• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.111-118
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• 2009

Puopose : Exposure to dietary phytoestrogens such as genistein during early childhood is a growing public health concern. We examined the effect of early exposure to genistein on sexual maturation in immature rats. Methods : Weaning (3wk-old) Sprague-Dawley female rats were assigned to three groups (n=6 for each): fed by high dose of genistein (100 mg/kg/d), low dose of genistein (10 mg/kg/d) and control group. First vaginal opening (VO) day was observed. Structural alterations in the ovary and uterus were assessed by histologically. Expression of genes of $ER{\alpha}$, $ER{\beta}$, and progesterone receptor (PR) in the ovary and uterus were investigated by RT-PCR. Results : High genistein group had earlier VO than control and low genistein group. Graafian follicles and corpora lutea were observed from the ovary of genistein-treated groups, while primary, secondary follicles and small atretic follicles were observed in the control group. Hypertrophy of luminal and glandular uterine epithelia were found in the genistein-treated groups while poor development of gland and fewer myometrial cell layers were evident in control group. In ovary, the transcriptional activities of $ER{\alpha}$ and $ER{\beta}$ were higher in high genistein group than in controls. In uterus, the transcriptional activities of $ER{\alpha}$, $ER{\beta}$ and PR were higher in low genistein group than in controls. Conclusion : Acute exposure to genistein during the prepubertal period could activate the reproductive endocrine system resulting in the early onset of puberty in female rats. Further clinical investigation on the effect of genistein on the sexual maturation in children is warranted.

• CELLMED
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• v.8 no.2
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• pp.6.1-6.7
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• 2018

Myristica fragrans Houtt is commonly known as "nutmeg", it produces two spices: mace and nutmeg. Mace and nutmeg are strongly aromatic in nature and known as jowzabuwa and javetri/bisbasah respectively in the Unani system of medicine. M. fragrans was used as early as 700 BCE by Indian, however, ancient Greeks and Romans were not aware of it. Later Arab traders introduce M. fragrans into Europe followed by Portuguese and Dutch merchants. Mace is very useful medicine in the Unani system of medicine because of its therapeutic uses in salasal al-bawl (urinary incontinence), amrad-i-qalb (cardiac diseases), amrad-i-dimagh (central nervous system), zo'fe bah (sexual debility), amrad al-rahim (uterine diseases), and su-i-hazim (indigestion). The most important constituents of mace essential oil are ${\alpha}-pinene$, sabinene, myrcene, limonene, 1,8-cineole, terpinen-4-ol, myristicin, ${\gamma}-terpinene$, and safrole. The seed and mace extract of nutmeg contain quite high tannins, flavonoids, and terpenoids. Mace has pharmacological functions such as antibacterial and antifungal, anti-inflammatory, analgesic, antidiarrhea, antioxidant, chemoprotective, neuropharmacologic, and antidiabetic properties. To explore the correlation between the traditional uses and the same proven by recent researches, a comprehensive review is highlighted in this paper. Further, pharmacological activities which are not reported in classical texts are also discussed.

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.137-137
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• 2001

Purpose： The purpose of this study was to identify cerebral cortices related with sexual arousal fro visual sexual stimulation in healthy males using BOLD-based functional MR imaging Method： Sixteen male volunteers with sexually potent(mean age：24) were examined for thi study. Functional MRI was performed on a 1.5T MR scanner(GE Signa Horizon) with birdcage-type head coil. In this study, blood oxygenation level dependent(BOLD) technique was utilized to create fMR image reflecting local brain activities. The BOLD-based fMRI d were obtained from 7 oblique planes using gradient-echo EPI with $90^{\circ}$flip angle, 50ms TE 6000ms TR, $26cm{\times}26$ cm FOV, $128{\times}128$ matrix, and 10mm slice thickness. The sexual stimulation paradigm consisted of two alternating periods of rest and activati and it began with a 1 minute rest, followed by a 2 minute stimulation by a documentary a erotic video film. Brain activation maps were generated by cross-correlation of imag acquired during rest and activation periods. The index of activation was used to compare t number of pixels activated by each task in each volunteer, where the significance of th differences was evaluated by using Students t-test.

