• Journal of the Korean Institute of Rural Architecture
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• v.17 no.4
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• pp.57-65
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• 2015

In contrast to apartments, detached houses offer the possibility of more than one entrance connecting interior and exterior spaces. This study examines the location, function, and use of second doors in detached houses in rural areas. The study employs survey and interviews conducted in 2015, focusing on 18 detached houses among 40 houses previously surveyed in 1995. In 1995, 21 second doors were found, while in 2015, 19 were found. The study led to the following conclusions. First, most houses did have second doors installed by 1995 or 2015. Second doors tended to be installed in kitchen and utility rooms. The function of second doors was most closely connected to the kitchen because utility rooms were placed adjacent to kitchens. Secondly, changes in the use and number of second doors were changes in family life cycle and composition, the need for new equipment facilities, the use of new architectural materials, and the installation of new second doors for extension of space. Finally, exterior spaces accessed by second doors tend to be a meeting of semi-interior or semi-exterior space and exterior space only. Those spaces tended to be designed for kitchen fixtures or to support kitchen activities.

• The Research Journal of the Costume Culture
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• v.18 no.3
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• pp.452-464
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• 2010

The purpose of the study was to give a help in making a successful expansion of fashion brand by making a close inquiry into an effect of the main brand in fashion brand on an image of the second brand and into an effect of satisfaction and loyalty for main brand on satisfaction and loyalty for the second brand. The study made a survey of the total eight brands including four main brands and each second brand, and used 217 questionnaires. The results of this study are as follows. First, The main brand image and second brand image did not match. Second, the satisfaction of the main brand affected the satisfaction of their second brand, especially in the main brand of the image, design, user experience, staff friendliness, variety of products and brands on display. Third, the ranking of main brand loyalty and the ranking of second brand loyalty were different. All the main brand loyalty had a significant effect on the second brand. The consumers who preferred the main brand had a high confidence and a strong tendency to repurchase.

• Journal of Fashion Business
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• v.14 no.3
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• pp.97-115
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• 2010

The purpose of this study is to compare and analyze the relationship among image, customer satisfaction and loyalty of fashion Extension brands. It is expected that this study will provide guidance to fashion companies that are planning to expand their brand in setting up marketing strategies and service strategies. The results of the study are the following. First, women consumers in their 20s had an perception that second brands provided diverse and unique products at cheap prices. However, after purchasing the products, they recognized that the second companies' service level was not so satisfying. Second, consumers were satisfied with the brand awareness, reputation, image, design, color, and packing conditions of the second brands while being not satisfied with the pricing. Third, when the study examined brand loyalty of second brands, consumers have shown high loyalty to the four subsidiary brands. Fourth, the satisfaction level for the four second brands had a significant effect on the brand loyalty for each second brands.

• Korean Journal of Mathematics
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• v.28 no.3
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• pp.439-447
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• 2020

Let M be a lattice module over a C-lattice L. Let Spec^s(M) be the collection of all second elements of M. In this paper, we consider a topology on Spec^s(M), called the second classical Zariski topology as a generalization of concepts in modules and investigate the interplay between the algebraic properties of a lattice module M and the topological properties of Spec^s(M). We investigate this topological space from the point of view of spectral spaces. We show that Spec^s(M) is always T₀-space and each finite irreducible closed subset of Spec^s(M) has a generic point.

• International Journal of Reliability and Applications
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• v.7 no.1
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• pp.71-77
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• 2006

The market for second hand products has been growing for a variety of reasons (e.g., new products appearing at a faster rate and the expected life of products increasing due to rapid advances in technology). The demand for warranties for second-hand products has been growing along with the growth of the market for second-hand products. Warranty for new products (consumer durables, industrial and commercial, and specialized defense products) has received a lot of attention. In contrast, warranties for second-hand product have received very little attention. Often, dealers of second-hand product such as cars offer 2D-warranties (Year and Kilometers). The expected warranty cost associated with a second-hand product for 2D-Policies is a function of the age of the item and its usage (as it affects failures over the warranty period), the warranty terms and the servicing strategy used by the dealer. This paper deals with development of models for warranty cost analysis along with the decision on sale price and warranty cover for 2D-Warranty policies associated with sale of second-hand products.

