• 지역사회간호학회지
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• 제15권2호
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• pp.197-208
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• 2004

Purpose: This study was to develop an effective evaluation tool for evaluation of hypertension prevention and management program(HPMP) in community health posts (CHPs). Method: Evaluation tool composed from the literature review, the field visiting, and the in-depth interviews with the community health practitioners. Result: The evaluation tool had four domains, each with different maximum points:, hypertension prevention (35), hypertension management (40), environment of the CHPs(10), and evaluation system of the HPMP(15). The first domain was hypertension prevention with sub-domains of health education, and early detection of patients with hypertension. The second domain was hypertension management with sub-domains of management of health records of patients, education and counseling, and treatment and follow-up of patients. The third domain was the environment of the CHPs with subdomains of accessibility of CHPs to residents, accessibility of general health data to the public, and availability of health information to the public by multimedia. The fourth domain was the evaluation system of the HPMP with the subdomains of planning of program, formative evaluation, process evaluation, and summative evaluation. Conclusion: The newly developed evaluation tool will contribute not only to plan and set goals for evaluation of HPMP in CHPs.

• 가정과삶의질연구
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• 제30권3호
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• pp.1-11
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• 2012

The purpose of this study is to analyze the effects of attitudes toward reasons for which abortion is permitted on needs for abortion prevention policies among 232 unmarried female students at the middle schools, high schools, and universities located in Seoul. The respondents were requested to complete the self-administered questionnaire, and the principal component analysis, t-tests, Pearson's correlations, and hierarchical multiple regression analyses were performed for analyzing data. The major findings of this study were as follows: First, the principal component analysis identified three reasons for which abortion is permitted. These are reasons under the maternal & child health law, socioeconomic reasons, and normatively unqualified reasons. Second, the female students showed permissive attitudes toward reasons for abortion under the maternal & child health law, disapproval attitudes toward socioeconomic reasons for abortion, and neutral attitudes toward abortion by normatively unqualified reasons. Students also showed high levels of needs for abortion prevention policies. Finally, hierarchical regression analyses revealed that female students' attitudes toward reasons for which abortion is permitted significantly predicted levels of needs for abortion prevention policies, after controlling their sciodemographic characteristics. The implications of the study results are discussed.

• 교육녹색환경연구
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• 제14권2호
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• pp.45-63
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• 2015

본 연구는 지속적으로 증가하고 있는 학교안전사고를 저감시키기 위한 방안으로 델파이 기법을 활용하여 학교안전사고 예방정책을 제시하는데 목적이 있다. 델파이 조사결과 분야별 학교안전사고 예방정책 개선 방안은 다음과 같다. 첫째, 학교시설을 기획, 설계 및 시공, 유지관리, 평가 등 4단계로 구분하여 체계적인 안전정책을 수립할 필요가 있다. 둘째, 학교안전정책이 학교현장에서 유용한 대책으로 활용되기 위해서는 시설안전 담당자들이 부담으로 느끼는 책무성과 예산상 한계를 극복할 수 있는 연구가 필요하다. 셋째, 예방대책이 지속적으로 안전정책에 반영되기 위해서는 각 분야별 관련부서의 검토를 통하여 해당 법령이 개정되도록 노력할 필요가 있다.

• Parasites, Hosts and Diseases
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• 제58권5호
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• pp.589-592
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• 2020

Cyclospora cayetanensis is an apicomplexan protozoan and is one of the most common pathogens causing chronic diarrhea worldwide. Eight stool samples with diarrheal symptom out of 18 Korean residents who traveled to Nepal were obtained, and examined for 25 enteropathogens including 16 bacterial species, 5 viral species, and 4 protozoans in stool samples as causative agents of water-borne and food-borne disease. Only C. cayetanensis was detected by nested PCR, and 3 PCR-positive samples were sequenced to confirm species identification. However, the oocysts of C. cayetanensis in fecal samples could not be detected by direct microscopy of the stained sample. As far as we know, this is the first report of a group infection with C. cayetanensis from a traveler visiting Nepal, and the second report of a traveler's diarrhea by C. cayetanensis imported in Korea.

