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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

  • Song, Young-Hoon (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Nam, Sun-Young (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Young-Jin (Biochip Research Center, Hoseo University) ;
  • Kim, Jeong-Hwa (Graduate School of Social Welfare, Ewha Womans University) ;
  • Kim, Young-Sick (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
  • Received : 2012.07.06
  • Accepted : 2012.08.27
  • Published : 2012.08.31
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Abstract

The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

Keywords

References

  1. Allakhverdi Z, Comeau MR, Jessup HK, Yoon BR, Brewer A, Chartier S, Paquette N, Ziegler SF, Sarfati M, Delespesse G. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med. 2007;204:253-258. https://doi.org/10.1084/jem.20062211
  2. Arafa HM, Aly HA, Abd-Ellah MF, EI-Refaey HM. Hesperidin attenuates benzo [alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance. Toxicol Ind Health. 2009;25:417-427. https://doi.org/10.1177/0748233709106624
  3. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H, ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733-43. https://doi.org/10.1016/S0140-6736(06)69283-0
  4. Bailey WC, Clark NM, Gotsch AR, Lemen RJ, O'Connor GT, Rosenstock IM. Asthma prevention. Task force on research and education for the prevention and control of respiratory diseases. Chest 1992;102(3 Suppl):216S-231S.
  5. Benavente-Garcia O, Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 2008;56:6185-6205. https://doi.org/10.1021/jf8006568
  6. Bunyavanich S, Melen E, WIlk JB, Granada M, Soto-Quiros ME, Avila L, Lasy-Su J, Hmininghake GM, Wickman M, Pershagen G, O'COIlllor GT, Weiss ST, Celedon JC. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clin Mol Allergy. 2011 ;9:e1. https://doi.org/10.1186/1476-7961-9-1
  7. Butterfield JH, Weiler D, Dewald G, Gleich G.J. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res. 1988;12:345-355. https://doi.org/10.1016/0145-2126(88)90050-1
  8. Camargo CA Jr, Rachelefsky G, Schatz M. Managing asthma exacerbations in the emergency department: summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines for the management of asthma exacerbations. J Emerg Med. 2009;37(2 Suppl):S6-S17. https://doi.org/10.1016/j.jemermed.2009.06.105
  9. Choi IY, Kim SJ, Jeong HJ, Park SH, Song YS, Lee JH, Kang TH, Park JH, Hwang GS, Lee EJ, Hong SH, Kim HM, Um JY. Hesperidin inhibits expression of hypoxia inducible factor-1 alpha and inflammatory cytokine production from mast cells. Mol Cell Biochem. 2007;305:153-161. https://doi.org/10.1007/s11010-007-9539-x
  10. Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1 beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007;322:8-15. https://doi.org/10.1124/jpet.107.119792
  11. Ford, ME, Edwards G, Rodriguez JL, Gibson RC. Tilley BC. An empowerment-centered, church-based asthma education program for African American adults. Health and Social Work. 1996;21:70-75. https://doi.org/10.1093/hsw/21.1.70
  12. Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells:negative, as well as positive, regulators of immunity. Nat Rev Immunol. 2008;8:478-486. https://doi.org/10.1038/nri2327
  13. Han NR, Moon PD, Kim HM, Jeong HJ. Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Life Sci. 2012;90:147-153. https://doi.org/10.1016/j.lfs.2011.10.015
  14. Han NR, Kim HM, Jeong HJ. Kanamycin activates caspase-1 in NC/Nga mice. Exp Dermatol. 2011;20:659-663. https://doi.org/10.1111/j.1600-0625.2011.01291.x
  15. Hansel NN, Matsui EC, Rusher R, McCormack MC, Curtin-Brosnan J, Peng RD, Mazique D, Breysse PN, Diette GB. Predicting future asthma morbidity in preschool inner-city children. J Asthma. 2011;48:797-803. https://doi.org/10.3109/02770903.2011.604887
  16. Jeong HJ, Choi Y, Kim KY, Kim MH, Kim HM. C-Kit Binding Properties of Hesperidin (a Major Component of KMP6) as a Potential Anti-Allergic Agent. PLoS One. 2011;6:e19528. https://doi.org/10.1371/journal.pone.0019528
