• Toxicological Research
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• 제16권2호
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• pp.163-172
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• 2000

Recently, there is a worldwide concern that a great number of man-made chemicals have a hormone-like action both in humans and in animals. DECD is developing screening programs using validated test systems to determine whether certain substances may have an effect in humans. In the present study. the establishment oj repeated-dose toxicity test method was tried. Flutamide. an anti-androgenic agent. was administered by gavage to Sprague-Dawley rats for 28 days at dose levels of 0. 0.5. 3 and 18 mg/kg body weight (10-15 rats/sex/group) to examine the effects on general findings. especially reproductive and endocrine parameters. Clinical signs. body weights, food consumption, and sexual cycle were checked and measured. For the gross and microscopic examinations. 10 rats/sex/group were sacrificed at the end of dosing period and the remaining animals of control and high dose groups (5 each) were sacrificed after 14 days recovery. Examinations for hematology and clinical chemistry were carried out at necropsy. There were no treatment-related changes in clinical signs. body weights, food consumption. gross necropsy. hematology and clinical chemistry at all doses of both sexes. The period and regularity of sexual cycle were not adversely affected at all doses by the test agent. At 18 mg/kg. both decreased weights of prostate, seminal vesicle and epididymis in males and increased weights of spleen and thymus in females were observed. In addition, decreased number of spermatids and sperms. increased serum testosterone concentration and increased incidence (100%) of interstitial cell hyperplasia were seen in males. At 18 mg/kg of the recovery group. decreased prostate weight. reduced sperm count and increased incidence (20%) of interstitial cell hyperplasia in males and increased thymus weight in females were observed. At 3 mg/kg. reduced sperm count was found. There were no adverse effects on parameters examined at 0.5 mg/kg of both sexes. The results suggested that the potential target organs of flutamide may be accessory sexual glands including testes for males and spleen and thymus for females. Taken together. this test method was found to be a useful screening test system for endocrine disrupting chemicals.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6497-6500
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• 2012

Cervical cancer is the second most common cancer in females in the World with around 500,000 new cases occurring annually, but the first in the developing countries with a high mortality if not diagnosed early. Papanicolau (Pap) smear is a cheap, easy-to-apply and widely accepted test which has been long used to detect cervical cancer at very early stages. However, despite being available for nearly 60 years, the test can hardly be considered to have become successfully applied in many communities. We aimed in this study to present the results of a screening survey for cervical cancer which targeted a women population aged between 35 and 40 living in a semi-rural area in the province of Hatay, located in the eastern Mediterranean region of Turkey, with specific aims of increasing early diagnosis, education and raising population awareness about cancers. This community-based descriptive study covered 512 women between 35 and 40 years of age living at Armutlu with a mean age of $37.6{\pm}1.7$. Gynecologic examinations revealed cervical erosion in 8 (1.6%), vaginitis in 193 (37.7%) and normal findings in 311 (60.7%); pathological evaluation reports of the smears were negative in 290 (56.6%), inflammation in 218 (42.6%) and ASC-US in 4 (0.8%), according to the 2001 Bethesda classification. It can be concluded that Pap smear test - proven to be a very valuable test at the clinical level- should also be widely used at the community level to detect cervical cancer at very early stages to reduce both the mortality and morbidity among healthy people. The need for continuous community-based cervical cancer screening programs is strongly suggested.

• 한국사회복지학
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• 제37권
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• pp.67-88
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• 1999

본 연구조사는 사회복지학계에서는 최초로 국내외에서 개발된 다양한 알코올사용장애 선별도구를 이용하여 신뢰성이 높은 알코올사용장애율을 밝히는 것을 주목적으로 하였다. 조사대상자는 전국에 거주하는 성인으로 충화표집을 이용하여 추출되었고 총 614명이 본 조사에 참여하였다. Alcohol Use Disorder Identification Test, Brief Michigan Alcoholism Screening Test, 한국형 알코올 중독선별 도구를 이용하여 조사대상자의 음주문제를 측정하였고 조사대상자의 음주빈도, 음주 양, 폭음정도를 측정하였다. 본 조사의 주요결과로는 한국성인의 32.2%가 음주와 관련된 문제를 경험한 것으로 나타났으며 전체 성인의 4.2% (한국성인의 134만명)가 알코올사용장애가 있는 것으로 선별되어 우리 나라 성인의 음주문제가 상당히 심각한 수준에 와 있는 것으로 제시하고 있다. 사회복지사는 우리 나라 성인의 음주문제의 심각성을 인식하고 초기면접시 AUDIT나 NAST 같은 선별도구를 사용하여 클라이언트의 음주문제를 항상 파악하여야 할 것이고 알코올 및 약물사용으로 인해 고통 받고 있는 개인들과 그들의 가족을 위한 효과적인 프로그램과 자원을 개발하는데에도 노력을 기울여야 할 것이다. 마지막으로 후속연구를 위한 세 가지 제안점을 언급하고 있다.

