• 한국가축번식학회지
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• 제5권1호
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• pp.43-63
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• 1981

This study aimed to determine the effects of adrenalectomy on the sexual gland, the thyroid gland and the serum components. A total of 192 Wister strain albino rats were evenly divided into 4 sexually equal groups for the comparisons. Each groups was divided into a control and a treatment group by sexuality. Each tissue of the sexual gland and the thyroid gland was microscopically examined, and at the same time body weight and serum components were also examined on the 1st, 7th, 14th, 28th, 42nd, 56th, 70th and 84th day respectively following adrenalectomy. The results obtained were as follows: 1. The body weight was sufficiently retarded in decreasingly after the adrenalectomy as compared to that of control. 2. The histological change of testis started atrophy of spermatogonia and degeneration of spermatocyte. There was a, pp.ared no cell division activity. Spermatozoa in the seminiferous tuble was not noticed but degeneration of interstitial cell was started and spermatozoa in the epididymal duct disa, pp.ared. 3. Degeneration of oocyte and follicular cell was noticed as the histological change of ovary. There was not a, pp.arance of primary follicle and corpus Iuteum but interstitial cell was proliferated. 4. For the effect of adrenalectomy on the histological change of the thyroid gland, the number of small follicle decreased and that of large follicle increased as the time passed following the adrenalectomy. And the follicular epithelial cell became squamous as typical condition of functional decreased. 5. It was shown that in the total contents of serum protein no difference with control occurred with in the 70th day for male and female adrenalectomized, respectively. But the differences in protein contents were significanly decreased on the 70th day. 6. No difference occurred in the total serum lipids on the 7th day, but they decreased significantly on the 42nd day, and (P<0.01) on the 56th, and 70th day. A tendency to decrease was noted as time elapsed following adrenalectomy. 7. Increase and decrease were intercrossed in the serum cholesterol contents between the control and th treatment groups on the 28th day. But the difference significantly decreased on the 42nd, 56th, and 70th day after adrelalectomized. The contents showed tendency to decrease as time elapsed following adrenalectomy. 8. The blood glucose contents rapidly decreased with time. The difference were significant on the 28th and 42nd day, and highly significant on the 56th and 70th day for male adrenalectomized. 9. In case of solium, there was no noticeable sexual distinction. There was slight in creasing or decreasing for the control group. But the treatment group tended continuously to decrease for male and female. 10. It was shown that potassium contents tended to increase on the 28th day for male and female, but the differences were small. 11. As for chlorine, it tended to decrease rapidly on 7th day for male and female adrenalectomized, and the tendency continued.

• 생약학회지
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• 제27권4호
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• pp.397-407
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• 1996

This study was attempted to investigate the effect of Composite Preparation (Sam Whang Sasim-Tang: SWST, Whang Ryun Haedok-Tang: WRHT) on the activities of GOT and GPT, the content of total lipids, triglyceride, total cholesterol. Phospholipid and ${\beta}-lipoprotein$ in the serum, and the change ratio of body and liver weight in the experimentally induced hyperlipemic rats, making use of the extract 150, 200, 300 and 500 mg/kg p.o. Significant test was performed by comparision with the values of corresponding experimentally hyperlipemic rats. The activities of S-GPT was significantly decreased in all dose of SWST and WRHT respectively. The activities of S-GPT was significantly decreased in dose of SWST 500 mg/kg and in all dose of WRHT respectively. The content of total lipids, triglyceride, total cholesterol and phospholipids were significantly decreased in all dose of two the extract. The rate of decrease on total lipids and triglyceride were remarkable in dose of SWST 300, 500 mg/kg and WRHT 200, 500 mg/kg, and then the content of total cholesterol was more remarkable in dose SWST 300, 500 mg/kg, and WRHT 150, 300 mg/kg, and the content of phospholipids was more remarkable in dose of the extract 150, 200 and 300 mg/kg. The content of ${\beta}-lipoprotein$ was significantly decreased in dose of WRHT 150, 200 and in all dose of SWST. Increase ratio of the body and liver weight were significantly decreased in dose of two the extract 300, 500 mg/kg respectively.

• Journal of Nutrition and Health
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• 제32권8호
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• pp.897-907
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• 1999

