• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.199-202
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• 2006

One of the major sources of error in precise GPS positioning since the turn-off the Selective Availability(SA) is the ionospheric propagation delay. For the last decades, a lot of the ionospheric researches based on a GPS network have been implemented throughout the world. Especially researches of the ionospheric modeling for Wide Area Argumentation System(WAAS) have been undertaken and published. In mid-latitude regions, typical spatial and temporal variations in ionospheric models delay tend to minimal. The developed ionospheric model calls for a 1.25 degree grid at latitudes and a 2.5 degree grid at longitudes. The precise grid TEC estimated by the inversion technique is also compared with global ionosphere maps(GIMs) which have been provided by several analysis centers(ACs). The results of initial investigations into the suitability of the proposed ionospheric modeling scheme in north-east Asia are presented.

• The Korean Journal of Nuclear Medicine
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• v.37 no.1
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• pp.53-62
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• 2003

After the development of two major techniques - SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) to image the human subjects in a three-dimensional direction in the 1980s, many radiotracers have been used for functional neuroimaging. Still it would be very important study to develop selective radiotracers for functional neuroimaging. New radiotracers will help to expand the knowledge of neurotransmitter systems and of the genetic contribution to receptor or transporter availability. Neurotransmitter depletion-restoration studies, the distribution of brain functions and their modulation by neurotransmitter system aid in better understanding and limiting the side effects of drugs used as well as newly developed. In audition, these radiotracers will be thus very useful to gain a better understanding in biochemical and pharmacological interactions in living human. This review mentions the introduction of radioligands for the functional neuroimaging. Although significant progress has been achieved in the development of new PET and SPECT ligands for in vivo imaging of those receptors and transporters, there are continuous needs of new diagnostic radioligands.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.50-53
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• 2010

최근 DSMS의 연구가 활발히 진행되고 있고, 그에 따른 고가용성 서비스를 제공하기 위한 환경으로 확장되고 있다. DSMS와 같은 실시간 데이터베이스 응용 시스템 분야나 임무 결정적인 응용 시스템을 다루는 산업 분야에서 가용성을 유지 하지 못하는 것은 치명적인 결과를 초래 할 수 있다. 이런 DSMS환경에서 고가용성을 유지하는 기법으로는 Active/Active 알고리즘과 Active/Standby기법이 있다. 하지만 이 기법들의 고가용성을 유지하기 위해 주 서버와 동일한 규모의 보조 서버를 유지해야 하는 단점이 있다. 본 논문에서는 질의를 두 가지 타입으로 나누어 누적 데이터가 필요한 질의들만 실시간 동기화를 통해 보조 서버에 유지하고 나머지 질의들에 대해서는 메타 데이터들만 보조 서버에 유지해 보조 서버의 규모를 줄일 수 있었다.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.30 no.4
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• pp.413-422
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• 2012

After development of GPS in the 1960's, the United States released SA(Selective Availability) in 2000 and then the GPS has become commercialized to the present. The result of repeatedly developed GPS observation, the GPS real-time observation methods is RTK which basically always needs two base stations and has a fault of the accuracy decreasing as the distance between a mobile station and a receiver is increasing. Because of these weakness, VRS method has come out. VRS(Virtual Reference Station) generates the imaginary point near mobile station from several observatory datum of GPS, sets the accurate location of mobile station, thus shows high reliability and mobility. Now, the cadastral datum point is used with azimuth, repetition, and graphical traversing method for traverse network. The result of measurement indicates many problems because of different accomplishment interval given point, restrictions on the length of the conductor, many errors on the observations. So, this study did comparative analysis of the cadastral datum points through VRS method by Continuously Operating Reference Station. Through the above comparative analysis, The comparative result between surveyed result with repetition method through total station observed Cadastral Control Points and surveyed result with VRS-RTK has shown that average error of x-axis is -0.08m, average error of y-axis, +0.07m and average distance error is +0.11m.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2005.04a
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• pp.53-60
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• 2005

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting $1\%$ of the population above the age of 65 and is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although the underlying cause of dopaminergic cell death or the mechanism by which these cells degenerate is still not clearly understood, oxidative stress, mitochondrial dysfunction, and protein misfolding are thought to play important roles in the dopaminergic degeneration in PD. Tetrahydrobiopterin (BH4) is synthesized exclusively in the monoaminergic, including dopaminergic, cells and serves as an endogenous and obligatory cofactor for syntheses of the potential oxidative stressors dopamine and nitric oxide. In addition to its contribution toward the syntheses of these two potentially toxic molecules, BH4 itself can directly generate oxidative stress. BH4 undergoes oxidation during the hydroxylation reaction as well as nonenzymatic autooxidation to produce hydrogen peroxide and superoxide radical. We have previously suggested BH4 as an endogenous molecule responsible for the dopaminergic neurodegeneration. BH4 exerts selective toxicity to dopamine-producing cells via generation of oxidative stress, mitochondrial dysfunction, and apoptosis. BH4 also induces morphological, biochemical, and behavioral characteristics associated with PD in vivo. BH4 as well as enzyme activity and gene expression of GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis pathway, are readily upregulated by cellular changes such as calcium influx and by various stimuli including stress situations. This points to the possibility that cellular availability of BH4 might be increased in aberrant conditions, leading to increased extracellular BH4 subsequent degeneration. The fact that BH4 is specifically and endogenously synthesized in dopaminergic cells, Is readily upregulated, and generates oxidative stress-related cell death provides physical relevance of this molecule as an attractive candidate with which to explain the mechanism of pathogenesis of PD.