• Clinical and Experimental Pediatrics
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• 제63권2호
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• pp.34-43
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• 2020

Phenylketonuria is a disease caused by congenital defects in phenylalanine metabolism that leads to irreversible nerve cell damage. However, its detection in the early days of life can reduce its severity. Thus, many countries have started disease screening programs for neonates. The present study aimed to determine the worldwide prevalence of classic phenylketonuria using the data of neonatal screening studies.The PubMed, Web of Sciences, Sciences Direct, ProQuest, and Scopus databases were searched for related articles. Article quality was evaluated using the Joanna Briggs Institute Critical Appraisal Evaluation Checklist. A random effect was used to calculate the pooled prevalence, and a phenylketonuria prevalence per 100,000 neonates was reported. A total of 53 studies with 119,152,905 participants conducted in 1964-2017 were included in this systematic review. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand. A total of 46 studies were entered into the meta-analysis for pooled prevalence estimation. The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates (95% confidence interval, 5.07-6.93). The meta-regression test showed high heterogeneity in the worldwide disease prevalence (I²=99%). Heterogeneity in the worldwide prevalence of phenylketonuria is high, possibly due to differences in factors affecting the disease, such as consanguineous marriages and genetic reserves in different countries, study performance, diagnostic tests, cutoff points, and sample size.

• 무역상무연구
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• 제58권
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• pp.287-311
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• 2013

In this study, the scope of previous logistics security were focused only on port and ship. Because of it now extends to the overall (export and import) supply chain areas and in regards with supply security programs in the international level, it reviewed supply chain security programs categorized them into 'ships and port security system', 'container screening system', 'logistics chain authorization system' which are expanded to be adopted in the international level. The major features of those programs are summarized as in building risk management system, providing information ahead, selectivity test and benefits to AEO authorized companies in the customs administration level. The government and companies which are to ensure supply chain security and trade facilitation in order to cope actively with international customs administrative atmosphere need to do the followings : First, they need to build an intra-government integrated supply chain security and make efforts to conclude AEO MRA in order to increase trade competitiveness among major trading countries. Second, they need to build supply chain risk management system in order to enhance management performance through overseas market and company level strategy to obtain and maintain AEO authorization in the company level.

• 치위생과학회지
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• 제2권2호
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• pp.69-73
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• 2002

The purpose of this study was to obtain baseline data for developing oral health education program. The questionaire about oral health knowledge and behaviors were given to 1419, 12 year-old children who lived in Seongnam City. The results were obtained as follows; 1) Of respondents, 46.2% visited dental offices within a year. And 33% of them were for the purpose of routine examinations and prevention. 2) 67.1% of them exhibited toothbrushing before bedtime and only 11.3% and 8.9% of them toothbrushed after between-meal intake and lunch. 3) 47.7% of them experienced dental health education programs and 72.3% of the programs had been during elementary school days. 4) 56.2% of them chose dentifrices without standards and 21.6% of them considered the presence of fluoride. 5) Of respondents, 57.4% and 46.4% knew the importances of toothbrushing and dietary pattern. But only 18.7% and 8.5% of them knew the methods of using fluoride and scaling. 6) 33% of them replied negatively to the probabilities of preventing dental caries. 7) Also, it is necessary to expand the oral health education programs for 12 year-old children in Seongnam City and include the annual screening dental examination, toothbrushing, dentifrice selection, using fluoride and scaling.

• 한국농촌간호학회지
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• 제17권2호
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• pp.67-74
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• 2022

Purpose: This study aimed to describe a non-face-to-face dementia prevention and physical activity program in small rural villages during the COVID-19 pandemic. Methods: The study used a case report provided by a primary healthcare post in Gyeonggi-do in 2020. Results: The program was "From head to toe, stay healthy", which was largely divided into dementia prevention ("Dementia Zero Zone") and physical activity ("The less fat, The healthier body"). Five elderly people aged 75 and over participated for preventing dementia, and 13 residents joined the health promoting programs over 80 times in total. This program was designed one-to-one customized and person-centered program, including counseling, education, and health services. The program participants responded that the amount of physical activities was increased even under strict social distancing and they felt less isolated and less depressed. Moreover, the number of screening for dementia was increased with this program. Conclusion: This case has shown the applicability of a new approach to sustain health promotion programs in the context of limited interaction with rural nurses. Under the challenging environment that requires adaptation to information and communication technologies (ICTs), it will be necessary to solve not only technical problems but also digital literacy issues of rural residents.

