• Educational Technology International
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• 제17권2호
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• pp.203-228
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• 2016

This study was designed to determine the factors affecting learner satisfaction and examine the relationships of these factors in mobile learning linked to pre-existing e-learning in universities. In the structural model used, three mobile learning quality factors are the endogenous variables, namely, system quality (SYQ), information quality (INQ) and service quality (SEQ) perceived by students, and learner satisfaction (LS), whereas students' self-efficacy (SE) and experience (EX) in mobile learning are the exogenous variables. The subjects were 900 students who registered for mobile learning courses offered by a private university in Seoul, Korea. The results indicated that SE in mobile learning had positive effects on SYQ, INQ, and SEQ. Furthermore, SE influenced LS when analyzed without quality factors as parameters. Mobile learning EX directly affected INQ, but not SYQ or SEQ. EX likewise had a direct effect on LS when analyzed without quality factors as parameters. Meanwhile, both SYQ and INQ showed a positive effect on LS, but not SEQ. SE and EX affected LS indirectly when SYQ and INQ were used as parameters. This study addresses the importance of increasing SE, EX, SYQ, and INQ to increase LS in mobile learning in universities

• Tuberculosis and Respiratory Diseases
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• 제79권2호
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• pp.85-90
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• 2016

Background: Lung cancer is the most common cause of cancer related death. Alterations in gene sequence, structure, and expression have an important role in the pathogenesis of lung cancer. Fusion genes and alternative splicing of cancer-related genes have the potential to be oncogenic. In the current study, we performed RNA-sequencing (RNA-seq) to investigate potential fusion genes and alternative splicing in non-small cell lung cancer. Methods: RNA was isolated from lung tissues obtained from 86 subjects with lung cancer. The RNA samples from lung cancer and normal tissues were processed with RNA-seq using the HiSeq 2000 system. Fusion genes were evaluated using Defuse and ChimeraScan. Candidate fusion transcripts were validated by Sanger sequencing. Alternative splicing was analyzed using multivariate analysis of transcript sequencing and validated using quantitative real time polymerase chain reaction. Results: RNA-seq data identified oncogenic fusion genes EML4-ALK and SLC34A2-ROS1 in three of 86 normal-cancer paired samples. Nine distinct fusion transcripts were selected using DeFuse and ChimeraScan; of which, four fusion transcripts were validated by Sanger sequencing. In 33 squamous cell carcinoma, 29 tumor specific skipped exon events and six mutually exclusive exon events were identified. ITGB4 and PYCR1 were top genes that showed significant tumor specific splice variants. Conclusion: In conclusion, RNA-seq data identified novel potential fusion transcripts and splice variants. Further evaluation of their functional significance in the pathogenesis of lung cancer is required.

• Genomics & Informatics
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• 제17권1호
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• pp.3.1-3.4
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• 2019

Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast cancer is a significant challenge for effective treatment. Using single-cell RNA sequencing (RNA-seq) data from a public resource, an ERBB pathway activated triple-negative cell population was identified. The differential expression of three subtyping marker genes (ERBB2, ESR1, and PGR) was not changed in the bulk RNA-seq data, but the single-cell transcriptomes showed intratumor heterogeneity. This result shows that ERBB signaling is activated using an indirect route and that the molecular subtype is changed on a single-cell level. Our data propose a different view on breast cancer subtypes, clarifying much confusion in this field and contributing to precision medicine.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1996년도 제24회 춘계학술대회
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• pp.121-125
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• 1996

자동차의 환경규제, 고성증화에 맞추어 새로이 규격이 제정된 ILSAC GF-2 가솔린엔지유는 SEQ VI와 SEQ VIA를 통한 연비시험 결과 ILSAC GF-1엔지유에 비해서 연비성능이 향상되었으며, phosphorous함량 규제에 따라 ZnDDP의 첨가량을 줄였음에도 불구하고 다른 산화방지제와 마모방지제를 투입함으로써 규격엔진시험을 통과하였고 실파를 이용한 시험에서는 ILSAC GF-1에 비해서 우수한 마모방지성능과 산화안정성을 보였다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2020년도 추계학술발표대회
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• pp.912-915
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• 2020

최근 자연어 처리 기술은 지속적으로 발전하고 있으며, 많은 분야에서 활용되고 있다. 그 중 번역 기술은 가장 널리 사용되고 있는 자연어 처리 기술 중 하나이다. 본 논문에서는 기존의 seq2seq 모델의 단점을 극복하기 위해 개발된 Transformer 를 통해 영어-한국어 번역기를 만드는 것의 가능성을 제시한다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제10권11호
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• pp.535-540
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• 2021

다중문서는 하나의 주제가 아닌 다양한 주제로 구성된 문서를 의미하며 대표적인 예로 온라인 리뷰가 있다. 온라인 리뷰는 정보량이 방대하기 때문에 요약하기 위한 여러 시도가 있었다. 그러나 기존의 요약모델을 통해 리뷰를 일괄적으로 요약할 경우 리뷰를 구성하고 있는 다양한 주제가 소실되는 문제가 발생한다. 따라서 본 논문에서는 주제의 손실을 최소화하며 리뷰를 요약하기 위한 기법을 제시한다. 제안하는 기법은 전처리, 중요도 평가, BERT를 활용한 임베딩 치환, 임베딩 클러스터링과 같은 과정을 통해 리뷰를 분류한다. 그리고 분류된 문장은 학습된 Transformer 요약모델을 통해 최종 요약을 생성한다. 제안하는 모델의 성능 평가는 기존의 요약모델인 seq2seq 모델과 ROUGE 스코어와 코사인 유사도를 평가하여 비교하였으며 기존의 요약모델과 비교하여 뛰어난 성능의 요약을 수행하였다.