• Journal of East-West Nursing Research
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• v.2 no.1
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• pp.83-95
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• 1997

Cooking food is very important in Chinese medicine when we regard the food to be the principal origin of the nutrition of human body and the condition required to maitain the activities of the life of human body. Chinese medicine has accumulated the diverse and rich experience of cooking food through long clinical experience as well as made an important contribution to the healthy and long life through the unique theory of cooking food. Chineses medicine has deep view on the relations between food cooking and healthy and long life as well as presented the principle of cooking food created unique ways of food cooking such as food treatment. As the above, from the ancient times, Chinese medicine established Chinese medical science of nutrition under the consciousness of the theory that food and medicine have the same origin and practiced the methods of promoting the health through rightly selecting the foods. Therefore it has been thought that human beings can enjoy healthy life by rich supply of the nutrition. Comfortable ways of sleeping requie the emotion and peace with temperation in pleasure and anger, and also we should be temporate in eating, acting, sleeping posture and be flee from the wind, and we should not put on a quilt when sleep, and we should sleep alone and be careful about sexual life. The concrete measures for sexual intercourse are that: 1) we should marry at the right age not to be married at early age. 2) we should obey nature and not live unmarried life. 3) we should be temperate in having sexual intercoure and in excessive sexual desire. Regarding the residence and clothes: the residence environment should be calm and beautiful and the room for the residence should be well designed to be clean and sanitary and we should wear suitable clothes. All living creatures are living according to the rhythm of the living body and the change of the great nature. The Reason why the living things show the periodical rhythm is not that it is the truth of the great nature, but that the living life itself shall be ceased to be existed in case of running counter to such rhythm. There are 2 specially important things: one is about food in biological view and the other is the residence in social side. By starting from the theory that food and medicine have the same origin and root, we should rightly select the foods to promote the health at the maximum, and it is very important for human to be well obeying the environment and temperate in the life of residence and mind (Choi, Sam Byun, Shon, Sook Young, 1997). As the above, the cook in Chinese medicine suggests us the suitable ways of achieving the goal of nursing. Therefore the continuous study of this field is necessary based on this my study though it is unsatisfactory at this time but it would be the basic materals in establishing the nursing science of Chinese medicine.

• Journal of Korean Academy of Nursing
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• v.28 no.1
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• pp.171-183
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• 1998

The purpose of this study was to identify the incidence of urinary incontinence in adult women and to identify factors related to life style and sexual intercourse that were related to incontinence. The sample consisted of 1,065 women living in Seoul or one of five provinces. Data for this study were collected from January 16 to June 23 using structured questionnaires. The Urinary Symptom Questionnaire developed by Jackson and a demographic questionnaire were used to collect the data. The data were analyzed using frequency, percentage with an SPSS/PC$^{+}$ program. The major finding are as follows : 1. The distribution of age of subjects was as follows : 20-29(10.1%), 20-39(17.8%), 40-49(27.3%). 50-59(22.3%), 60-69(12.9%), 70-79(6.1%). 80-89(2.8%), more than 90(0.6%). The frequency of normal delivery, 0(155%), 1-2(36.0%), 3-4(29.2%), 5-6(13.0%). more than 7(6.3%). The rate of subjects with menopause was 40.8%. 2. It was reported that 50.7% of the subjects experienced urinary incontinence with stress, mixed. and urgency incontinence being 49.8%, 43.4%, 6.8% respectively. 3. The lower urinary symptoms and incidence with urinary incontinence were as follows : Daily frequency. 22.3%, nocturia. 40.8%, urgency, 71.2%, bladder pain 47.8%, unexplainned incontinence, 32.4%, noctural incontinence, 16.1%, and frequency of incontinence, 37.7%. In term of quantity of incontinence, drop/pants damp, 29.5%, dribble/pants wet, 20.5%, flood or soaking through to outer clothing, 1.7%, and flood or running down legs or onto floor, 0.2%. 4. The symptoms related to sexual intercourse and incidence of urinary incontinence were as follows : dry vagina, 39.1%, sex life trouble, 10.8%, pain during sexual intercourse, 27.4%, and urine leakage during sexual intercourse. 8.8%. 5. Life style problems related to urinary incontinence were as follows : fluid intake restriction, 20.0%, affected daily task, 24.5%. avoidance of placess and situations, 35.0%, interference in physical activities, 30.6%, interference in relationships with other people. 19.0%. interference in relationships with husband/companion, 8.1%, and time after attack of urinary symptoms, 76.9%. In term of the feeling about the rest of their lifves the women reported : perfectly happy, 11.3%. pleased, 16.9%. mostly satisfied, 20.2%, mixed feelings, 21.0%, mostly dissatisfied, 21.0%, very unhappy 8.5%, and desperate. 1.0%. In conclusion. this study was a preliminary study to provide nursing practices guidelines for incontinence in adult women. Nurse working with adult women should develop and provide adequate care for these women.n.