• 여성건강간호학회지
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• 제7권4호
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• pp.560-578
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• 2001

The purpose of this study was to develop prevention and educational programs for battered women. The first stage was to assess battered women's health status and health needs. The second stage was to develop prevention and educational programs to improve battered women's health. A survey research design was used to gather data from June-November 1999 by the counselor. Research sample was recruited from shelter and women's counseling centers in Seoul, Inchon, Chooncheon, Taejeon, and Jeoju. Trained counselors contacted 218 women, who agreed verbally to participate in the study. The researcher did a literature review and developed the tool used. We did ten pretests and three counselors checked the tool for content validity. The reliability and validity of the instrument were acceptable. The second stage of the research consisted of lay-professional groups discussing the abuse problems and possible solutions. Each group had five professionals (counsellor, nurse, minister, psychiatrist, social worker) and five women who have experienced battering from her husband in community. Result of the survey and two(lay persons and professionals) group discussions showed that victims need more assessment of physical, mental and spiritual needs. Victims were beaten more often during their pregnancies than at other times. Various kind of strategy were frequently utilized, but still the number of women abused and suicides committed increased. Both studies showed that the women experienced severe beating, that they felt powerless, that they need to understand that society abuser characteristics, that they lack a protection support system and that society lacks would an understanding of battered women. Based on the result of both studies, we developed model for prevention and education of battered women. This educational program will increase women s power to solve the abuse problems. The ultimate goal of the program is to develop a one-stop center to give wholistic approach care to women in abuse situations.

• 경영과정보연구
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• 제30권4호
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• pp.73-92
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• 2011

명품브랜드의 대중화는 소비자가 명품브랜드를 이용하는 방식과 소비하는 목적과 동기가 다양해진다는 것을 의미한다. 명품브랜드 시장을 보다 잘 이해하기 위해서는 차별화된 다양한 접근법이 필요하다. 본 연구는 명품 브랜드의 가치와 브랜드 선호도간 관계에서 조절초점 조절효과를 검토하는데 목적이 있다. 명품 브랜드에 대한 지각된 가치는 소비자의 조절초점성향에 따라 브랜드 태도에 미치는 영향에 차이가 있는지를 분석하였다. 분석결과, 품질가치와 경제적 가치는 향상초점 소비자집단보다 예방초점 소비자 집단에서 더 높게 나타난 반면에 심리적 가치는 예방초점 소비자 집단보다 향상초점 소비자집단에서 높게 나타났다. 또한, 향상초점 소비자일수록 과시적 가치와 감정적 가치가 명품브랜드 태도에 더 큰 영향을 미치는 반면, 예방초점 소비자일수록 품질가치와 경제적 가치를 더 중시하는 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2453-2459
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• 2013

Bevacizumab has been approved for use in combination with chemotherapy to treat many types of cancer but associated neutropenic events, including febrile neutropenia, have been reported. To estimate the incidence and relative risk of neutropenic events in cancer patients treated with bevacizumab combination therapy, we searched PubMed, EMBASE, and Web of Science literature databases, as well as abstracts presented at the American Society of Clinical Oncology conferences, to identify relevant studies published from January 1966 to December 2011. Studies that compared bevacizumab plus chemotherapy or biological therapy with chemotherapy or biological therapy alone, and that had adequate safety data profiles, were selected for analysis. Statistical analyses were conducted to calculate the summary incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) using fixed- or random-effects models. A total of 22 clinical trials involving 15,056 patients were included in the analysis. The summary incidences of high-grade neutropenia (HGN) and high-grade febrile neutropenia (HGFN) in patients receiving bevacizumab was 27.3% (95% CI: 26.4%-28.3%) and 3.91% (95% CI: 3.51%-4.37%), respectively. The risks of HGN (RR=1.10; 95% CI: 1.02-1.19; P=0.02) and HGFN (RR=1.31; 95% CI: 1.08-1.59; P=0.005) were significantly increased in bevacizumab-treated patients, compared to those who did not receive bevacizumab. The RR of bevacizumab-associated HGN, but not HGFN, varied significantly with tumor types (P=0.005). The increased risk of bevacizumab-associated neutropenic events was dose-dependent, as the RR was greater at a dose of 5 mg/kg/week than at 2.5 mg/kg/week. Our findings suggest that bevacizumab addition to cancer therapy significantly increases the risk of serious neutropenic events, and this risk may be dose-dependent.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.289-294
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• 2012

