• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.65-71
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• 2016

Although high mammographic density is one of the strongest predictors of breast cancer risk, X-ray based mammography cannot be performed before the recommended screening age, especially not in adolescents and young women. Therefore, new techniques for breast density measurement are of interest. In this pilot study in Guam and Hawaii, we evaluated a radiation-free, bioimpedance device called Electrical Breast Densitometer$^{TM}$ (EBD; senoSENSE Medical Systems, Inc., Ontario, Canada) for measuring breast density in 95 women aged 31-82 years and 41 girls aged 8-18 years. Percent density (PD) was estimated in the women's most recent mammogram using a computer-assisted method. Correlation coefficients and linear regression were applied for statistical analysis. In adult women, mean EBD and PD values of the left and right breasts were $230{\pm}52$ and $226{\pm}50{\Omega}$ and $23.7{\pm}15.1$ and $24.2{\pm}15.2%$, respectively. The EBD measurements were inversely correlated with PD ($r_{Spearman}=-0.52$, p<0.0001); the correlation was stronger in Caucasians ($r_{Spearman}=-0.70$, p<0.0001) than Asians ($r_{Spearman}=-0.54$, p<0.01) and Native Hawaiian/Chamorro/Pacific Islanders ($r_{Spearman}=-0.34$, p=0.06). Using 4 categories of PD (<10, 10-25, 26-50, 51-75%), the respective mean EBD values were $256{\pm}32$, $249{\pm}41$, $202{\pm}46$, and $178{\pm}43{\Omega}$ (p<0.0001). In girls, the mean EBD values in the left and right breast were $148{\pm}40$ and $155{\pm}54{\Omega}$; EBD values decreased from Tanner stages 1 to 4 ($204{\pm}14$, $154{\pm}79$, $136{\pm}43$, and $119{\pm}16{\Omega}$ for stages 1-4, respectively) but were higher at Tanner stage 5 ($165{\pm}30{\Omega}$). With further development, this bioimpedance method may allow for investigations of breast development among adolescent, as well as assessment of breast cancer risk early in life and in populations without access to mammography.

• Tuberculosis and Respiratory Diseases
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• 제78권4호
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• pp.349-355
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• 2015

Background: The tuberculin skin test (TST) is the standard tool to diagnose latent tuberculosis infection (LTBI) in mass screening. The aim of this study is to find an optimal cut-off point of the TST+ rate within tuberculosis (TB) contacts to predict the active TB development among adolescents in school TB outbreaks. Methods: The Korean National Health Insurance Review and Assessment database was used to identify active TB development in relation to the initial TST (cut-off, 10 mm). The 7,475 contacts in 89 schools were divided into two groups: Incident TB group (43 schools) and no incident TB group (46 schools). LTBI treatment was initiated in 607 of the 1,761 TST+ contacts. The association with active TB progression was examined at different cut-off points of the TST+ rate. Results: The mean duration of follow-up was $3.9{\pm}0.9years$. Thirty-three contacts developed active TB during the 4,504 person-years among the TST+ contacts without LTBI treatment (n=1,154). The average TST+ rate for the incident TB group (n=43) and no incident TB group (n=46) were 31.0% and 15.5%, respectively. The TST+ rate per group was related with TB progression (odds ratio [OR], 1.025; 95% confidence interval [CI], 1.001-1.050; p=0.037). Based on the TST+ rate per group, active TB was best predicted at TST+ ${\geq}$ 16% (OR, 3.11; 95% CI, 1.29-7.51; area under curve, 0.64). Conclusion: Sixteen percent of the TST+ rate per group within the same grade students can be suggested as an optimal cut-off to predict active TB development in middle and high schools TB outbreaks.

• 한국직업건강간호학회지
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• 제8권2호
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• pp.115-129
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• 1999

