• Title/Summary/Keyword: single feeding

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Effects of Olanzapine on the Schedule-Induced Polydipsic Rats (Olanzapine이 백서의 Schedule-Induced Polydipsia에 미치는 영향)

  • Lee, Gi-Chul;Lee, Kyung-Kyu;Chang, Hwan-Il;Lee, Jung-Ho;Kim, Hyun-Woo;Ha, Jun-Myung;Jeong, Jae-Hyun;Jeong, Hong-Kyung
    • Korean Journal of Biological Psychiatry
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    • v.6 no.2
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    • pp.240-245
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    • 1999
  • Object : This study was designed to evaluate the effects of olanzapine on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered olanzapine as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol for the dopamine antagonist to rats which showed schedule-induced polydipsic behavior. Methods : Spraque-Dawley rats weighing 200-250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT-60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered olanzapine(3mg/kg, i.p), olanzapine(10mg/kg, i.p), fluoxetine(5mg/kg, i.p.), haloperidol(0.1mg/kg, i.p.), and vehicle(1cc/kg, i.p.) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a posthoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results and Conclusion : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake over the 3 weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 3mg group showed significant decrease in the amount of water intake at 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 10mg group showed significant decrease in the amount of water intake at 2nd and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their average amount of polydipsic water intakes. 3) The fluoxetine group showed significantly lower amounts of water intake than the haloperidol group at 2nd weeks of drug treatment. And also the fluoxetine group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. The olanzapine 3mg group and the olanzapine 10mg group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The authors assume that the serotonin hypothesis and the serotonin-dopamine interaction hypothesis are preferred to the dopamine hypothesis in the biological etiology of obsessive-compulsive disorder.

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Effects of Feeding Split Diets for a.m. and p.m. on Laying Hen Performance and Feed Cost (산란계에 대한 오전용 사료와 오후용 사료의 별도 급여가 산란능력과 경제성에 미치는 영향)

  • 이규호;정연종
    • Korean Journal of Poultry Science
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    • v.23 no.1
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    • pp.27-37
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    • 1996
  • This experiment was carried out to study the effects of feeding split diets for a.m. and p.m. on laying hen performance and feed cost with 480 ISA Brown layers for three periods during 32∼36, 52∼56 and 72∼76 wk of age, respectively. The control group(C) was fed a conventional single diet throughout the day and split diet groups (T$_1$, T$_2$, T$_3$, T$_4$ and T$\_$5/) were offered high energy-high protein-low Ca diets, and low energy-low protein-high Ca diets in a.m. and p.m., respectively. In split diet groups, feed intake, ME and CP consumption, and feed cost were significantly reduced(P<0.05) compared to the C, while the hen-day egg production was significantly improved. However, the average egg weight was not influenced by the feeding system. Due to the reduced daily feed, ME, and CP intakes, and the improved egg production, the conversions of feed, ME, CP, and feed cost required per kg egg mass were also significantly improved (P<0.05) in splits diet groups. Among split diet groups, the T$_2$ group fed the diet devoid of Ca supplement from the conventional laying hen diet in a.m., and the diet containing the Ca supplement 2 times the conventional diet in p.m., was superior in conversion of nutrients and feed cost per kg egg mass to the other split diet groups. It was concluded that daily feed and nutrients cousumption and daily feed cost could be reduced 5∼6% while hen-day egg production could be improved about 4%, so that about 10% of the feed and nutrients and feed cost per kg egg mass could be spared by introducing the split diet feeding for a.m. and p.m. based on T$_2$ treatment in laying hens.

