• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.5
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• pp.945-951
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• 1998

The purpose of this study was to investigate the effects of dietary xylooligosaccharide on lipid levels of serum in rats fed high cholesterol diet. Male Sprage-Dawley rats weiging 100$\pm$10g were randomly assigned to groups of two normal(N, N+10X) and four high cholesterol diets which contained 1%(w/w) cholesterol. High cholesterol diet groups were classified to xylooligosaccharide free diet (C group), 5% xylooligosaccharide diet(C+5X group), 10% xylooligosaccharide diet(C+10X group) and 15% xylooligosaccharide diet(C+15X group) according to the level of dietary xylooligosaccharide supplementation. These experimental diets were fed ad libidum for 4 weeks. The weight gain of high cholesterol diet group were significantly increased more than that of normal group, but those of 10% and 15% dietary xylooligosaccharide groups were significantly decreased more than that of high cholesterol diet(C)group. The higher content of xylooligosaccharide, the more food intake was increased. The food efficiencies of 10%, 15% cholesterol diet groups were lower than that of high cholesterol diet(C)group. The levels of serum triglyceride(TG) and total cholestoral were significantly high in cholesterol diet groups compared with normal diet group but were decreased in groups fed 5% and 10% dietary xylooligosaccharide. Especially, the lowest level showed in group fed high cholesterol diet containing 10% xylooligosacchride. High cholesterol diet group containing 10% xylooligosaccharide increased HDL-cholesterol level and then decreased LDL-cholesterol level and atherogenic index compared with other groups. The level of TBARS(thiobarbituric acid reactive substances) in serum was decreased in rat group fed xylooligosaccharide in high cholesterol diet. The higher content of xylooligosacchride, the more gastrointestinal transit time was decreased. The results indicate that dietary xylooligosaccharide can improve status of TG and total cholesterol and repress lipid peroxidation in serum lipid at hypercholesterolemia induced by high cholesterol diet.

• Journal of Pharmaceutical Investigation
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• v.8 no.1
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• pp.17-26
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• 1978

Effects of Acanthopanax EtOH Extract (AEE) on the serum total cholesterol content of normal and cholesterol administered rabbits were investigated as a series of studies on pharmacological action, especially blood pressure to Korean Acanthopanax. AEE was administered orally(100mg/kg/day) and subcutaneously (30mg/kg/day) in both normal and cholesterol administered rabbits for 36 days. In this experiment the results obtained by comparing with values of the corresponding control group were as follows; 1) In the normal rabbits, long-term administration of AEE for 36 days did not entirely influence the serum total cholesterol content measured at 12th, 24th and 36th day and also not affect the original blood pressure and changes of blood pressure to norepinephrine, angiotensin and acetylcholine recorded at 36th day. 2) In the cholesterol administered rabbits, hypercholesteremia was induced by oral administration of cholesterol(300mg/kg/day) with feed. The rise rate of serum total cholesterol content was not modified at 12th day, whereas significantly inhibited at 24th and 36th days after begining this examination in both groups orally and subcutaneously administered AEE. Original blood pressure was declined and depressor action of acetylcholine was weakened in only group admininstered orally AEE of cholesterol-fed groups. Changes of blood pressure to norepinephrine and angiotensin in these all cholesterol-fed groups, and to acetylcholine in subcutaneous group of these cholesterol-fed groups were not affected significantly by AEE.

• Advances in Traditional Medicine
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• v.10 no.2
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• pp.59-65
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• 2010

In India, Tectona grandis is traditionally used in the treatment of diabetes mellitus and lipid disorder. In the present study, the antihyperglycemic and lipid lowering effect of ethanolic extract of bark of Tectona grandis (TG) was evaluated using alloxan induced diabetes in rats. Alloxan was given at the dose of 140 mg/kg, i.p. After induction of diabetes, TG was administered for 42 days p. o. and simultaneously different biochemical parameters like plasma glucose, liver glycogen content, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol and liver glycogen content. Treatment with TG showed significant reduction (P < 0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P < 0.01) by TG. TG treatment for 42 days showed significant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDL-cholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in liver glycogen content which was significantly increased (P < 0.05) by treatment with TG. Hence, from the result obtained in the present study it can be concluded that Tectona grandis has the potential to treat diabetes condition and associated lipid disorder.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.8
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• pp.1177-1181
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• 2003

