• Title/Summary/Keyword: senkyunolide A

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NFAT Transcription Factor Inhibitory Constituents from Cnidium officinale

  • Lee, Im-Seon;Huong, Dang Thi Lan;Lee, Mi-Sun;Kim, Jung-Woo;Na, Doe-Sun;Kim, Young-Ho
    • Natural Product Sciences
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    • v.8 no.3
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    • pp.94-96
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    • 2002
  • Four hundred varieties of plant extracts were screened for inhibitory activity against the NFAT transcription factor which plays an important role in inducing immune response. Among them, the MeOH extract of Cnidium officinale showed potent activity, and the activity-guided separation yielded butylidenephthalide, senkyunolide A and falcarindiol as the active constituents. The $IC_{50}$ value of butylidenephthalide was $1.3{\times}10^{-4}\;M$ and was similar to that of senkyunolide A $(2.1{\times}10^{-4}\;M)$. Interestingly, falcarindiol showed higher activity $(IC_{50},\;2.6{\times}10^{-5}\;M)$ than the two phthalides.

A study on the Qualitative and Quantitative Analysis of Essential oil in Angelicae tenuissimae Radix or Ligustici rhizoma (한국산과 중국산 고본(藁本)중 정유성분의 정성.정량에 관한 연구)

  • Park, Ho-Koon;Lee, Sang-In;Lee, Sun-Hyun;Park, Hyun-Mee;Lee, Jae-Seong
    • Korean Journal of Food Science and Technology
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    • v.29 no.2
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    • pp.189-193
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    • 1997
  • Major separation for the active ingredients and structural identification were performed in order for qualitative and quantitative analysis on Ligustici rhizoma or Angelicae tenuissimae Radix as an oriental herbal medicine for anodyne. The structure, composition and contents of ingredients for essential oil were determined by means of GC/MS. Several Angelicae tenuissimae Radix harvested in Korea were extracted, which has shown the higher crude content compared to that from China. The major component in Angelcae tenuissimae Radix extract was found to be Z-ligustilide (70-80%), which is very different from that in Ligustici rhizoma of which major component is proven to be senkyunolide (39%) with GC/MS.

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Inhibitory effects of Cnidium officinale extracts on $\alpha-MSH$ induced melanogenesis

  • Lee, Ghang-Tai;Lee, Jeong-No;Lee, Kwang-Sik;Jeong, Ji-Hean;Jo, Byoung-Kee
    • Proceedings of the SCSK Conference
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    • 2003.09b
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    • pp.44-49
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    • 2003
  • $\alpha$-MSH plays an important role in UV induced melanogenesis in human skin. It is believed to exert its effects by binding to $\alpha$-MSH receptor that in turn activates adenylate cyclase and increase melanocyte proliferation, dendricity and melanogenesis. In this study, we evaluated plant extracts showing the inhibitory activity on $\alpha$-MSH induced melanogenesis. The Cnidium officinale extracts showed high inhibitory activity on $\alpha$-MSH induced melanogenesis. It ($50{\mu}\textrm{g}$/ml) inhibited the melanin synthesis activated by $\alpha$-MSH in B-16 melanoma cells. Also, we isolated active compound from C. officinale extracts by Mass spectrophotometer, HPLC. It was identified as Senkyunolide A. It showed the same inhibitory activity as C. officinale extracts at the lower concentration. Finally, Senkyunolide A from Cnidium officinale extracts could playas $\alpha$-MSH antagonist and be used as a strong ingredient for skin whitening cosmetics.

