• Korean Journal of Acupuncture
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• 제30권4호
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• pp.319-328
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• 2013

Objectives : The purpose of this research was to compare the effect of general acupuncture therapy to Hominis placenta Pharmacopuncture therapy on pain and discomfort of severe dyspepsia in upper abdomen. Methods : We investigated 60 cases of patients with severe dyspepsia, who had been treated at Dept. of Internal Medicine, College of Oriental Medicine Dongeui University from May 2011 to September 2012. We divided patients into two groups : Group I was treated by general acupuncture(ACU, n=30) and Group II was treated by Hominis placenta Pharmacopuncture therapy(PHA, n=30). The symptoms and quality of life were measured with the Nepean dyspepsia index-Korean version(NDI-K) at baseline and 2 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores. Results : In ACU group, the 13 symptom scores were significantly decreased after treatment(p<0.05). In PHA group, the 9 symptom scores were significantly decreased after treatment(p<0.05). In ACU group, the 3 Quality of life(QOL) scores were significantly increased after treatment(p<0.01). In PHA group, the 3 QOL scores were significantly increased after treatment(p<0.05). Conclusions : General acupuncture therapy and Hominis placenta Pharmacopuncture therapy improves the symptoms and the quality of life in patients with severe dyspepsia. But there were no significant differences statistically between the two groups.

• Journal of Yeungnam Medical Science
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• 제16권2호
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• pp.244-254
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• 1999

1998년 1월 1일부터 12월 31일까지 영남대학교와 동국대학교 의과대학 부속병원을 내원한 기능성 소화불량증 환자 90명의 심리적 특성을 알아보기 위하여, 정신과 외래 환자 64명을 대조군으로 하여 다면적 인성검사와 질병행동 설문지 조사를 실시하였으며, 그 결과는 다음과 같다. 다면적 인성검사를 통한 비교에서, 기능성 소화불량증 환자군과 정신과 외래환자군 사이에 유의한 차이가 없이 유사한 성적분포를 보였다. 양군에서 건강염려증, 우울증, 히스테리 척도에서 상대적으로 높은 점수를 보였다. 질병행동 설문지를 통한 비교에서 기능성 소화불량증 환자군이 정신과 외래환자군보다 질병집착심과 정서적 혼란 소척도에서 성적이 낮게 나왔으며, 다른 소척도들은 비슷한 성적분포를 보였다. 다면적 인성검사 성적을 이용하여 기능성 소화불량증 환자를 중다변인 군집분석한 결과, 정신과 외래의 신경증환자와 같은 집단<집단 1>, 정상인과 같은 집단<집단 2>, 신경증적 경향이 심한 집단<집단 3>으로 나눌 수 있었다. 분류된 집단들 간의 다면적 인성검사 성적 비교에서, 신경증적 경향이 심한 집단<집단 3>은, 건강염려증, 우울증, 히스테리, 강박증, 정신분열증 등의 소척도 점수가 높게 나왔다(P<.05). 신경증적인 경향이 심한 집단<집단 3>의 질병행동 설문지 결과를 보면 다른 집단들과 정서적 억압척도를 제외한 모든 척도 즉, 건강염려증, 질병집착심, 심리적 대 신체적 관심, 정서적 혼란, 부정, 자극과민성 등의 척도에서 유의하게 차이가 있는 것으로 나타났다(P<.05). <집단 3>처럼 심한 신경증적인 질병행동을 보이는 군은 정신의학적 접근이 도움을 줄 수 있는 집단이다.

• 대한한방내과학회지
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• 제42권3호
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• pp.437-443
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• 2021

Objective: This study explored the clinical usefulness of Nangan-jeon decoction to treat refractory functional dyspepsia. Methods: A 61-year-old female had been suffering from severe functional dyspepsia for about 40 years, but the dyspeptic symptoms rapidly improved after taking Nangan-jeon decoction. The clinical outcome was assessed by the numerical rating scale (NRS) and the self-reporting method. Result: After there was no improvement from various herbal treatments in a department of a Korean college hospital, the patient moved to the author's clinic. She had been diagnosed with the pattern identification of "liver-kidney deficiency cold" and prescribed with Nangan-jeon decoction. This herbal drug rapidly improved her dyspeptic symptoms, from NRS 10 to NRS 2 (after 3 weeks) and NRS 1 (after 7 weeks). Conclusion: This case report is the first to present the potential of Nangan-jeon decoction to improve refractory functional dyspepsia.