This study was conducted to investigate the kinds of health promotion program which workers want, worker's intention for participation, proper method, time, duration and manager. A self-administered questionnaire method was used to collect data from 412 employees of 3 worksites in Chungpook and Kyungkee. This survey was carried out from Aug. 10 to Aug. 20, 1998. The results of this study are as follows: 1. In male, among health promotion programs, favorite ones were physical fitness(32.2%), periodic health check-up(24.6%), and stress management(18.0%). In female, among health promotion programs, favorite ones were periodic health check-up(26.0%), physical fitness(22.0%), and body weight control(19.5%). 2. The more young subjects are, the more they like physical fitness program, and the female like body weight control program regardless of BMI. Manufacturing worker preferred back pain prevention program to clerical worker did. In female, drinker preferred stress management program to non-drinker did. 3. The more old subjects are, the more they like back pain prevention program, and non-smoker preferred body weight control program to smoker did. 4. In health promotion program format which the subjects wanted, learning of self-examination techniques was 41.1%, worksite screening was 3l.0%, availability of pamphlets and audiovisual materials was 20.0%, presentation of worksite educational sessions was 7.9%, and the most wanted manager for the program was medical doctor and then nurse, physical trainer, psychological counselor. The favorite health promotion program duration was less than 30 minutes(49.6%), and the favorite time was before work(49.6%). 5. Among respondents, 48.5% was smokers, 81.8% was drinkers, 39.9% engaged in the regular exercise, 68.2% engaged in regular diet habit. In vaccination, 50.2%, if possible, wanted to be vaccinated and 37.6% never wanted to be vaccinated. 6. Ex-smoker, ex-drinker, the subjects in the regular exercise, and in the regular diet habit responded they were in good health. There was a significant difference between exercise and health status. Need and intention for participation of health promotion program were high in ex-smoker, ex-drinker, the subjects in the regular exercise, and in the regular diet habit. According to results for this study, if the favorite programs, exercise, periodic health check-up, stress management program, are operated at a proper time and with managers they want, this programs can really raise the participation of employees. And as employees want to learn self-examination techniques if worksite educational sessions are performed, health promotion program can effectively be operated.

• 재활복지
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• 제22권4호
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• pp.43-58
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• 2018

영양 섭취와 일상생활 삶의 질에 영향을 미치는 삼킴장애는 신경장애 환자뿐만 아니라 정상 노년층에게서도 적지 않게 나타난다. 본 연구에서는 노인의 삼킴 문제를 조기 선별하여 진단 검사로 연결될 수 있도록 도움을 주기 위한 기초연구로서, 주관적 삼킴장애 평가도구인 삼킴곤란척도(Swallowing Disturbance Questionnaire, SDQ)를 한국인의 정서와 문화에 맞게 번안하여 신뢰도와 타당도를 검증하고, 뇌졸중 환자 105명을 대상으로 하여 그 유용성을 검증하였다. 연구 결과, 한국판 SDQ의 문항내적 일관성 신뢰도는 .601, 검사-재검사 신뢰도는 .97, 공인타당도는 .956이었고, 절단점 8점을 기준으로 민감도가 46.8%, 특이도가 81.6%인 것으로 나타났다. 객관적 삼킴장애 검사인 비디오투시조영검사와 한국판 SDQ 검사 상 관찰된 삼킴곤란 유무와의 비교 결과, 음성예측도(negative predictive value, NPV)는 81%, 양성예측도(positive predictive value, PPV)는 53%로 나타났다. 한국판 SDQ는 뇌졸중 환자들의 삼킴장애 유무를 변별하는데 유용한 검사도구로 활용될 수 있을 것으로 기대되며, 재활전문가에 의한 임상평가가 이루어지기 전에 대상자가 보이는 삼킴곤란을 미리 선별하여 진단검사를 의뢰하거나, 삼킴문제가 없는 뇌졸중 환자를 정확하게 선별하여 잉여적인 추가 검사 노출을 배제하는 차원에서 그 임상적 의의가 크다고 볼 수 있다.

• 방사성폐기물학회지
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• 제16권4호
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• pp.441-454
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• 2018

2017년 고리 1 호기 영구정지를 계기로 국내 원자력발전소의 해체가 점차 가시화되고 있다. 앞으로 원전 해체가 본격적으로 추진될 경우 원전 1기 당 약 16만 t의 콘크리트 폐기물이 발생될 것으로 예측되었으며, 이들 콘크리트 폐기물은 대부분 오염준위가 매우 낮아 자체처분 대상으로 고려될 수 있다. 따라서, 국내 자체처분 폐기물(원자력안전위원회 고시 2017-65호에 따른 자체처분 허용농도 또는 자체처분 허용선량을 만족하는 폐기물)에 대한 현행 규제체계가 대량의 콘크리트 폐기물에 대한 무제한적 자체처분에 대해서도 유효성을 유지할 수 있는지를 사전에 확인할 필요가 있다. 이와 관련, 국내 자체처분 규정 개발 시 참조기준인 IAEA SRS No. 44를 심층분석하고, 국내 산업계 현황을 반영한 입력값과 계산식을 이용하여 4가지 자체처분 시나리오에 대한 예상 피폭방사선량을 평가하였다. 그 결과, 재활용 시나리오에 대한 예상선량은 대부분 정상 시나리오에 대한 자체처분 선량 기준(즉, $0.01mSv{\cdot}y^{-1}$)보다 낮은 것으로 평가되었으나, 성토 후 거주 시나리오의 경우 보수적인 가정을 적용하면 자체처분 선량 기준을 초과할 가능성도 배제할 수 없는 것으로 나타났다. 따라서, 대량의 해체 콘크리트 폐기물의 안전하고 지속가능한 자체처분을 위해서는 폐기물 처리업체 다변화, 성토 시나리오에 대한 보다 구체적인 평가, 성토를 통한 자체처분에 대한 부분적 제한조건 설정 등을 고려할 수 있다.

• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.125-135
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• 2021

Objective : This study aimed to validate the Korean version of the Repeatable Battery for the Assessment of Neuropsychological Status Update (K-RBANS). Methods : We performed a retrospective analysis of 283 psychiatric and neurosurgery patients. To investigate the convergent validity of the K-RBANS, correlation analyses were performed for other intelligence and neuropsychological test results. Confirmatory factor analysis was used to test a series of alternative plausible models of the K-RBANS. To analyze the various capabilities of the K-RBANS, we compared the area under the receiver operating characteristic (ROC) curves (AUC). Results : Significant correlations were observed, confirming the convergent validity of the K-RBANS among the Total Scale Index (TSI) and indices of the K-RBANS and indices of intelligence (r=0.47-0.81; p<0.001) and other neuropsychological tests at moderate and above significance (r=0.41-0.63; p<0.001). Additionally, the results testing the construct validity of the K-RBANS showed that the second-order factor structure model (model 2, similar to an original factor structure of RBANS), which includes a first-order factor comprising five index scores (immediate memory, visuospatial capacity, language, attention, delayed memory) and one higher-order factor (TSI), was statistically acceptable. The comparative fit index (CFI) (CFI, 0.949) values and the goodness of fit index (GFI) (GFI, 0.942) values higher than 0.90 indicated an excellent fit. The root mean squared error of approximation (RMSEA) (RMSEA, 0.082) was considered an acceptable fit. Additionally, the factor structure of model 2 was found to be better and more valid than the other model in χ2 values (Δχ2=7.69, p<0.05). In the ROC analysis, the AUCs of the TSI and five indices were 0.716-0.837, and the AUC of TSI (AUC, 0.837; 95% confidence interval, 0.760-0.896) was higher than the AUCs of the other indices. The sensitivity and specificity of TSI were 77.66% and 78.12%, respectively. Conclusion : The overall results of this study suggest that the K-RBANS may be used as a valid tool for the brief screening of neuropsychological patients in Korea.

• 환경생물
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• 제39권2호
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• pp.207-217
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• 2021

본 연구는 전국자연환경조사 어류 데이터를 이용하여 국내 담수 생태계에 도입된 배스의 분포 현황을 파악하고 공간분석을 통해 핫스팟 지역을 분석하였다. 위해성 평가를 통해 배스의 잠재적 침습성을 평가하여 수생태계 생물 다양성 교란에 대한 영향을 재고하였다. 분포 분석 결과, 제주도 지역을 포함하여 한강권역과 낙동강권역, 금강권역, 영산강·섬진강권역 전체에서 분포하는 것으로 분석되었다. 낙동강권역에서 가장 높은 출현율을 나타내었으며, 제주도 지역을 제외한 영산강·섬진강권역에서 비교적 낮은 출현율을 나타내는 것으로 분석되었다. 배스의 공간적 군집 밀도가 높은 지역으로는 낙동강권역의 낙동강수계가 선정되었으며, 반대로 낮은 지역으로는 한강권역과 금강권역의 인접한 지역으로 분석되었다. 국내 대부분의 담수하천에 서식하는 것으로 나타난 배스의 위해성 평가를 실시한 결과, 31점의 높은 침습성을 보이는 것으로 분석되었다. 본 연구를 통해 우리나라 담수 생태계에 정착한 것으로 파악되는 생태계교란종인 배스로부터 실질적인 관리 우선지역을 도출하여 담수 생태계 다양성 보전을 위한 과학적 기초자료를 마련할 수 있을 것으로 전망한다.