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Studies on Essential Oils of Plants of Angelica Genus in Korea ( II ). -Essential Oils of the Root of Angelica tenuissima- (Angelica속 생약의 정유 성분에 대한 연구 ( II ). -고본의 정유 성분-)

  • Kim, Hyun-Soo;Chi, Hyung-Joon
    • Korean Journal of Pharmacognosy
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    • v.20 no.1
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    • pp.13-20
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    • 1989
  • In continuation of our studies on essential oils of Angelica genus(Umbelliferae), We report on the components of essential oils obtained from the root of Angelica tenuissima Nakai(藁子). Oils were obtained from the dried roots by steam distillation and fractionated by column chromatography. Each isolate or fraction was identified by GC, GC-MS and spectral analysis. Essential oils of the root of A. tenuissima(Gaoben) were found to contain $\alpha-pinene,\;camphene,\;\beta-pinene,\;myrcene,\;\alpha-phellandrene,\;\Delta-3-carene,\;p-cymene,\;limonene,\;\gamma-terpinene,\;terpinolene,\;4-vinylguauacol,\;\gamma-elemene$, one aromatic compound, three unidentified sesquiterpene alcohols, butylidenephthalide, senkyunolide and Z-ligustilide which was the most abundant compound comprising 75% of the whole oil. Also butylphthalide and hydroxybutylidenephalide were tentatively identified.

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The Flavor Components of Korean Cnidium officinale Makino (국내산 천궁의 향기 성분)

  • 최성희;김혜정
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.29 no.4
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    • pp.582-585
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    • 2000
  • This study was performed to identify the flavor compnenets of Korean Cnidium officinale M.. The extraction of the flavor compounds of Cnidium officinale M. was accomplished by a simultaneous distillation and extraction method using a Likens and Nickerson's extraction apparatus. The concentrated extract was analyzed and identified by gas chromatography and GC-mass spectrometry. The change of the 림팩 contents in each samples was determined in terms of two different storage conditions. The flavor contents of sample at low temperature storage were higher than those at room temperature storage, and increased until storage period of 70 days. The major components of Cnidium officinale M. were terpene compounds including α-pinene, β -selinene, γ-selinene, and phthalides including butylidenephthalide, cnidilide, neocnidilide, senkyunolide A, ligustilide, which are believed to contribute to the characteristic flavor of the Cnidium officinale M.. Especially, great amount of cnidilide and ligustilide was shown in sample of low temperature storage.

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Physicochemical Characteristics of Medicinal Herbs Ganjang (약용식물 추출물을 첨가한 간장의 이화학적 특성)

  • Shim, Sung-Lye;Ryu, Keun-Young;Kim, Won;Jun, Sam-Nyeo;Seo, Hye-Young;Han, Kyu-Jai;Kim, Jun-Hyeong;Song, Hyun-Pa;Cho, Nam-Chul;Kim, Kyong-Su
    • Food Science and Preservation
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    • v.15 no.2
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    • pp.243-252
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    • 2008
  • We investigated the physicochemical properties of Ganjang added to a medicinal herb extract (functional Ganjang). 1be proximate compositions of conventional Ganjang (control) and functional Ganjang (supplemented with 3% or 5% of an hem extract) were not significantly different Analysis of total and free amino acids indicated 17 different amino acids in both types of Ganjang. Glutamic acid was the most common, followed by valine, leucine, isoleucine, lysine, methionine, phenylalanine, and threonine. Sensory tests of conventional and functional Ganjang found no significant differences. An analysis of flavoring components indicated that flavor-active compounds (paeonol, senkyunolide A, and cnidilide) were present in both forms of Ganjang. Our results suggest that the extract could be used to manufacture fermented soybean products.

Constituents Comparison of Components in Native and Cultivated Species of Angelica tenuissima Nakai (자생종과 재배종 고본의 성분함량 비교)

  • Lee, Hye-Won;Choi, Ji-Hyun;Park, So-Young;Choo, Byung-Kil;Chun, Jin-Mi;Lee, A-Yeong;Kim, Ho-Kyoung
    • Korean Journal of Medicinal Crop Science
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    • v.16 no.3
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    • pp.168-172
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    • 2008
  • The root of Angelica tenuissima Nakai (Umbelliferae) has been used in traditional medicines of Korea as a headache, common cold and a fever remedy. A. tenuissima contains ferulic acid and various compounds of essential oil group such as limonene, 3-butylidenephthalide, ${\gamma}$-terpinene, neocnidilide, ligustilide, senkyunolide and neocnidilide. This study carried out to compare the contents of ferulic acid, z-ligustilide and n-butylidenephthalide between native and cultivated species of A. tenuissima by HPLC. The average contents of ferulic acid, z-ligustilide and n-butylidenephthalide indicated that native species (9 samples) were 0.060%, 0.616%, 0.025% and cultivated species (15 samples) were 0.037%, 0.141%, 0.029%, respectively. All samples were collected from different places in Korea.