• Child Health Nursing Research
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• v.6 no.2
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• pp.167-185
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• 2000

The goal of this research was to provide the basic data of sexual education for late schooler by finding out what they want to know about sex, or to see, if any, its relevancy between female and male students and between each grade. The sample for this research was a total of 453 students in 4th, 5th and 6th grade from 12 different classes at two elementary schools which were located in C city and in B province. The children were requested to write down three points on what they want to know or to learn most about sex, and their answers were put through two analytical stages in order to classify and to examine. The followings are the conclusions from the data. 1. The female cluster took 44.2% out of the whole sample, and there were 151 students per each grade. The specific girl ratios for each grade were 42.4%, 50.3% and 39.7% respectively. 2. It was noted that a total of 1,195 questions were gathered from the students writings, 45% of the questions was raised by the female students. The 4th grade students raised 432questions (43.8% by the girl) while the 5th. and the 6th grade students raised 387 (53.2% by the girl) and 376 questions (42.3% by the girl) respectively. The average number of questions per students was 2.6 while the female students raised 2.8 questions which was more than the average 2.5 questions by male students. It was the 4th grade female student cluster, which raised the most question (3.0) while the 6th grade male students raised the least question (2.4) in average. 3. The questions raised by the children could be divided into seven categories of the knowledge need on sex. They were Reproduction (310 questions, 25.9%), Sexual Culture (230, 19.2%), Concept of sex (125, 18.0%), Changes of Puberty (172, 14.4%), Sexual Health (119, 10.0%), Anatomy and Physiology of Reproductive System (78, 6.5%) and Sexual Tendency and behavior (71, 5.9%). 4. 'Reproduction' was the most frequently raised questions not only by both sex groups but also by the 5th grade students. Both sexes in the 4th grade showed the highest interest in Sexual Culture while it was Changes in Puberty for the both sexes in the 6th grade. The knowledge need on sex of the children indicated what they understand sexuality. They apprehended sex as sex, gender and sexuality in an inclusive way. They showed a major interest in the biological sex and the sexual activities. It seems that the children managed to understand clearly the meaning of gender, furthermore, they even pointed out that the streotyped sex role, patrimonial system and the sexual discrimination were unreasonable. The students possessed not only the least but also the most negative understanding in regard of sexuality. Two suggestions were made from the above conclusions for the practical sex education as well as its research. 1. For the practice: The sex education for the elementary upper grade school student should be relevant with their cognitive characteristics, also it should be more specific on the reproductive organs of both sexes, the actual scenes of the pregnancy and child delivery procedures. The gender concept should be added to the biological sex education, which will lead them to understand the unreasonableness of today's male-superior phenomenon and correct them. It is also necessary to develop educational programs for this age group so as to help them to understand sex in the sense of sexuality as well. 2. For the research: It is not easy to draw out a through conclusion since this study was carried out as one-time data collection. Yet it is undeniably helpful for the sex education if we can understand what the children want to know about sex, how much they know about it by conducting deep-interview researches through a small number of sample.

• Journal of Families and Better Life
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• v.20 no.4
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• pp.37-52
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• 2002

