• 응용통계연구
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• 제32권2호
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• pp.291-300
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• 2019

본 논문에서는 반응변수가 이진형인 분류모형에 대한 평가측도들의 특성을 파악하고 사용하기 적합한 평가측도인가를 살펴보았다. 고려한 측도는 정분류율, 민감도, 특이도, 정밀도, F-measure, HSS (Heidke's skill score)의 6개이다. 각 측도들은 이원분할표에서 x(실제로 1인 비율), y(1로 예측되는 비율), z(실제와 예측이 모두 1인 비율)을 사용하여 표현하였다. 본 연구는 평가측도가 사용하기 적합한 측도가 되기 위한 조건으로 두 가지를 제안하였다. 제1조건은 랜덤모형인 경우에 평가측도는 x와 y에 대해 상수이고, 제2조건은 평가측도의 식이 세 변수들(x, y, z) 모두로 이루어지고 z에 대해서 증가함수이고 x와 y에 대해서 감소함수이어야 한다는 것이다. HSS는 두 조건을 모두 만족하므로 이진형 반응변수의 분류모형에 대한 평가측도로 항상 사용이 적합하고, 다른 측도들은 제한된 범위 내에서만 사용하는 것이 좋다.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.71-76
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• 2020

While montelukast (ML), a cysteinyl-leukotriene type 1 receptor (CysLT1) antagonist is widely used to treat symptoms of rhinitis or asthma, its formulations are mainly limited to solid preparation due to its instability. Recently, there have been attempts to develop various ML dosage forms, and this situation increases the demand of sensitive and creditable methods to determine ML in various samples such as plasma. Thus, here, a simple and efficient method to determine ML in rat plasma using liquid-liquid extraction (LLE) and multiple reaction monitoring was presented. The mixture of DCM:EtOAc (25:75, v/v), the optimized extract solvent for LLE was found to be effective to extract ML without hydrophilic salts and proteins from the sample with limited volume. Also, the use of zafirlukast, instead of expensive ML-d6, as the internal standard makes the present method economical. The developed method was successfully validated in terms of selectivity, matrix effects (-14.8--6.9%), linearity (r230.998 within 0.5-500 ng/mL), sensitivity (the limit of detection and the lower limit of quantitation, ≤0.5 ng/mL), accuracy (88.4-100.6%), precision (3.0-13.3%), and recovery (80.8-86.3%) by following the FDA guidelines. Finally, the applicability of the validated method to pharmacokinetics (PK) studies was confirmed by the successful determination of PK parameters through it following oral administration of Singulair® granule in rats. Therefore, the present method can contribute to the development of new ML formulations through its performance to determine ML in rat plasma efficiently and sensitively.

• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.120-130
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• 2021

The spinal cord or CSF surgery is a very complex process. It requires continuous pre and post-surgery evaluation to have a better ability to diagnose the disease. To detect automatically the suspected areas of tumors and symptoms of CSF leakage during the development of the tumor inside of the brain. We propose a new method based on using computer software that generates statistical results through data gathered during surgeries and operations. We performed statistical computation and data collection through the Google Source for the UK National Cancer Database. The purpose of this study is to address the above problems related to the accuracy of missing hybrid KNN values and finding the distance of tumor in terms of brain cancer or CSF images. This research aims to create a framework that can classify the damaged area of cancer or tumors using high-dimensional image segmentation and Laplace transformation method. A high-dimensional image segmentation method is implemented by software modelling techniques with measures the width, percentage, and size of cells within the brain, as well as enhance the efficiency of the hybrid KNN algorithm and Laplace transformation make it deal the non-zero values in terms of missing values form with the using of Frobenius Matrix for deal the space into non-zero values. Our proposed algorithm takes the longest values of KNN (K = 1-100), which is successfully demonstrated in a 4-dimensional modulation method that monitors the lighting field that can be used in the field of light emission. Conclusion: This approach dramatically improves the efficiency of hybrid KNN method and the detection of tumor region using 4-D segmentation method. The simulation results verified the performance of the proposed method is improved by 92% sensitivity of 60% specificity and 70.50% accuracy respectively.

• Journal of Periodontal and Implant Science
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• 제52권3호
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• pp.220-229
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• 2022

Purpose: The aim of this study was to evaluate and compare the accuracy performance of dental professionals in the classification of different types of dental implant systems (DISs) using panoramic radiographic images with and without the assistance of a deep learning (DL) algorithm. Methods: Using a self-reported questionnaire, the classification accuracy of dental professionals (including 5 board-certified periodontists, 8 periodontology residents, and 31 dentists not specialized in implantology working at 3 dental hospitals) with and without the assistance of an automated DL algorithm were determined and compared. The accuracy, sensitivity, specificity, confusion matrix, receiver operating characteristic (ROC) curves, and area under the ROC curves were calculated to evaluate the classification performance of the DL algorithm and dental professionals. Results: Using the DL algorithm led to a statistically significant improvement in the average classification accuracy of DISs (mean accuracy: 78.88%) compared to that without the assistance of the DL algorithm (mean accuracy: 63.13%, P<0.05). In particular, when assisted by the DL algorithm, board-certified periodontists (mean accuracy: 88.56%) showed higher average accuracy than did the DL algorithm, and dentists not specialized in implantology (mean accuracy: 77.83%) showed the largest improvement, reaching an average accuracy similar to that of the algorithm (mean accuracy: 80.56%). Conclusions: The automated DL algorithm classified DISs with accuracy and performance comparable to those of board-certified periodontists, and it may be useful for dental professionals for the classification of various types of DISs encountered in clinical practice.