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Effect of Bulnesia sarmienti Single and Complex Extracts on Serum Lipid and Body Fat in Rats Fed High-fat Diet (고지방식이를 섭취한 흰쥐에서 Bulnesia sarmienti 단일추출물과 복합추출물이 혈청지질 및 체지방에 미치는 영향)

  • Park, Chang-Ho;Kim, Dae-Ik;Jung, Hee-Kyoung;Lee, Gee-Dong;Kim, Kil-Soo;Hong, Joo-Heon
    • Korean Journal of Food Science and Technology
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    • v.40 no.4
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    • pp.449-454
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    • 2008
  • This research examined whether feeding single extracts or complex extracts of Bulnesia sarmienti, together with a high fat diet, could improve serum lipid levels and reduce fat mass in rats. Test groups were fed the extracts, combined with a high fat diet, for eight weeks, and subdivided into seven groups: normal, control, and five treatment groups (BS: B. sarmienti extracts; BS-S: B. sarmienti and Salvia miltiorrhiza Bunge extracts; BS-M: B. sarmienti and Morus alba Linne extracts; BS-SM1: B. sarmienti, Salvia miltiorrhiza Bunge and Morus alba Linne extracts; and BS-SM2: BS-SM1 extracts at a 2-fold concentration). After feeding the test substance for 8 weeks, no significant differences were found for food intake, water intake, change in body weight, or food efficiency ratios (FER) among the groups. However, serum LDL-cholesterol had increased by 14.1% in the BS-S group. When compared with the control group, total cholesterol levels in the BS, BS-S, BS-M, BS-SM1, and BS-SM2 groups were reduced by 36.0, 14.5, 40.4, 17.5, and 22.5%, respectively, with the greatest change shown in the BS-M group. In terms of triglycerides, levels in BS, BS-S, BS-M, BS-SM1, and BS-SM2 had decreased by 41.9, 8.5, 62.3, 17.7, and 14.5%, respectively. Compared to the control group, the BS group showed a significant decrease in fat mass. In conclusion, the BS and BS-M groups showed significant effects with respect to improved serum lipid profiles and body fat mass when they were fed a high fat diet in combination with the respective extracts.

Restriction of Metabolizable Energy in Broiler Growers and Its Impact on Grower and Breeder Performance

  • Sunder, G. Skyam;Kumar, Ch. Vijaya;Panda, A.K.;Raju, M.V.L.N.;Rao, S.V. Rama;Gopinath, N.C.S.;Reddy, M.R.
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.8
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    • pp.1258-1265
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    • 2007
  • Metabolizable energy (ME) required for basal metabolism, activity and growth was considered as the criterion for targeting specific increases in body weight (100 g/week) of broiler chicks during the grower phase (5-20 weeks) and its impact was evaluated on breeder performance. Broiler female chicks (460) from a synthetic dam line were randomly distributed to 4 test groups with 23 replicates of 5 birds each and housed in cages. The first group (ME-100) was offered a calculated amount of ME by providing a measured quantity of grower diet (160 g protein and 2,600 kcal ME/kg) which increased with age and weight gain (133-294 kcal/bird/day). The other three groups were offered 10 or 20% less ME (ME-90 and ME-80, respectively) and 10% excess ME (ME-110) over the control group (ME-100). From 21 weeks of age, a single breeder diet (170 g protein and 2,600 kcal ME/kg) was uniformly fed to all groups and the impact of grower ME restriction on breeder performance evaluated up to 58 weeks. The targeted body weight gain of 1,600 g in a 16-week period was achieved by pullets of the ME-100 group almost one week earlier by gaining 8.7 g more weight per week. However, pullets in the ME-90 group gained 1,571 g during the same period, which was closer to the targeted weight. At 20 weeks of age, the conversion efficiency of feed (5.21-5.37), ME (13.9-14.1 kcal/g weight gain) and protein (0.847-0.871 g/g weight gain), eviscerated meat yield, giblet and tibia weights were not influenced by ME restriction, but the weights of abdominal fat and liver were higher with increased ME intake. Reduction of ME by 10% in the grower period significantly delayed sexual maturity (169.3 d), but increased egg production (152.5 /bird) with better persistency. Improved conversion efficiency of feed, ME and protein per g egg content were also observed in this group up to 56 weeks. The fertility and hatchability at 58 weeks of age were higher in the ME-90 group compared to the control and 10% excess ME feeding. In conclusion, the present study revealed the possibility of achieving targeted weight gain in broiler growers by feeding measured quantities of ME during the rearing period with consequential benefits in breeder performance.