• 한국컴퓨터정보학회논문지
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• 제25권8호
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• pp.1-8
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• 2020

본 논문에서는 드노보 전사체 어셈블리의 수행시간을 단축하기 위해 RNA-seq 서열을 유전자계 정보를 활용하여 여러 노드로 분산이 가능한 방법을 제시한다. 제안하는 전사체 서열 데이터 분산기법의 성능을 측정하기 위해 애기장대의 리드를 4개의 데이터 셋(전체 비분류 리드, 완전 분류 리드, 모델 분류 리드, 무작위 분류 리드)으로 구성하여 실험을 수행하였다. 전체 비분류 데이터와 비교하여 생성된 유전자 콘티그(Contig)는 95% 일치하였고 동일한 리소스들을 사용하는 단일 노드에 비해 본 연구에서 제시하는 분산환경분산 환경 기반의 어셈블리 수행시간은 4.2배 단축되었다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.102-102
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• 2017

In this study, QTL analysis of allelopathy was conducted. A total of 171 of F8 RILs developed from the cross between Nongan(low allelopathic cultivar) and Sathi(high allelopathic cultivar) were used . the performance of allelopathy were evaluated using 'ECAM(Equal Compartment Agar Method)', where the root length of lettuce cultivated with the RILs were measured. The distribution of the performance was followed as normal distribution. In order to identify the location of QTLs related to allelopathy, QTL-seq with BSA(Bulked-segregant analysis) was performed with 20 highest and 10 lowest RILs. As a result, Two Sliding window coordinate region of candidate QTLs were detected on Chr4 (5,050,001 - 14,800,000, 18,650,001 - 22,500,000), Chr8 (2,550,001 - 8,250,000, 21,150,001 - 26,800,000) and One region on Chr7 (1 - 3,300,000), Chr9 (1 - 13,300,000) respectively.

• Asian-Australasian Journal of Animal Sciences
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• 제29권3호
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• pp.343-351
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• 2016

Although the chemical, physical, and nutritional properties of bovine milk have been extensively studied, only a few studies have attempted to characterize milk-synthesizing genes using RNA-seq data. RNA-seq data was collected from 21 Holstein samples, along with group information about milk production ability; milk yield; and protein, fat, and solid contents. Meta-analysis was employed in order to generally characterize genes related to milk production. In addition, we attempted to investigate the relationship between milk related traits, parity, and lactation period. We observed that milk fat is highly correlated with lactation period; this result indicates that this effect should be considered in the model in order to accurately detect milk production related genes. By employing our developed model, 271 genes were significantly (false discovery rate [FDR] adjusted p-value<0.1) detected as milk production related differentially expressed genes. Of these genes, five (albumin, nitric oxide synthase 3, RNA-binding region (RNP1, RRM) containing 3, secreted and transmembrane 1, and serine palmitoyltransferase, small subunit B) were technically validated using quantitative real-time polymerase chain reaction (qRT-PCR) in order to check the accuracy of RNA-seq analysis. Finally, 83 gene ontology biological processes including several blood vessel and mammary gland development related terms, were significantly detected using DAVID gene-set enrichment analysis. From these results, we observed that detected milk production related genes are highly enriched in the circulation system process and mammary gland related biological functions. In addition, we observed that detected genes including caveolin 1, mammary serum amyloid A3.2, lingual antimicrobial peptide, cathelicidin 4 (CATHL4), cathelicidin 6 (CATHL6) have been reported in other species as milk production related gene. For this reason, we concluded that our detected 271 genes would be strong candidates for determining milk production.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2019년도 추계학술발표대회
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• pp.898-900
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• 2019

SPARQL(SPARQL Protocol and RDF Query Language)은 지식 베이스를 위한 표준 시맨틱 질의 언어이다. 최근 인공지능 분야에서 지식 베이스는 질의 응답 시스템, 시맨틱 검색 등 그 활용성이 커지고 있다. 그러나 SPARQL 과 같은 질의 언어를 사용하기 위해서는 질의 언어의 문법을 이해하기 때문에, 일반 사용자의 경우에는 그 활용성이 제한될 수밖에 없다. 이에 본 논문은 신경망 기반 기계 번역 기술을 활용하여 자연어 질의로부터 SPARQL 을 생성하는 방법을 제안한다. 우리는 제안하는 방법을 대규모 공개 지식 베이스인 Wikidata 를 사용해 검증하였다. 우리는 실험에서 사용할 Wikidata 에 존재하는 영화 지식을 묻는 자연어 질의-SPARQL 질의 쌍 20,000 건을 생성하였고, 여러 sequence-to-sequence 모델을 비교한 실험에서 합성곱 신경망 기반의 모델이 BLEU 96.8%의 가장 좋은 결과를 얻음을 보였다.