• CELLMED
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• v.2 no.3
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• pp.29.1-29.9
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• 2012

The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.12
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• pp.1529-1538
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• 1999

광대역 액세스 망은 B-ISDN 환경에서 다양한 유형의 가입자들을 서비스 노드로 집선하는 기능을 수행한다. ITU-T의 SG13에서는 광대역 액세스 망과 서비스 노드 사이에서 ATM 자원의 동적인 할당 및 해제를 위하여 연결 제어 프로토콜의 표준화를 수행하고 있다. ATM 연결의 설정을 위한 연결 제어 프로토콜과 신호 프로토콜의 연동 기능은 서비스 노드에서 수행되며, ITU-T에서는 순차적 연동 모델을 채택하고 있다. 순차적 연동 모델은 SN에서 각 프로토콜의 절차가 순차적 방식으로 연동되므로 연결 지연이 크다. 본 논문에서는 광대역 액세스 망의 도입으로 인한 연결 설정 지연을 최소화하기 위하여 병렬형으로 수행되는 연동 모델을 제시하였다. 그리고 본 논문에서 제안한 병렬형 연동 모델의 성능 분석을 통하여 순차적 연동 모델과의 연결 설정 지연 및 완료비에 대한 비교, 분석을 수행하였다. 성능 분석에서 사용된 워크로드 파라미터는 RACE MAGIC 프로젝트의 결과를 적용하였다. Abstract In B-ISDN environment, various subscribers are concentrated into a service node via a broadband access network. The SG13 of ITU-T is standardizing a connection control protocol which provides dynamic allocation of ATM resources between an access network and a service node. To establish an ATM connection, interworking functions between the connection control protocol and the signaling protocol are performed at the service node. ITU-T adopts the sequential interworking model. In this paper, we propose the parallel interworking model which minimizes the overall connection setup delay by introducing the access network. Using the performance analysis, we compare our proposed parallel model with the existing sequential model in terms of connection setup delay and completion ratio. The workload parameters of RACE MAGIC project are applied to the analysis and simulation.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.11
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• pp.1414-1428
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• 1999

ATM/B-ISDN 신호 프로토콜과 같은 통신 프로토콜의 상호운용성을 시험하기 위한 시험경우를 생성하는 알고리즘이 제안되었다 1]. 현재까지 상호운용성 시험경우 도출을 자동화하거나 이에 대한 커버리지를 분석한 경우는 없다. 본 논문은 1]에서 제안한 알고리즘을 프로그램으로 구현하여 TCP 연결설정 프로토콜에 적용하고 결과를 분석한다. 이 과정에서 (1) TCP 연결설정 프로토콜의 3방향 핸드 쉐이킹 부분을 다루지 못했던 기존의 알고리즘을 개선하고, (2) 개선된 알고리즘을 프로그램으로 구현하여 TCP 연결설정 프로토콜의 상호운용성 시험경우를 도출하고, (3) 생성된 상호운용성 시험경우를 트랜지션 커버리지 관점에서 분석하고, (4) 향상된 트랜지션 커버리지를 얻기 위하여 알고리즘 확장 방안을 제시한다.Abstract A test derivation method suitable for testing interoperability for the class of communication protocols like the ATM/B-ISDN signaling protocol was proposed 1]. Up to now, there is no work on automating derivation of the interoperability test suite and analyzing its coverage. In this paper, we implement the algorithm proposed by 1], apply it to the Transmission Control Protocol (TCP), and analyze its results. In this process, we (1) improve the algorithm that is not applicable to the TCPs three-way handshaking, (2) implement the improved algorithm as a program and derive an interoperability test suite automatically from a given pair of TCP FSMs, (3) analyze generated interoperability test suite in view of transition coverage, and (4) present a method in order to extend the algorithm for better transition coverage.

• Journal of Ginseng Research
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• v.42 no.1
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• pp.98-106
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• 2018

Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.262.1-262.1
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• 2014

Lipid peroxidation induces functional deterioration of cell membrane and induces cell death in extreme cases. These phenomena are known to be related generally to the change of physical properties of lipid membrane such as decreased lipid order or increased water penetration. Even though the electric property of lipid membrane is important, there has been no report about the change of electric properties after lipid peroxidation. Herein, we demonstrate the molecular energy band change in red blood cell membrane through peroxidation by air-based atmospheric pressure DBD plasma treatment. Ion-induced secondary electron emission coefficient (${\gamma}$ value) was measured by using home-made gamma-focused ion beam (${\gamma}$-FIB) system and electron energy band was calculated based on the quantum mechanical Auger neutralization theory. The oxidized lipids showed higher gamma values and lower electron work functions, which implies the change of surface charging or electrical conductance. This result suggests that modified electrical properties should play a role in cell signaling under oxidative stress.