The purpose of this study was to investigate the pattern of individual fatty acid intake and to compare total serum lipid levels and total serum fatty acid composition of elementary school children in Seoul by fish and meat intakes. The subjects were divided into High-Fish / Low-Meat(HFLM, n=49) and Low-Fish/High-Meat(LFHM, n=47) group. The total energy from fat of HFLM and LFHM group was 22.0 and 30.0% respectively. The average intake of cholesterol was 237-287mg in HFLM group and 358-387mg in LFHM group. The average P/M/S ratio for all subjects was 1.1-1.4/1.1 - 1.2/1.0, which was very similar to desired ratio. The $\omega$6/$\omega$3 ratio of dietary fatty acids of HFLM and LFHM group were 8.0-10.9 and 18.9-29.3 respectively, which in case of LFHM group, was fat beyond the suggested range, 4/1 - 10.1. Serum lipid levels of all subjects fell within the normal range and there was no significant difference in serum lipid levels between HFLM and LFHM groups, except for HDL-cholesterol in upper grades(4th-6th grades). In lower grades(1st-3rd grades), serum PUFA composition of HFLM (40.8%) group was significantly higher than that of LFHM (38.3%) group (p<0.05) and SFA composition of HFLM(33.8%) was significantly lower than that of LFHM group, (p<0.001) between them. The $\omega$6/$\omega$3 ratio of serum fatty acid tended to be higher in LFHM than in HFLM group but there was no significant difference between two groups. This study suggests that the dietary fat pattern of growing children could affect the change in total serum fatty acid composition though it did not influence serum lipid levels significantly. Energy and EPA intakes were negatively correlated with HDL-cholesterol levels(p<0.05). Serum fatty acid compositions were more closely correlated with serum triglyceride(TG) levels than serum cholesterol levels. Especially, total SFA (p<0.001) and individual SFA, such as C14:0(p<0.001) and C16:0(p<0.001)compositions were positively correlated with serum TG levels, but stearic acid(p<0.01) was negatively correlated with it.

• 대한간호학회지
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• 제35권5호
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• pp.924-930
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• 2005

Purpose: The purpose of this study was to evaluate the effect of web-based diabetic education on plasma glucose and serum lipids in obese people with diabetes. Method: A random allocation design with control and experimental groups being assessed pre- and post-intervention was used. Eighteen patients were randomly allocated to an intervention group and 16 to a control group. Participants were requested to input their blood glucose levels weekly for 3 months at http://www.biodang.com by cellular phone or wire Internet. The researcher sentoptimal recommendations to each patient weekly for 3 months using a short message service (SMS) of the cellular phone and wire Internet. Results: Patients in the intervention group had a mean decrease of $1.2\%$ in glycosylated haemoglobin ($HbA_{1}c$) levels and those in the control group had no difference in HbA1c levels. There was a significant mean change in 2-hour post prandial blood glucose (2HPPG) for the intervention group, with a mean change of -120.1 mg/dl. The mean change in the control group, however, was not significant. Conclusion: These findings indicate that this web-based intervention using SMS of the cellular phone for 3 months improved $HbA_{1}c$ and 2HPPG, but did not affect total cholesterol, triglyceride, and high density lipoprotein cholesterol in obese type 2 diabetic patient.

• 동아시아식생활학회지
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• 제13권1호
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• pp.39-55
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• 2003

This study was conducted to investigate the effect of an uncooked powdered food(UPF) on the weight loss and changes of the biochemical nutritional status for 20 overweight and 26 obese women in Iksan area. We just replaced common breakfast and dinner of the subjects with UPF. Their dietary intake status was evaluated by 24-hour recall method. Also anthropometric and biochemical measurements before and after the UPF program were estimated. The intake of energy, lipid and protein decreased and the quality of meals improved as people started to take UPF. Due to the energy loss by taking UPF, weight and body fat decreased significantly. The percentage of the body fat was high among the weight lost, from which we judged that the process of losing weight was successful. It is hard to predict whether weight loss will occur to people who are already in shape or not, but if overweight and obesity people regularly take UPF instead of other food products, we assume that UPF will help lessening the body fat. The most positive change among biochemical changes by taking UPF was the decrease of serum lipid contents. When overweight and obesity women replaced two out of three meals with UPF for 3 month period, no significant nutritional problems occurred. It seems that the 12weeks of UPF program used in this study was effective in improving anthropometric indices without producing the deficiency of iron or other susceptible nutrients.

• 동아시아식생활학회지
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• 제7권2호
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• pp.153-158
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• 1997

This study was designed to find out the effects of soybean protein and milk protein between nondiabetic and diabetic rats. The experimental results are summarized as follows. 1. Total food intake was higher in diabetic soybean protein group than other groups but it was not significant. 2. The change of body weight was lower in diabetic soybean protein group than other groups and the soybean protein was effective to maintain the ideal body weight. 3. The effects of lowering total cholesterol and glucose in serum was higher in soybean protein groups than the milk protein groups.

• 생명과학회지
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• 제9권1호
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• pp.35-43
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• 1999

이탈리안 라이그라스로부터 갈변을 방지시켜 white LP를 제조하여 4주령의 Wistar 계 수컷 흰쥐에 14일 급여, 혈청지질농도 및 혈중 유리 아미노산 패턴에 대하여 단백질원으로 대두단백질 및 카제인 급여와 비교하였으며 혈중 유리 아미노산이 혈청 지질농도에 대하여 어떠한 관련이 있는지를 검토하였다. 갈변을 방지하여 조제한 LP 의 질소 함량 및 소화율이 거의 대두단백질 수준까지 높여 단백질의 품질에 대한 영향을 확인하였다. 혈청 총 콜레스테롤 및 LDL-콜레스테롤은 카제인군에 비하여 이탈리안 라이그라스 white LP 군이 유의적으로 낮고, 대두 단백질군과 같은 수준이었다. 이때 혈중유리아미노산을 비교한 결과, LP 군과 대두단백질군과는 거의 닮은 패턴을 나타내고 카제인군에 대해서는 glycine 만 높고 다른 아미노산은 차가 없든지 유의적으로 낮았다. 그리고, 카제인 수준을 15.0% 로 낮추어 대두 단백질과 비교하였다. 그 결과, 혈청 콜레스테롤 농도는 카제인군이 유의적으로 높고 혈중 glycine 농도가 낮고, methionine 농도의 높은 폐턴은 일치하였다. 이상의 결과로부터 혈중 유리아미노산 패턴은 급여 단백질의 종류에 의해 어느정도 규제되어지며 아미노산 패턴은 혈청지질과 어떠한 관련이 있는 것으로 인정되었다. 더욱이, LP 와 대두단백질의 혈중 유리 아미노산 패턴은 매우 유사한 것이 관찰되어 LP 의 혈청 콜레스테롤 강하작용의 메카니즘은 대두 단백질의 메카니즘과 유사한 것으로 생각되어진다.