• Journal of Genetic Medicine
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• 제5권1호
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• pp.21-25
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• 2008

목 적 : 최근 여러 국가에서 빠르게 탠덤매스 신생아 선천성 대사이상질환 선별 프로그램을 채택하고 있으며 많은 질환들이 검출되고 있다. 본 기관에서는 2001년 4월부터 탠덤 매스 선천성 대사이상 질환 신생아 선별 검사를 시작하였다. 연구자들은 한국에서의 탠덤매스 선천성 대사이상질환 검출율 및 탠덤매스 유용성에 대해 평가하고자 하였다. 방 법 : 2001년 4월부터 2007년 12월까지 본원에서는 탠덤매스를 이용하여 신생아 및 고위험군에 대해 선별검사를 시행하였다. 검체로부터 아실카르틴과 아미노산을 추출하여 부탄올로 유도체화시킨 후 탠덤매스에 장착하여 분석하였다. 탠덤매스 선별검사 재검, 소변 유기산 및 혈장 아미노산 검사 등을 포함한 확진 검사는 개별적으로 시행되었다. 결 과 : 총 의뢰건수는 284,933건으로 신생아 251,799건 및 고위험군 33,134건이었다. 소환율은 0.4%(1158건)이었으며, 이들 중 true positive는 117건(0.04%)이었다. 아미노산 대사 이상 질환은 총 78건(25/53), 유기산 대사이상 질환은 총 27건(16/11건) 및 지방산 산화대사이상 질환은 총 12건(5/7건)으로 전체 질환에 대한 검출율은 신생아 1:5,000이었으며 전체군 1:2,000이었다. 결 론 : 탠덤매스 신생아 선별검사는 조기 진단 및 치료가 필요한 많은 선천성 대사이상질환의 검출을 용이하게 해주었다. 그러므로, 반드시 모든 신생아들에 대한 국가지원 탠덤매스 선별검사 확대 적용 및 추적관리 시스템이 구축이 필요할 것으로 판단된다.

• 한국직업건강간호학회지
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• 제23권4호
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• pp.197-207
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• 2014

Purpose: The purpose of this study was to investigate the status and characteristics of visiting nurses' management for elders with cognitive impairment living in a community focused on health centers in a metropolitan city and five medium-sized cities. Methods: Data were collected from 47 visiting nurses working in a metropolitan city and 47 visiting nurses working in five medium-sized cities from November to December 2012. Results: There were no statistically significant differences in knowledge, attitudes, and nursing behaviors of cognitive impairment between two groups (F=2.13, p=.148; F=3.64, p=.060; F=0.28, p=.595). Among the elders referred to a physician in a metropolitan city by visiting nurses, 42.4% were diagnosed as mild cognitive impairment and 15.2% were diagnosed as severe dementia. The major intervention programs which visiting nurses currently applied for elders were medication and exercise intervention programs, and the intervention programs which they would want to apply in the future were playing, music and recall intervention programs. Conclusion: The cognitive impairment screening test can be done effectively by visiting nurses. This study also suggests to develop various kinds of intervention programs to improve cognitive function for elders living in a community.

• 한국보건간호학회지
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• 제17권1호
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• pp.47-57
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• 2003

The purpose of this study was to investigate health status and health promoting behaviors of female elderly, and their needs for health-related services in an urban-rural combined city. The data were collected from the subjects registered in senior welfare center and senior citizens' clubs. A total of 119 women were participated in the survey. The results of the study are as follows; 1. The subjects perceived their health status relatively unhealthy. Their health promotion behavior score was 10.82 (range 0-17), and more than $60\%$ of them performed well in smoking and drinking control, regular meal. taking breakfast, and maintaining good relationship with others. 2. The most needed service was health screening followed by health risk assessment, disease diagnosis and treatment. 3. The most demanded education was on dementia prevention, followed by exercise, balanced diet, and maintenance of memorial and mental capability. 4. As the health interest and the health responsibility increased, the need for health service increased as well. Likewise, the health education needs increased as the health interest, health responsibility, and health promotion behavior increased. The results show that the health promotion programs for female elderly need to be focused, primarily, on health screening, health risk assessment, medical services for disease diagnosis and treatment, and health consulting and education. And health consulting and education programs should be designed to promote health interest and health responsibility of female elderly, change positively their attitude to aging, and include education on dementia prevention, exercise and nutrition management. Recommendations are discussed.