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Delayed Cerebral Toxoplasmosis in a Kidney Transplant Patient: a Case Report

  • Myeong, Hosung;Park, Moowan;Kim, Ji Eun;Park, Sun Won;Lee, Sang Hyung
    • Parasites, Hosts and Diseases
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    • v.60 no.1
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    • pp.35-38
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    • 2022
  • Cerebral toxoplasmosis is often life-threatening in an immunocompromised patient due to delayed diagnosis and treatment. Several differential diagnoses could be possible only with preoperative brain images of cerebral toxoplasmosis which show multiple rim-enhancing lesions. Due to the rarity of cerebral toxoplasmosis cases in Korea, the diagnosis and treatment are often delayed. This paper concerns a male patient whose cerebral toxoplasmosis was activated 21 years post kidney transplantation. Brain open biopsy was decided to make an exact diagnosis. Cerebral toxoplasmosis was confirmed by immunohistochemistry and PCR analyses of the tissue samples. Although cerebral toxoplasmosis was under control with medication, the patient did not recover clinically and died due to sepsis and recurrent gastrointestinal bleeding.

The Effect of Pulsatile Flow on Ultrafiltration In-Vitro Study and Comparison with Roller Pump

  • Lee K.;Jeong J. H.;Mun C. H.;Lee J. C.;Min B. G.
    • Journal of Biomedical Engineering Research
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    • v.26 no.5
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    • pp.337-341
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    • 2005
  • Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.

Hypersensitivity Reactions to Oxaliplatin: Clinical Features and Risk Factors in Koreans

  • Kim, Mi-Yeong;Kang, Sung-Yoon;Lee, Suh-Young;Yang, Min-Suk;Kim, Min-Hye;Song, Woo-Jung;Kim, Sae-Hoon;Kim, Yo-Jung;Lee, Keun-Wook;Cho, Sang-Heon;Min, Kyung-Up;Lee, Jong-Seok;Kim, Jee-Hyun;Chang, Yoon-Seok
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1209-1215
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    • 2012
  • Background and Aim: Oxaliplatin hypersensitivity is a well-known adverse reaction but the prevalence varies and data for frequency and clinical features have not been reported for Korea. Here we evaluates the prevalence and risk factors for hypersensitivity reactions to oxaliplatin after chemotherapy. Methods: Clinical information on all patients treated with oxaliplatin was retrospectively reviewed in electronic medical records between August 2009 and July 2010 in Seoul National University Bundang Hospital. Patients who experienced hypersensitivity reactions to oxaliplatin were compared with those who did not. Results: A total of 393 patients received oxaliplatin, with 42 (10.7%) experiencing hypersensitivity reactions including three cases of anaphylaxis. Median cycle of the first hypersensitivity reaction was 8. Reactions correlated with lower dexamethasone doses. Other variables were not significant. Conclusions: The prevalence of hypersensitivity reactions was 10.7%, symptoms being mostly mild and cutaneous. Lower dexamethasone doses could be a predictor for hypersensitivity reactions to oxaliplatin.

Parasitic infections in HIV-infected patients who visited Seoul National University Hospital during the period 1995-2003

  • GUK Sang-Mee;SEO Min;PARK Yun-Kyu;OH Myoung-Don;CHOE Kang-Won;KIM Jae-Lip;CHOI Min-Ho;HONG Sung-Tae;CHAI Jong-Yil
    • Parasites, Hosts and Diseases
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    • v.43 no.1 s.133
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    • pp.1-5
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    • 2005
  • The prevalence of parasitic infections was investigated in human immunodeficiency virus (HIV)-infected patients (n = 105) who visited Seoul National University Hospital, Seoul, Korea, during the period from 1995 to 2003. Fecal samples were collected from 67 patients for intestinal parasite examinations, and sputum or bronchoalveolar lavage samples from 60 patients for examination of Pneumocystis carinii. Both samples were obtained from 22 patients. Thirty-three ($31.4\%$) of the 105 were found to have parasitic infections; Cryptosporidium parvum ($10.5\%$; 7/67), Isospora belli ($7.5\%$; 5/67), Clonorchis sinensis ($3.0\%$; 2/67), Giardia lamblia ($1.5\%$; 1/67), Gymnophalloides seoi ($1.5\%$; 1/67), and Pneumocystis carinii ($28.3\%$; 17/60). The hospital records of the 11 intestinal parasite-infected patients showed that all suffered from diarrhea. This study shows that parasitic infections are important clinical complications in HIV-infected patients in the Republic of Korea.

Site and Erection of the Government Complex Seoul in Capital Seoul (수도 서울에서 정부종합청사의 입지와 건립)

  • Lee, Sumin;Woo, Don-Son
    • Journal of architectural history
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    • v.27 no.2
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    • pp.51-62
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    • 2018
  • This study examines the site and erection of the Government Complex Seoul which was a project attempted to assemble dispersed government buildings in a certain place. The study focuses on the fact that the project is situated between the 1960s' making of capital Seoul and Seoul urban planning, and the way how the project achieved symbolism in capital Seoul. The project, one of the 1960s' Major Government Buildings, led both plan of capital Seoul and transforming city Seoul. The 1960s' Major Government Building Plan had identical drive with the 1950's Major Government Building Plan, however the 1960s' had additional layer: Seoul urban planning. After restoration of the Capital building, Sejongro the capital street was planned to the site arranging government offices. The Government Complex Seoul was set to be a modern building on a site with historical context according to the plan. Because of the site, the Government Complex Seoul was constructed in aware of other buildings that represented a competitive high-rise atmosphere in the late 1960s, including the Capital building nearby. PAE International's plan was completed through a series of design modification, and it boasted a vertical aspect, unlike the horizontal-looking plan that was already won after the design competition. The Government Complex Seoul tried to acquire the symbolism in the central space of the capital Seoul and high-rised city Seoul. "The new construction method" was a requirement to achieve the height.