• Nutritional Sciences
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• 제8권1호
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• pp.28-34
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• 2005

To examine the combined effects of a high-protein diet and aerobic exercise on body weight and composition and blood lipid profiles in overweight women, 30 young women were recruited and placed into three groups: The high-protein diet and exercise group (HPE), the exercise-only group (EXO) and the control group (CON) (30$\pm$3%, 27$\pm$2%, and 29$\pm$3% body fat, respectively) for an 8-week experimental period. Daily diet included 25% isolated soybean protein (>90% protein, approximately 400 kcal) combined with each subject s usual diet for the HPE group. The exercise program consisted of aerobic-type exercises undertaken >3 times/wk and for>30 min/session at 50-60% of maximal capacity. Physical fitness, body composition, serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG) and glucose were measured before and after the experiment. Maximal aerobic capacity increased by the end of experiment in both the HPE (from 27.2$\pm$3.5 to 35.l$\pm$5.9 ml/kg/min, p<0.01) and EXO (from 30.3$\pm$5.4 to 33.8$\pm$3.8 mㅣ/kg/min, p<0.05) groups. Percent body fat decreased by 3.3% (p<0.01) in the HPE group and by 1.5% (p<0.05) in the EXO group by the end of the experiment, but not in the CON group. Lower back strength and agility increased only in the HPE group. In the HPE group, TC decreased from 168$\pm$20 to 155$\pm$18 mg/dL and HDL-C increased from 57$\pm$l0 to 61$\pm$9 mg/dL in HPE (p<0.01). But TC and HDL-C did not change in the EXO and CON groups. TG and glucose did not vary among the groups. Although the EXO group showed a similar outcome to that of the HPE group, a favorable change in body composition and blood lipids as well as an improvement in aerobic capacity was more marginal in the latter group.

• 대한임상검사과학회지
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• 제36권1호
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• pp.49-54
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• 2004

The purpose of this study was to investigate the effects of Lycii fructus extract on the serum lipids in hyperlipemia rats. The rats were divided five groups including negative control, positive control and treated L. fructus extract at dose of 50, 100, 200 mg/kg. To induce the hyperlipemia, 4 groups of rats, not including the negative control group, were fed experimental diets consisting of cholesterol, lard, corn oil, and normal diet for experiment period. As a result, the L. fructus extract decreased total cholesterol(T. Cho), trigryceride(TG), low density lipoprotein cholesterol(LDL-C), and free fatty acid(FFA) significantly compared with positive control. However, no significant difference was found in high density lipoprotein(HDL-C) and phospholipid(PPL) level. Otherwise, in serum lipid level including, T-Cho, TG, LDL-C, FFA and PPL was decreased dose dependently by treatment of L. fructus extract. But HDL-C was increased by L. fructus extract too. Thereby having beneficial effect on hyperlipermia by influencing the serum lipid change, it is expected that Lycii fructus extract can suppress arteriosclerosis and obesity.

• 한국식품영양과학회지
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• 제29권2호
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• pp.274-279
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• 2000

중요한 식물성 자원 식품 중의 하나인 감자로부터 생리활성 인자를 탐색할 목적으로, 강자의 폴리페놀 화합물을 추출하여 콜레스테롤 무첨가 식이 및 콜레스테롤 식이에 각각 0.5% 수준으로 첨가한 반합성 식이를 흰쥐에 급여하여 혈청 및 간장지질 농도, 혈당치, 뇨 단백질량에 미치는 영향을 검토하였다. 콜레스테롤 첨가 식이에서 감자 폴리페놀 화합물 첨가에 의해 혈청 총 콜레스테롤 및 VLDL+ LDL-콜레스테롤 농도, 동맥경화 지수는 유의성은 없었으나 약간 감소하였고, 콜레스테롤 무첨가 식이에서는 이러한 경향들이 나타나지 않았다. 뇨 단백질량은 콜레스테롤 무첨가식이 및 콜레스테롤 첨가 식이에 감자 폴리페놀 화함물 첨가에 의하여 실험 1주일 째에는 각각 12% 및 27% 증가하였으나, 2주일 째에는 콜레스테롤 무첨가 식이군 수준으로 회복되었다. 혈당치는 각 실험군에 유의적인 차이는 없었다.