• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9859-9863
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• 2014

Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second-degree relatives was $67.0{\pm}7.31%$ and $43.1%{\pm}9.80%$, respectively, and the summing up powered heritability was $53.2{\pm}6.74%$. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.

• Journal of Plant Biology
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• 제36권2호
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• pp.127-132
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• 1993

Self-incompatibility in Brassica campestris is controlled by multi-allele system in a single genetic locus, the S locus, and it is elucidated that S-glycoproteins are S gene products. In this experiments, we examined the genetic mode(pollen tube behavior and segregation of S-glycoprotein), characteristic of S-glycoproteins and DNA constitution within nuclear genome on S gene family that unexplained by single locus model, and investigated the segregation pattern of S-glycoproteins in bred F1 generation. By diallel cross among the 15 plants within one family the existence of three types of homozygotes and three types of heterozygotes were observed, and segregation of S-allele could not explained by single locus model. From the results of IEF-immunoblot analysis for non-segregated individual plant, the segregation pattern of S specific bands was corresponded with results of diallel cross except with one case(SaSa genotype). The molecular weight of 6 different S-genotype varied in near by 50 kD, and each genotype expressed with 2 or 3 bands. Specific bands in SaSa, SbSb, ScSc has almost similar molecular weight between them. Southern analysis of genomic DNA probed with S-glycoprotein cDNA for 6 different genotypes revealed that there are clear difference in polymorphism, multiple bands of hybridization, when restriction enzymes of EcoR I were used. It could be assumed that there are several sequences related to the S-glycoprotein structural genes within their nuclear genome. Therefore, we suggested the possibilities that S-allele system could be controlled by multi-locus, that dominance-recessive interactions could be explained by modifier gene or supressor gene based on the results of abnormal segregation of S-glycoprotein in bred F1. The F2 analyses are progressing in now.

• Journal of Preventive Medicine and Public Health
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• 제22권4호
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• pp.474-479
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• 1989

This research was conducted to evaluate the effect of improvement in work environment and of segregation in a fluorescent lamp manufacturing factory. Among the total of 80 workers, 8 workers whose mercury concentration in urine reached a hazardous level ($200-299{\mu}g/l$) were moved to mercury free workplace. The follow-up examination for their mercury concentration in urine was done three times ; on May 3, 1988, September 1, 1988 and April 3, 1989. The results were as follows : 1. Mercury concentration in the air was reduced from 0.140 to 0.107 $mg/m^3$ in 4 months, and to $0.087mg/m^3$ in one year after environmental improvement in workplace. However the level still exceeded the Threshold Limit Value. 2. The geometric mean of urinary mercury concentration among 80 workers was $173.0{\mu}g/l\;(5.1{\sim}458.6{\mu}g/l$). The distribution of workers according to urinary mercury concentration showed that 9 workers (11.2%) were above the mercury poisoning level ($300{\mu}g/l$), 24 workers (30.0%) were $200-299{\mu}g/l$, 35 workers (43.8%) were $50-199{\mu}g/l$, and 12 workers (15.0%) were below 50 ${\mu}g/l$. 3. Among the 24 workers whose urinary mercury concentration was 200-299 $50-199{\mu}g/l$, 8 were able to be followed up. Their mean urinary mercury concentration before segregation was $244.9{\mu}g/l$, but decreased to $151.4{\mu}g/l$ in four months, $128.8{\mu}g/l$ in six months, and $46.8{\mu}g/l$ in one year after segregation.

• 한국지반환경공학회 논문집
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• 제24권9호
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• pp.41-46
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• 2023

동상은 토양과 외부 환경적 영향으로 인해 수치해석적 평가에 어려움이 있다. 열-수리-역학 연계 해석은 입력변수가 과도하고 주로 점토성 토양에 대한 검증에 국한되어 실제 동상에 민감한 실트질 토양에 적용하기에는 한계가 있다. 열역학 관점의 경험적 접근 방법은 비교적 간단하게 동상 해석이 가능하고, 구성방정식과 동상 해석 결과를 연계하여 역학적 해석도 가능하다는 장점을 보유하고 있다. 본 논문에서는 Segregation Potential(SP)을 이용한 동상 해석 모델을 소개하고 실트질 함유량에 따른 동상 실험 결과와 비교·분석을 통해 신뢰성을 평가하고 있다. SP 모델은 본 연구에서 검토된 실트질 토양의 동상 해석이 가능하지만, 다양한 실트질 토양에 대한 추가적인 검토를 통해 핵심 입력변수에 대한 자료수집이 필요하다.

