• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.2
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• pp.21-27
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• 2018

FRN (Full range Naphtha) is distilled from crude oil in a Naphtha Splitter Unit and is separated into the Light Straight Naphtha, Heavy Naphtha, and kerosene according to the boiling point in sequence. This separation is conducted using a series of binary-like columns. In this separation method, the energy consumed in the reboiler is used to separate the heaviest components and most of this energy is discarded as vapor condensation in the overhead cooler. In this study, the first two columns of the separation process are replaced with the Petlyuk column. A structural design was exercised by a stage to stage computation with an ideal tray efficiency in the equilibrium condition. Compared to the performance of a conventional system of 3-column model, the design outcome indicates that the procedure is simple and efficient because the composition of the liquid component in the column tray was designed to be similar to the equilibrium distillation curve. An analysis of the performance of the new process indicated an energy saving of 12.3% under same total number of trays and with a saving of the initial investment cost.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.41.2-41.2
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• 2018

EL CVn-type eclipsing binaries are composed of a massive A-type main-sequence primary star and a hotter B-type secondary one. These are worthy of particular attention because the secondary stars are rare objects to be extremely low-mass white dwarf precursors (ELM proto-WD) with the mass of ${\leq}0.2M_{\odot}$, evolving to higher effective temperatures and higher surface gravities. A few of them were discovered to show multi-periodic pulsations in one or both components. We monitored one of these rare and interesting objects, J0247-25 (=1SWASP J024743.37-251549.2), at two KMTNet sites of SAAO in South Africa and SSO in Australia. The observations were performed with the KMTNet 1.6m telescopes and pre-science 4K CCD cameras during the system test run from July to November 2014. Using the photometric data obtained for a total of 23 nights, we constructed well-defined eclipsing light curves in B/V-bands and derived absolute parameters (mass and radius, etc.) of each binary component. After subtracting model eclipsing curves from the data, we detected seven frequencies with 33~53 cycles per day (c/d) and identified them to be Delta Sct-type pulsations originated from the A-type primary component. Five frequencies were turned out to be excited by rotational splitting of non-radial pressure modes, enabled us to investigate rotational properties. We could not detect any frequency higher than 100 c/d, implying that pulsation amplitudes of the proto-WD secondary decrease greatly.

• International Commerce and Information Review
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• v.9 no.2
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• pp.257-283
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• 2007

As Global industrial structure is diversified, multinational corporations accomplished fast internationalization to introduction of new management policy by development of an IT technology. Enterprise' business environment is changing transcending border. To overcome raging waves of change accident and to be secured enterprise's future, the logistics is recognized the third profit source joining in curtailment of sale enlargement, production cost. To seek cost saving or reform in logistics class that is last area of pursuit of profits within ancient city life in the fast lane from these viewpoint, importance of study that integrates and manages international logistics bases supply neck walk is emphasized. Specially, to meet on in terms of competitive power security regarding curtailment of logistics cost is available through link between logistics bases, various consumer's request, merchandise and service logistics management that supply fixed quantity as is reliable in right place at good season was embossed by point game plan of business management, and SCM efficiency anger of mortification international logistics activity importance of study that see at that dominate competitive advantage point bring. This study analyzes interrelation and presents model for integration of international logistics bases supply network with supply network habit at factor and supply chain, and supply network activity in integration of supply chain process and production. Also, it establishes following method of study to achieve study purpose for actual proof analysis for integration sequence of international logistics bases supply network. Specially, immersion of network and supply network, very high interrelation appeared by thing which is with international logistics base supply network integration. The integration of international logistics base supply network means that the enterprises which give trust and sincerity deal with market environment change positively and can decide proceeding of various cooperative work. Also, it means the possibility by necessity of cooperative relation and interdependence to continuous immersion and normative immersion, for the maintain of long business relations.

• Journal of Microbiology and Biotechnology
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• v.22 no.1
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• pp.34-45
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• 2012

A thermophilic Bacillus stearothermophilus F1 produces an extremely thermostable serine protease. The F1 protease sequence was used to predict its three-dimensional (3D) structure to provide better insights into the relationship between the protein structure and biological function and to identify opportunities for protein engineering. The final model was evaluated to ensure its accuracy using three independent methods: Procheck, Verify3D, and Errat. The predicted 3D structure of F1 protease was compared with the crystal structure of serine proteases from mesophilic bacteria and archaea, and led to the identification of features that were related to protein stabilization. Higher thermostability correlated with an increased number of residues that were involved in ion pairs or networks of ion pairs. Therefore, the mutants W200R and D58S were designed using site-directed mutagenesis to investigate F1 protease stability. The effects of addition and disruption of ion pair networks on the activity and various stabilities of mutant F1 proteases were compared with those of the wild-type F1 protease.

• Journal of Species Research
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• v.1 no.2
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• pp.105-132
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• 2012

The saga of Megascolides orthostichon (Schmarda, 1861)-the first native worm described from Australasia-continues as its type-locality is unequivocally returned from Hobart, Tasmania to Mt Wellington, Auckland where a brief survey failed to unearth it. Since it has not been seen for 150 yrs, it may qualify under NZTCS or IUCN classification as 'Nationally Critical' if not 'Extinct'. New reports are for exotic Megascolecidae Anisochaeta kiwi sp. nov. and A. kiwi mihi sub-sp. nov. plus addition to the NZ faunal list of Australian Anisochaeta macleayi (Fletcher, 1889) that, due to its wide distribution in Australia and now New Zealand, may be a candidate model-species suitably resilient for eco-toxicological culture and monitoring. For holarctic Lumbricidae, new records are of Dendrobaena attemsi (Michaelsen, 1903) and the Murchieona muldali (Omodeo, 1956) morph or subspecies of M. minuscula (Rosa, 1906), neither lumbricid previously uncovered in Asia/Australasia. Also found for the first time outside its East Asian homeland is Eisenia japonica (Michaelsen, 1892) (which is compared to Japanese E. japonica hiramoto sub-sp. nov. and to E. anzac Blakemore, 2011). Records of these exotics plus recent new native species described by the author-including two, Rhododrilus mangamingi and Deinodrilus orcus spp. novae, herein-raise the numbers of megadriles known from New Zealand to 228 (sub-)species in five families. Preliminary mtDNA COI sequence barcodes are presented. Genus Tokea Benham, 1904 is revived on its lack of dorsal pores, losing or gaining some species with Megascolides M'Coy, 1878. An updated checklist of all 228 New Zealand taxa is appended.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.4
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• pp.159-167
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• 2015

