• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7859-7863
• /
• 2015

Purpose: To compare the efficacy and toxicity of gemcitabine versus docetaxel in a second-line setting of nonsmall cell lung cancer (NSCLC) patients previously treated with platin-based combination chemotherapy. Materials and Methods: We retrospectively evaluated the medical records of 57 patients treated with single agent gemcitabine or docetaxel in second-line setting of advanced NSCLC who received one prior platinum-based therapy. Results: The mean age was $56.7{\pm}8.39$ years with 55 (96.5%) males and two (3.5%) females. Forty of them received docetaxel and 17 gemcitabine. The mean number of chemotherapy cycles was $6.8{\pm}4.0$ in the gemcitabine group, while it was $4.6{\pm}3.0$ in the docetaxel group. Overall response rates were 8% and 12% (P=0.02) for gemcitabine and docetaxel, respectively. The median survival time was 22 versus 21 months for gemcitabine and docetaxel, respectively. The median times to progression were 8 and 5 months. There was no difference between the two groups in terms of incidence of adverse affects (40% vs 47.1%). All of the hematological side effects were grade 1/2. No major toxicity was encountered necessitating stopping the drug for either group. Conclusions: Treatment with gemcitabine demonstrated clinically equivalent efficacy with a significantly improved safety profile compared with those receiving docetaxel in the second-line setting for advanced NSCLC in this study. Based on these results, treatment with gemcitabine should be considered a standard treatment option for second-line NSCLC.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1171-1176
• /
• 2012

Objective: The current study aimedto screen for possible factors which affect prognosis of chondrosarcoma. Methods: Thirty seven cases were selected and analyzed statistically. The patients received surgical treatment at our hospital between December 2005 and March 2008. All of them had complete follow-up data. The survival rates were calculated by univariate analysis using the Kaplan-Meier method and tested by Log-rank. ${\chi}^2$ or Fisher exact tests were carried out for the numeration data. The significant indexes after univariate analysis were then analyzed by multivariate analysis using COX regression model. Based on the literature, factors of gender, age, disease course, tumor location, Enneking grades, surgical approaches, distant metastasis and local recurrence were examined. Results: Univariate analysis showed that there were significant differences in Enneking grades, surgical approaches and distant metastasis related to the patients' 3-year survival rate after surgery (P<0.001). No significant difference was not found in gender, age, disease course, tumor location or local recurrence (P>0.05). Multivariate analysis showed that Enneking grade (P=0.007) and surgical approaches (P=0.010) were independent factors affecting the prognosis of chondrosarcoma, but distant metastasis was not (P=0.942). Conclusion: Enneking grades, surgical approaches and distant metastasis are risk factors for prognosis of chondrosarcoma, among which the former two are independent factors.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.6099-6104
• /
• 2015

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.2115-2120
• /
• 2012

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권24호
• /
• pp.10773-10777
• /
• 2015

Background: Treatment for breast cancer is mainly performed by surgical resection of primary tumors and chemotherapy. However, after tumor invasion and metastases, breast cancer is hard to control. Clarification of the pathogenic mechanisms would be helpful to the prognosis or therapy for the breast cancer. The aim of this study is to investigate the clinical and prognostic implications of legumain protein Materials and Methods: In this study, we examined mastectomy specimens from 114 breast cancer and matching, 26 adjacent non-cancerous tissues using immunohistochemistry. Results: The results indicated that positive expression of legumain protein in breast cancer was 51.8 % (59/114) and the positive expression of legumain protein in adjacent non-cancerous tissue was 11.5% (3/26). It appeared to be related with lymph node metastasis of breast cancer (p=0.02) and correlation analysis indicated that legumain expression was correlated positively with the estrogen receptor (ER) and mutant-type p53 expression (both p<0.05). Positive legumain expression was significantly associated with shorter overall survival time in breast cancer patients (log-rank p<0.01). Multivariate survival analysis suggested that the positive legumain expression was an independent predictor of poorer overall survival in patients with breast cancer (HR=0.24; 95%CI 0.11-0.65, p=0.03). Conclusions: Legumain might be a new potential biomarker for breast cancer, which may reflect the prognosis and overall survival.

