• 한국임상수의학회지
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• 제19권2호
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• pp.165-173
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• 2002

The purpose of this study was to evaluate the effect of chitosan-calcium sulfate mixture on early bony consolidation in osteodistracted dogs. The experimental group was divided into 3 groups: saline group(Control), chitosan group(Group CH) and chitosan-calcium sulfate mixture group(Group CH+CS). Four dogs were allocated to each group and classified into B week observation subgroups and 5 week observation subgroups, respectively. Two dogs were allocated to each subgroup. The lateral surface of the left mandibular body was exposed in the subperiosteal plane and vertical osteotomy was carried out on the mandibular body. An external distraction device was applied to the mandibular body. Mandibular distraction was started 5 days after the osteotomy at a rate of 1 m per day for a total of 10 w distraction for 10 days. After completion of distraction, chitosan, chitosan-calcium sulfate and saline were injected into the distracted zone of the group CH, group CH+CS and control. The external device was left in place for 3 or 5 weeks to allow for bony consolidation. Serial radiographs were carried out every week. Two dogs of each group, six dogs in total, were sacrificed at 3 weeks, and the other six dogs at 5 week after distraction. Bone specimens of the distracted mandibles were taken for histologic examination. New bone was not noted in the distracted zone of 3 week observation subgroups in the control and group CH. However, new bone was developed in the group CH+CS with a narrow fibrous interzone in the area of the distracted zone. While osteogenesis was mild in the margin of the distracted Bone of 5 week observation subgroup in the control, new bone was noted much in the group CH and group CH+CS. However, osteogenesis was noted more significantly in the group CH+CS than that of group CH. In conclusion, chitosan-calcium sulfate mixture was more effective on early bony consolidation in distraction osteogenesis

• 한국환경성돌연변이발암원학회지
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• 제22권4호
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• pp.266-273
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• 2002

The dose dependence of the severity of radiation-induced thymic lymphoma in C57BL/6J mice was studied. Mice were exposed to fractionated irradiation at the total doses of 4.0, 6.0 and 8.0 Gy (four irradiations at 8-day intervals) starting from 33 days after birth. Pathological and histological changes of each mouse were observed after periodical sacrifice at day 75, 100, 125, 150, 175, 200, 250, 300 after the first irradiation. The severity of cancers were classified into 4 stages by clinical signs with respect to the enlargement of the thymus, spleen, liver, the progression of the cancer in the thymus, and the metastasis to the spleen, liver, lung and the lymphatic nodes. Among the 490 mice observed, 146 mice had thymic lymphoma. A clear dose-effect relationship was observed as well as the dose-response relationship. Also, periodical observation showed that thymic lymphoma was first induced in mice sacrificed at day 100 (130days old), and metastasize in the order of spleen, lung, liver and then the lymphatic nodes. The results suggest that radiation may be involved not only as a tumor initiator but also as a tumor promoter, and a tumor progression-enhancing agent.

• 대한한방내과학회지
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• 제29권3호
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• pp.595-607
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• 2008

Objectives: The aim of this study was to determine the effects of Salvia miltiorrhiza (SM) extract in urethane-induced lung tumorigenesis in A/J mice. Methods : We examined change of body weight, histological, apoptosis, immunohistochemical and gene expression of cyclooxygenase (COX-2) in lung tumors. Mice were divided into 3 groups: normal, saline, and experimental group administered SM extract after injection with urethane. Results : Histological observation showed shrunken alveoli in the control group, but recovered from damage in the SM extract administered group. The COX-2 positive materials were observed in the smooth muscle of terminal bronchiole and alveoli from the control group, but these positive materials decreased in the SM extract treatment group. The results of electron microscopical observation, dilated capillary and degenerated endothelia were observed in the control group. The apoptotic nuclei increased more in the control group compared with the normal and SM extract administered groups. Serial sections of the whole lung showed solid and papillary tumors. The size and number of tumors decreased in the SM groups compared with the control groups. Conclusions : These results suggest the possibility that SM may exert an anti-tumor effect on urethane-induced lung tumorigenesis.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 추계종합학술대회
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• pp.172-175
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• 2003

국립해양조사원, 국립수산과학원, 해양경찰청, 해군, 해양관련 대학 등에서는 과학적 탐사(해양환경, 어군조사 등)를 위해 자체적으로 해양조사선을 보유하고 있다. 해양조사선에는 탐사목적에 맞는 다양한 탐사장비 들이 탑재되어 있다. 본 논문에서는 다양한 탐사장비를 해양조사선의 선내 네트워크 기반으로 통합하고, 효율적 과학탐사를 위해 탐사장비간 인터페이스 방안, 인터페이스용 유틸리티에 대한 경험에 의한 구축방안 제시와 네트워크 기반의 통합 DB 환경을 구축하여 이를 이용한 다양한 소프트웨어에 대한 구축방안을 제시하고자 한다. 또한, 해양 조사선의 네트워크 기반의 통합환경 구축 및 소프트웨어 개발에 대한 방안 및 향후 나아가야 할 방향에 대해서도 언급하도록 한다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2001년도 춘계종합학술대회
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• pp.167-172
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• 2001