• Journal of Ginseng Research
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• 제46권5호
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• pp.646-656
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• 2022

Background: In addition to its use as a health food, ginseng is used in cosmetics and shampoo because of its extensive health benefits. The ginsenoside, Rh2, is a component of ginseng that inhibits tumor cell proliferation and differentiation, promotes insulin secretion, improves insulin sensitivity, and shows antioxidant effects. Methods: The effects of Rh2 on cell survival, extracellular matrix (ECM) protein expression, and cell differentiation were examined. The antioxidant effects of Rh2 in UV-irradiated normal human dermal fibroblast (NHDF) cells were also examined. The effects of Rh2 on mitochondrial function, morphology, and mitophagy were investigated in UV-irradiated NHDF cells. Results: Rh2 treatment promoted the proliferation of NHDF cells. Additionally, Rh2 increased the expression levels of ECM proteins and growth-associated immediate-early genes in ultraviolet (UV)-irradiated NHDF cells. Rh2 also affected antioxidant protein expression and increased total antioxidant capacity. Furthermore, treatment with Rh2 ameliorated the changes in mitochondrial morphology, induced the recovery of mitochondrial function, and inhibited the initiation of mitophagy in UV-irradiated NHDF cells. Conclusion: Rh2 inhibits mitophagy and reinstates mitochondrial ATP production and membrane potential in NHDF cells damaged by UV exposure, leading to the recovery of ECM, cell proliferation, and antioxidant capacity.

• Geomechanics and Engineering
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• 제28권6호
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• pp.599-611
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• 2022

Tendon reinforced cemented soil is applied extensively in foundation stabilisation and improvement, especially in areas with soft clay. To solve the deterioration problem led by steel corrosion, the glass fiber-reinforced polymer (GFRP) tendon is introduced to substitute the traditional steel tendon. The interface bond strength between the cemented soil matrix and GFRP tendon demonstrates the outstanding mechanical property of this composite. However, the lack of research between the influence factors and bond strength hinders the application. To evaluate these factors, back propagation neural network (BPNN) is applied to predict the relationship between them and bond strength. Since adjusting BPNN parameters is time-consuming and laborious, the particle swarm optimisation (PSO) algorithm is proposed. This study evaluated the influence of water content, cement content, curing time, and slip distance on the bond performance of GFRP tendon-reinforced cemented soils (GTRCS). The results showed that the ultimate and residual bond strengths were both in positive proportion to cement content and negative to water content. The sample cured for 28 days with 30% water content and 50% cement content had the largest ultimate strength (3879.40 kPa). The PSO-BPNN model was tuned with 3 neurons in the input layer, 10 in the hidden layer, and 1 in the output layer. It showed outstanding performance on a large database comprising 405 testing results. Its higher correlation coefficient (0.908) and lower root-mean-square error (239.11 kPa) were obtained compared to multiple linear regression (MLR) and logistic regression (LR). In addition, a sensitivity analysis was applied to acquire the ranking of the input variables. The results illustrated that the cement content performed the strongest influence on bond strength, followed by the water content and slip displacement.

• 센서학회지
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• 제31권5호
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• pp.307-311
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• 2022

With the development of Internet of Things (IoT) technologies, numerous people worldwide connect with various electronic devices via Human-Machine Interfaces (HMIs). Considering that HMIs are a new concept of dynamic interactions, wearable electronics have been highlighted owing to their lightweight, flexibility, stretchability, and attachability. In particular, wearable strain sensors have been applied to a multitude of practical applications (e.g., fitness and healthcare) by conformally attaching such devices to the human skin. However, the stretchable elastomer in a wearable sensor has an intrinsic stretching limitation; therefore, structural advances of wearable sensors are required to develop practical applications of wearable sensors. In this study, we demonstrated a 3-dimensional (3D), porous, and piezoelectric strain sensor for sensing body movements. More specifically, the device was fabricated by mixing polydimethylsiloxane (PDMS) and polyvinylidene fluoride nanoparticles (PVDF NPs) as the matrix and piezoelectric materials of the strain sensor. The porous structure of the strain sensor was formed by a sugar cube-based 3D template. Additionally, mixing methods of PVDF piezoelectric NPs were optimized to enhance the device sensitivity. Finally, it is verified that the developed strain sensor could be directly attached onto the finger joint to sense its movements.

