• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.77-85
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• 2011

Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathway studio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.

• Korean Journal of Clinical Pharmacy
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• v.31 no.4
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• pp.324-331
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• 2021

To investigate signals of adverse drug reactions of finasteride by using the Korea Adverse Events Reporting System (KAERS) database. This pharmacovigilance was based on the database of the drug-related adverse reactions reported spontaneously to the KAERS from 2013 to 2017. This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of finasteride. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). The signals of finasteride were compared with those of the other drugs; dutasteride (similar mechanism of action), minoxidil (different mechanism but similar indications for alopecia), silodosin (different mechanism but similar indications for BPH). It was examined whether the detected signals exist in drug labels in Korea. The total number of adverse event-drug pairs was reported 2,665,429 from 2013 to 2017, of which 1,426 were associated with finasteride. The number of investigated signals of finasteride was 42. The signals that did not include in the drug label were 29 signals, including mouth dry, hypotension, dysuria etc. The signal of finasteride was similar to that of dutasteride and silodosin but was different to that of minoxidil. Early detection of signals through pharmacovigilance is important to patient safety. We investigated 29 signals of finasteride that do not exist in drug labels in Korea. Further pharmacoepidemiological studies should be needed to evaluate the signal causality with finasteride.

• Proceedings of the Acoustical Society of Korea Conference
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• 1998.08a
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• pp.87-92
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• 1998

In general, the synthesis unit database was constructed by recording isolated word. In that case, each boundary of word has typical prosodic pattern like a falling intonation or preboundary lengthening. To get natural synthetic speech using these kinds of database, we must artificially distort original speech. However, that artificial process rather resulted in unnatural, unintelligible synthetic speech due to the excessive prosodic modification on speech signal. To overcome these problems, we gathered thousands of sentences for synthesis database. To make a phone level synthesis unit, we trained speech recognizer with the recorded speech, and then segmented phone boundaries automatically. In addition, we used laryngo graph for the epoch detection. From the automatically generated synthesis database, we chose the best phone and directly concatenated it without any prosody processing. To select the best phone among multiple phone candidates, we used prosodic information such as break strength of word boundaries, phonetic contexts, cepstrum, pitch, energy, and phone duration. From the pilot test, we obtained some positive results.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.8
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• pp.742-747
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• 2004

Outdoors we can easily acquire our accurate location by GPS. However, the GPS signal can't be acquired indoors because of its weak signal power level. Adequate positioning method is demanded for many indoor positioning applications. At present, wireless local area network (WLAN) is widely installed in various areas such as airport, campus, and park. This paper proposes a positioning algorithm using WLAN signal strength to provide the position of the WLAN user indoors. There are two methods for WLAN based positioning, the signal propagation method uses signal strength model over space and the empirical method uses RF power propagation database. The proposed method uses the probability distribution of the power propagation and the maximum likelihood estimation (MLE) algorithm based on power strength DB. Test results show that the proposed method can provide reasonably accurate position information.

• Herbal Formula Science
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• v.18 no.2
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• pp.227-239
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• 2010

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.2
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• pp.385-391
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• 2001

In this study, we will develop the sea surface interpretation system that can aware the target in the bottom of the sea. we will setup the database whose records would be the signal patterns of formation about mud, sand, rock and sea shell achieved by using supersonic. then we will convert analog signal received in fish detector to digital one using A/D converter So we can process and analyze this signal pattern then compare it to the one in our Database at the real time to identify the target in the bottom of the sea. After enough times of experiments from the background of the results that have been achieved from many studies(including a water tank experiment and a field investigation), we can aware the exact information of the sediment and the sand in the sea. By analyzing the first, second and third signal of the supersonic characters reflected from the body of a fish categorized by its family and from the body of shellfish, muddy sand, sand and rocks, We will develop the sea surface decipherment system which abstracts the first signal that shows the target in the bottom of the sea and makes the second and third signals filtering.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.45 no.4
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• pp.42-50
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• 2008

The real-time bio-signal monitoring system based on the ZigBee and SIP/RTP has proposed and implemented for telemedicine but that has some problems at the stabilities to transmit bio-signal from the sensors to the other sides. In this paper, we designed and implemented a real-time bio-signal monitoring system that is focused on the reliability and efficiency for transmitting bio-signal at real-time. We designed the system to have enhanced architecture and performance in the ubiquitous sensor network, SIP/RTP real-time transmission and management of the database. The Bluetooth network is combined with ZigBee network to distribute traffic of the ECG and the other bio-signal. The modified and multiplied RTP session is used to ensure real-time transmission of ECG, other bio-signals and speech information on the internet. The modified ECG compression method based on DWLT and MSVQ is used to reduce data rate for storing ECG to the database. Finally we implemented a system that has improved performance for transmitting bio-signal from the sensors to the monitoring console and database. This implemented system makes possible to make various applications to serve U-health care services.

• Proceedings of the KIEE Conference
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• 2006.04a
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• pp.48-50
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• 2006

In this paper, we propose a method to minimize the baseline wandering that make hard to detect R wave in ECG. This method uses a different signal between ECG and ascending slope tracing waves to minimize the baseline wandering. When the slope of ECG signal maintains the value or falls, the ascending slope tracing wave fellows ECG signal directly, and this wave holds that value of ECG signal when the slope begins to rises in a certain time(=hold time). After this hold time, this wave traces ECG signal again. To evaluate this minimizing method for baseline wandering, the experiments are carried out with 5 ECG data in the database of MIT/BIH. R waves in the proposed different signal are detected by using descending slope trace waves and compared with the annotation file. The results show that the proposed method Is sure to minimize the baseline wandering in ECG.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.2C
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• pp.181-185
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• 2009

When we classify underwater transient signals with frame-by-frame decision, a database design method for reference feature vectors influences on the system performance such as size of database, computational burden and recognition rate. In this paper the LBG vector quantization algorithm is applied to reduction of the number of feature vectors for each reference signal for efficient classification of underwater transient signals. Experimental results have shown that drastic reduction of the database size can be achieved while maintaining the classification performance by using the LBG vector quantization.

• Smart Media Journal
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• v.7 no.4
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• pp.90-98
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• 2018

A Multilinear LDA Method of Tensor Representation for ECG Signal Based Individual Identification Electrocardiogram signals, included in the cardiac electrical activity, are often analyzed and used for various purposes such as heart rate measurement, heartbeat rhythm test, heart abnormality diagnosis, emotion recognition and biometrics. The objective of this paper is to perform individual identification operation based on Multilinear Linear Discriminant Analysis (MLDA) with the tensor feature. The MLDA can solve dimensional aspects of classification problems in high-dimensional tensor, and correlated subspaces can be used to distinguish between different classes. In order to evaluate the performance, we used MPhysionet's MIT-BIH database. The experimental results on this database showed that the individual identification by MLDA outperformed that by PCA and LDA.