• 한국소음진동공학회논문집
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• 제16권9호
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• pp.937-948
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• 2006

In this study, a fluid/structure coupled analysis system for simulating complex flow-induced vibration (FIV) phenomenon of cascades has been developed. The flow is modeled using Euler and Wavier-Stokes equations with different turbulent models. The fluid domains are modeled using the unstructured grid system with dynamic deformations due to the motion of structural boundary. The Spalart-Allmaras (S-A) and the SST ${\kappa}-{\omega}$ turbulent models are used to predict the transonic turbulent flows. A fully implicit time marching scheme based on the Newmark direct integration method is used in order to solve the coupled governing equations for viscous flow-induced vibration phenomena. For the purpose of validation for the developed FIV analysis system, comparison results for computational analyses of steady and unsteady aerodynamics and flutter analyses are presented in the transonic flow region. In addition, flow-induced vibration analyses for the isolated cascade and multi-blades cascade models have been conducted to show the physical fluid-structure interaction effects in the time domain.

• 천문학회보
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• 제35권1호
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• pp.69.1-69.1
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• 2010

IC 443 is famous for its interaction with nearby molecular clouds and intense H2 emission lines in infrared. Therefore, it has been studied extensively for the understanding of molecular shocks. We observed H2 mission lines toward the shock-cloud interaction regions of IC 443, known as clumps B, C, and G. The observations were performed with the InfraRed Camera (IRC) onboard a satellite AKARI over 2.5-5.0 um, where previous space observations, e.g. Infrared Space Observatory (ISO) and Spitzer, do not cover. Our AKARI observations provide spectra of sequential pure-rotational and ro-vibrational H2 emission lines. For the clumps C and G, combining with previous mid-infrared observational results, we found that the H2 level populations show a significant separation between v=0 and v=1 levels; v=1 levels are under-populated than v=0 levels, therefore, the population cannot be described by two temperature LTE model, as many people have analyzed for the shocked H2 gas. We also applied the thermal admixture model, dN(H2; T)~T^(-b) dT, with varying ortho-to-para ratios according to the temperature, to describe the level population, and obtained plausible ranges of the H2 gas density and power-law index b.

• 천문학회보
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• 제42권1호
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• pp.54.3-55
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• 2017

The nature and physical environments of SNRs are diverse, and for this reason, the understanding of the properties of nearby SNRs is useful in interpreting the emission from SNRs in remote galaxies where we cannot resolve them. In this regard, the LMC is a unique place to study SNRs due to its proximity, location, and composition compared with our galaxy. We carried out a multi-wavelength study of SNR N63A in the LMC, a young remnant of the SN explosion of one of the most massive (> 40 Msun) stars in a cluster. It is currently expanding within a large H II region formed by OB stars in the cluster and engulfing a molecular cloud (MC). As such, N63A is a prototypical SNR showing the impact of SN explosion on the cluster and its environment. Its morphology varies strongly across the wave bands, e.g. the size in X-ray is three times larger than in optical. However, the bright optical nebula would correspond to a MC swept up by the SNR, and consequently the interaction SNR-MC is limited to the central portion of the SNR. We aimed to study the overall structure of N63A, using near-IR imaging and spectroscopic observations to obtain the physical parameters of the atomic shocks, and also to understand how the SNR- MC interaction works and reveal the structure of the shocked cloud as well as the consequences of the impact of the SNR shock on the MC, comparing information obtained in different wavelengths.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 춘계학술대회논문집
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• pp.793-802
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• 2006

In this study, a fluid/structure coupled analysis system for simulating complex flow-induced vibration (FIV) phenomenon of cascades has been developed. The flow is modeled using Euler and Wavier-Stokes equations with different turbulent models. The fluid domains are modeled using the unstructured grid system with dynamic deformations due to the motion of structural boundary. The Spalart-Allmaras (S-A) and the SST ${\kappa}-{\omega}$ turbulent models are used to predict the transonic turbulent flows. A fully implicit time marching scheme based on the Newmark direct integration method is used in order to solve the coupled governing equations for viscous flow-induced vibration phenomena. For the purpose of validation for the developed FIV analysis system, comparison results for computational analyses of steady and unsteady aerodynamics and flutter analyses are presented in the transonic flow region. In addition, flow-induced vibration analyses for the isolated cascade and multi-blades cascade models have been conducted to show the physical fluid-structure interaction effects in the time domain.