• International Journal of Computer Science & Network Security
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• 제23권8호
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• pp.17-25
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• 2023

The alarming global prevalence of Type 2 Diabetes Mellitus (T2DM) has catalyzed an urgent need for robust, early diagnostic methodologies. This study unveils a pioneering approach to predicting T2DM, employing the Extreme Gradient Boosting (XGBoost) algorithm, renowned for its predictive accuracy and computational efficiency. The investigation harnesses a meticulously curated dataset of 4303 samples, extracted from a comprehensive Chinese research study, scrupulously aligned with the World Health Organization's indicators and standards. The dataset encapsulates a multifaceted spectrum of clinical, demographic, and lifestyle attributes. Through an intricate process of hyperparameter optimization, the XGBoost model exhibited an unparalleled best score, elucidating a distinctive combination of parameters such as a learning rate of 0.1, max depth of 3, 150 estimators, and specific colsample strategies. The model's validation accuracy of 0.957, coupled with a sensitivity of 0.9898 and specificity of 0.8897, underlines its robustness in classifying T2DM. A detailed analysis of the confusion matrix further substantiated the model's diagnostic prowess, with an F1-score of 0.9308, illustrating its balanced performance in true positive and negative classifications. The precision and recall metrics provided nuanced insights into the model's ability to minimize false predictions, thereby enhancing its clinical applicability. The research findings not only underline the remarkable efficacy of XGBoost in T2DM prediction but also contribute to the burgeoning field of machine learning applications in personalized healthcare. By elucidating a novel paradigm that accentuates the synergistic integration of multifaceted clinical parameters, this study fosters a promising avenue for precise early detection, risk stratification, and patient-centric intervention in diabetes care. The research serves as a beacon, inspiring further exploration and innovation in leveraging advanced analytical techniques for transformative impacts on predictive diagnostics and chronic disease management.

• 인간식물환경학회지
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• 제22권5호
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• pp.455-466
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• 2019

This study was carried out to analyze trends in floral products and services through the big data analysis of various social networking services (SNSs) and then to provide objective marketing directions for the floricultural industry. To analyze the big data of SNSs, we used four analytical methods: Cotton Trend (Social Matrix), Naver Big Data Lab, Instagram Big Data Analysis, and YouTube Big Data Analysis. The results of the big data analysis showed that SNS users paid positive attention to flower one-day classes that can satisfy their needs for direct experiences. Consumers of floral products and services had their favorite designs in mind and purchased floral products very actively. The demand for flower items such as bouquets, wreaths, flower baskets, large bouquets, orchids, flower boxes, wedding bouquets, and potted plants was very high, and cut flowers such as roses, tulips, and freesia were most popular as of June 1, 2019. By gender of consumers, females (68%) purchased more flower products through SNSs than males (32%). Consumers preferred mobile devices (90%) for online access compared to personal computers (PCs; 10%) and frequently searched flower-related words from February to May for the past three years from 2016 to 2018. In the aspect of design, they preferred natural style to formal style. In conclusion, future marketing activities in the floricultural industry need to be focused on social networks based on the results of big data analysis of popular SNSs. Florists need to provide consumers with the floricultural products and services that meet the trends and to blend them with their own sensitivity. It is also needed to select SNS media suitable for each gender and age group and to apply effective marketing methods to each target.

• Journal of Preventive Medicine and Public Health
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• 제56권1호
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• pp.41-49
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• 2023

Objectives: Rwanda reported a stunting rate of 33% in 2020, decreasing from 38% in 2015; however, stunting remains an issue. Globally, child deaths from malnutrition stand at 45%. The best options for the early detection and treatment of stunting should be made a community policy priority, and health services remain an issue. Hence, this research aimed to develop a model for predicting stunting in Rwandan children. Methods: The Rwanda Demographic and Health Survey 2019-2020 was used as secondary data. Stratified 10-fold cross-validation was used, and different machine learning classifiers were trained to predict stunting status. The prediction models were compared using different metrics, and the best model was chosen. Results: The best model was developed with the gradient boosting classifier algorithm, with a training accuracy of 80.49% based on the performance indicators of several models. Based on a confusion matrix, the test accuracy, sensitivity, specificity, and F1 were calculated, yielding the model's ability to classify stunting cases correctly at 79.33%, identify stunted children accurately at 72.51%, and categorize non-stunted children correctly at 94.49%, with an area under the curve of 0.89. The model found that the mother's height, television, the child's age, province, mother's education, birth weight, and childbirth size were the most important predictors of stunting status. Conclusions: Therefore, machine-learning techniques may be used in Rwanda to construct an accurate model that can detect the early stages of stunting and offer the best predictive attributes to help prevent and control stunting in under five Rwandan children.