• 한국안전학회지
• /
• 제13권3호
• /
• pp.143-162
• /
• 1998

There are two ways to prevent labor from Industrial accident One is pre-prevention, another is compensation. Onless It happens the compensation problem from The pre-prevention, It will be best way to solve. To prevent lobar widely first, the application range should be wide which is base of repayment second, assoradiy to reconsideration of apportionment properly The Max-Min limitative cost of compensative should be paid, one the other hands, The lay-off payment of limitative and The fixed payment of Funeral should be introduce Third, The specialization of examination.

• 산업융합연구
• /
• 제17권4호
• /
• pp.87-94
• /
• 2019

본 연구의 목적은 노인 치매예방을 위해 스마트폰에서 제공되고 있는 치매예방 게임 앱과 치매진단 앱의 이용에 대한 유용성 및 그 기대효과를 예측하는 것이다. 연구방법은 첫째, 치매예방프로그램의 효과성을 검증하기 위하여 사용되고 있는 6개의 치매진단도구를 선정하고 각 진단도구가 검증하고 있는 인지기능영역을 추출하였다. 둘째는 29개의 스마트폰 치매예방 게임 앱과 치매관리 앱을 선정하여 이 앱들을 이용한 이후의 기대효과를 치매진단도구에서 추출된 인지영역과 연계하여 분석하였다. 연구 결과, 스마트폰 치매예방 앱을 이용하여 지속적으로 게임을 하거나 치매관리를 할 경우 특정 영역의 인지기능을 증진함으로써 치매예방 관리에 도움이 될 것으로 기대되었다. 스마트폰 치매예방 앱은 시공간을 초월한 이용의 용이성, 지속적 사용성 그리고 경제성을 통하여 오프라인으로 운영되고 있는 치매예방프로그램의 한계점을 보완함으로써 노인의 인지능력을 증진시키고 치매를 예방하는 데 유용할 것이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권9호
• /
• pp.4067-4070
• /
• 2014

Background: The Chinese Hui ethnic group has diverse origins, including Arab, Persian, Central Asian, and Mongol. The standardized mortality rate of gastric cancer in the Hui population is higher than the overall Chinese population. In this study, we investigated whether COX-2-765G>C polymorphism, an extensively studied polymorphism, contributes to gastric cancer and its precursor lesions (GPL) in the Chinese Hui ethnic group. Materials and Methods: COX-2-765G>C polymorphism was determined by pyrosequencing in 100 gastric cancer cases, 102 gastric cancerand its precursor lesions cases and 105 controls. Data were statistically analyzed using Chi-square tests and logistic regression models. Results: Among the Chinese Hui ethnic group COX-2-765 C allele carriers were at increased risk for gastric cancer (OR=1.977, 95%CI=1.104-3.541). We also found an interaction between COX-2 -765 C carriers and Helicobacter pylori infection and eating pickled vegetables. Conclusions: Our findings suggest a multi-step process of gene-environment interaction contributes to gastric carcinogenesis.

• 한국콘텐츠학회논문지
• /
• 제11권6호
• /
• pp.311-325
• /
• 2011

청소년 범죄는 사소한 비행에서 시작되어 재범을 반복하는 생활을 하기 쉬운 첫 단계로 초기 단계에서 적극적인 선도대책을 시행함으로써 청소년 범죄를 감소시킬 수 있는 방안 마련이 시급하다. 비행 소년 범법 소년 사건처리에서 가장 중요한 것은 법적인 절차로 판단을 내리는 것 보다는 선도절차에 초점을 맞추어 재범을 방지하고 사회의 정상적인 구성원으로 복귀시키는 것이 최상의 방안이다. 이러한 맥락에서, 비행소년 범법 소년의 재범률 감소를 위한 다이버전 프로그램 개발 및 활성화 방안으로 전문가 활성화 및 초범에 대한 적절한 대응, 부모교육의 필요성, 멘토의 활성화, 후속 프로그램 개발을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권6호
• /
• pp.2735-2738
• /
• 2012

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE- in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.