• 한국방사선학회논문지
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• 제11권3호
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• pp.109-115
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• 2017

본 연구의 목적은 128 MDCT(Multi-detector computed tomography)의 CareDose 4D 선량감소 효과와 임상적 유용성을 평가하고자 시행되었다. Phantom과 임상 복부 검사 연구라는 두 가지 방법을 통해 128 MDCT CareDose 4D 시스템 적용 전후의 피사체 피폭선량과 영상 평가를 실시하였다. Phantom 연구에서는 CareDose 4D 적용 전후의 두 그룹에 대하여 중앙과 3, 6, 9, 12시의 방향으로 ROI(Region of interest)를 위치시켰고, 임상 연구에서는 간의 각 8구획에 대하여 CareDose 4D 적용 전 후 두 그룹에 대하여 ROI를 위치하여 CT Number, Noise, DLP(Dose length product)선량을 측정하였다. 측정결과 Phantom 및 임상연구에서 CT Number는 적용 전 후 값에 차이가 없었고(p>.05), 선량관련 CTDIvol(CT dose index volume) 측정값 및 유효선량은 CareDose 4D 적용 후가 낮았다 (p<.05). 결론적으로 CareDose 4D를 사용하면 영상의 화질을 저하시키지 않고 최적의 영상정보를 획득하면서 환자 선량이 감소되는 효과를 얻을 수 있다.

• 대한수의학회지
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• 제46권4호
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• pp.323-326
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• 2006

Suaeda (S.) asparagoides $M_{IQ}$, one of the halophyte groups, has been used as a folk remedy for digestive disturbances in Korea. However, its pharmacological activity on gastrointestinal motility has not been reported yet. In this study, the effects of this halophyte extracts with various solvent fractions (ethanol, hexane, chloroform, ethyl acetate, butanol, and water) on mice ileal spontaneous motility was examined. All solvent fractions at the concentration of $100{\mu}g/ml$ showed inhibitory actions on spontaneous motility of ileum with the potency order of water > 70% ethanol > hexane ${\gg}$ chloroform ${\geq}$ butanol ${\geq}$ ethyl acetate, respectively. In addition, the water fraction of extracts from S. asparagoides $M_{IQ}$ (WFSA) dose-dependently ($1-100{\mu}g/ml$) inhibited the amplitude of spontaneous phasic contraction and area under the contractile curve (AUC). The inhibitory effect of water fraction at the concentration of $10{\mu}g/ml$ was not affected by tetrodotoxin (TTX), $Na^+$ channel blocker ($1{\mu}M$), and $N^w$-nitro-L-arginine Methyl Ester (L-NAME), nitric oxide synthase inhibitor ($100{\mu}M$). However, cyclopiazonic acid (CPA, $10{\mu}M$), inhibitor of sarcoplasmic reticulum $Ca^{2+}$-ATPase, almost blocked the inhibitory effects of WFSA ($10{\mu}g/ml$) on the spontaneous phasic contraction of mouse ileum. But, CPA did not inhibit the lowering basal tone effects of WFSA. The result of this study showed that various extracts of S. asparagoides $M_{IQ}$ induce inhibitory effects on spontaneous contraction of mice ileal segments. More over, the polar solvent fractions were shown to be more potent than non-polar solvent fractions. The effects of S. asparagoides $M_{IQ}$ extracts are not mediated by nerve or nitric oxide. The inhibitory effects of WFSA at least partially mediated by sarcoplasmic reticulum $Ca^{2+}$-ATPase. However, further study is required to determine the exact pharmacological mechanisms of this halophyte on its gastrointestinal motility inhibitory effects.