• The Journal of the Acoustical Society of Korea
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• v.22 no.7
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• pp.603-611
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• 2003

This paper proposes an effective feature compensation scheme based on speech model for achieving robust speech recognition. Conventional model-based method requires off-line training with noisy speech database and is not suitable for online adaptation. In the proposed scheme, we can relax the off-line training with noisy speech database by employing the parallel model combination technique for estimation of correction factors. Applying the model combination process over to the mixture model alone as opposed to entire HMM makes the online model combination possible. Exploiting the availability of noise model from off-line sources, we accomplish the online adaptation via MAP (Maximum A Posteriori) estimation. In addition, the online channel estimation procedure is induced within the proposed framework. For more efficient implementation, we propose a selective model combination which leads to reduction or the computational complexities. The representative experimental results indicate that the suggested algorithm is effective in realizing robust speech recognition under the combined adverse conditions of additive background noise and channel distortion.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.152-152
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• 2019

This study demonstrates a novel approach of remotely sensed estimates of stream flow at fifteen hydrological station in the Han River Basin, Korea. Multi-temporal data of the European Space Agency's Sentinel-1 SAR satellite from 19 January, 2015 to 25 August, 2018 is used to develop and validate the flow estimation model for each station. The flow estimation model is based on a power law relationship established between the remotely sensed surface area of water at a selected reach of the stream and the observed discharge. The satellite images were pre-processed for thermal noise, radiometric, speckle and terrain correction. The difference in SAR image brightness caused by the differences in SAR satellite look angle and atmospheric condition are corrected using the histogram matching technique. Selective area filtering is applied to identify the extent of the selected stream reach where the change in water surface area is highly sensitive to the change in stream discharge. Following this, an iterative procedure called the Optimum Threshold Classification Algorithm (OTC) is applied to the multi-temporal selective areas to extract a series of water surface areas. It is observed that the extracted water surface area and the stream discharge are related by the power law equation. A strong correlation coefficient ranging from 0.68 to 0.98 (mean=0.89) was observed for thirteen hydrological stations, while at two stations the relationship was highly affected by the hydraulic structures such as dam. It is further identified that the availability of remotely sensed data for a range of discharge conditions and the geometric properties of the selected stream reach such as the stream width and side slope influence the accuracy of the flow estimation model.

• Journal of Advanced Marine Engineering and Technology
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• v.30 no.1
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• pp.81-87
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• 2006

In marine air pollution control, SCR (Selective Catalytic Reduction) is reconized as the most effect method to control NOx, but on the other hand. seawater scrubber applying the basic characteristic that is naturally alkaline (pH typically around 8.1) is viewed as an economical SOx removal system at present. Especially, seawater scrubber would not be necessary to follow any of the various land based flue gas desulfurization methods. i.e. wet, dry or alkali scrubbing. However, these methods are not readily adaptable to marine conditions due to the quantifies of consumables required i.e. lime or limestone, the means of operation and the commercial availability. This research is undertaken to develop a new method as the main target of eliminating all exhaust emissions, particularly vessel, because of easy access to seawater and apt to apply a wet scrubber system. First, using the acidic seawater by seawater electrolysis, nitric monoxide(NO) is adequately oxidized to nitric dioxide $(NO_2)$by ClOx-in the acidic seawater, the electrolyzed alkaline seawater by electrolysis which contains mainly NaOH together with alkali metal ions $(i.e\;Na^{+}\;K^{+},\;Mg_{2}\;^{+},\;Ca_{2}\;^{+})$, is used as the absorption medium of NOx, the SOx are absorbed by relatively high solubility compared to other components of exhaust pollutants. The results found that the NOx and SOx removals could be achieved nearly Perfect.

• Journal of Advanced Navigation Technology
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• v.4 no.2
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• pp.152-161
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• 2000

Recently, it is considered to combine the GPS receiver with the GLONASS for the improvement of performance and accuracy. This combined system reduces errors by SA for GPS, and has merits to select receivable satellite. In this paper, aperture-coupled patch antenna and small sized ceramic dielectric patch antenna are designed and implemented for GPS/GLONASS combined receiver, which show a wideband characteristics with circular polarization. The manufactured antennas have the bandwidth more than 240 MHz, VSWR less than 1.5:1, and the axial ratio less than 3dB, and satisfy required characteristics of the GPS/GLONASS antenna.

• Korean Journal of Biological Psychiatry
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• v.11 no.1
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• pp.14-25
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• 2004

The current understanding of the mechanisms of pharmacotherapy for depression is characterized by an emphasis on increasing synaptic availability of serotonin, noradrenaline, and possibly dopamine, while minimizing side effects. The acute effects of current available effective antidepressants include blocking selective serotonin or noradrenaline reuptake, alpha2 autoreceptors or monoamine oxidase. Although efficacious, current treatments often produce partial or limited symptomatic improvement rather than remission. While current pharmacotherapies target monoaminergic systems, distinct neurobiological underpinnings and other systems are likely involved in the pathogenesis of depression. Recently, several promising hypotheses of depression and antidepressant action have been formulated. These hypotheses are largely based on dsyregulation of neural plasticity, CREB, BDNF, corticotropin-releasing factor, glucocorticoid, hypothalamic-pituitary adrenal axis and cytokines. Based on these new theories and hypotheses of depression, a number of new and novel agents, including corticotropin-releasing factor antagonists, antiglucocorticoids, and substance P antagonists show a considerable promise for refining treatment options for depression. In this article, the current available pharmacotherapies, current understanding of neurobiology and pathogenesis of depression and new and promising directions in pharmacological research on depression will be discussed.