Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Constituents Comparison of Components in Native and Cultivated Species of Angelica tenuissima Nakai

자생종과 재배종 고본의 성분함량 비교

  • Published : 2008.06.30
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Abstract

The root of Angelica tenuissima Nakai (Umbelliferae) has been used in traditional medicines of Korea as a headache, common cold and a fever remedy. A. tenuissima contains ferulic acid and various compounds of essential oil group such as limonene, 3-butylidenephthalide, ${\gamma}$-terpinene, neocnidilide, ligustilide, senkyunolide and neocnidilide. This study carried out to compare the contents of ferulic acid, z-ligustilide and n-butylidenephthalide between native and cultivated species of A. tenuissima by HPLC. The average contents of ferulic acid, z-ligustilide and n-butylidenephthalide indicated that native species (9 samples) were 0.060%, 0.616%, 0.025% and cultivated species (15 samples) were 0.037%, 0.141%, 0.029%, respectively. All samples were collected from different places in Korea.

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References

  1. Choi GP, Chung BH, Lee DI, Lee HY, Lee JH, Kim JD (2002) Screening of inhibitory activities on angiotensin converting enzyme from medicinal plant. Korean J. Medicianl Crop. 10(5):399-402
  2. Choi HW, Koo DH, Lee WK, Kim SY, Sung JS, Seong NS, Shu YB, Bang JW (2005) Cytogenetic analysis of sever Angelica species. Korean J. Medicianl Crop. 13(3):118-121
  3. Kim DH, Park CB, Kang CH, Kim JY, Lim JR, Cho JS, Choi YG (2003) Environment and growth characteristics of Asparagus cochinchinensis (Lour.) Merr, Korean J. Medicinal Crop Sci. 11(3):212-215
  4. Kim MH, Kim YG, Lee JH, Hong KP, Hong JK, Kong YJ, Lee HY (2000) Screening of biologically active essential oils from Ligusticum tenuissimum, Kor. J. Appl. Microbiol, Biotechnol. 28(2):97-104
  5. Kim HS, Chi HJ (1989) Studies on essential oils of plants of Angelica Genus in Korea(II). Essential oils of the root of Angelica tenuissima, Kor. J. Pharmacogn. 20(1):13-20
  6. Hu L, Chen X, Kong L, Su X, Ye M, Zou H (2005) Improved performance of comprehensive two-dimensional HPLC separation of traditional Chinese medicines by using a silica monolithic column and normalization of peak heights, J. chrom. A. 1092:191-198 https://doi.org/10.1016/j.chroma.2005.06.066
  7. Ka MH, Choi EH, Chun HS, Lee KG (2005) Antioxidative activity of volatile extracts isolated from Angelica tenuissima roots, peppermint leaves, pine ceedles, and sweet flag leaves, J. Agric. Food Chen. 53(10):4124-4129 https://doi.org/10.1021/jf047932x
  8. Li HB, Chen F (2004) Preparative isolation and purification of chuanxiongzine from the medicineal plant Ligusticum chuanxiong by high-speed count-current chromatography, J. chrom. A. 1047:249-253 https://doi.org/10.1016/S0021-9673(04)01103-3
  9. Li HX, Ding MY, Yu JY (2002) Separation and Identification of the Phthalic Anhydride Derivatives of Liqusticum Chuanxiong Hort by GC-MS, TLC, HPLC-DAD, and HPLC-MS, Journal of chromatographic science, 40:156-161 https://doi.org/10.1093/chromsci/40.3.156
  10. Li SL, Chan SSK, Lin C, Ling L, Yan R, Chung HS, Tam YK (2003) Simultaneous Analysis of Seventeen Chemical ingradients of Ligusticum chuanxiong by On-Line High Performance Liquid Chromatography-Diode Array Detector- Mass Spectrometry, Planta Med. 69:445-451 https://doi.org/10.1055/s-2003-39709
  11. Lu GH, Chan K, Chan CL, Leung K, Jiang ZH, Zhao ZZ (2004) Quantification of ligustilides in the roots of Angelica sinensis and related. umbelliferous medicinal plants by highperformance liquid chromatography and liquid chromatographymass spectrometry, J. chrom. A. 1046:101-107 https://doi.org/10.1016/S0021-9673(04)01031-3
  12. Kuang X, Yao Y, Du JR, Liu YX, Wang CY, Qian ZM (2006) Neuroprotective role of z-ligustilide against forebrain ischemic injury in ICR mice. Brain Research. 1102:145-153 https://doi.org/10.1016/j.brainres.2006.04.110
  13. Park HK, Lee SI, Lee SH, Park HM, Rhee JS (1997) A study on the qualitative and quantitative analysis of essential oil in Angelicae tenuissimae Radix or Ligustici rhizoma. Korean J. Food sci. Technol. 29(2):189-193
  14. Ru Y, Song LL, Hoi SC, Yun KT, Ge L (2005) Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography, Pharm Biomed Anal. 37:87-95 https://doi.org/10.1016/j.jpba.2004.09.054
  15. Tang CK, Xu QY (1992) Effects of natural oil of Ligusticum sinense Oliv. on anoxia, Zhongguo Zhong Yao Za Zhi. 17:745-746, 764
  16. Yook CS, Kang CK, Inn MK, Kim KO, Kim CW (1997) The essential oils of Ligusticum tenuissimum Roots. Yakhak Hoeji. 41(2):27-30
  17. Zhang H, Shen P, Cheng Y (2004) Identification and determination of the major constituents in traditional Chinese medicine Si-Wu-Tang by HPLC coupled with DAD and ESIMS, J. chrom. A. 34:705-713
  18. Zhang JL, HE XF, Zhou ZH (1996) HPLC determination of five constituents in plants of Genus Ligusticum, Acta Pharmaceutica Sinica, 31(8):622-625
  19. Zhang JL, Zhou ZH, Chen RY, Xie FZ, Cheng GF, Yu DQ, Zhou TH (2002) Study on chemistry and pharmacology of genus Ligusticum, China. pharm. J. 37(9):654-657
  20. Zhu YP (1998) Chinese materia medica chemistry, Pharmacology and applications. Harwood Academic Publishers, The Netherlands, p. 72-73
  21. 김호철 (2004) 한약약리학, 집문당, 서울, p. 77-79, 318-320
  22. 김민회 (2001) 고본 정유성분의 생리활성 고찰, 강원대학교 박사학위논문, p. 3-10
  23. 식품의약품안전청 (2002) 대한약전외한약(생약)규격집, 동원문화 사, 서울, p. 62
  24. 식품의약품안전청 (2002) 대한약전 제8개정, 약업신문, 서울, p. 1654-1656
  25. 육창수, 유기욱, 김형근, 심재호 (1992) 韓藥學 II, <기원, 약리, 처 방, 임상응용>, 광명의학사, 서울, p. 498-499
  26. 한방약리약 교재편찬위원회 (2005) 한방약리학, 신일상사, 서울, p. 129-130
  27. 한의과대학 본초학 편집위원회 (2005) 본초학, 영림사, 서울, p. 167-168
  28. 國家藥典委員會 (2005) 中和人民共和國藥典, 化學工業出版社, 北 京, p. 263-264