• 한국컴퓨터정보학회논문지
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• 제24권11호
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• pp.71-78
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• 2019

현재 상용화된 대부분의 3D 디스플레이는 왼쪽 눈과 오른쪽 눈의 입력영상을 다르게 만들어 입체감을 만드는 양안시차 방식을 적용하고 있다. 하지만 상용화된 3D 영상 출력 장치는 성능 부족에 의한 시청자의 불편 유발과 시청위치의 제약 등의 문제들이 있다. 본 논문에서는 기존 Dual-cell 구조 대비 시야각, Crosstalk 감소, 광투과도를 향상할 수 있는 Single-cell 구조의 편광안경식 입체영상 시스템을 개발하고, 투과도 실험과 시야각 평가를 통해 Single-cell 구조의 편광안경식 입체영상 시스템 특성분석과 Dual-cell 구조 대비 성능향상 효과 분석을 진행하였다. 분석 결과 Single-cell 구조가 Dual-cell 구조 대비 투과도 부분에서 약 25% 이상의 높은 성능을 보이며, 시야각 평가 중 입체 영상 특성품질의 주요지표인 3D crosstalk 지표는 약 37% 이상 향상되는 것을 확인할 수 있었다.

• 대한전기학회논문지
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• 제45권2호
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• pp.224-229
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• 1996

Performance characteristics of single cell in phosphoric acid fuel cell were studied for various electrode fabrication parameters such as teflon content, electrode structure, thickness of electrocatalyst layer, platinum content and electrode area. The performance of single cell was decided from the measured voltage-current through a load change. The electrode of 40wt.% teflon exhibited high initial performance of single cell, but in the long term operation, the cell performance of 45 wt.% teflon was better. Also the single cell appeared good performance in case of electrodes with duplicate structure, thin electrocatalyst in thickness, more platinum content, and small area. These results of cell performance were discussed as related to the electrolyte flooding, formation of 3 phase boundary area, internal resistance of electrode, and microstructure of electrode.

• BMB Reports
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• 제50권6호
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• pp.283-284
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• 2017

Single cell transcriptome analysis is a powerful tool for defining cell types or sub-populations within a heterogeneous bulk population. Tumor-associated microenvironment is a complex ecosystem consisting of numerous cell types that support tumor growth, angiogenesis, immune evasion, and metastasis. With the success of checkpoint inhibitors targeting the immune cell compartment, tumor microenvironment is emerging as a potential anti-cancer target, and understanding it has become an imminent subject in cancer biology.

• Genomics & Informatics
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• 제18권3호
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• pp.26.1-26.6
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• 2020

Single-cell RNA sequencing (scRNA-seq) has been widely applied to provide insights into the cell-by-cell expression difference in a given bulk sample. Accordingly, numerous analysis methods have been developed. As it involves simultaneous analyses of many cell and genes, efficiency of the methods is crucial. The conventional cell type annotation method is laborious and subjective. Here we propose a semi-automatic method that calculates a normalized score for each cell type based on user-supplied cell type-specific marker gene list. The method was applied to a publicly available scRNA-seq data of mouse cardiac non-myocyte cell pool. Annotating the 35 t-stochastic neighbor embedding clusters into 12 cell types was straightforward, and its accuracy was evaluated by constructing co-expression network for each cell type. Gene Ontology analysis was congruent with the annotated cell type and the corollary regulatory network analysis showed upstream transcription factors that have well supported literature evidences. The source code is available as an R script upon request.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1996년도 하계학술대회 논문집 C
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• pp.1707-1709
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• 1996

For the improvement of the performance and life time of phosphoric acid fuel cell, the management of electrolyte in the electrocatalyst layer and electrolyte matrix in the cell structure is very important. Porous bipolar pinto structure, that is known as an advanced type, is generally used for the storage of electrolyte in the cell. In this paper, the single cell was made of the electrode by coating directly electrocatalyst layer on porous bipolar plate. The single cell showed $186\;mA/cm^2$ at 0.6V. This performance is similar to the performance of the conventional nonporous plate single cell. The technology of porous plate single cell could be directly used to the fabrication of stack in order to improve the performance and life time of phosphoric acid fuel cell.

