• 시스템엔지니어링학술지
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• 제18권2호
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• pp.24-39
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• 2022

For the success of the plant project, it is necessary to review the project's progress through technical and business reviews at an appropriate time, such as design and construction, and determine whether to invest or to proceed with the project to manage risks. In particular, since the plant development projects are not mass-produced, trial and error in design and construction can have severe impacts in terms of cost and schedule. To this end, gate reviews are currently being conducted in plants and other industrial sectors, but there are few studies on how to conduct gate reviews suitable for the plant field. In addition, there is little literature to refer to when conducting gate reviews. So, in this study, we present an overall framework that includes the types of gate reviews to be performed and items to be checked in each gate review on small and medium-sized plant development projects in which the owner directly develops and operates plants.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.89.2-90
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• 2003

Potato late blight, caused by Phytophthora infestans, is one of the important diseases in potato cultivation areas. Though the incidence of late blight was depend on the inoculums and climatic condition In each fields, the foliar blight was reached to 100％ under the severe disease pressure condition in 2003. Outbreak of foliar blight was concentrated from May and July and evaluation of ten fungicides to control of late blight was made at Daekwallryoung area in potato fields. Based on the company recommendation, those fungicides were applied by a sprayer at the recommended rates on a weekly application schedule. Effect of ten fungicides on foliar blight was based on area under disease progress curve (AUDPC). Across all fungicides was reduced by 77％ in AUDPC and dimethomorph was reduced by 92％ in AUDPC during the same period, respectively. Those fungicide were inhibited the mycelial growth of isolate with different rate in chemical amended medium and several fungicides were completely limited the growth of isolate.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.36-41
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• 2013

With the increased interest in green buildings, the building industry has been experiencing a fast-growing demand for LEED (Leadership in Energy and Environmental Design) certification for the last decade. Still, it is not unusual to see various barriers and issues during its implementation, and experience tells that they can result in harming the overall project performance with reworks, lower productivity, schedule delays, and cost overruns. In order to better understand the industry's observation on issues and their consequences during LEED implementation, we distributed an online survey, and a total of 53 responses were received. The survey results indicate that (1) both designers and non-designers (e.g., contractors) select 'added costs to design and construction' as the biggest barrier; (2) both designers and non-designers select 'decision made too late in the design process' as the most frequently observed issue; and (3) non-designers indicate higher perceived severity in every consequence criteria than designers. The statistical analyses reveal that cost overruns are the most severe impact observed and have a statistically significant relationship with responses in regard to the barrier to LEED implementation.

• Journal of the Korean Wood Science and Technology
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• 제41권6호
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• pp.535-543
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• 2013

본 연구에서 국산 낙엽송재의 공학목재로의 이용가능성, 특히 교호집성재 라미나로서의 이용가능성을 확인하기 위하여 열기건조 중과 건조 후 판재 내 잔류응력을 분석하였다. 연구결과를 통해 이쿼라이징 처리에 의한 함수율 동일화 효과가 증명되었고, 컨디셔닝 처리에 의한 잔류응력의 감소효과가 정량화되었다. 건조 중 목재 내 잔류응력 분석을 위하여 프롱법과 슬라이스법을 실시하였다. 프롱 제작 후 표면경화율을 측정하였고, 슬라이스의 절단 후 탄성변형량을 기준으로 표면으로부터 약 10 mm 깊이까지의 건조응력을 정량적으로 분석하였다. T10-C4와 T12-D5 열기건조 스케줄 적용 시 열기건조 중 판재 표면의 인장응력과 압축응력은 모두 2.2 MPa을 넘지 않음을 확인하였다. 낙엽송의 횡단방향 인장강도와 압축강도가 평균 2.65 MPa, 4.60 MPa인 점을 고려하면, 더욱 강한 건조스케줄 적용이 추천된다. 건조 후처리에 의해 폭굽음과 비틀림을 약 40% 줄일 수 있었다.