A Study on the Standardization of Ligustici Rhizoma and Angelicae Tenuissimae Radix including the Comparison for the Biological Activity on the Active Ingredients (Ligustici Rhizoma(고본(藁本))와 Angelica tenuissimae Radix(한국고본(韓國藁本)뿌리)의 규격화(規格化) 및 유효성분(有效成分)의 진통효과(鎭痛效果) 비교(比較)에 관한 연구(硏究))

  • Kim, Kwan-Ho;Lee, Sang-In;Kim, Ho-Cherl;Park, Ho-Koon;Rhee, Jae-Seong
    • The Journal of Korean Medicine
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    • v.18 no.1
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    • pp.187-197
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    • 1997
  • Major separation for the active ingredients and characterization of chemical properties in conjunction with screening test on animal were performed in order to analyze and standardize Ligustici Rhizoma or Angelicae Tenuissimae Radix as an important oriental herbal medicine for antiphlogistic or an important oriental herbal medicine for antiphlogistic or an anodyne. Furthermore the structure, composition and contents of ingredients for essential oil in Angelicae Tenuissimae Radix(Suckpo, Korea) were determined by means of Ge/MS followed by screening test on Z-ligustilide(82%) known as major ingredient as well as butylidenephthalide collected by HPLC with normal phase semiprep-column. The total active ingredient in Ligustici Rhizoma from China or Angelicae Tenuissimae harvested at Choonyang(Kyungnam, Korea), Jungsun(Kangwon, Korea), Suckpo(Kyungnam Korea), Youngchun(Kyungnam, Korea) have been determined showing higher abundant for three times on the product in Korea compared to that in China. In addition, the major component in Ahgelicae Tebyussunae Radux extract was found to be Z-ligustilide(70-80%) which is very different from that in Ligustici Rhizoma senkyunolide(39%) as major species. For screening test of Ligustici Rhizoma or Angelicae Tenuissimae Radix extracts toward the target animal, the efficiency has been shown the similarity on both extracts. Taking into account the level of ingredient, the total efficiency may be three times higher on Angelicae Tenuissimae Radix in Korea compared to Ligustici Rhizoma in China. As a result of present study, it is preferable to distinguish between Ligustici Rhizoma and Angelicae Tenuissimae Radix for better usage of oriental herbal medicine because of very different composition and abundant in spite of their similar screening effect.

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Effects of Forest Environments on Growth and Active Compound Contents of Ligusticum chuanxiong Hort. among Different Forest Sites (기후대별 산림환경에 따른 토천궁의 생육 및 유효성분 특성)

  • Kim, Nam Su;Jeon, Kwon Seok;Lee, Hyunseok
    • Korean Journal of Plant Resources
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    • v.33 no.5
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    • pp.419-427
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    • 2020
  • Ligusticum chuanxiong Hort. is included in Umbelliferae family, it is one of the Korean traditional medicinal plants as the roots have been used to treat diseases. In this study, the growth characteristics and active compound contents of L. chuanxiong were compared among the different forest sites. As a result, root diameter and root length of L. chuanxiong was the highest in Jeongseon. Also, the fresh weight and dry weight of L. chuanxiong were the highest in Jeongseon. The total content of active compound was 23.27 mg/g the highest in Bonghwa, and 21.59 mg/g in Jeongseon, 15.87 mg/g in Hamyang was accumulated. In this study compares three forest site for cultivating of L. chuanxiong in different climate zone that the best site to product yield were Jeongseon. In this sites were located in higher altitue and lower temperature than other sites, also there were shown that lower soil moisture contents and well-drained soil. It was shown yield and active compound contents of L. chuanxiong was influenced by micro-environment conditions like as altitude, temperature, soil conditions.