• 한국수산과학회지
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• 제36권4호
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• pp.346-351
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• 2003

Single-cell gel electrophoresis (comet assay) was used to detect DNA single strand break in blood cells from several marine fish species. Three fish species were collected from Georgia coastal area. Mummichog, Fundulus heteroclitus showed higher DNA damage than sea bass, Lateolabrax japonicus and trout, Oncorhynchus masou masou under the same experimental conditions. Mummichogs had more alkaline-labile sites on their DNA than other fish species. The comet assay with mummichog blood cells at pH 12.5 showed a dose-response curve with the increasing concentrations of hydrogen peroxide. While the isolated leucocytes showed no increase of DNA damage after in vitro exposure to 2-methyl-1,4-naphthoquinone (MNQ), erythrocytes showed dose-dependent DNA damage. These results indicate that the comet assay can be applied successfully as a bioassay using erythrocyte for environmental monitoring.

• 한국수소및신에너지학회논문집
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• 제13권4호
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• pp.313-320
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• 2002

The characteristics of the AISI bipolar plates have been investigated to replace the expensive graphite bipolar plates. It was found from the contact resistance evaluation of graphites, composites, and AISI that the contact resistance of AISI was the lowest, but it could approach to that of composites at higher compression forces. The single cell operation using the AISI bipolar plates revealed that the lower performance of the AISI single cell compared to the graphite one was due to not only the higher contact resistance but the flooding effect caused by high wettability of AISI. The performance of the AISI single cell could be improved if the channels were modified appropriately. The large size AISI single cell was operated to investigated the size effect on the performance.

• 한국수소및신에너지학회논문집
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• 제26권6호
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• pp.554-559
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• 2015

Single cell of PEMFC (polymer electrolyte membrane fuel cell) is composed of bipolar plates, gasket, GDL and the MEA. Bipolar plate's function is the collecting electricity, helping oxygen/hydrogen gas diffuse evenly and draining the water and heat. In this work, we have conducted experiments to low contact resistance and improve the performance of a $25cm^2$ single cell by using metal forms. We have following experimental cases: 1) Conventional graphite serpentine channel bipolar plate; 2) Channel-less bipolar plate with nickel(Ni) based metal foam which coated by various materials. We focused the difference in contact resistance and performance of the single cell with metal foam depending on various coating materials. The experimental results show the similar performance of single cells between with serpentine channel bipolar plates and with channel-less bipolar plate using metal foams. In addition, single cell with metal foam shows potential to higher performance than conventional channel.

• Genomics & Informatics
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• 제17권1호
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• pp.3.1-3.4
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• 2019

Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast cancer is a significant challenge for effective treatment. Using single-cell RNA sequencing (RNA-seq) data from a public resource, an ERBB pathway activated triple-negative cell population was identified. The differential expression of three subtyping marker genes (ERBB2, ESR1, and PGR) was not changed in the bulk RNA-seq data, but the single-cell transcriptomes showed intratumor heterogeneity. This result shows that ERBB signaling is activated using an indirect route and that the molecular subtype is changed on a single-cell level. Our data propose a different view on breast cancer subtypes, clarifying much confusion in this field and contributing to precision medicine.

• Genomics & Informatics
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• 제16권4호
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• pp.17.1-17.6
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• 2018

Tumor heterogeneity, the cellular mosaic of multiple lineages arising from the process of clonal evolution, has continued to thwart multi-omics analyses using traditional bulk sequencing methods. The application of single-cell sequencing, in concert with existing genomics methods, has enabled high-resolution interrogation of the genome, transcriptome, epigenome, and proteome. Applied to cancers, these single-cell multi-omics methods bypass previous limitations on data resolution and have enabled a more nuanced understanding of the evolutionary dynamics of tumor progression, immune evasion, metastasis, and treatment resistance. This review details the growing number of novel single-cell multi-omics methods applied to tumors and further discusses recent discoveries emerging from these approaches, especially in regard to immunotherapy.