• Toxicological Research
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• 제8권2호
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• pp.217-233
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• 1992

This study was performed to determine the toxic effects of graded dose levels of SKI 2053R after repeated administration. Three groups of Sprague-Dawley rats(10M and 10F per group) were given a total of 25 i.v. injections of SKI 2053R (1.50,3.75,9.38mg/kg/day). In order to compare the toxic effects of SKI 2053R with those of cisplatin, one group of Sprague-Dawley rats (10M and 10F per group) were given a total of 25 i.v.injections of cisplatin (1.70mg/kg/day). The dosing schedule was divided into five courses of 5 consecutive days with 16-day dose-free intervals between each course. No drug-related toxicity occurred in low dose level group (1.50mg/kg/day) of SKI2053R. From the results of hematological examination, peripheral WBC counts, RBC counts and hemoglobin of high dose level group(9.38mg/kg/day)of SKI 2053R were significantly lower than those of no-treated group. Other toxicities including reduced final body weight, proteinuria and hematuria were observed in high dose level group of SKI 2053R. But, no change was detected in serum biochemical values of SKI 2053R treated groups. All of the rats in cisplatin treated group were died between 3 and 13 weeks, while rats treated with SKI2053R survived to the end except one rat of middle dose level group(3.75mg/kg/day). In histopathological examinations, rats that received cisplatin manifested severe tubular damage in kidney and hemosiderosis in spleen, but no critical pathological lesion was observed in rats of other groups. Considering the results of this study, it was concluded that non-toxic dose of SKI 2053R in this treatment schedule was estimated to be 3.75 mg/kg/day and the maximum tolerated dose was to be higher than 9.38mg/kg/day. The toxic profiles fo SKI 2053R were different from those of cisplatin, and its toxicity was considerably lower than that of cisplatin.

• 한국수자원학회논문집
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• 제40권11호
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• pp.861-867
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• 2007

본 연구는 가뭄시 제한급수를 할 경우 이에 대한 소비자의 지불의사를 추정코자 하였다. 7대 특 광역시와 32개 가뭄상습지역에 거주하는 일반인을 대상으로 가정용수 수요패턴과 가뭄을 고려한 가정용수의 가치를 추정하였다. 조사결과 상대적으로 부유한 특 광역시 주민들은 수돗물의 수량보다는 수질을 더 중요하게 생각하였고 상습가뭄지역의 주민들은 수질도 중요하지만 수량의 중요성을 강조하고 있다. 지불의사 추정을 위한 설문은 양분선택형과 개방형을 혼합하였고, 모형은 Tobit모형을 이용하였다. 예상대로 교육수준이 높을수록, 가구수가 많을수록, 소득이 높을수록 지불의사가 높은 것으로 나타났다. 가뭄으로 인해 가정용수의 25% 제한시 일인당 WTP가 약 2,010원으로 추정되었다. 그러나 예상과는 반대로, 50% 제한시에는 25% 경우 보다 조금밖에 증가하지 않았다. 이는 소비자들의 조세저항 때문이기도 하고 실제 그 같은 가뭄을 경험하지 못했기 때문일 것이다. 그럼에도 불구하고 실제 가뭄상황에 대한 소비자들의 WTP는 본 연구보다 훨씬 높을 것으로 판단된다. 중앙정부 및 지방정부들은 가까운 미래에 찾아올지도 모르는 가뭄으로 인한 물부족에 대비하여 보다 효율적인 물공급 및 분배체계를 갖추어야 할 것이며 소비자들 역시 생활용수의 확보를 위해 현재의 물 값 이상의 비용을 지불할 의사가 있음을 제시하고 있다. 따라서 정부는 상수도의 급수체계조정 및 비상시 대체수자원을 확보할 수 있는 대안을 시급히 강구해야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2391-2395
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• 2015

Objective: The aim of this retrospective study was to evaluate the feasibility and efficacy of response to continuous-infusion ifosfamide and doxorubicin combination as second-line chemotherapy for patients with recurrent or refractory osteosarcoma. Materials and Methods: Eighteen recurrent or refractory osteosarcoma patients who were treated with continuous-infusion ifosfamide and doxorubicin combination between May 1999 and April 2011 were included in the analysis. Ifosfamide at $12g/m^2$ was administered by intravenous continuous infusion over 3 days, and doxorubicin $60mg/m^2$ was administered as an intravenous bolus injection on day 1. The combination therapy was repeated every 3 weeks. Treatment was continued until evidence of disease progression or unacceptable toxicity. Results: The patients (ages 7-53 years) received a total of 42 cycles of chemotherapy (median: 2 courses; range: 2-5 courses). The overall response rate was 0% and the disease control rate was 22.3%, with four patients having stable disease. The median time to progression and overall survival time were 2 months (range: 2-5 months) and 9 months (range: 3-29 months), respectively. Major severe toxicities were leucopenia 7 (38.9%), nausea and vomiting 3 (16.7%) and alopecia 9 (50%). There were no treatment-related deaths. Conclusions: In our experience, continuous-infusion ifosfamide and doxorubicin combination therapy at this dosage and schedule was found to be well tolerated and moderate effective, which could be considered as salvage therapy for patients with recurrent or refractory osteosarcoma. Further assessment is necessary to confirm the safety and efficacy of this treatment.