• 대한한방내과학회지
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• 제30권3호
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• pp.604-611
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• 2009

Objectives : The aim of this study was to investigate the relationship between headache and gastric dysmotility in patients with functional dyspepsia by using electrogastrogram and bowel sounds analysis. Methods : 127 patients(male 40, female 87) with functional dyspepsia were enrolled. By using inquiry and the questionnaire, we examined whether each patient had headache and abdominal pain. All patients were divided into 4 groups according to the above symptoms. Gastric motility was measured during the fasting-postprandial state by using electrogastrogram and bowel sounds analysis. Results : 33 patients complained of headache. There was a significant difference between headache patients and non-headache patients in gastric arrhythmia of the fasting state. Moreover, in headache patients without abdominal pain, postprandial improvement of gastric arrhythmia was poorer than the other groups. So, headache patients without abnormal pain had more severe gastric myoelectrical rhythm disorder than headache patients with abdominal pain. Conclusion : Headache could be one of symptoms induced by gastric dysmotility in patients with functional dyspepsia. Especially, headache in functional dyspepsia was related to gastric arrhythmia.

• 대한한방소아과학회지
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• 제16권2호
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• pp.199-213
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• 2002

We have surveyed the epidemiology of functional dyspepsia in 7 cases of Children and investigated the therapeutic effect on Functional Dyspepsia following 4 weeks medication of Naesowhajung-tang using Electrogastrogram. The Results were as followings: 1. Sex ratio are 6 males, 1 female; their mean ages, $9.0{\pm}1.41(7-11years)$; length, $137.2{\pm}13.86cm$; body weight, $35.3{\pm}l1.34kg$. 2. Most of subjects have a normal growth state. But one case have severe growth disturbance. Familial tendency for this disease is noted in 85.8%. 3. Abdominal pain was seen in 100% of subjects. The indicated symptom was lowed in order of abdominal pain(100%), nausea vomiting(71.43%), general fatigue(65.34%), vertigo headache(57.14%), belching(55.38%), etc. 4. The EGG finding after treatment was improved in 53%, aggrevated in 43. In cases, postprandial improvement was more remarkable than fasting improvement. Common cold and antibiotics seems to have functioned as an aggrevating factor on gastric motility. From the above results, Naesowhajung-tang seems to have been used in the treatment of functional dyspepsia for children.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권4호
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• pp.264-270
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• 2018

Purpose: The aim of this study was to describe functional gastrointestinal disorders (FGID) presented in a tertiary medical center, characteristics of patients and results of the diagnostic work-up together with an outcome during the follow up. Methods: This was a retrospective, single center, observational study including all patients who were diagnosed with FGID based on Rome III criteria from January to December 2015 in tertiary medical center. Results: Overall 294 children were included (mean age, 8.9 years [range, 1-18 years]; 165 females). Majority had functional constipation (35.4%), followed by functional abdominal pain (30.6%), irritable bowel syndrome (17.0%), functional dyspepsia (12.6%), functional nausea (3.4%) and abdominal migraine (1.0%). Regression model found that only significant factor associated with improvement of symptoms is the establishment of the functional diagnosis at the first visit (hazard ratio, 2.163; 95% confidence inverval, 1.029-4.544). There was no association between improvement of symptoms and presence of alarm signs/symptoms (weight loss, nocturnal symptoms and severe vomiting) at diagnosis. Furthermore, in pain symptoms (functional abdominal pain, irritable bowel syndrome, dyspepsia) no treatment positively correlated with pain improvement. Conclusion: Regardless of the initial diagnosis of FGID, positive diagnosis at the first visit increases a chance for resolution of symptoms.