This study is preliminary study of the status of school counseling and demands for service at middle and high schools from universities to provide the youth middle and high schools in Changwon with counseling and educational service. The results of this research are below, First, the excessive workload became the most difficulties for operateschool counseling systems and counseling activities. Second, school counseling activities focused mainly on the formal and narrow areas of counseling such as career guidance, personality programs and intelligence test and so on. Third, the most problems which we have counselled, were friendship problems in the personal relationship, school absences in the delinquent, lack of information of sex in the sexual field, conflicts with Parents, in the family relationship, poor academic progresses in the academical and future directional problems and. character of personality difficulties in the psychological field. Fourth, the major offers from the teachers to counsel students in the school were advices, suggestions, career guidance, Preventative activities, and providing information through school counseling. Fifth, though the middle and high schools were in need of outside institutions related to counseling, It was difficult to get help because of being Ignorant of procedures or methods for using counseling and being lacking in enough information on such organizations. Sixth, ordinary students and students in danger of maladjustment besides problem students wanted to get a lot of help. Seventh, the counseling which are the most wanted from out of school was an opposite-sex relationship in the personal relationship, a lack of information on sex in the sexual fields, conflict with parents in the family problems, a strong unwillingness of study in the academical and future directional fields, and personalty difficulties In the psychological fields. Eighth, the subjects wanted to get counseling and educational service in regard to sex, addiction to PC, smoking, and ostracism and so on in counseling and education for young people. Ninth, education designed to have an adequate understanding of children turned out to be mostly needed as educational programs for parents Based on the above results, the proposals from universities for provide youth counseling and educational services are below. 1) setting up the positive publicity strategies E) developing and execution of various counseling and educational programs 3) expanding the counseling and education from maladjusted students to general students 4) expanding youth counseling and education to parental education and family counseling 5) continuous human resources improvement and training 6) reinforcement relationships with middle and high school organizations 7) building cooperation with local counseling organizations

• CELLMED
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• v.3 no.4
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• pp.26.1-26.7
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• 2013

Ginger (Zingiber officinale) belonging to the family Zingiberaceae is a perennial herb. It is widely distributed in tropical Asia. In India, it is cultivated mainly in Kerala, Andhia Pradesh, Uttar Pradesh, West Bengal and Maharashtra. It is one of the most common spices, which is in use since centuries for its versatile medicinal actions like antiemetic, stomachic, expectorant, anti-inflammatory, aphrodisiac etc in traditional system of medicine (Unani, Ayurveda, and Chinese medicine). It is useful for the treatment of various gastrointestinal, pulmonary, cardiovascular and sexual disorders. The phytochemical study of ginger showed the presence of many volatile oils and oleo-resins like gingerol, zinger one, zingiberol etc. Numerous experimental and clinical trials have proven ginger for its range of therapeutic activities such as antibacterial, antidiabetic, antiemetic, hypolipidaemic, hepatoprotective etc properties. The present article aims to explore traditional Unani and pharmacological activities of this herb reported till date.

• Journal of the Korean Home Economics Association
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• v.41 no.8
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• pp.79-95
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• 2003

The main goal of this program is to build a healthy adolescent culture tv broadening the understanding of adolescents and recognition of the environment as well through the development of educational programs centering on the domains of peer relationships, intimacy in dating relationships and sex, leisure activities, and consumption life of adolescents. The program was carried out to 10 young boys and girls for two days/one night and the major findings of the effects of the program through a qualitative evaluation were as follows: First, the program provided adolescent with a proper opportunity to promote a sense of self-confidence through the self-reevaluation process. Secondly, the program provided adolescents with a chance to firmly recognize to become good friends with others though the enhancement of self-esteem, which helped them to build a healthy peer relationship. Thirdly, adolescents were able to promote their views on sex and sexual decision-making by acquiring a proper knowledge of intimacy in dating relationships and of sex, and by candidly expressing their own opinions on sex with instructors. Fourthly, the program provided adolescents with an opportunity to look back on their leisure life with family members which had been neglected thus far and to renew their recognition of active leisure activities. Fifthly, the program provided adolescents with a chance to reflect on their unplanned consumption life and to be firmly determined to refrain from impulsive purchasing and extravagance.

• Development and Reproduction
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• v.18 no.1
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• pp.57-64
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• 2014

The flower buds of Syzygium aromaticum (clove) have been used as traditional medicine for the treatment of male sexual disorders in Asian countries. Recently, there are some reports about the effects of the clove on reproductive activities in mammals. Therefore, its effect on testicular function was examined in male golden hamsters whose reproductive activity is inhibited by photoperiod such as winter climate. The male animals were given by daily oral administrations (56 consecutive days) in three doses (4 mg, 20 mg, and 100 mg/kg BW) of the alcoholic extract of the clove. Generally lower dose (4 mg) of the extract continued to keep the reproductive activities of testes. The both middle and high doses (20 mg and 100 mg) of the extract completely inhibited the testicular activity in some animals. Taken together, these results suggest a possible biphasic action of alcoholic extract of Syzygium aromaticum flower bud on testicular function.