• Molecules and Cells
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• 제37권10호
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• pp.713-718
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• 2014

Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hall-mark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecular mechanism behind aneuploidy includes the chromosome mis-segregation in mitosis by the compromise of spindle assembly checkpoint (SAC). SAC is an elaborate network of proteins, which monitor that all chromosomes are bipolarly attached with the spindles. Therefore, the weakening of the SAC is the major reason for chromosome number instability, while complete compromise of SAC results in detrimental death, exemplified in natural abortion in embryonic stage. Here, I will review on the recent progress on the understanding of chromosome missegregation and cancer, based on the comparison of different mouse models of BubR1, the core component of SAC.

• 미생물학회지
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• 제26권2호
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• pp.82-87
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• 1988

The genetic analysis and characterization of protoplast fusion hybrids between complementary auxotrophic mutants of Candida pseudotropicalis were carried out. Nuclear fusion appeared to occur in fusion hybrids (e.g., F15 and F33), as strongly suggested by isolation of recombinants after mitotic segregation of parental genetic markers. This was confirmed by KNA content, nuclear staining and comparison of survival rate to UV light. After keeping fusion hybrids for approximately one year, the frequency of spontaneous mitotic segregation was $3.0\times 10^{-4}$ - $8.1\times 10^{-4}$ while that of induced mitotic segregation was $1.4\times 10^{-3}$- $1.7\times 10^{-3}$. These results suggested that they maintained stable karyogamy state. It was also found that the production of $\beta$-D-galactosidase from F15, F33 and F158 was somewhat increased when compared with that from either auxotrophic parents or wild type.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.774-777
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• 2004

A rheology casting technology has some advantages compared with conventional forming processes such as die casting, squeeze casting and hot/cold forming. The liquid segregation is important on mechanical properties of materials using rheology casting. In this study, so, molecular dynamics simulations were performed for the control of liquid segregation. Because the dynamics of fluid flow about nano-scaled materials is completely different from continuum, molecular dynamics simulations were used. The behavior of particles was far from the truth according to boundary conditions in simple flow. But various movement of particles appear at two or more molecular simulations.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 가을 학술발표회 논문집
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• pp.275-280
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• 2001

Recently, self-compacting concrete is applied in order to achieve workability improvement and rationalization in construction. But self-compacting concrete using viscosity agent has a difficulty in practical use because viscosity agent is invested small quantity and by man-power. Therefore in this paper we have been focused on the development and practical use of self-compacting concrete by hydraulic composition containing the segregation-reducing agent. According to mix variable, we find out right quantity of water, binder and rate of admixture replacement, and also we find out the optimum mix proportion. In the result, self-compacting concrete by hydraulic composition containing the segregation reducing agent gave satisfaction with standard and its demand will increase in the future.

• 한국세라믹학회지
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• 제31권9호
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• pp.941-948
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• 1994

An underwater grout on material resistance against segregation in water were studied by water soluble polymer (methyl cellulose and acrylic acid ester and styrene). The mechanical properties of the grout agents were investigated through the observation of the microstructure and application of fracture mechanic. When the soluble polymer MC+AAES added with 0.6 wt% to the underwater grout agents the compressive strength, flexural strength and Young's modulus were about 58 MPa, 10 MPa and 3.2 GPa respectively, and critical stress intensity was about 0.8 MNm-1.5. It can be considered that the strength improvement and fracture toughness increase may be due to the pore decrease and bonding force by material resistance against segregation in water.

• Journal of Microbiology and Biotechnology
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• 제25권3호
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• pp.307-316
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• 2015

Beginning from the recognition of FtsZ as a bacterial tubulin homolog in the early 1990s, many bacterial cytoskeletal elements have been identified, including homologs to the major eukaryotic cytoskeletal elements (tubulin, actin, and intermediate filament) and the elements unique in prokaryotes (ParA/MinD family and bactofilins). The discovery and functional characterization of the bacterial cytoskeleton have revolutionized our understanding of bacterial cells, revealing their elaborate and dynamic subcellular organization. As in eukaryotic systems, the bacterial cytoskeleton participates in cell division, cell morphogenesis, DNA segregation, and other important cellular processes. However, in accordance with the vast difference between bacterial and eukaryotic cells, many bacterial cytoskeletal proteins play distinct roles from their eukaryotic counterparts; for example, control of cell wall synthesis for cell division and morphogenesis. This review is aimed at providing an overview of the bacterial cytoskeleton, and discussing the roles and assembly dynamics of bacterial cytoskeletal proteins in more detail in relation to their most widely conserved functions, DNA segregation and coordination of cell wall synthesis.