• Journal of Gastric Cancer
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• 제18권1호
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• pp.58-68
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• 2018

Purpose: Generally, adjuvant chemotherapy (AC) should be initiated as soon as possible after surgery to eradicate microscopic cancer cells. In this study, we investigated the effect of early AC on the survival of stage II/III gastric cancer patients. Materials and Methods: Four hundred sixty patients who received AC (S-1 or XELOX) for pathologic stage II/III gastric cancer at Seoul National University Bundang Hospital between January 2008 and December 2014 were included. Patients were divided into 2 groups: early AC administration (within 4 weeks) and late AC administration (more than 4 weeks). Patients in the early AC group (n=174) were matched 1:1 with patients in the late AC group (n=174) by propensity scoring to adjust for clinical differences. Three-year relapse-free survival (RFS) was evaluated according to the timing of AC. Results: Three-year RFS was 98.1% in stage IIA (n=109), 85.0% in stage IIB (n=83), 87.4% in stage IIIA (n=96), 83.5% in stage IIIB (n=91), and 62.5% in stage IIIC (n=81). After propensity score matching, RFS was similar between early and late AC groups (hazard ratio [HR],1.04; 95% confidence interval [CI], 0.62-1.74; P=0.889). Pathologic stage and histological type were independent prognostic factors of RFS (HR, 2.05; 95% CI, 1.06-3.96; P=0.033 and HR, 2.61; 95% CI, 1.42-4.80; P=0.002, respectively). Conclusions: Early initiation of AC within 4 weeks does not affect survival rates in stage II/III gastric cancer.

• Pediatric Infection and Vaccine
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• 제30권1호
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• pp.33-38
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• 2023

Ralstonia mannitolilytica는 다양한 종류의 상수도에 퍼져 있는 그람 음성세균으로써 병원체로는 흔하지 않지만 골수염, 수막염, 균혈증, 패혈증 등 심각한 결과를 초래하는 기회감염을 일으킬 수 있다. 저자들은 신생아 중환자실에서 발생한 R. mannitolilytica bacteremia 단일사례를보고한다. 재태주수 38주 6일에 2,770 g으로출생한환아는대혈관전위, 심실중격결손, 폐동맥협착이 있어 신생아 중환자실로 입실해 프로스타글란딘E1을 투약 받았으며, 생후 7일부터 간헐적으로 발열이 있어 감염을 배제한 후 체온을 낮추기 위해 가습기를 사용하였다. 생후 34일에 39.2℃의 고열이 있어 시행한 혈액배양 검사에서 R. mannitolilytica가 동정되었다. 이전에 R. mannitolilytica가 기관에서 검출된 적이 없었을뿐더러 항생제 치료에도 균혈증이 지속되어 환경 조사 및 의료기기에 대한 감시 배양를 시행하였다. 환아에게 사용한 가습기에서 R. mannitolilytica가 동정되었고, 가습기 사용을 중단한 후로 균혈증, 발열이 호전되었다. 이 증례는 새로운 또는 흔하지 않은 감염이 있을 경우 감염원에 대한 면밀한 조사가 중요함과 적절한 항생제 치료에도 반응이 없을 경우 환경조사가 필요함을 시사한다.

• Journal of Chest Surgery
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• 제47권4호
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• pp.398-401
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• 2014

Severe tricuspid regurgitation resulting from a flail leaflet is a rare cause of neonatal cyanosis. We report a neonate with profound cyanosis and severe tricuspid regurgitation caused by a rupture of the papillary muscle supporting the anterior leaflet, without other structural heart defects. Ductal patency could not be established. The repair of the tricuspid valve was performed after initial stabilization by using extracorporeal membrane oxygenation.

• Journal of Chest Surgery
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• 제50권5호
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• pp.382-385
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• 2017

A 47-year-old man with myasthenia gravis (MG) was admitted for a lung transplant. He had bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation due to acute myeloid leukemia. MG developed after stem cell transplantation. Bilateral sequential lung transplantations and a total thymectomy were performed. The patient underwent right diaphragmatic plication simultaneously due to preoperatively diagnosed right diaphragmatic paralysis. A tracheostomy was performed and bilevel positive airway pressure (BiPAP) was applied on postoperative days 8 and 9, respectively. The patient was transferred to the general ward on postoperative day 12, successfully weaned off BiPAP on postoperative day 18, and finally discharged on postoperative day 62.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2017년도 하계학술대회
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• pp.207-208
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• 2017