This study investigated the effects of cod liver oil and chromium picolinate on the serum traits and egg yolk fatty acids and cholesterol content in laying hens. One hundred 45-week old single comb white Leghorn laying hens were assigned randomly to four groups. These groups were: (1) control (soybean oil), (2) 1,000 ppb (${\mu}g/kg$) chromium (organic form chromium picolinate) (Crpic), (3) 3% cod liver oil (CLO), and (4) 1,000 ppb chromium with 3% cod liver oil (CLO+Crpic). The experiment was conducted for 40 days. Results indicated that serum triacylglycerol (TG) and cholesterol contents in the CLO group and the serum glucose content in the Crpic group were significantly lower than those in the control group (p<0.05-0.01). The yolk cholesterol content in the CLO and Crpic groups were also lower than the control group (p<0.01). The lipoprotein profile displayed that in the Crpic group, high-density lipoprotein (HDL) and HDL-cholesterol (HDL-C) were significantly higher (P<0.05) than the control group. Meanwhile, low-density lipoprotein+very low-density lipoprotein (LDL+VLDL) and LDL-C+VLDL-C were significantly lower (p<0.05) than the control group. Notably, of all four groups, the CLO group displayed a more profound effect on serum traits and lipoprotein (p<0.05-0.001). Furthermore, the fatty acid composition of the egg yolks presented that C18:2 in the CLO and Crpic groups was significantly lower (p<0.05-0.001) compare to the control. However, only in the CLO group, C18:3, C20:5 and C22:6 were significantly higher (p<0.001) than the control. Only serum glucose and LDL+VLDL showed the CLO${\times}$Crpic interaction (p<0.05), most parameters did not. Therefore, supplemented chromium picolinate or cod liver oil in the diet of laying hens had beneficial effects. However, when these two factors were combined, there was no interaction with most parameters.

• Journal of Nutrition and Health
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• v.20 no.1
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• pp.38-45
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• 1987

This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.

• The Journal of Dong Guk Oriental Medicine
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• v.3
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• pp.299-315
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• 1994

In order to investigate the effects of Mangumtang(MT) and Gamimangumtang(GMT) experimental studies were performed in Ex.1(treated with cholesterol and administration of sample at a time) and Ex.2(administration of sample after the treatment of cholesterol). The results were summerized as follows : 1. The content of Total cholesterol in the serum was not significantly decreased in MT group, whereas in GMT group significantly decreased compared with control group in Ex.1 and all significantly decreased in MT group and GMT group in Ex.2. 2. The content of Triglyseride in the serum was all significantly decreased in MT group and GMT group in all case. 3. The content of Phospholipid in the serum was not significantly decreased in MT group, whereas in GMT group was significantly decreased compared with control group in Ex.1 or Ex.2. 4. The content of Free Fatty Acid in the serum was all significantly decreased in MT group and GMT group in all case. 5. The content of HDL-Cholesterol in the serum was tended to decreased compared with control group but did not show a significance in Ex.1 or Ex.2. 6. The content of LDL-Cholesterol in the serum was not significantly decreased in MT group and GMT group in Ex.1, whereas in Ex.2 not significantly decreased in MT group but significantly decreased in GMT group. According to the above results, it is assumed that Mangumtang and Gamimangumtang have a valid effect on Hyperlipidemia, especially Gamimangumtang have a more valid effect on prevention and cure of Hyperlipidemia.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.1
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• pp.212-217
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• 1999

The effects of nuruk and wheat bran on cholesterol level in serum and activities of free radical metabolizing enzymes were investigated in rats. The rats were fed a diet containing nuruk or wheat bran for one month. Body weight and food intake were measured. Animals were sacrificed after one month. The increased food efficiency ratio throughout whole growth period was observed in the rats fed with either nuruk containing Aspergillus terreus or wheat bran compared with control group on normal diet. In the rats fed with nuruk, hepatic GSH content, glutathione S transferase activity, hepatic cytochrome P 450 content, and aniline hydroxylase activities were generally increased. In the rats fed with nuruk containing other fungi except Aspergillus terreus, xanthine oxidase activity was decreased. The decreased cholesterol level in serum was observed in rats fed with nuruk prepared from Aspergillus terreus and wheat bran. LDL cholesterol level was decreased in rats fed with nuruk prepared with other fungi such as Penicillium sp. and Rhizopus sp. But HDL cholesterol level was increased in all groups fed with nuruk from any fungi and wheat bran. These results suggested that nuruk or wheat bran supplemented diet might exert their effect by decreasing cholesterol level in serum and amount of oxygen free radical level.