Efficacy of an Integrated Biological Control of an Egg Parasitoid, Trichogramma evanescens Westwood, and Microbial Insecticide Against the Oriental Tobacco Budworm, Helicoverpa assulta (Guenée) Infesting Hot Pepper (고추를 가해하는 담배나방[Helicoverpa assulta (Guenée)]의 효과적 방제를 위한 쌀좀알벌(Trichogramma evanescens Westwood)과 미생물제제의 종합생물방제 효과)

  • Kim, Geun-Seob;Heo, Hye-Jung;Park, Jung-A;Yu, Yong-Suk;Hahm, Eun-Hye;Kang, Sung-Young;Kwon, Ki-Myeon;Lee, Keon-Hyung;Kim, Yong-Gyun
    • Korean journal of applied entomology
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    • v.47 no.4
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    • pp.435-445
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    • 2008
  • Due to internal feeding behavior, the oriental tobacco budworm, Helicoverpa assulta ($Guen\acute{e}e$), infesting hot pepper has been regarded to be effectively controlled by targeting egg and neonate larval stages just before entering the fruits. This study aimed to develop an efficient biological control method focusing on these susceptible stages of H. assulta. An egg parasitoid wasp, Trichogramma evanescens Westwood, was confirmed to parasitize the eggs of H. assulta. A mixture of Gram-positive soil bacterium, Bacillus thuringiensis subsp. kurstaki, and Gram-negative entomopathogenic bacterium, Xenorhabdus nematophila ANU101, could effectively kill neonate larvae of H. assulta. A sex pheromone trap monitored the occurrence of field H. assulta adults. The microbial insecticide mixture was proved to give no detrimental effects on immature development and adult survival of the wasp by both feeding and contact toxicity tests. A combined treatment of egg parasitoid and microbial pesticide was applied to hot pepper fields infested by H. assulta. The mixture treatment of both biological control agents significantly decreased the fruit damage, which was comparable to the chemical insecticide treatment, though either single biological control agent did not show any significant control efficacy. This study also provides morphological and genetic characters of T. evanescens.

Effect of Feeding Probiotics on Performance and Intestinal Microflora of Broiler Chicks (생균제의 급여가 육계의 생산성과 장내 미생물의 변화에 미치는 영향)

  • 류경선;박홍석
    • Korean Journal of Poultry Science
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    • v.25 no.1
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    • pp.31-37
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    • 1998
  • Two experiment were conducted to evaluate the feeding value of probiotics for the broiler chicks. Basal diets based on corn and soybean meal with no supplemental probiotics contained 21% dietary crude protein for the first 3 weeks and 19% for the rest of two weeks. In experiment 1, 0.2 % probiotics containing 2X 10 6 cfu /ml of Saccharomyces cerevisiae(S), Clostridium butyricum(C), Lactobacillus acidophilus(L), Bacillus polyfermenticus(B) were respectively supplemented to control groups. Two hundred day-olo chicks were randomly assigned to five treatments which had four replicates of 10 chicks each per treatment. Weight gain, feed consurnption, feed conversion ratio (FCR) were weekly measured for 5 weeks. The number of intestinal microflora was examined at the end of experiment. In experiment 1, Weight gain and feed intake of chicks fed probiotics exhibited a significant response compared to those of control for the first three weeks(P<0.01). Weight gain of S or C treatments was higher than that of control for the rest of two weeks, whereas it was significantly lower in L and B treatments than S or C treatments (P<0.01). Chicks fed S or C was significantly increased weight gain(P <0.05) compared to that of control at five weeks of age. FCR of C treatment seemed to improve relative to other supplemental probiotics groups, but was not significantly different. The number of intestinal anaerobes and Lactobacillus in large intestine of chicks fed probiotics supplements was significantly decreased compared to control groups(P<0.01). In experiment 2, there were six treatments: Ti, control; T2, 0.2%S; T3, 0.2%S + 0.2%C; T4, 0.2%S + 0.2%L; T5, 0.2%S + 0.2%B; T6, 0.2%S + 0.1%C + o.i%L + 0.1%B. Control diet based on corn soybean meal contained 21% CP and 3,2OOca1 /g ME with no probiotics. There were four replicates of 10 chicks each per treatment. Weight gain of chicks fed probiotics tended to increase compared to control groups, but were not significantly different between them. FCR was also improved in probiotics treatments. However, there were no significant differences between probiotics supplementation and control groups. The results of these experiments indicated that dietary supplemental probiotics improved weight gain, feed efficiency for the first three weeks of young broiler chicks, whereas supplementation of C, L, B combined probiotics to young broiler chicks was not superior to those of single or two probiotics.