• 한국잡초학회지
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• 제16권4호
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• pp.309-316
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• 1996

파대가리를 스크리닝 실험재료로 이용하거나 자연조건에서의 방제를 위한 기초자료를 획득하고자 번식기관의 발아특성과 제초제에 대한 반응을 조사하였다. 1. 파대가리 휴면타파(休眠打破)에는 저온습윤과 고온건조가 효과적이었으며 저온습윤 조건에서는 1-2 개월 저장으로, $40^{\circ}C$ 고온에 저장할 경우는 3개월째 이상의 저장이 필요하였다. 근경(根莖)의 경우는 휴면(休眠)이 없거나 매우 낮았다. 파대가리 종자의 발아최적온도는 $30^{\circ}C$ 내외인 반면에 근경(根莖)의 경우는 16-$20^{\circ}C$ 범위로서 두 번식 기관간에 다른 온도반응을 보였으며 종자의 발아에는 광(光)이 요구되었다. 2. 근경(根莖)이 3cm 깊이에 심겨 있으면 번식정도가 50% 정도 감소되었으며 4cm 에서는 80% 이상 감소되었다. 파종당시에 담수처리(湛水處理)된 번식기관은 전혀 발아되지 못하였다. 생육중에 담수처리(湛水處理)를 할 경우 근경(根莖)으로부터 나온 유묘(幼苗)는 잎이 물속에 담겨 있을지라도 어느 정도 생육이 되었지만 종자로부터 나온 유묘(幼苗)는 더 이상 생육하지 못하였다. 근경(根莖)의 생체중 감소가 50% 이상 될 정도로 건조되면 출아력(出芽力)이 상실되는 경향이었다. 3. 처리된 약제들중 토양처리효과가 비교적 뚜렷한 것은 amitrole, DTP, fluridone, bensulfuron 등이었고, 경엽처리효과가 양호한 것은 fluridone, bentazone, benfuresate, bensulfuron 등이었다.

• 대한핵의학회지
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• 제34권6호
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• pp.487-496
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• 2000

목적: 국소 심근 벽 운동과 수축기 심근두꺼워짐에 대한 자동정량화 소프트웨어의 재현성을 알아보고자 하였다. 대상 및 방법: 31명의 무작위 추출한 관상동맥질 환자에서 부하 게이트 Tc-99m-MIBI SPECT를 시행하는 중에, 게이트 심근 SPECT를 1회 시행한 이후 바로 이어 한번 더 게이트 SPECT를 시행하였다. 얻어진 영상으로부터 AutoQUANT 소프트웨어를 이용하여 분절별, 심근벽별로 심근벽 운동과 수축기 심근두꺼워짐의 자동정량값을 얻어, 1회째 값과 2회째 값 사이의 상관계수를 계산하고 Bland-Altman 도표를 통해 변이의 범위를 보았다. 또 각 값들을 등급화한 수치 간에 kappa 값을 구해보았다. 결과: 재현성 분석에서 1회와 2회 시행간의 상관계수는 각각 0.948, 0.878이었으며, weighted kappa 값은 0.807, 0.708로 아주 좋은 일치도를 보였다. Bland-Altman 분석에서 변이의 2 표준편차 범위는 각각 ${\pm}2.0mm,\;{\pm}20.2%$였다. 각각의 재현성은 분절영역, 성별, 관류의 수준에 따라 차이를 보이지 않았다. 결론: 이 연구에서 우리는, 심근 벽 운동과 수축기 심근두꺼워짐의 자동정량화 소프트웨어가 좋은 재현성을 가지고 있음을 알았으며, 또한 추적 검사나 치료효과 판정시 심근 벽 운동과 수축기 심근두꺼워짐의 변화 판정 기준을 마련하였다.

• 대한핵의학회지
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• 제26권2호
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• pp.265-273
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• 1992

Rest gated blood pool scan (Rest GBP scan) and dipyridamole $^{99m}Tc-MIBI$ SPECT were Performed in 34 patients with or suspected coronary artery disease. Both studies were performed within $2\sim32$ days (mean 8.1 days). A significant correlation was present between left ventricular ejection fraction (r= -0.7356, p<0.001) and peak ejection rate and peak filling rate in rest GBP scan and perfusion defect in MIBI SPECT. And there were acceptable correlations (0.05$26.2{\pm}10.8%$, severe hypokinesia, akinesia or dyskinesia in 16 regions: $78.2{\pm}23.7$, p<0.001). These data indicate there is a significant coupling between the degree of myocardial perfusion and the myocardial functional change in coronary artery disease.

