• 국제초고층학회논문집
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• 제5권4호
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• pp.263-270
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• 2016

In this paper, the stability requirements for diagrid and mega braced structures are examined. The role of the secondary bracing system for the stability of a diagrid structure is discussed. A simple procedure is proposed for the design of the secondary bracing system when it is required. As a case study, the design of the Hearst Tower diagrid and its secondary bracing system are presented.

• 사물인터넷융복합논문지
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• 제7권4호
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• pp.15-21
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• 2021

본 연구에서는 농촌지역에 목구조로 형성된 건축유산의 소방안전대책이 갖는 문제점 파악하고, 개선책을 제시하고자 한다. 문제점 도출을 위하여 연구대상으로 당진지역에 현존하는 목구조로 형성된 천주교 공소의 건물 구조, 주변 환경 등 문화유산의 특수성을 파악하고, 천주교 공소에서 발생 가능한 화재와 안전 요소에 대하여 분석하였다. 그 결과 목구조 공소가 갖는 역사성과 장소성, 지역의 정체성을 갖는 중요한 문화유산 임에도, 화재 등 안전에 대한 취약성 및 소방 활동을 위한 화재 인지 및 초기 화재 대응에 어려움 등 방재시스템의 문제가 나타났다. 따라서 좀 더 강화된 방화 등에 방재 체제가 필요하며, 목구조 공소의 특성에 적합한 소방 시설을 설치하고 방화활동에 주체를 확보하여 건축유산인 공소의 방재체계를 개선해야 할 필요성이 도출되었으며, 또한 공소는 대부분 농촌지역에 위치하고 있어 산불과 같은 자연재난에서 목구조 공소 방재 활동을 강화하고 화재 시 대응방안과 마련이 시급한 것으로 나타났다.

• 한국자기공명학회논문지
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• 제20권2호
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• pp.50-55
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• 2016

Backbone $^1H$, $^{13}C$ and $^{15}N$ resonance assignments are presented for the anticodon binding domain (residues 557-674) of human glycyl-tRNA synthetase (GRS). Role of the anticodon binding domain (ABD) of GRS as an anticancer ligand has recently been reported and its role in other diseases like Charcot-Marie-Tooth (CMT) and polymyositis have increased its interest. NMR assignments were completed using the isotope [$^{13}C/^{15}N$]-enriched protein and chemical shifts based secondary structure analysis with TALOS+ demonstrate similar secondary structure as reported in X-ray structure PDB 2ZT8, except some C-terminal residues. NMR signals from the N-terminal residues 557 to 571 and 590 to 614 showed very weak or no signals exhibiting dynamics or conformational exchange in NMR timescale.

• BMB Reports
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• 제40권2호
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• pp.232-238
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• 2007

The p13 gene is uniquely present in Group II nucleopolyhedroviruses (NPVs) and some granuloviruses, but not in Group I NPVs. p13 gene was first described by our laboratory in Leucania separatamultiple nuclear polyhedrosis virus (Ls-p13) in 1995. However, the functions of Ls-P13 and of its homologues are unknown. When Ls-p13 was inserted into Autographa californica nucleopolyhedrovirus, a Group I NPV, polyhedra yield was inhibited. However, this inhibition was prevented when the leucine zipper-like domain of Ls-p13 was mutated. To determine the cause of this marked difference between Ls-P13 and leucine zipper mutated Ls-P13 (Ls-P13mL), oligomerization and secondary structure analyses were performed. High performance liquid chromatography and yeast two-hybrid assays indicated that neither Ls-P13 nor Ls-P13mL could form oligomers. Informatics and circular dichroism spectropolarimetry results further indicated marked secondary structural differences between Ls-P13 and Ls-P13mL. The LZLD of Ls-P13 has two extended heptad repeat units which form a hydrophobic surface, but it is short of a third hydrophobic heptad repeat unit for oligomerization. However, the mutated LZLD of Ls-P13mL lacks the above hydrophobic surface, and its secondary structure is markedly different. This difference in its secondary structure may explain why Ls-P13mL is unable to inhibit polyhedra yield.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1991년도 가을 학술발표회 논문집
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• pp.63-68
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• 1991

The frequency window method has been extended to include strong coupling and multiple connections between the primary structure and the secondary structures. The rational polynomial expansion of the eigenvalue problem and the analytical methods for its solution are novel and distinguish this work from other eigenvalue analysis methods. The key results are the identification of parameters which quantify the resonance and coupling characteristics; the derivation of analytical dosed-form expressions describing the fundamental modal properties of the frequency windows; and the development of an iterative procedure which yields accurate convergent results for strongly-coupled primary-secondary structures.