• Journal of Korean Neurosurgical Society
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• 제65권2호
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• pp.315-324
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• 2022

Objective : The aim of this study was to verify the equivalence and effectiveness of the tablet-administered Korean Repeatable Battery for the Assessment of Neuropsychological Status (K-RBANS) for the prevention and early detection of dementia. Methods : Data from 88 psychiatry and neurology patient samples were examined to evaluate the equivalence between tablet and paper administrations of the K-RBANS using a non-randomly equivalent group design. We calculated the prediction scores of the tablet-administered K-RBANS based on demographics and covariate-test scores for focal tests using norm samples and tested format effects. In addition, we compared the receiver operating characteristic curves to confirm the effectiveness of the K-RBANS for preventing and detecting dementia. Results : In the analysis of raw scores, line orientation showed a significant difference (t=-2.94, p<0.001), and subtests showed small to large effect sizes (0.04-0.86) between paper- and tablet-administered K-RBANS. To investigate the format effect, we compared the predicted scaled scores of the tablet sample to the scaled scores of the norm sample. Consequently, a small effect size (d≤0.20) was observed in most of the subtests, except word list and story recall, which showed a medium effect size (d=0.21), while picture naming and subtests of delayed memory showed significant differences in the one-sample t-test. In addition, the area under the curve of the total scale index (TSI) (0.827; 95% confidence interval, 0.738-0.916) was higher than that of the five indices, ranging from 0.688 to 0.820. The sensitivity and specificity of TSI were 80% and 76%, respectively. Conclusion : The overall results of this study suggest that the tablet-administered K-RBANS showed significant equivalence to the norm sample, although some subtests showed format effects, and it may be used as a valid tool for the brief screening of patients with neuropsychological disorders in Korea.

• Clinical and Experimental Pediatrics
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• 제52권11호
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• pp.1185-1193
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• 2009

An act of children's welfare was made in 1961 for the first time in Korea but it had been nothing but the name in view of practical impact to prevention of child abuse. Real undertakings of Child Abuse Prevention were commenced overtly since 2000 in Korea, when the law for children's welfare was revised to put protective settings for the victims and to establish criterion for children's safety. The history of Child Abuse Prevention is very short in Korea but the reporting cases increased very fast from 4,133 cases in 2001 up to 9,570 cases in 2008 with the enthusiastic activities from people of the associated organizations along with the national supports. But the portion reported by the mandated reporters such as teachers or doctors is still low compared to those of the developed countries. The National Child Protection Agency (NCPA) was founded in 2001 by the Ministry of Health and Welfare to prevent child abuse and to aid recovery of abused and neglected children including their families, through the cooperation of related organizations. NCPA refers reported cases of child abuse to appropriate local centers, operates a computer database system for case management, publicizes national reports of child abuse on a yearly basis and technically supports the Local Child Protection Agency (LCPA) by developing scales for assessment of child abuse and neglect and distributing programs for the education of mandatory reporters. LCPAs operate 24-hour telephone hotline, investigate and visit homes and provide in home services networking with local resources, and operate multidisciplinary teams for screening child abuse victims and supervising case management through multimodal systems. We summarized the present state of child abuse in Korea and reviewed the operating systems for child protection in this country. Through this article, we hope that medical peoples are to be informed on the seriousness of child abuse and to be able to devote themselves for the prevention of child abuse.

• Toxicological Research
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• 제18권1호
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• pp.59-64
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• 2002

Substantial evidences have been accumulated about the hormone-like effects of exogenous substances such as pesticides and industrial chemicals during past years. The effects of these substances on the endocrine system are believed to be either enhancing or reducing of various endocrine action. It is necessary to identify putative causal agents by the batter system and to assess their ability to disrupt the endocrine system. A variety of in vitro and In vivo approaches have been used to determine the androgenic effects of environmental chemicals. To establish the method for assessment of the putative endocrine disruptors with androgenic activity, we carried out the cell proliferation assay by MTS method after treatment with the various concentration of testosterone in LNCaP cells (human prostatic cancer cell line) and also observed the expression of androgen-related genes by quantitative RT-PCR. In the cell proliferation assay, the results showed that the grouth of LNCaP cells increased within level of at least 10pM testosterone. We measured by quantitative RT-PCR method on the effects of testosterone on mRNA expression of androgen receptor (AR), prostate-specific antigen (PSA), bone morphogenetic protein (BMP) and BMP receptor (BMPR) In LNCaP cells. The results demonstrated that mRNA expression of PSA and BMPR-IB was observed differently within level of at least 0.01 pM testosterone compared with non-treated control. These observations suggest that the detection of PSA and BMPR-IB mRNA by the quantitative RT-PCR in LNCaP cells is very sensitive method to identify the endocrine disruptors to have the androgenic effects.