• 대한핵의학회지
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• 제26권2호
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• pp.274-279
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• 1992

Clinical role of $^{99m}Tc-MIBI$ myocardial scintigraphy in the diagnosis of coronary artery disease (CAD) is now well accepted, however, the role of it in the identification of viable myocardium in patients with chronic CAD has not yet been clarified. To determine the usefulness of rest-injected $^{99m}Tc-MIBI$ scan as a marker of myocardial viability, the regional uptake of this agent at rest was compared with that of $^{201}Tl$ on reinjection and 24 hours after reinjection images. Subject patients were 13 chronic CAD patients who showed irreversible perfusion defect(s) on standard pharmacologic (dipyridamole) stress-redistribution images. Immediately after the redistribution images were obtained, 37 MBq thallium was injected at rest, and images were reacquired at 10 minutes and 24 hours after reinjection. After then 740 MBq $^{99m}Tc-MIBI$ was injected, and 1 hour later rest MIBI myocardial imaging was performed. Five sets of imagestress, redistribution, reinjection, delayed images of thallium, and rest image of MIBI) were then analyzed qualitatively and quantitatively. Left ventricle was arbitrarily divided into 9 segments (apex, basal and apical portions of anterior, septal, inferior, and lateral walls). Seven patients and 30 regions showed a fixed perfusion defect on the stress-redistribution images. Among 30 regions, 15 showed positive uptakes and 6 showed negative uptakes on both $^{201}Tl$ reinjection/delayed images and $^{99m}Tc-MIBI$ rest images. Five regions showed only thallium uptake and were regarded as viable clinically. Of four regions which showed only $^{99m}Tc-MIBI$ uptake, two were regarded as viable, while the other two were regarded as a nonviable scar tissue clinically. In conclusion, $^{201}Tl$ reinjection technique was more reliable in the identification of viable myocardium. However, the role of $^{99m}Tc-MIBI$ in identification of viable myocardium was still remained to be clarified because 2 of 9 regions showed only $^{99m}Tc-MIBI$ uptake and were regarded as viable tissues.

• 수산해양교육연구
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• 제11권2호
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• pp.203-215
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• 1999

Floating debris was recorded from a training ship, Kaya, of Pukyong National University with about 12 knots speed at July 19~21, 1999 and July 24~26. The sampled area is the Yellow Sea (YS) connected from Cheju Is. of Korea to Qindao harbor of China, divided into 88 unit segments on survey routes. Debris fabrication materials were categorized with 6 items using the following; man-made or natural wood items, paper and cardboard, nylon netting and rope, styrofoams, vinyl and plastics, floating metal and glass containers. All identified items within a $120{\pm}20m$ wide band were recorded but ignored if beyond this boundary. The results of distribution of floating debris in the area are as follows: 1. The greatest quantities of marine debris discovered during the survey were $184pieces\;per\;km^2$ near Qindao harbor. The next polluted areas, Sohuksan islands, positioned in the eastern part of YS were scattered in about $40pieces/km^2$ or so. 2. Among items, woods, paper and cardboard, vinyl and plastics were found out near Qindao Coast of China. On the other hand, there were many styrofoams, nylon netting and rope near the area of Sohuksan islands in the eastern part of YS. 3. The distribution densities of western part of YS near Qindao are varied with largely range in items and quantities but those of the eastern part, near Sohuksan islands were nearly constant. 4. Styrofoams were composed of 63% among all debris in YS, next paper and cardboard 15%, and wood item, vinyl and plastics each 10%. Therefore, marine debris of YS is revealed that distribution characteristics and composition are very different in each area. These phenomena are concluded that they largely depend on the life styles in land and the utilities of the sea. And of items, styrofoams is dominated by the distribution pattern of YS. Furthermore, surveys are continuously being investigated, and from this it is hoped that a much wider coverage can be achieved, perhaps all sites of the YS and contributed to the finding sources, the stationary area and removal method of debris joined the flow patterns.