• 한국해양환경ㆍ에너지학회지
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• 제15권3호
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• pp.186-197
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• 2012

새만금호 내부개발에 따른 호 내측의 수리특성과 수질환경 영향을 분석하기 위해 EFDC 모형을 이용한 심층적인 수치모의가 수행되었다. 개발이 진행되면서 방수제 및 준설 영향으로 표 저층간의 흐름특성이 변화된다. 특히 관리수위 적용에 따른 제한적인 배수갑문 운영은 기존과 다르게 표 저층간 성층발달을 심화시켜 새만금호 내측의 수질환경을 악화시키는 주요 인자로 확인되었다. 무작위행보에 의한 입자추적방법을 이용한 내부 체류시간 분석을 통해 확인된 특성은 평수시와 홍수시 그 특성이 크게 다르지만, 만경호 북측구역은 일종의 사대로 변화되어 오염물질이 장기간 체류되면서 침적된 저니층의 용출로 인해 수질환경이 악화되는 주요 원인으로 작용할 것으로 추론되었다.

• 대한간호학회지
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• 제50권5호
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• pp.646-657
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• 2020

Purpose: The purpose of this study was to identify the quality of sleep in novice and experienced shift work nurses and compare the factors associated with their quality of sleep. Methods: We analyzed the data of 192 and 256 novice and experienced nurses, respectively. The quality of sleep, sleep hygiene, job stress, and fatigue were measured using Insomnia Severity Index, Sleep Hygiene Practice Scale, the Korean Occupational Stress Scale, and Fatigue Severity Scale. Data were analyzed using SPSS 25.0 to calculate descriptive statistics and logistic regression. Results: Sleep quality was lower in experienced nurses (12.55 ± 5.71) than in novice nurses (11.18 ± 5.78). Fatigue was more severe in experienced nurses (4.47 ± 1.13) than in novice nurses (4.23 ± 1.12). In the logistic regression, factors related to sleep quality in novice nurses were sleep hygiene (odds ratio; OR = 1.06, p < .001) and fatigue (OR = 2.49, p < .001). Factors related to sleep quality in the experienced nurses were also sleep hygiene (OR = 1.04, p = .001) and fatigue (OR = 1.53, p = .012). Conclusion: Sleep quality of experienced nurses is lower than those of novice nurses. Factors associated with sleep quality in novice and experienced nurses are equally identified as sleep hygiene and fatigue. Therefore, personal efforts to improve sleep hygiene, such as providing comfortable sleep environment, are needed. Furthermore, organized efforts to decrease fatigue, such as constructing a working environment with a bright light at night and providing a fatigue-decreasing program that includes meditation, are required.

• 한국임상약학회지
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• 제25권1호
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• pp.56-58
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• 2015

Summary: We report the first hepatic adverse effect of tosufloxacin tosylate in a muscle invasive bladder cancer patient with normal liver functions and with scheduling to undergo a surgical operation for a neobladder. Tosufloxacin tosylate 150 mg was administered to a 57-year-old man who maintained transurethral resection of bladder tumor (TUR-BT) postoperative multiple medications. His labs presented significant increases in alanine amino transferase (ALT) and aspartate amino transferase (AST) levels with 2-week compliance of 150 mg tablet three times a day. After discontinuing tosufloxacin tosylate, the levels slowly decreased and completely returned to normal ranges without any intervention in a few weeks. The Naranjo Causality Algorithm indicates a probable relationship between increased ALT and tosufloxacin. The patient was to have the second surgical operation as scheduled after getting normal range of ATL level. Therefore, tosufloxacin should be avoided in patients at risk for having liver dysfunctions or diseases if the patients have a schedule for any operation. Background: Tosufloxacin tosylate has been shown to have favorable benefits as an antibiotic. Tosufloxacin tosylate may be considered to have the adverse effects such as nauseas, vomiting, diarrhea, abdominal pain, stomatitis, tendonitis, tendon rupture, headache, dizziness, drowsiness, insomnia, weakness, agitation including hemolysis in the event of glucose-6-phosphate dehydrogenase deficiency as other fluoroquinolones. More severe adverse reactions of tosufloxacin tosylate over the above common adverse effects of fluoroquinolones were thrombocytopenia and nephritis. It also is not well known that tosufloxacin can cause hepatic problem. Here the study reports the first hepatic reaction from tosufloxacin and might arouse heath care providers' attention to appropriate drug choice for patients.