammatory response cells of the central nervous system and widely held to play important pathophysiologic roles in Alzheimer's disease (AD) in both potentially neurotoxic responses and potentially beneficial phagocytic responses. In the study, we examined whether ginsonoside Rg3, a by-product of red ginseng, enhances the microglial phagocytosis of $A{\beta}$. We found that Rg3 promoted $A{\beta}$ uptake, internalization, and digestion. Increased maximal $A{\beta}$ uptake was observed at 4 and 8 h after Rg3 pretreatment (25 ${\mu}g/mL$), and the internalized $A{\beta}$ was almost completely digested from cells within 36 h when pretreated with Rg3 comparing with single non-Rg3-treated groups. The expression of MSRA (type A MSR) was also up-regulated by Rg3 treatment in a dose- and time-dependent manner which was coincidently identified in western blots for MSRA proteins in cytosol. These results indicate that microglial phagocytosis of $A{\beta}$ may be enhanced by Rg3 and the effect of Rg3 on promoting clearance of $A{\beta}$ may be related to the MSRA-associated action of Rg3. Thus, stimulation of the MSRA might contribute to the therapeutic potentials of Rg3 in microglial phagocytosis and digestion in the treatment of AD.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.5.1-5.22
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• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.111-117
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• 2016

Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent $K^+$ current ($I_{KAch}$) was used to examine the effect of vagal activation. A simulation of cardiac wave dynamics was performed in a realistic 3D model of the atrium. A model of the ganglionated plexus (GP) and nerve was developed based on the "octopus hypothesis". The pattern of cardiac wave dynamics was examined by applying vagal activation to the GP areas or randomly. AF inducibility in the octopus hypothesis-based GP and nerve model was tested. The effect of the ACh concentration level was also examined. In the single cell simulation, an increase in the ACh concentration shortened $APD_{90}$ and increased the maximal slope of the restitution curve. In the 3D simulation, a random distribution of vagal activation promoted wavebreaks while ACh secretion limited to the GP areas did not induce a noticeable change in wave dynamics. The octopus hypothesis-based model of the GP and nerve exhibited AF inducibility at higher ACh concentrations. In conclusion, a 3D in silico model of the GP and parasympathetic nerve based on the octopus model exhibited higher AF inducibility with higher ACh concentrations.