• 대한한의학회지
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• 제37권2호
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• pp.119-124
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• 2016

Objectives: To demonstrate a clinical course and feature of a female patient with a severe liver injury (DILI) during antituberculosis treatment for her intestinal tuberculosis, whom traditional Korean medicine completely recovered. Methods: A female patient with diagnosed as DILI by antituberculosis drugs had been treated with herbal drugs; and then the clinical outcome and biochemical parameters had been monitored. Result: A 45-year old female had taken antituberculosis drugs for about 2 months, and complained severe abdominal discomfort and dyspepsia. The RUCAM score was 10, which met the criteria for DILI (AST 584 IU/L, ALT 1212 IU/L, ALP 100 IU/L, and GGT 161 IU/L, total bilirubin 0.9 mg/dL). She had been treated with herbal drugs and acupuncture as inpatient and outpatient, and then her symptoms had been completely recovered with normalization of hepatic enzymes. Conclusion: This report provides a clinical characteristic for a severe hepatotoxicity induced by antituberculosis drugs, and showed an example of TKM-based application.

• Integrative Medicine Research
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• 제6권3호
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• pp.317-324
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• 2017

Background: Bu-Zhong-Yi-Qi-Tang (BZYQT) has long been used for the treatment of severe weakness caused by general fatigue, loss of appetite, or indigestion. The aim of this feasibility study is to assess the effectiveness and safety of BZYQT for the treatment of functional dyspepsia (FD) with spleen qi deficiency. Methods: This study will be conducted at a single center as a prospective, nonrandomized, nonblinded, single-arm feasibility study. A total of 30 participants diagnosed with FD in accordance with the Rome III criteria will be enrolled. All patients will receive BZYQT for 4 weeks. The primary outcome is the change in the Nepean Dyspepsia Index-Korean version (NDI-K) scores between the baseline and 4-week images. The secondary outcomes include the tongue coating thickness, blood parameters, and BZYQT Questionnaire score. The NDI-K score will be acquired four times, at Weeks 0 (baseline), 2 (during treatment), 4 (after treatment), and 8 (after follow-up). Written informed consent will be obtained from all study participants prior to enrollment. This study has been approved by the Institutional Review Board of Kyung Hee University Korean Medicine Hospital. This study protocol is registered with the national clinical trial registry of the World Health Organization International Clinical Trials Registry Platform. Results will be published in a journal and will be disseminated both electronically and in print. Discussion: The results of this study may serve as a guide for researchers seeking to effectively evaluate the effects of BZYQT.

• 대한한방내과학회지
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• 제23권2호
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• pp.228-237
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• 2002

Acute hepatitis is caused by virus, alcohol. toxins and drugs. Clinical symptoms of acute hepatitis are severe fatigue, jaundice, nausea, hepatomely, lymphadenopathy. We encountered two cases of acute hepatitis, one C type viral hepatitis and the other hepatitis by overuse of medicine. The symptoms of the latter are severe fatigue, petechia and heartburning. The symptoms of the latter are severe fatigue, nausea, dyspepsia, yellow urine and skin. We recognized that total bilirubin. direct bilirubin, serum transaminase, alkaline phosphatase and gamma glutamyl transferase were elevated. We treated both patients with herb medicine(Gagamsaenggan-tang). Gagamsaenggan-tang has been used to hepatic diseases and have been known to have beneficial effects. The patients' symptoms began to improve after about two weeks of treatment. After 3 weeks on medication, the clinical symptoms and liver function of two patients were improved.

• 동의생리병리학회지
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• 제24권1호
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• pp.152-157
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• 2010

The aim of this study was to investigate the effects of traditional Korean medical therapy in patients with functional dyspepsia evaluted using multi-channel electrogastrography. Before the treatment, the EGG of 14 outpatients (male 3, female 11) with functional dyspepsia were recorded and their dominant frequency(DF), percentage of gastric slow waves, percentage of Power ratio, and percentage of slow wave couplings were analysed. For 8 weeks, the patients received acupuncture treatment. After 8 weeks, EGG was rechecked and compared with the previous data. After treatment, normogastria was significantly increased in channel 1 and channel 3($53.70{\pm}18.94$% vs $72.64{\pm}15.49$% in channel 1, P<0.05; $79.74{\pm}18.09$ vs $90.86{\pm}8.86$ in channel 3, P<0.05). arrythmia was significantly decreased in channel 3($14.34{\pm}15.21$ vs $5.93{\pm}6.90$, P<0.05). The patients who had less severe decrease in EGG indexes showed improvement of those indexes through 8 weeks of outpatient care. EGG channel 3 was shown to be the most adequate standard of evaluation. But there was no significant improvement in slow wave coupling rate which is a new index of multichannel EGG.