• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.3 s.58
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• pp.173-180
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• 2006

Sesame (Sesamum indicum L.), one of the oldest oilseed crops, has been known to posses antioxidative and inflammatory effects. This seed contains lignan compounds such as sesamin, sesamol, sesaminol, sesaminol diglucosides (SDG), and sesaminol triglucosides (STG). Sesamin, a major lignan in sesame, displayed several biological activities including a protective effects against oxidative damage in the skin. In the present study, we investigated the effect of sesamin, sesamol, sesaminol, SDG, and STG, on nitric oxide (NO) induction and inducible nitric oxide synthane (iNOS) and cyclooxygenases-2 (COX-2) expression in lipopolysaccharides (LPS)-treated RAW 264.7 cells. The results showed that sesamol and sesaminol significantly inhibited NO generation but they were also cytotoxicity however, sesamin effectively inhibited NO production ($IC_{50}: 64{\mu}M$) without my cytotoxic effect in LPS-stimulated macrophage RAW 264.7 cells. In further study, it was founded that sesamin inhibited the expression of inducible nitric oxide synthase but not COX-2 expression. These results suggest that sesamin may be useful for improvements of the inflammatory diseases.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.6
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• pp.443-447
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• 2002

This study was carried out to determine the differences in the growth, grain yield, and seed quality of sesame plant according to seeding date between P,E. vinyl-house and outdoor cultures. Reproductive growth period in vinyl-house culture was shorter than in outdoor culture. Stem length and capsule setting length of sesame were much longer in vinyl-house culture than in outdoor culture. Also, number of capsules per plant and 1,000 grain weight in vinyl-house culture were higher, specially the grain yield was approximately 57% more than in outdoor culture. In vinyl house culture, sesame plants sown on June 8 had longer capsule setting length, more capsules per plant, higher 1,000 grain weight, and higher percent ripened grain at the upper part of the capsule settings than those sown in May 9. They also had higher 1,000 grain weight at the middle and lower part of the capsule settings compared to May 9 seeding. However, no difference in grain yield of in seeding dates was observed. In outdoor culture, sesame plants, which was sown on May 9, had more effective branch number and capsule number and plant compared to those sown on June 8. Though sesame plants sown on May 9 had lower percent ripened grain at the upper and middle part of the capsule settings and lower 1,000 grain weight, the seed yield was similar to those sown on June 8. No difference in chromaticity value $L^*$ of sesame seeds between two culture conditions was observed. The $a^*$ value was higher in vinyl-house culture than outdoor culture while $b^*$ value was higher in outdoor culture. Sesaminol triglucoside content of sesame seeds was higher in vinyl-house culture than in outdoor culture. On the other hand, the content of sesamin and sesamolin from sesame seeds in vinyl-house culture were lower than in outdoor culture.