  17. Kang TH, Han NR, Kim HM, Jeong HJ. Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III. J Nat Prod. 2011;74:223-227. https://doi.org/10.1021/np100686a
  18. Kitajima J, Kamoshita A, Ishikawa T, Takano A, Fukuda T, Isoda S, Ida Y. Glycosides of Atractylodes lancea. Chem Pharm Bull. 2003;51:673-678. https://doi.org/10.1248/cpb.51.673
  19. Kimura I. Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions. Yakugaku Zasshi. 2006;126:133-143. https://doi.org/10.1248/yakushi.126.133
  20. Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002;416:194-199. https://doi.org/10.1038/416194a
  21. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science. 1995;267:2000-2003. https://doi.org/10.1126/science.7535475
  22. Leonard WJ. TSLP: Finally in the limelight. Nat Immunol. 2002;3:605-607. https://doi.org/10.1038/ni0702-605
  23. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 2000;105: 860-76. https://doi.org/10.1067/mai.2000.106484
  24. Liu YJ. Thymic stromal lymphopoietin: Master switch for allergic inflammation. J Exp Med. 2006;203:269-273. https://doi.org/10.1084/jem.20051745
  25. Miller GE, Cohen S. Psychological interventions and the immune system: A meta-analytic review and critique. Health Psychology. 2001;20:47-63. https://doi.org/10.1037/0278-6133.20.1.47
  26. Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A. Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol. 2008;38: 1487-1492. https://doi.org/10.1002/eji.200737809
  27. Miyazah D, Nakamura T, Toda M, Cheung-Chau KW, Richardson RM, Ono SJ. Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J Clin Invest. 2005;115:434-442. https://doi.org/10.1172/JCI18452
  28. Moon PD, Kim HM. Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-KB pathway in mast cells. Cytokine. 2011;54:239-243. https://doi.org/10.1016/j.cyto.2011.03.007
  29. Oh HA, Kim HM, Jeong HJ. Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract (KMP6). Immunopharmacol Immunotoxicol. 2012b;34:135-142. https://doi.org/10.3109/08923973.2011.587128
  30. Oh HA, Ryu JG, Cha WS, Kim HM, Jeong HJ. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. TANG. 2012a:2:e9. https://doi.org/10.5667/tang.2011.0002
  31. Parker-Oliver D. Asthma management: A role for social work. Health and Social work. 2005;30:167-170. https://doi.org/10.1093/hsw/30.2.167
  32. Rahman S, Sultana S. Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in Swiss albino mice. J Enzyme Inhib Med Chem. 2007;22:363-369. https://doi.org/10.1080/14756360601074094
  33. Reed SD, Lee TA, McCrory DC. The economic burden of allergic rhinitis. Pharmacoeconomics. 2004;22:345-361. https://doi.org/10.2165/00019053-200422060-00002
  34. Sakurai T, Yamada H, Saito K, Kano Y. Enzyme inhibitory activities of acetylene and sesquiterpene compounds In atractylodes rhizome. Biolo Pharm Bull. 1993;16: 42-145.
  35. Takei M, Kobayashi M, Herndon DN, Pollard RB, Suzuki F. Glycyrrhizin inhibits the manifestations of anti-inflammatory responses that appear In association with systemic inflammatory response syndrome (SIRS)-like reactions. Cytokine. 2006;35:295-301. https://doi.org/10.1016/j.cyto.2006.10.002
  36. Tanaka K, Hasegawa J, Asamitsu K, Okamoto T. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappa B. Eur J Pharmacol. 2007;565:212-219. https://doi.org/10.1016/j.ejphar.2007.01.095
  37. Taylor BC, Zaph C, Troy AE, Du Y, Guild KJ, Comeau MR, Artis D. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med. 2009;206:655-667. https://doi.org/10.1084/jem.20081499
  38. Wu X, Guo R, Chen P, Wang Q, Cunningham PN. TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism. Am J Physiol Renal Physiol. 2009;297:F316-326. https://doi.org/10.1152/ajprenal.00089.2009
  39. Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL; PATCH Study Group. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011;48:503-10. https://doi.org/10.3109/02770903.2011.576743
  40. Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L375-382. https://doi.org/10.1152/ajplung.00045.2007
  41. Ziegler SF, Artis D. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol. 2010;11:289-293. https://doi.org/10.1038/ni.1852

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