본 논문에서는 해양 조사ㆍ관측선에 탑재되는 조사ㆍ관측장비를 조사선내의 NETWORK을 통해 인터페이스 시키고, 각 계측된 데이터를 데이터베이스에 통합적으로 데이터를 구축하여 이를 이용하여 사용자에게 효율적이고 빠른 조사ㆍ관측이 가능하도록 지원하는 종합정보통신망에 대한 구축방안을 설명하였다. 그리고, 효율적인 조사ㆍ관측작업을 위해 종합정보통신망의 LAN 및 직렬 인터페이스와 각 조사장비의 출력정보를 연관지어 효율적인 조사ㆍ관측을 위해 필요한 환경학적, 물리학적, 생물학적, 화학적 연관관계를 이용한 효율적인 소프트웨어 구현방안에 대하여 기술하였고, 선박과 육상국간의 데이터 전송을 위한 선박 데이터 통신 서비스 방안과 선내에 필요한 네트워크 관련 서비스에 대하여 다루었다.

• 수산해양기술연구
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• 제7권1호
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• pp.9-27
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• 1971

Oceanography of the Subarctic North Pacific Ocean is reviewed. The submarine topography and the current systems in the region are explained. Recent serial observation data reveals that. though the upper mixed layer of low salinity is relatively thick. the pattern of the property distribution in winter is essencially similar to that in summer. Alaskan Stream Extension Water. which influences the abundance and the location of demersal fishes. extends northward to 58${\circ}$ N Lat in the Bering Sea. A southeastward intrusion of the Bering Borcal Cold Water causes the formation of a sharp oceanic front. where the demersal fishes such as Alaska pollacks and cods arc concentrated. The Alaska pollacks seem to avoid the low salinity water of the Alaskan Coastal Water.

• 수산해양기술연구
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• 제7권1호
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• pp.8-8
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• 1971

Oceanography of the Subarctic North Pacific Ocean is reviewed. The submarine topography and the current systems in the region are explained. Recent serial observation data reveals that. though the upper mixed layer of low salinity is relatively thick. the pattern of the property distribution in winter is essencially similar to that in summer. Alaskan Stream Extension Water. which influences the abundance and the location of demersal fishes. extends northward to 58${\circ}$ N Lat in the Bering Sea. A southeastward intrusion of the Bering Borcal Cold Water causes the formation of a sharp oceanic front. where the demersal fishes such as Alaska pollacks and cods arc concentrated. The Alaska pollacks seem to avoid the low salinity water of the Alaskan Coastal Water.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2002년도 추계 학술발표회 논문집
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• pp.265-272
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• 2002

An Integer-valued autoregressive integrated (INARI) model is introduced to eliminate stochastic trend and seasonality from time series of count data. This INARI extends the previous integer-valued ARMA model. We show that it is stationary and ergodic to establish asymptotic normality for conditional least squares estimator. Optimal estimating equations are used to reflect categorical and serial correlations arising from panel count data and variations arising from three random processes for obtaining observation into estimation. Under regularity conditions for martingale sequence, we show asymptotic normality for estimators from the estimating equations. Using cancer mortality data provided by the U.S. National Center for Health Statistics (NCHS), we apply our results to estimate the probability of cells classified by 4 causes of death and 6 age groups and to forecast death count of each cell. We also investigate impact of three random processes on estimation.

• 한국해양학회지
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• 제12권2호
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• pp.67-74
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• 1977

With the serial observation data and the tidal records at Busan and Izuhara from 1966 to 1973, the geostrophic current velocity and its relation to the difference of mean sea level of both sides were studied in order to estimate indirectly the average current velocity from the tidal observations. The results shows that the current velocity is estimated by the relationship V=4.016(H-98.3) with the 95% confidence limits of V 4.2 cm/sec. Ther relationship between the observed current velocity and the simultaneous daily mean sea level difference shows a similar result, V=4.717(H-99.6). The two equations were applied to the evaluation of annual variations of current velocity from the average monthly mean sea level data of both stations.

• 대한전자공학회논문지
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• 제23권3호
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• pp.389-396
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• 1986

A pulsed ultrasonic doppler flowmeter for mesurements of velocity profils in man is described. The device projects a beam of ultrasound in burst of 570 ns duration at 3.5 MHz. The back-scattered signals are processed to produce a signal oxrresponding to the mean velocity over a small region of the flowing stream. The observation range of 112mm is divided into 128 depth channels. The size of this sample volume determines the flowmeter sensitivity and accuracy. The device uses a quadrature detector to detect the direction of the moving target(hemoglobin). The main feature of the novel instrumnet is its simple hardware structure due to sequential signal processing.