최근 보급되는 스마트 디바이스들은 실외뿐만 아니라 실내의 위치를 측정할 수 있는 기술들을 제공하고 있다. 실외 위치 측위 같은 경우는 기존의 GPS(Global Positioning System)를 사용하는 것이 일반적이지만, 실내 위치 측위는 기존의 GPS 방법으로는 한계가 있어 다양한 새로운 방법들이 연구 중에 있다. 그 중 가장 대표적인 방법은 BLE(Bluetooth Low Energy) 기반의 비콘(beacon)을 활용하는 것이다. 그러나 이 또한 추가적인 하드웨어가 필요할 뿐만 아니라 충전이 필요하다는 단점이 존재한다. 따라서 본 논문은 상기 단점들을 극할 수 있는 OCC(Optical Camera Communication)를 활용한 실내 위치 측위 기술을 고려한다. 특별히 공연장 내에서 관객들이 소지하고 있는 스마트 디바이스 카메라의 상대적인 위치정보를 획득하는 시스템을 제안한다. 이는 추가적인 하드웨어를 필요로 하지 않고 비동기식 접근이 가능하다는 장점이 있다. 본 논문에서 제안한 시스템을 통해 획득된 위치정보들은 촬영한 영상과 함께 저장되어 다양한 시점을 제공하는 응용데이터로 활용될 수 있을 것으로 기대한다.

• 한국수정란이식학회지
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• 제26권3호
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• pp.219-222
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• 2011

Eight female Himalayan tahrs (Hemitragus jemlahicus) were estrus-synchronized, and transcervically inseminated with frozen-thawed semen in September, 2009, about 2 to 3 months earlier than their natural breeding season. Intravaginal progesterone-releasing devices were inserted into vaginas of six Himalayan tahrs on September 7, and the other two on September 8 to suppress luteal function of ovaries. The devices had been placed deep inside the vagina prior to withdrawal on September 23. A day before CIDR removal, a combination of PMSG 400 IU and hCG 200 IU was intramuscularly injected. Forty hours later, frozen-thawed semen was transcervically inseminated. Pregnancy diagnosis was performed 39 days later by analyzing progesterone level of serum. Every treatment was done under anesthesia inducted by xylazine injection. In conclusion, vaginal discharge of cervical mucus, hormonal changes induced by implant-typed or muscularly injectable hormones and widening of cervix enough to insert an insemination gun into uterine body were achieved in non-breeding season. Moreover, the first inseminated Himalayan tahr, 36 hours after CIDR removal was assumed to be pregnant but the fetus may have been lost due to the use of anesthetic drug.

• Journal of Korean Neurosurgical Society
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• 제49권6호
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• pp.359-362
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• 2011

Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is an unusual malignancy with aggressive behavior. ES/PNET in the cerebellopontine angle (CPA) is extremely uncommon, and we report on a rare case here. A 31-year-old man presented with one month history of left facial palsy, hearing loss, swallowing difficulty, and hoarseness. Magnetic resonance images showed a large mass in the left CPA and a small one in the right cerebellar hemisphere. The patient underwent a surgery for the CPA mass lesion, and the pathology was compatible with ES/PNET. Radiation therapy and chemotherapy were administered. In contrast to the initial radiologic findings resembling vestibular schwannoma or meningioma, ES/PNET had several distinct clinical features. A patient with a CPA mass and presenting unusual clinical features should be suspected of having a rare malignancy.

• Journal of Chest Surgery
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• 제46권2호
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• pp.156-158
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• 2013

Thoracic extramedullary hematopoiesis (EMH) is a rare disease entity that is usually associated with hematologic disorders, such as myelodysplastic or hemolytic disease. Because thoracic EMH is usually encountered as a mass during radiologic examinations, it should be differentiated from posterior mediastinal neurogenic tumors. Here, the authors report a case of EMH associated with hereditary spherocytosis. The patient underwent a complete excision by thoracoscopic surgery to differentiate it from other mediastinal tumors.

• Annals of Clinical Neurophysiology
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• 제11권2호
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• pp.74-77
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• 2009

We report a 23-year-old woman with adult Sandhoff disease, who presented with motor neuron disease phenotype. The patient had experienced progressive motor weakness in four extremities since 1 year prior to admission. Electrophysiological study revealed wide-spread denervation potentials, and the assay of total hexosaminidase involving A and B activities showed decreased levels of these activities, which was consistent with Sandoff disease. This is the first Korean case of adult Sanhoff disease presented as a motor neuron disease phenotype.

• Journal of Chest Surgery
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• 제47권5호
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• pp.478-482
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• 2014

A 39-year-old man presented with cough, chest discomfort, and weight loss. On the basis of the patient history and laboratory findings, he was diagnosed with the hypereosinophilic syndrome. Transthoracic echocardiography revealed a large thrombus in the left ventricle. Medical treatment with anticoagulation and immunosuppression was commenced immediately. Fourteen days after the initial diagnosis, the patient presented with acute pain in his right leg. Computed tomographic angiogram showed embolic occlusion of the infrarenal abdominal aorta and bilateral iliac (including common, external, and internal iliac) arteries. Emergent thromboembolectomy and left ventricular thrombectomy were performed. The postoperative course was uneventful, and the patient has undergone follow-up for 2 months without any evidence of recurrence of thromboembolism.