• 대한교통학회지
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• 제31권3호
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• pp.55-64
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• 2013

교통부문에서 온실가스 배출량은 주로 연료사용량에 의해 산정되었다(Tier 1 방식). 그러나 이 방법은 연료사용량을 측정할 수 없는 도로 구간에서 발생하는 배출량 산정에 사용되기 어렵다. 도로구간의 대기오염물질 배출량 또한 연료사용량에 의해 정확히 측정되어질 수 없는데 이는 대기오염물질 배출량이 속도, 차종, 차령, 유종 등의 함수이기 때문이다. 이러한 배경에서 본 연구의 목적은 ITS 정보를 이용하여 지역 간 도로에서 발생되는 이산화탄소와 질소산화물의 배출량을 Tier 3 수준으로 산정하는 방법론을 정립하는 것이다. 이 방법론은 집계단위가 작은 ITS 검지기 정보를 이용하기 때문에 배출계수의 오목한 형태에서 기인하는 과소추정의 오류를 피할 수 있는 장점을 갖는다. 제시된 방법론을 4개 사례 도로구간에 적용한 결과는 중차량의 속도관리가 이산화탄소 또는 질소산화물 배출량 관리에 매우 중요함을 시사하였다.

• 동의생리병리학회지
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• 제24권6호
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• pp.983-988
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• 2010

The present study aims to investigate a possible mechanism of electroacupuncture (EA) in the spinal dorsal horn that may underlie N-methyl-D-aspartate (NMDA) receptor-associated extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) signaling pathways. The hot plate latency of the ipsilateral hindpaw of EA-treated rats was significantly decreased compared with complete Freund's adjuvant (CFA)-injected ones. The expressions of NR1 and NR2B subuint mRNA of NMDA receptor in the whole L4-5 segments are decreased by CFA treatment, but NR2B subunit was significantly recovered by EA treatment. When we detected the expression of ERK, there were no significant difference between normal and CFA-treated rats with EA or NMDA receptor antagonist MK801. But phosphorylated ERK expressions were markedly induced by CFA, but these inductions were significantly modulated by EA treatment. Although hosphorylation of ERK was also arrested by MK801, these inductions of CFA-injected rats was markedly inhibited only by co-treatment with EA and MK801. Phosphorylated cAMP response element-binding protein (CREB), ERK-related transcriptional factor, showed a significant increase in CFA-treated rats and this increase was slightly inhibited by EA and MK801 treatments. But immunoreaction for phosphorylated CREB were significantly increased by CFA treatment in the superficial laminae of the dorsal horn and these inductions were significantly arrested by co-treatment of EA and MK801. Consequently, the hyperalgesia induced by CFA are associated NMDA receptor and EA and MK801 may showed anti-hyperalgesia via same mechanism for inhibition of ERK and CREB phosphorylation in the dorsal horn.

• Journal of Plant Biotechnology
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• 제40권3호
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• pp.147-155
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• 2013

이 실험에서 우리는 더덕의 기내 소비대근형성에 의한 대량생산을 처음으로 보고하였다. 첫번째로, 다경지유도를 위한 싸이토키닌의 효과를 실험하였다. 2.0 $mg{\cdot}L^{-1}$ kinetin 처리는 줄기유도비율(19.1%)뿐만 아니라 줄기의 길이신장(17.1 mm)이 가장 높았다. 두번째로, 절간절편에서 유도되는 기내 소비대근형성에서 탄소급원의 효과를 연구하였다. 비대근의 직경은 1/2 MS배지에 145.9 mM Suc첨가시 증가하였다. 조직학적 분석은 비대근 내에 전분입자가 포함된 유세포의 수가 증가하였다. 게다가 세근은 비대근과 달리 관다발이 피층내에 흩어져 존재하였다. 세번째로, 소비대근의 보전과 발아 촉진을 위하여 $4^{\circ}C$ 저온저장고에 9달 동안 저장 후 이것을 인공상토로 이식한 결과 생존율 75%, 발아율 70%라는 결과를 보였다. 이러한 결과 더덕의 대량 번식은 기내 소비대근 형성에 의해 얻을 수 있고 이러한 방법은 우수클론의 번식 뿐만 아니라 더덕 유전자원 보존을 위해 제공될 수 있을 것으로 사료된다.