• 대한의생명과학회지
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• 제9권2호
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• pp.105-110
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• 2003

Ankyrins are a ubiquitously expressed family of intracellular adaptor proteins involved in targeting diverse proteins to specialized membrane domains in both the plasma membrane and the endoplasmic reticulum. Canonical ankyrins are 190-220 kDa proteins expressed in most tissues and cell types and comprise a membrane-binding domain (MBD) of 24 ANK repeats, a spectrin-binding domain, a death domain and a C-terminal domain. Rescue studies with ankyrin-B/G chimeras have identified the C-terminal domain of ankyrin-B as the defining domain in specifying ankyrin-B activity, but the function of C-terminal domain of ankyrin-B is, however, not known. We report here that the C-terminal domain of ankyrin-B is capable of interacting with the C-terminal Region of Hsp40. The Hsps are induced not only by heat shock but also by various other environmental stresses. Hsps are also expressed constitutively at normal growth temperatures and have basic and indispensable functions in the life cycle of proteins as molecular chaperones, as well as playing a role in protecting cells from the deleterious stresses. The binding sites required in the interaction between C-terminal domain of ankyrin-B and C-terminal region of Hsp40 were characterized using the yeast two-hybrid system and GST-pull down assay. The interaction between ankyrin-B and Hsp40 represents the first direct evidence of ankyrin's role as chaperones.

• 천문학회지
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• 제36권3호
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• pp.89-95
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• 2003

Observations of dark matter dominated dwarf and low surface brightness disk galaxies favor density profiles with a flat-density core, while cold dark matter (CDM) N-body simulations form halos with central cusps, instead. This apparent discrepancy has motivated a re-examination of the microscopic nature of the dark matter in order to explain the observed halo profiles, including the suggestion that CDM has a non-gravitational self-interaction. We study the formation and evolution of self-interacting dark matter (SIDM) halos. We find analytical, fully cosmological similarity solutions for their dynamics, which take proper account of the collisional interaction of SIDM particles, based on a fluid approximation derived from the Boltzmann equation. The SIDM particles scatter each other elastically, which results in an effective thermal conductivity that heats the halo core and flattens its density profile. These similarity solutions are relevant to galactic and cluster halo formation in the CDM model. We assume that the local density maximum which serves as the progenitor of the halo has an initial mass profile ${\delta}M / M {\propto} M^{-{\epsilon}$, as in the familiar secondary infall model. If $\epsilon$ = 1/6, SIDM halos will evolve self-similarly, with a cold, supersonic infall which is terminated by a strong accretion shock. Different solutions arise for different values of the dimensionless collisionality parameter, $Q {\equiv}{\sigma}p_br_s$, where $\sigma$ is the SIDM particle scattering cross section per unit mass, $p_b$ is the cosmic mean density, and $r_s$ is the shock radius. For all these solutions, a flat-density, isothermal core is present which grows in size as a fixed fraction of $r_s$. We find two different regimes for these solutions: 1) for $Q < Q_{th}({\simeq} 7.35{\times} 10^{-4}$), the core density decreases and core size increases as Q increases; 2) for $Q > Q_{th}$, the core density increases and core size decreases as Q increases. Our similarity solutions are in good agreement with previous results of N-body simulation of SIDM halos, which correspond to the low-Q regime, for which SIDM halo profiles match the observed galactic rotation curves if $Q {\~} [8.4 {\times}10^{-4} - 4.9 {\times} 10^{-2}]Q_{th}$, or ${\sigma}{\~} [0.56 - 5.6] cm^2g{-1}$. These similarity solutions also show that, as $Q {\to}{\infty}$, the central density acquires a singular profile, in agreement with some earlier simulation results which approximated the effects of SIDM collisionality by considering an ordinary fluid without conductivity, i.e. the limit of mean free path ${\lambda}_{mfp}{\to} 0$. The intermediate regime where $Q {\~} [18.6 - 231]Q_{th}$ or ${\sigma}{\~} [1.2{\times}10^4 - 2.7{\times}10^4] cm^2g{-1}$, for which we find flat-density cores comparable to those of the low-Q solutions preferred to make SIDM halos match halo observations, has not previously been identified. Further study of this regime is warranted.

• Coupled systems mechanics
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• 제11권4호
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• pp.315-333
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• 2022

Fluid-Structure Interaction (FSI) modeling is highly effective to reveal deformations, fatigue failures, and stresses on a solid domain caused by the fluid flow. Mechanical properties of the solid structures and the thermophysical properties of fluids can change under different operating conditions. In this study, we investigated the interaction of [45/-45]₂ wounded composite tubes with the fluid flows suddenly pressurized to 5 Bar, 10 Bar, and 15 Bar at the ambient temperatures of 24℃, 66℃, and 82℃, respectively. Numerical analyzes were performed under each temperature and pressure condition and the results were compared depending on the time in a period and along the length of the tube. The main purpose of this study is to present the effects of the variations in fluid characteristics by temperature and pressure on the structural response. The variation of the thermophysical properties of the fluid directly affects the deformation and stress in the material due to the Wall Shear Stress (WSS) generated by the fluid flow. The increase or decrease in WSS directly affected the deformations. Results show that the increase in deformation is more than 50% between 5 Bar and 10 Bar for the same operating condition and it is more than 100% between 5 Bar and 15 Bar by the increase in pressure, as expected in terms of the solid mechanics. In the case of the increase in the temperature of fluid and ambient, the WSS and Von Mises stress decrease while the slight increases of deformations take place on the tube. On the other hand, two-way FSI modeling is needed to observe the effects of hydraulic shock and developing flow on the structural response of composite tubes.