We consider a wafer lot transfer/release planning problem from semiconductor wafer fabrication facilities to probing facilities with the objective of minimizing the deviation of workload and total tardiness of customers' orders. Due to the complexity of the considered problem, we propose a two-level hierarchical production planning method for the lot transfer problem between two parallel facilities to obtain an executable production plan and schedule. In the higher level, the solution for the reduced mathematical model with Lagrangian relaxation method can be regarded as a coarse good lot transfer/release plan with daily time bucket, and discrete-event simulation is performed to obtain detailed lot processing schedules at the machines with a priority-rule-based scheduling method and the lot transfer/release plan is evaluated in the lower level. To evaluate the performance of the suggested planning method, we provide computational tests on the problems obtained from a set of real data and additional test scenarios in which the several levels of variations are added in the customers' demands. Results of computational tests showed that the proposed lot transfer/planning architecture generates executable plans within acceptable computational time in the real factories and the total tardiness of orders can be reduced more effectively by using more sophisticated lot transfer methods, such as considering the due date and ready times of lots associated the same order with the mathematical formulation. The proposed method may be implemented for the problem of job assignment in back-end process such as the assignment of chips to be tested from assembly facilities to final test facilities. Also, the proposed method can be improved by considering the sequence dependent setup in the probing facilities.

• Entomological Research
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• v.48 no.6
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• pp.533-539
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• 2018

The RNA interference (RNAi) has been considered as an important genetic tool and applied to develop a new living modified (LM) crop trait which is an improvement of nutrient quality or pest management. The RNAi of DvSnf7 has been used for resistance to LM maize and the Western Corn Rootworm which is a major agricultural pest for the US Corn Belt. Most of the environmental risk assessments (ERA) of double strand RNA (dsRNA) have been performed using in vitro transcript products, and not in vivo expressed product. A large amount of dsRNA was required for the acute toxicity assay of water fleas. Therefore development of massive dsRNA purification techniques is critical. Daphnia, a freshwater microcrustacean, is a model organism for studying cellular and molecular mechanism involved in life history traits and ecotoxicology. In this study, we established the massive dsRNA purification method using Escherichia coli and implemented acute toxicity assays to Daphnia magna. As a result, the present RNase A and DNase I, dsRNA was efficiently purified without any special techniques or equipment. Even though purified dsRNA existed during the acute toxicity test, lethality or abnormal behavior were not observed in D. magna. These results indicated that GFP and DvSnf7 dsRNA were not significantly affected to D. magna due to their lack of sequence matching in its genome. The purification method of dsRNA and the acute toxicity assay of water fleas using purified dsRNA would be suitable for the toxicological studies of LMOs to aquatic non-target organisms.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.2
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• pp.170-178
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• 2005

An in silico approach was developed to survey the genes expressed in four internal organs of pig: liver, kidney, spleen and small intestine. The major procedures of the approach included: (1) BLAST searching against GenBank "est_others" database using human cDNA sequences as queries to screen the porcine orthologous expressed sequence tags (ESTs), (2) classifying the porcine ESTs records by resources according to certain criteria and (3) analyzing data for ESTs specifically expressed in each organ. In order to do so, four Java programs were developed. Based on the ESTs available in the GenBank database, it was found that there were at least 2,100 genes expressed in these four organs, including 128 in the liver, 81 in the kidney, 780 in the spleen, and 1,423 in the small intestine respectively (a few genes co-expressed in these tissues). Gene expression patterns, such as co-expressed genes, preferentially expressed genes and basic active genes were also compared and characterized among these organs. This study provides a comprehensive model on how to use the bioinformatics approach and Genbank databases to facilitate the discovery of new genes in livestock species.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.5
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• pp.747-752
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• 2016

This study aimed to estimate the change of stress level in horses based on cortisol concentration levels in their saliva. A total of 61 horses were divided into the following three groups: i) tourist riding experience (TR, n = 23); ii) resting group (RR, n = 14); and iii) horse-riding education (ER, n = 24). The saliva samples of TR and ER groups were taken using plain cotton Salivettes four times a day: at 07:00 (basal), 11:00 (Exercise 1, after 1-hour exercise in the morning), 14:00 (Exercise 2, after 1-hour exercise in the afternoon), and 16:00 (Exercise 3, after 1-hour exercise in the afternoon). The saliva samples of RR were measured at the same time. The samples were analyzed using the SAS program general linear model procedure. In a percentage relative to the base value, cortisol levels in Exercise 3 were confirmed to decrease in all groups as compared to the basal value percentage in the following sequence: ER>TR>RR. The highest peak was confirmed in Exercise 2 (approximately 131%) of RR group and the lowest peak appeared in Exercise 3 (approximately 52%) of ER group. Therefore, resting without any particular exercise can also increase the stress level of horses. Thus, it is better to exercise, as exercise can reduce the stress level, even in cases when riders are clumsy or lack appropriate horse-riding experience. The results of the present study are useful to equestrian center owners and educational riding instructors in that they provide a meaningful insight into a better horse management.