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Design of Dual-Polarization Antenna with High Cross-Polarization Discrimination (높은 교차편파 분리도를 가지는 이중편파 안테나 설계)

  • Lee, Sang-Ho;Oh, Taeck-Keun;Ha, Jung-Je;Lee, Yong-Shik
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.10 no.3
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    • pp.199-205
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    • 2017
  • In a small cell base station used in densely populated areas, a dual polarized multiple antenna(MIMO) is mainly used to increase the cell capacity. This paper demonstrates a dual-polarization antenna with high cross-polarization discrimination(XPD) that can improve the capacity of a small cell using a dual polarization multiple antenna (MIMO). By using the symmetric structure and differential feeding, high XPD in all directions is achieved. In addition, a very similar radiation pattern is observed between each polarization. Because of high XPD and similar radiation pattern in all directions, proposed antenna is well adopted for small-cell multiple-input multiple-output(MIMO) system. Experimental results shows that the proposed antenna has a bandwidth of 180 MHz (2.51~2.7 GHz), a maximum gain of 4.5 dBi (3.5~4.5 dBi), and a half-power beam width of 85 degrees. In addition, average XPD of 26.4 dB in all directions, more than 13.8 dB increase than previous dual-polarization antennas which use single emitter by using different feeding or selectively use polarization through switching.

Feed Intake Patterns and Growth Performance of Purebred and Crossbred Meishan and Yorkshire Pigs

  • Hyun, Y.;Wolter, B.F.;Ellis, M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.6
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    • pp.837-843
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    • 2001
  • Two experiments were conducted to compare the feed intake patterns and growth performance of Meishan and Yorkshire growing pigs. Experiment 1 was carried out over a 6-wk period and used 48 barrows with equal numbers of purebred Meishan (M) and Yorkshire (Y). Pigs were allocated to four groups of 12 pigs consisting of equal numbers of M and Y. Initial BW were $36.4{\pm}0.32kg$ and $42.1{\pm}1.41kg$ for M and Y, respectively. Experiment 2 was carried out over a 5-week period and used 48 pigs consisting of equal numbers of both barrows and gilts and of crossbred Meishan$\times$Yorkshire (MY) and purebred Yorkshire (Y) animals. Pigs were allotted to 6 pens of 8 pigs, with 4 single- and 2 mixed-genotype groups (initial $BW=28.5{\pm}0.99kg$). In both experiments, pigs were given ad libitum access to a grower diet (17% crude protein, 0.9% lysine, 3365 kcal/kg ME) via feed intake recording equipment (F.I.R.E.). Pigs carried an ear-tag transponder with an unique identification which allowed the time, duration, and size of individual meals to be recorded. In Exp. 1, Y had higher ADG (721 vs 353 g, p<0.01), daily feed intake (DFI; 2.338 vs 1.363 kg, p<0.01), made more frequent visits to the feeder per day (NFV; 18.5 vs 7.7, p<0.01), had a shorter feeder occupation time per visit (FOV; 7.4 vs 12.9 min, p<0.01), and ate less feed per visit (FIV; 130 vs 177 g, p<0.01) than M pigs. Feed consumption rates (CR) were greater for Y compared to M (19.3 vs 14.8 g/min, p<0.01). Feeder occupation time per day (FOD) was longer for Y than M (114.3 vs 82.8 min/pig, p<0.01). Yorkshire pigs visited the feeder more frequently between 0800 and 1100 h. Meishan pigs showed more frequent feeder visits between 0600 and 0800 h, and between 1600 and 2100 h when feeding competition with Y was reduced. In Exp. 2, there was no effect of genotype or group composition on DFI, ADG or gain:feed ratio. Crossbred pigs (MY) made fewer feeder visits (12.6 vs 17.7, p<0.01), and had greater FIV (124 vs 98 g/visit, p<0.01), and longer FOV (8.11 vs 7.24 min/visit, p<0.01) and FOD (112 vs 100 min, p<0.05) than Y pigs. Results of this study suggest substantial genetic variation in feeding patterns as well as in growth performance.

