• 대한한의학방제학회지
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• 제28권4호
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• pp.429-441
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• 2020

Objectives : Systemic sclerosis(SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. The purpose of this study was to investigate the trend in the research on SSc using herbal medicine. Methods : We searched for papers which had both systemic sclerosis and herbal medicine from Pubmed, KCI and NDSL. After searching papers, we classified according to the study design and analyzed selected studies. Results : 18 studies were searched. The types and numbers of study were as follows: 11 were in vitro or in vivo studies using herbal medicine or active components, and 7 were clinical research including case reports. 1. Herbal medicines include the therapeutic effects of "tonifying qi(補氣)" or "active blood(活血)" improved systemic sclerosis in vivo and in vitro studies. 2. Active components isolated from Herbal Medicine such as Astragalus membranaceus(黃芪), Zhizi(梔子), Salvia miltiorrhiza(丹蔘) have anti-fibrotic effects. 3. Clinical trials showed that herbal medicine can improve the symptom of systemic sclerosis including skin fibrosis, Raynaud's phenomenon, pain and gastric dysmotility. Conclusions : This study showed that herbal medicine can be effective for treating SSc. However, further studies are needed to develop novel medicine for SSc.

• Clinical and Experimental Pediatrics
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• 제51권7호
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• pp.766-770
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• 2008

심장의 원발성 종양은 소아에서는 매우 드문 질환이다. 횡문근종은 태아, 영아 및 소아 연령에서 가장 흔한 원발성 심장 종양으로 결절성 경화증이 동반되는 것으로 보고되고 있다. 결절성 경화증은 뇌, 심장, 피부 및 기타 장기들을 침범하는 신경피부 증후군으로, 결절성 경화증을 가진 영아의 50-64%에서 동반된다. 심장 횡문근종은 종괴는 심방을 비롯하여 심실 중격과 심실벽에 다발성으로 존재하며 종양의 위치와 크기, 침범 정도에 따라 심장 유출로 협착 및 심부전과 같은 여러 가지 임상 양상을 보일 수 있다. 드물지만 부정맥을 주증상으로 발현하는 경우도 보고되고 있다. 하지만 대부분 심장의 횡문근종이 특별한 문제를 일으키지 않고 성장과 함께 쇠퇴되는 경향을 보이므로 극히 일부분에서만 장기적인 항부정맥제 사용이 요구된다. 환자의 최종적인 예후는 동반되는 뇌병변에 의해 결정되는 경향이 있다. 저자들은 상심실성 빈맥으로 입원치료 중 진단된 심장 횡문근종을 가진 결절성 경화증 1예를 경험하였기에 보고하는 바이다.

• Journal of Acupuncture Research
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• 제33권3호
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• pp.207-218
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• 2016

Objectives : The purpose of this study is to report the clinical effect of Korean Medical Treatment and acupuncture based on M-test theory & herbal medicine for treating systemic sclerosis. Methods : We treated a patient diagnosed with systemic sclerosis. We used general acupuncture & acupuncture based on M-test theory, herbal medicine, moxibustion, and physical therapy. The outcomes were evaluated by using peripheral body temperature measurement, numeric rating scale(NRS), visual analog scale(VAS), and an activities of daily living(ADL) questionnaire for systemic sclerosis. Results : The average peripheral body temperature increased from $36.16^{\circ}C$ to $36.38^{\circ}C$. The NRS showed no difference, but VAS decreased from 7.43 to 5.43. The ADL questionnaire score decreased from 17 to 12. Conclusion : This case study suggests that Korean Medical Treatment and acupuncture based on M-test theory & herbal medicine could be effective for treating systemic sclerosis. However, further studies are needed to confirm this result.

• 대한한방내과학회지
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• 제24권1호
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• pp.21-32
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• 2003

Objective : The aim of this study is to investigate the inhibitory effect of Injinchunggantang on hepatic sclerosis induced by $CCl_4$. Methods : Weight, liver function test and complete blood cell count, gross findings, and findings on liver tissue of the past(Hematoxylin & Eosin stain, Masson-Trichrome stain) were studied. Results : When it comes to the change of rats' body weight, The $CCl_{4^+}$Injinchunggantang group lost far less weight than The $CCl_{4^-}$only group. In the liver function test, which is focused on various areas such as total cholesterol, alkaline phosphotase, albumin, aspartate transaminase, alanine transaminase, The $CCl_{4^+}$Injinchunggantang group was much more closer to normal limit than the $CCl_4$ only group. In the complete blood cell count, including white blood cell, red blood cell, hemoglobin, hematocrite, platelet, The $CCl_{4^+}$Injinchunggantang group significantly closer to normal limit than $CCl_{4^-}$only group. In the gross findings of hepatic fibrosis models, Injinchunggantang showed inhibitory effect on hepatic fibrosis in the order. In the past findings of hepatic fibrosis models in Hematoxylin & Eosin, Masson-Trichrome staining, the liver in $CCl_{4^-}$only group showed atrophy and necrotic change with white nodules, whereas that of $CCl_{4^+}$Injinchunggantang group showed lesser significant change with the well_preserved tone of the tissue. In the extent of the inhibition of the hepatic fibrosis, the Injinchunggantang group showed statistically significant inhibitory effect(p<0.05) in the sclerosis model. Conclusions : These results show that Injinchunggantang have inhibitory effect on hepatic sclerosis induced by $CCl_4$ and further ultimately prevent liver cirrhosis. To obtain more credible results in this experiment, the invention of a new experimental model more similar to human hepatic sclerosis is still needed.