• 생명과학회지
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• 제26권1호
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• pp.101-108
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• 2016

본 연구에서는 미만형 위암조직에서의 임상병리학적 인자와 HSP70, BAG1, Raf-1의 발현간의 상관관계를 평가하고자 하였다. Hsp70은 열충격단백질(heat shock protein)의 환경적 스트레스로부터 세포를 보호하는 분자생물학적 chaperone으로 작용하는 것뿐 아니라 anti-apoptotic 작용을 통하여 암세포의 생존과 전이를 촉진시키는 것으로 알려져 있다. Proto-oncogene의 일종인 Raf는 사람을 포함한 진핵세포의 생장에 관여하는 중요한 신호전달경로인 mitogen-activated protein kinase (MAPK)경로의 중심인자로서 다양한 암에서 그 발현이 증가한다고 알려져 있다. Bcl-2에 결합하여 세포사멸을 저해하는 것으로 처음 보고된 Bcl-2-associated athanogene-1 (BAG-1)은 다양한 암에서 그 발현이 증가된다고 보고되었다. 또한 BAG-1은 HSP70과 상호작용하여 Raf-1-ERK signal pathway와 cell growth를 조절하는 것으로 보고되었다. Hsp70의 발현은 임파절 전이가 있는 경우 24례(64.9%)에서 양성, 13례(35.1%)에서 음성을 보였으며, 임파절 전이가 없는 경우 6례(26.1%)에서 양성, 17례(73.9%)에서 음성을 보여 임파절의 전이가 있는 경우가 임파절 전이가 없는 경우에 비해 유의하게 높은 발현율을 보였다(p=0.007). N-stage에 따른 발현은 N-stage가 증가함에 따라 발현율이 유의하게 증가하였다(p=0.006). BAG1의발현은 전체 대상 환자 중 43례(71.7%)에서 양성, 17례(28.3%)에서 음성소견을 보였으며, 65세 미만에서 65세 이상에 비해 유의하게 높은 발현율을 보였다(p=0.035). RAF1의 경우 전체 대상 환자 중 45례(75.0%)에서 양성, 15례(25.0%)에서 음성소견을 보였으며, BAG1 양성환자에서 RAF1의 발현이 유의하게 증가 하였다(p=0.021). 본연구 결과 Hsp70은 종양의 진행과 상관성이 있을 것으로 생각되어지며, BAG1과 Raf-1은 미만형위 암의 진단적 마커로 유용할 것으로 사료된다.

• 한국항공우주학회지
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• 제33권3호
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• pp.1-9
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• 2005

본 논문에서는 직접모사법을 이용하여 고 고도 희박 영역에서 로켓의 자세 제어에 필수적인 측면 제트 분사와 그에 따른 자유 흐름 유동과 측면 제트의 상호 작용에 대한 연구를 수행하였다. 밀도 차가 큰 자유 흐름 유동과 제트 유동을 동시에 모사하기 위해 입자 가중치 기법을 사용하였다. 두 수직한 평판 사이의 유동 및 측면 제트 분사에 의한 상호 작용 해석을 수행하였고 그 결과를 실험치와 비교하여 프로그램을 검증하였다. 좀 더 실제적인 로켓 모델로 blunted cone cylinder 형상에 대하여 받음각을 변화시켜가며 자유 흐름 유동과 측면 제트의 상호 작용에 대한 연구를 수행하였다. 표면 압력 차이의 분포를 기준으로 람다(lambda) 충격파와 후류의 영향을 토의하였다. 받음각이 있는 유동의 경우 leeward 방향으로는 제트와 자유 흐름 유동의 상호 작용이 약해지며, windward 방향으로는 상호 작용이 매우 강해지는 것을 확인할 수 있었다.

• 한국포장학회지
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• 제21권2호
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• pp.67-71
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• 2015

Shock and vibration inputs are transmitted from the transporting vehicle through the packaging to the fruit during the parcel delivery service. The vibration causes sustained bouncing of fruits against each other and the container wall. The steady state vibration input may cause serous fruit injury, and the damage is particularly severe if the fruits are bounced at its resonance frequency. The determination of the resonance frequencies of the fruits and vegetables may help the packaging designer to determine the proper packaging system providing adequate protection for the fruits, and to understand the complex interaction between the components of the fruits when they relate to expected transportation vibration inputs. To analyze the vibration properties of the apples for optimum packaging design during transportation for parcel delivery service, random vibration tests were carried out. In the random vibration test, the resonance frequency and PSD of the apples in packaging system for parcel delivery service in the test were in the range of 13 to 99 Hz and $0.0143{\sim}0.0923G^2/Hz$.