• The Journal of Korean Academy of Prosthodontics
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• v.29 no.2
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• pp.147-160
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• 1991

The purpose of this study was to examine, by the method of finite element analysis, how implant geometry with or without connection between natural tooth and osseointegrated abutments affected the stress distribution in surrounding bone and osseointegrated prosthesis. The mandibular first and second molars were removed and the two osseointegrated implants were placed in the first and second molar sites. Stress analysis induced by prostheses with connection(Model A)or without connection(Model B) between natural tooth(second bicuspid) and two osseointegrated abutments(first molar and second molar) was performed under vertical point load(Load P1) or distributed point load(Load P2). The results were as follows; 1. Under vertical point load, mesial tilting was shown in both Model A and Model B and inferior displacement of Model A was greater than that of Model B in the second bicuspid. 2. Under vortical point load, the first and second molars showed mesial tilting in both Model A and Model B, and inferior displacement of them was similar in Model A and Model B and was less than that of the second bicuspid. 3. Under distributed point load, mesial displacement was shown in Model A and Model B and inferior displacement of Model A was less than that of Model B in the second bicuspid. 4. Under distributed point load, mesial tilting was shown and inferior displacement of Model A was similar to that of Model B in the first and second molars. 5. In Model A under vertical point load, high stress was concentrated in the corneal portion of first molar and distributed throughout the second molar and the second bicuspid, and the stress distribution of the second molar was greater than that of the second bicuspid. 6. In Model B under vertical point load, high stress was concentrated in the coronal and mesio-cervical portion of the first molar. 7. In Model A under distributed point load, high stress was concentrated in the mesio-cervical portion of the first molar and evenly distributed throughout the second molar and the second bicuspid. 8. In Model B under distributed point load, high stress was concentrated in the disto-cervical portion of the second bicuspid and evenly distributed throughout the first and second molars.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3223-3228
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• 2012

HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.5.1-5.14
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• 2018

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stress-induced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol ($10{\mu}M$) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPK-PGC-$1{\alpha}$ signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.97-107
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• 2023

Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and is known to cause aristolochic acid nephropathy (AAN). AA-induced acute kidney injury (AKI) is a syndrome in AAN with a high morbidity that manifests mitochondrial damage as a key part of its pathological progression. Melatonin primarily serves as a mitochondria-targeted antioxidant. However, its mitochondrial protective role in AA-induced AKI is barely reported. In this study, mice were administrated 2.5 mg/kg AA to induce AKI. Melatonin reduced the increase in Upro and Scr and attenuated the necrosis and atrophy of renal proximal tubules in mice exposed to AA. Melatonin suppressed ROS generation, MDA levels and iNOS expression and increased SOD activities in vivo and in vitro. Intriguingly, the in vivo study revealed that melatonin decreased mitochondrial fragmentation in renal proximal tubular cells and increased ATP levels in kidney tissues in response to AA. In vitro, melatonin restored the mitochondrial membrane potential (MMP) in NRK-52E and HK-2 cells and led to an elevation in ATP levels. Confocal immunofluorescence data showed that puncta containing Mito-tracker and GFP-LC3A/B were reduced, thereby impeding the mitophagy of tubular epithelial cells. Furthermore, melatonin decreased LC3A/B-II expression and increased p62 expression. The apoptosis of tubular epithelial cells induced by AA was decreased. Therefore, our findings revealed that melatonin could prevent AA-induced AKI by attenuating mitochondrial damage, which may provide a potential therapeutic method for renal AA toxicity.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1281-1284
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• 2012

Background: Platinum-hased chemotherapy for advanced non-small cell lung cancer (NSCLC) is still considered the first choice, presenting a modest survival advantage. However, the patients eventually experience disease progression and require second-line therapy. While there are reliable predictors to identify patients receiving first-line chemotherapy, very little knowledge is available about the prognostic factors in patients who receive second-line treatments. The present study was therefore performed. Methods: We retrospectively reviewed 107 patients receiving second-line treatments from August 2002 to March 2012 in the Dicle University, School of Medicine, Department of Medical Oncology. Fourteen potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Result: The results of univariate analysis for overall survival (OS) were identified to have prognostic significance: performance status (PS), stage, response to first-line chemotherapy response to second-line chemotherapy and number of metastasis. PS, diabetes mellitus (DM), response to first-line chemotherapy and response to second-line chemotherapy were identified to have prognostic significance for progression-free survival (PFS). Multivariate analysis showed that PS, response to first-line chemotherapy and response to second-line chemotherapy were considered independent prognostic factors for OS. Furthermore, PS and response to second-line chemotherapy were considered independent prognostic factors for PFS. Conclusion: In conclusion, PS, response to first and second-line chemotherapy were identified as important prognostic factors for OS in advanced NSCLC patients who were undergoing second-line palliative treatment. Furthermore, PS and response to second-line chemotherapy were considered independent prognostic factors for PFS. It may be concluded that these findings may facilitate pretreatment prediction of survival and can be used for selecting patients for the correct choice of treatment.