• 한국해양바이오학회지
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• 제2권2호
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• pp.73-76
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• 2007

A large number of natural products were worldwidely discovered from maine organisms. There are many secondary metabolites produced by maine organisms which showed very strong bio-activities and distinct bio-active mechanisms. In korea, about 350 secondary metabolites including more than 280 novel compounds have been isolated and structually defined. Many researches for developing products such as cosmetics, functional food materials, anti-fouling substances are being performed using distinct activities of marine organisms. Although the research on marine natural products has been remained at its initial or developing stage of drug development, significant progress has been made for isolation, structure determination and bioassay of secondary metabolites.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.65-65
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• 2003

After many genome projects, algorithms and software to process explosively growing biological information have been developed. To process huge amount of biological information, high performance computing equipments are essential. If we use the remote resources such as computing power, storages etc., through a Grid to share the resources in the Internet environment, we will be able to obtain great efficiency to process data at a low cost. Here we present the performance improvement of the protein secondary structure prediction (PSIPred) by using the Grid platform, distributing protein sequence data on the Grid where each computer node analyzes its own part of protein sequence data to speed up the structure prediction. On the Grid, genome scale secondary structure prediction for Mycoplasma genitalium, Escherichia coli, Helicobacter pylori, Saccharomyces cerevisiae and Caenorhabditis slogans were performed and analyzed by a statistical way to show the protein structural deviation and comparison between the genomes. Experimental results show that the Grid is a viable platform to speed up the protein structure prediction and from the predicted structures.

• 소음진동
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• 제7권4호
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• pp.655-661
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• 1997

건물내 동적계가 수중에 있고 유체동적효과가 클 경우, 건물을 지진절연하면 일반적인 경향과는 달리 계의 지진응답이 오히려 증가될 수 있다. 본 논문에서는 건물내 수조에 잠긴 계에 대하여 단순화된 복합모델의 동적해석을 통하여 건물의 지진절연이 건물내 수중계의 지진응답에 어떻게 그리고, 최대로 얼마나 영향을 주는지를 보인다. 이 때 응답을 줄이기 위한 내진설계방안으로서 유체질량효과를 조절하는 유체간극의 최적화를 수행하여 그 효과를 살펴보았고, 간극조절이 곤란한 경우의 대안으로서 지진절연된 건물내 수중계를 다시 지진절연하는 방안을 제안하였으며 적절한 이중절연방식의 조합에 대한 효율을 비교하였다.

• Genomics & Informatics
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• 제20권4호
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• pp.41.1-41.9
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• 2022

The pathogen Gallibacterium anatis has caused heavy economic losses for commercial poultry farms around the world. However, despite its importance, the functions of its hypothetical proteins (HPs) have been poorly characterized. The present study analyzed the functions and structures of HPs obtained from Gallibacterium anatis (NCTC11413) using various bioinformatics tools. Initially, all the functions of HPs were predicted using the VICMpred tool, and the physicochemical properties of the identified virulence proteins were then analyzed using Expasy's ProtParam server. A virulence protein (WP_013745346.1) that can act as a potential drug target was further analyzed for its secondary structure, followed by homology modeling and three-dimensional (3D) structure determination using the Swiss-Model and Phyre2 servers. The quality assessment and validation of the 3D model were conducted using ERRAT, Verify3D, and PROCHECK programs. The functional and phylogenetic analysis was conducted using ProFunc, STRING, KEGG servers, and MEGA software. The bioinformatics analysis revealed 201 HPs related to cellular processes (n = 119), metabolism (n = 61), virulence (n = 11), and information/storage molecules (n = 10). Among the virulence proteins, three were detected as drug targets and six as vaccine targets. The characterized virulence protein WP_013745346.1 is proven to be stable, a drug target, and an enzyme related to the citrate cycle in the present pathogen. This enzyme was also found to facilitate other metabolic pathways, the biosynthesis of secondary metabolites, and the biosynthesis of amino acids.

• Journal of Power Electronics
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• 제7권4호
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• pp.301-309
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• 2007

The flyback converter is one of the most attractive isolated converters in small power applications because of its simple structure. However, it suffers from high device stress, large transformer size, and high voltage stress across its switch and diode. To solve these problems a new cost-effective PWM single-switch isolated converter is proposed. The proposed converter has no output filter inductor, reduced voltage stress on the secondary devices, and reduced transformer size. Moreover, the switch turn-off loss is reduced and no dissipative snubber across the secondary diode is required. Therefore, it features a simple structure, a low cost, and high efficiency. The operational principle and characteristics of the proposed converter are presented and compared with the flyback converter and then verified experimentally.