Background: Myofibroblasts play an important role in the development of oral submucous fibrosis (OSF). In the current study, we investigate the effect of curcumin on growth and apoptosis of myofibroblasts derived from human oral mucosa. Methods: Myofibroblasts were generated by incubating fibroblasts, obtained from human oral mucosa, with transforming growth factor-${\beta}1$ (TGF-${\beta}1$). MTT, PI staining, and FACS assays were used to investigate curcumin's effect on proliferation and cell cycle of fibroblasts and myofibroblasts. Annexin V/PI binding and FACS assays were used to examine apoptosis of myofibroblasts, Western blotting to determine the levels of Bcl-2 and Bax, and enzyme-linked immunosorbant assay was employed to examine the levels of collagen type I and III in the supernatants of myofibroblasts. Results: Curcumin inhibits proliferation of fibroblasts and myofibroblasts; it also disturbs the cell cycle, induces apoptosis and decreases the generation of collagen type I and III in myofibroblasts, which are more sensitive to its effects than fibroblasts. Curcumin induces apoptosis in myofibroblasts by down-regulating the Bcl-2/ Bax ratio. Conclusion: Our results demonstrate the antifibrotic effect of curcumin in vitro. It may therefore be a candidate for the treatment of OSF.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.579-583
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• 2012

Background: The SULT1A1 Arg213His polymorphism is reported to be associated with lung cancer risk. However, this relationship remains controversial. For better understanding a meta-analysis was therefore performed. Methods: An extensive search was performed to identify all case-control studies investigating association between SULT1A1 Arg213His polymorphism and lung cancer risk. The strength was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95%CI). Results: A total of five publications covering 1,669 cases and 1,890 controls were included in this meta-analysis. No significant association between SULT1A1 Arg213His polymorphism and lung cancer risk was observed in overall comparisons in all genetic models (dominant model: OR=1.33, 95%CI=1.00-1.76, P=0.05; additive model: OR=1.30, 95%CI=0.93-1.81, P=0.12; recessive model: OR=1.21, 95%CI=0.89-1.66, P=0.23). However, on subgroup analysis, an elevated risk in mixed populations with variant His allele was revealed in the dominant model (OR=1.66, 95% CI=1.06-2.62, P=0.03). Furthermore, the SULT1A1 Arg213His polymorphism was associated with an increased risk of lung cancer in both females and males in the dominant model (females: OR=1.72, 95%CI=1.29-2.27, P=0.00; males: OR=1.46, 95%CI=1.19-1.78, P=0.00). No significant association between this polymorphism and different smoking status (smokers and non-smokers) and the other ethnicities (Asians and Caucasians) was shown. Conclusions: The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is not associated with lung cancer risk in Asians and Caucasians, but possible elevation for genotype (GA/AA) in mixed populations and males and females needs further investigation.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4823-4826
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• 2012

Objective: To explore serum angiogenic factor expression in patients with osteosarcoma and its relationship with metastasis. Methods: Immunohistochemistry was used to test the expression of CD34 and FVIII-Rag in osteosarcoma tissues of 36 patients (osteosarcoma group) and microvessel density (MVD) was also recorded. In addition, ELISA was used to test the level of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor-${\beta}1$ (TGF-${\beta}1$) and endostatin (ES) in the osteosarcoma group and in a control group. Results: VEGF and ES level were significantly higher than in the control group before operation (P<0.01), VEGF, bFGF and TGF-${\beta}1$ correlating with the ES level (P<0.01). Serum VEGF and ES levels of osteosarcoma patients before surgery were closely related to relapse and metastasis; moreover, serum VEGF increased with MVD (P<0.01). Postoperative VEGF and ES levels were lower than the preoperation values (P<0.01); ES level in relapse group was significantly higher than that of the non-relapse group (P<0.01). Conclusion: Preoperative serum VEGF and postoperative ES levels have great predictive value with regard to relapse of osteosarcoma patients.