• Journal of Acupuncture Research
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• 제24권4호
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• pp.225-235
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• 2007

2007년 2월 20일부터 3월 12일까지 대전대학교 둔산 한방병원에 입원한 근위축성 측삭 경화증 환자 1례에 대한 임상 고찰을 통하여 다음과 같은 결론을 얻었다. 1. 본 증례의 환자는 한의학적으로 위증으로 진단 하였으며 폐열엽초(肺熱葉焦), 기혈양허(氣血兩虛)로 변증하였다. 2. 독취양명(獨取陽明)치법을 기준으로 비위경(脾胃經)의 경혈 위주로 자침하였고 입원초기의 한약은 기혈대보(氣血大補)하는 십전대보탕(十全大補湯), 자신양혈건보탕(滋腎養血健步湯)을 사용하였으나 입원 중기부터는 객담, 인후부 불편감을 사지무력감보다 심하게 호소하여 우담리습(祐痰利濕)의 효능이 있는 보음전(補陰煎), 절제화담환(節齊化痰丸)을 처방하였다. 3. 환자는 입원 초기 객담이 줄어들면서 연하작용도 완화되었으나 입원후기에는 객담이 다시 증가하여 연하 및 호흡곤란을 호소하였다. 4. 근육의 위축 속도 및 정도를 파악하기 위하여 1주일에 1회 하지둘레를 확인하였으며 입원 첫 주보다 퇴원 주에 1cm 가량 감소하였다. 5. 우상지부 악력은 입원 초기 6kg이었으나 입원 후기에는 11kg까지 증가하였다. 6. ALS는 아직 뚜렷한 치료법이 없는 상태로 향후 적극적인 한방치료에 대한 연구가 필요할 것이라고 사료된다.

• Annals of Clinical Neurophysiology
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• 제12권2호
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• pp.73-75
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• 2010

• 대한한방내과학회지
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• 제25권2호
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• pp.344-351
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• 2004

Systemic sclerosis Sine scleroderma(ssSSc) is an uncommon subtype of Systemic sclerosis(SSc), which is believed to attack internal organs without causing changes in the skin. Electrogastrography has been known to be a simple, non-invasive, and effective method in assessing gastric motility. In this new study, a case of Systemic sclerosis Sine Scleroderma exhibiting gastric symptoms was observed. For this, we applied herbal medicine. manual acupucture, electro-acupucture, and lumbar skin wanning. After applying these therapies, both systemic and dyspeptic symptoms of the patient improved. Electrogastrography suggests a relation between gastric myoelectrical activity and the patient's improvement in dyspeptic symptoms. Therefore, based on study of Oriental medical classics and recent medical articles, clinically emperical success in treating gastric dysmotility was seen in a patient with Systemic sclerosis Sine Scleroderma.

• Tuberculosis and Respiratory Diseases
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• 제44권5호
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• pp.1184-1193
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• 1997

저자들은 결절성 경화증과 동반된 폐의 임파관평활근종증 1예를 경험하였기에 증례와 함께 결절성 경화증과 폐의 임파관평활근종증과의 관계를 문헌고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제46권9호
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• pp.913-917
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• 2003

저자들은 응급 전기적 심율동 전환 및 지속적 항 부정맥 약물치료에도 불구하고 반복되는 심실성 빈맥을 보인 결절성 경화증 환아에서 심장 횡문근종의 외과적 절제 후 효과적으로 부정맥이 조절된 1례를 치험하였기에 보고하는 바이다.

• 대한장애인치과학회지
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• 제1권1호
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• pp.33-36
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• 2005

Manifestations in tuberous sclerosis such as seizure, mental retardation, end-stage renal disease (ESRD), and heart problems present a number of challenges to the dentist and anesthesiologist. Lack of cooperation in addition to the severe medical condition makes dental treatment more difficult. General anesthesia is often required for mentally and physically handicapped patients undergoing extensive dental treatment. We experienced a case of dental treatment under general anesthesia in a 36-year-old male patient with tuberous sclerosis associated with ESRD and mental retardation. He was treated on an outpatient basis followed by hemodialysis without any complications.