• Journal of Nutrition and Health
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• v.2 no.2
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• pp.71-78
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• 1969

This experiment was conducted for 4 weeks to compare the feeding values of dried meal of Russian Comfrey and Kale as green feeds with Acacia leaf meal and Ladino clover meal, and to investigate the effects of feeding these on the total cholesterol in blood serum and liver fat content. Seventy-five male chicks of Single Comb White Leghorn were allotted into 5 treatments. Fifteen birds in each treatment were received Russian Comfrey meal, Kale meal, Acasia leaf meal, Ladino clover meal or no dried meal, respectively. The results obtained are summarized as follows: 1. No significant differences were recognized between the treatments and control in the growth rate, feed consumption, feed efficiency, utilization of nutrients, nitrogen retention and metabolizable energy value. 2. Carotene content in Russian Comfrey and Kale has been decreased as the growing stage advanced, and the leaves of both vegetable contained significantly (p<0.01) more carotene than that in stems. Vitamin C content of leaves was also signifcantly (p<0.01) higher than that in stems, however, vitamin C content has been increased as the growing stage advanced. 3. Toltal cholesterol content in blood serum of the chickens fed the Acacia leaf meal or Russian Comfrey meal was significantly (p<0.05) lower than Ladino clover meal fed group or those received no green feeds. Kale seems to decrease cholesterol content a little. Above results indicated that Acacia leaf and Russian Comfrey might contain certain substances that would depressing the cholesterol content. 4. No significant differences in the liver fat were discovered among the treatment but it was observed that liver fat was decreased as the cholesterol content increased.

• Journal of the Korean Society of Food Culture
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• v.4 no.2
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• pp.185-189
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• 1989

Effect of perilla oil on the fatty acid composition, ACAT and HMG-CoA reductase in the liver microsomes, or cholesterol and protein in serum of rabbit were examined. 1. The content of total protein in serum was almost same amount of both groups, but ${\alpha_1}-globulin$ and r-globuline were incresed or ${\beta}-globulin$ was decresed compared with control. 2. The content of high density lipoprotein incresed, and the content of low density lipoprotein decresed in lipoprotein. 3. Total cholesterol and triglyceride were decresed, and the content of phospholipid was incresed. 4. Perilla oil did not effect for changing blood glucose and $Na^+,\;K^+$ electrolytes. 5. Perilla oil did not effect for changing serum GOT and GPT in rabbit. 6. The activity of ACAT decresed and the activity of HMG-CoA reductase incresed. The activity of ACAT and HMG-CoA reductase in liver microsomes were reciprocal. 7. There were arachidonic acid 20:4, eicosapentaenoic acid 20:5, and docosahexaenoic acid 22:6 in the liver microsomes of rabbits. These highly polyunsaturated fatty acids were convented from linolenic acid 18:3 n-3.

• Journal of the Korean Society of Food Science and Nutrition
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• v.14 no.3
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• pp.223-228
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• 1985

This experiment was designed to investigate the effect of dietary fibers on serum and liver lipids of cholesterol-fed rats. Forty-two male rats of Sprague-Dawley strain weighed $145{\pm}10\;g$ were divided into 6 groups, each group receiving a different diet for 6 weeks, i.e., basal diet, basal diet plus 0.5% cholesterol without fiber, basal diet plus 0.5% cholesterol and 5% pectin, basal diet plus 0.5% cholesterol and 5% agar, basal diet plus 0.5% cholesterol and 5% pectin plus tannic acid mixture and basal diet plus 0.5% cholesterol and 5% tannic acid. The lowest net weight gain and digestibility were found in 5% tannic acid-containing group. The weight of kidney, heart and lung was significant by different, however, those of liver and spleen was not significantly different among the groups tested. GOT and GPT of serum were significantly higher in 0.5% cholesterol-containing group without fiber, whereas those of 5% pectin-containing group were significantly lower. Highest total serum protein content was found in 0.5% cholesterol-containing group without fiber. However, albumin and A/G ratio were not significant. The content of total lipid and cholesterol in serum were not significant by different among the groups studied, whereas crude lipid contents of liver in 5% tannic acid and pectin plus tannic acid-containing groups were significantly lower. Cholesterol content in the liver was significantly lower in 5% tannic acid-containing group. Crude lipid and sterol content of feces were significantly higher in 5% pectin-containing group.