• The Korean Journal of Financial Management
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• v.21 no.1
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• pp.59-86
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• 2004

This study analyzed the effects of M&A announcement before and after the 1998 amendments of 'Securities and Exchange Act' through the event study. The M&A firms turned out to gain the abnormal returns during the entire periods. The cumulative average abnormal returns of M&A firms was 1.38%(market adjusted model) or 5.37%(industry-adjusted model) higher after the 1998 amendments than before. The differences of performance of M&A were significant also in case of the related M&A, vertical or horizontal M&A, M&A in booms. In regression analysis, the 1998 amendments of Act was the significant factor to explain the cumulative abnormal returns.

• The Journal of the Korea Contents Association
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• v.21 no.7
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• pp.386-403
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• 2021

Preannouncing a new product to its target audiences has been more and more prevalent in a wealth of industries, particularly industries that attach great importance to the speed of entry. Grounded in market signaling theory, the current research advances a theoretical model that takes full cognizance of the relation between preannounced information about an upcoming product and individual customers' behavioral intentions as well as significant moderating effects of prior product knowledge and new product innovativeness. In response, a web-based survey is conducted for data collection and the structural equation model is utilized for data analysis. Results of this study demonstrate that preannounced new product information attributes (i.e., quantity, clarity) may positively influence consumers' attitudes, in turn, lead to a favorable purchase intention. Moreover, the moderating effects of product knowledge and product innovativeness are also confirmed. Specifically, product knowledge moderates the quantity-attitude relation positively and moderates the clarity-attitude relation negatively, whereas product innovativeness does opposite. Both implications and limitations are also described.

• The Journal of the Korea Contents Association
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• v.19 no.5
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• pp.194-204
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• 2019

The mobile payment app market has been expanding recently. However, the usage rate of mobile payment apps is not meeting service providers' expectations due to concerns about security and privacy. This study investigated how personal predisposition and how the security signals of the payment app affect users' perceived privacy and security risks, and how these factors ultimately affect the trust of mobile payment apps. The results showed that privacy concerns increase the risk of perceived personal information leaks and reduce perceived mobile system security, while familiarity, perceived reputation, and assurance seal reduce the risk of perceived personal information leaks and increase perceived mobile system security. Finally, it revealed that the reduced risk of perceived personal information leaks and the increased security of mobile systems had a positive impact on the reliability of mobile payment apps.

• Journal of Ginseng Research
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• v.47 no.4
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• pp.493-505
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• 2023

In recent years, an increasing number of reports have explored the wound healing mechanism of these two traditional Chinese herbal medicines- Panax ginseng and Panax notoginseng, but there is no systematic research on the related core functions and different mechanisms in the treatment of wound healing up to now. Based on network pharmacology and meta-analysis, the present work aimed to comprehensively review the commonality and diversity of P. ginseng and P. notoginseng in wound healing. In this study, a wound healing-related "ingredients-targets" network of two herbs was constructed. Thereafter, meta-analysis of the multiple target lists by Metascape showed that these two medicines significantly regulated blood vessel development, responses to cytokines and growth factors and oxygen levels, cell death, cell proliferation and differentiation, and cell adhesion. To better understand the discrepancy between these two herbs, it was found that common signaling pathways including Rap1, PI3K/AKT, MAPK, HIF-1 and Focal adhesion regulated the functions listed above. In parallel, the different pathways including renin-angiotensin system, RNA transport and circadian rhythm, autophagy, and the different metabolic pathways may also explained the discrepancies in the regulation of the above-mentioned functions, consistent with the Traditional Chinese Medicine theory about the effects of P. ginseng and P. notoginseng.

• Journal of Korea Society of Industrial Information Systems
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• v.28 no.6
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• pp.173-187
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• 2023

This study aims to determine whether ESG performance positively affects foreign ownership for listed firms that publish sustainability reports. Furthermore, we test whether the disclosure of environmental information in the sustainability report in accordance with the TCFD recommendations moderates the relationship between ESG performance and foreign ownership. The results of the empirical analysis are as follows. First, there is a positive correlation between ESG performance in a given year and foreign ownership in the following year, i.e., the higher a firm's ESG performance, the higher its foreign ownership. Second, the presence of environmental disclosure in accordance with the TCFD recommendations positively moderates the relationship between ESG performance and foreign ownership, i.e., environmental disclosure in accordance with the TCFD recommendations strengthens the positive relationship between ESG performance and foreign ownership. In conclusion, this study shows that foreign investors invest more in companies with better ESG performance, and the effect is stronger for companies that disclose environmental information in accordance with TCFD recommendations.