• The Korean Journal of Applied Statistics
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• v.33 no.2
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• pp.203-213
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• 2020

The self-controlled case series (SCCS) study measures the relative risk of exposure to exposure period by setting the non-exposure period of the patient as the control period without a separate control group. This method minimizes the bias that occurs when selecting a control group and is often used to measure the risk of adverse events after taking a drug. This study used SCCS to examine the increased risk of side effects when two or more drugs are used in combination. A conditional Poisson model is assumed and analyzed for drug interaction between the narcotic analgesic, tramadol and multi-frequency combination drugs. Bayesian inference is used to solve the overfitting problem of MLE and the normal or Laplace prior distributions are used to measure the sensitivity of the prior distribution.

• Biomolecules & Therapeutics
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• v.21 no.4
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• pp.307-312
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• 2013

Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal behavioral tests using rodents to study the mechanism of quetiapine. Molecular biology techniques were also used to find out the action mechanisms of the drug. In the animal behavioral tests, quetiapine did not show any positive effect on the experimental animals in the climbing, jumping, and conditioned place preference tests. However, in the head twitch and self-administration tests, the experimental animals showed significant positive responses. In addition, the action mechanism of quetiapine was found being related to dopamine and serotonin release. These results demonstrate that quetiapine affects the neurological systems related to abuse liability and has the potential to lead psychological dependence, as well.

• Biomolecules & Therapeutics
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• v.22 no.6
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• pp.558-562
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• 2014

Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

• Korean Journal of Labor Studies
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• v.24 no.1
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• pp.157-196
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• 2018

This study analyzes non-standard workers' attitudes and behaviors towards standard workers' strikes using the case of a joint strike held by journalists at KBS and MBC in 2012. Tracing the process since 2008 by which a conservative government has tried to control the press and regular journalists have collectively resisted against it, we put our analytical focus on two major groups of freelance broadcast professionals: independent producers and writers in current affairs. Specifically, we examine 1) how they perceived and responded to a series of regular journalists' struggle to protect journalistic value, 2) how such perception of and response to regular journalists could be developed, and 3) how (de)solidarity could form and then deepened between freelance and regular journalists in the 2012 Media Strike. Our findings show that the ways in which regular journalists had controlled freelance journalists at work affected the relationship between class-based and occupation-based rationality freelance journalists held in their minds. Independent producers, who had developed a strong class-based rationality in response to the coercive input-output control, showed cynicism about regular journalists' strike pointing out their hypocrisy and contradiction. In contrast, freelance writers accommodated and joined the strike by regular workers in the spirit of solidarity based on occupational rationality which had developed from normative, process control. Our paper ends with theoretical and practical implications.