Design of Microstrip Patch Antenna using Inset-Fed Layered for Metallic Object in u-Port (U-항만 환경에서 금속부착을 위한 인셋 급전 마이크로패치 안테나 설계)

  • Choi, Yong-Seok;Seong, Hyeon-Kyeong
    • Journal of Satellite, Information and Communications
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    • v.10 no.2
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    • pp.80-85
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    • 2015
  • In this paper, we present, an indstrial RFID layered microstrip patch antenna is designed using an inset feed method in order to improve recognition rates in a long distance as tags are attached to metal object by improving a problem of feeding power in fabricating metal tags and reducing effects of metallic object. The inset feed shows a distinctive characteristic that has no separation between emitters and feed lines differing from a structure with the conventional inductive coupling feed. This structure makes possible to produce a type that presents a low antenna height and enables impedance coupling for tag chips. Although it shows a difficulty in the impedance coupling due to increases in the parasite capacitance between a ground plane and an emitter in an antenna according to decreases in the height of a tag antenna, it may become a merit in designing the tag antenna because the antenna impedance can be determined as an inductive manner if a shorted structure is used for feeding power. Therefore, in this paper the microstrip patch antenna is designed as a modified type and applies the inset feed in order to reduce effects of metallic objects where the antenna is be attached. Also, the antenna uses a multi-layer structure that includes a metal plate between radiator and ground instead of using a single layer.

Effects of Dietary Soybean Meal in Rainbow Trout (Oncorhynchus mykiss) II. On the Apparent Digestibility, Excretion and Body Composition (무지개송어(Oncorhynchus mykiss) 사료원으로써 대두박의 이용 효과 II. 소화율, 배설 및 체조성 변화)

  • Kim Pyong Kih;Jeon Joong-Kyung;Huh Hyung Tack;Jo Jae-Yoon
    • Journal of Aquaculture
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    • v.9 no.4
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    • pp.395-407
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    • 1996
  • A feeding experiment for 160 days was conducted to evaluate effects of dietary soybean meal (SBM) on the apparent digestibility, ammonia excretion and body composition of rainbow trout (Oncorhynchus mykiss). Seven diets containing $0\~70\%$ SBM were formulated based on iso-nitrogenous and iso-caloric basis of $44\%$ crude protein and approximately 4,200 Kcal/kg of gross energy. To evaluate the nutritional utilization of the SBM diets at the end of 60 and 120-day rearing with test diets, digestion rates of protein and lipid of SBM diets were measured. Fish fed the diets containing above $46\%$ SBM showed higher apparent digestibility for protein, but lower for lipid than did fish fed the control diet in both trials. Protein and fat contents in the carcass were similar for all experimental fish, except for fish fed $58\%$ and $70\%$ SBM which showed lower fat content than the others, but composition of fatty acid and amino acids were not affected by dietary SBM levels. Gill and urinary post-prandial ammonia ($NH_3-N$) excretions were measured at 12 and 24 hours after single feeding of the experimental diets. Excretions of $NH_3-N$ measured after 24 hours were almost 1 times higher than those measured after 12 hours. Total excretion fer the 24 hours by fish fed $70\%$ SBM was $15\%$ higher than that of fish fed the control diet. Results of present study may suggest that the rainbow trout which were fed above $34%\;or\;46\%$ of SBM diet showed a decrease gradually in lipid bioavailability compared to the control group.

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