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Evaluating Pharmacological Effects of Two Major Components of Shuangdan Oral Liquid: Role of Danshensu and Paeonol in Diabetic Nephropathy Rat

  • Chen, Ying;Liu, Zhuying;Zhou, Fuxing;Zhao, Hang;Yang, Qian;Li, Hua;Sun, Jiyuan;Wang, Siwang
    • Biomolecules & Therapeutics
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    • v.24 no.5
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    • pp.536-542
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    • 2016
  • Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.

A Study on the Optimization of Semantic Relation of Author Keywords in Humanities, Social Sciences, and Art and Sport of the Korea Citation Index (KCI) (한국학술지인용색인(KCI)의 인문학, 사회과학, 예술체육 분야 저자키워드의 의미적 관계 유형 최적화 연구)

  • Ko, Young Man;Song, Min-Sun;Lee, Seung-Jun
    • Journal of the Korean Society for Library and Information Science
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    • v.49 no.1
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    • pp.45-67
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    • 2015
  • The purpose of this study is to analyse the semantic relations of terms in STNet, a structured terminology dictionary based on author keywords of humanities, social sciences, and art and sport in the Korea Citation Index (KCI) and to describe the procedure for optimizing the relation types and specifying the name of relationships. The results indicate that four logical criteria, such as creating new names for relationships or limitation of typing the relationship by the appearance frequency of same type, consideration of direction of relationship, reflection to accept the existing name of relationships, are required for the optimization of the typing and naming the relationships. We applied these criteria to the relationships in the class "real person" of STNet and the result shows that 1,135 out of 1,743 uncertain relationships such as RT, RT_X or RT_Y are specified and clarified. This rate of optimization with ca. 65% represents the usefulness of the criteria applicable to the cases of database construction and retrieval.

First report of a newly naturalized Sisyrinchium micranthum and a taxonomic revision of Sisyrinchium rosulatum in Korea (한국 미기록 귀화식물 연등심붓꽃과 등심붓꽃의 분류학적 재검토)

  • Shin, Hye Woo;Kim, Myoung Jun;Lee, Nam Sook
    • Korean Journal of Plant Taxonomy
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    • v.46 no.3
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    • pp.295-300
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    • 2016
  • Sisyrinchium micranthum Cav., a newly naturalized species, was found in Seogwipo, Jeju-do. This species is native to Central and South America and is reported as a widely invasive species around the world. Sisyrinchium micranthum is a sister species of S. rosulatum E. P. Bicknell (Deung-Sim-But-Kkot in Korean), reported as an invasive species earlier in Korea, and both species are members of the subgenus Echthronema. Sisyrinchium micranthum is distinguished from S. rosulatum by the urceolate shape of its flowers and by the large size of its fruits and seeds. Its local name is "Yeon-Deung-Sim-But-Kkot" based on the light blue corolla. We also found that Sisyrinchium angustifolium Mill., previously used for Deung-Sim-But-Kkot, was misapplied. It belongs to the subgenus Sisyrinchium and is morphologically very different from S. rosulatum. We corrected the scientific name of Deung-Sim-But-Kkot by changing it from S. angustifolium to S. rosulatum based on the type specimens, original descriptions, and recent studies.

A New Species of Asarum: A. yeonbyeonense M. Kim & S. So (족도리풀속의 1신종 : 연변족도리풀(Asarum yeonbyeonense M. Kim & S. So))

  • So, Soonku;Hwang, Yong;Lee, Chung-Hee;Kim, Muyeol
    • Korean Journal of Plant Taxonomy
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    • v.40 no.4
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    • pp.255-261
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    • 2010
  • A new species, Asarum yeonbyeonense M. Kim & S. So, is named and described from Mt. Baekdu in Korea. This new species is distinctly different from the related species A. mandshuricum (Maxim.) M. Kim & S. So according to the purple band at the base of the calyx lobes and the thick calyx lobes. In addition, Asarum sieboldii var. viridiluteolum Y. Lee is closely related to A. yeonbyeonense M. Kim & S. So due to its reflexed calyx lobes; however, this variety has green calyx lobes and pubescent petioles. Therefore its scientific name was changed to Asarum yeonbyeonense var. viridiluteolum (Y. Lee) M. Kim & S. So, and its Korean name should be changed into Nokyeonbyeon-Jokdoripul.

A Taxonomic Review and Nomenclature of the Opuntia ficus-indica (L). Mill. in Jeju Island (제주도 민속식물인 선인장(Opuntia ficus-indica (L.) Mill.)의 분류학적 검토 후 명명)

  • Yang, Young-Soo;Choi, Byoung-Ki;Oh, Hong-Shik
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.38 no.4
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    • pp.68-73
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    • 2020
  • The purpose of this study is to classify species and correct misidentification of cacti (Opuntia) in Jeju area through morphological characteristics comparison. As a result of the study, it was found that Opuntia ficus-indica and O. ficus-indica var. saboten, which has been reported to grow naturally in Jeju Island, is Opuntia stricta. In the morphological comparison of species, it was confirmed that O. stricta showed clear differences in plant size, cladode shape, color of flowers and fruits, and characteristics of areole compared to the existing reported species. Based on the research results, the scientific name of Jeju cactus was corrected as Opuntia stricta, and the Korean name 'Hae-an-sun-in-jang' was newly named. Furthermore, it was suggested that various research literatures and national biodiversity management organizations need to confirm and correct the misidentification of species.

Carex brevispicula (Cyperaceae), a new species from Korea (좀목포사초, 한국에서 발견된 1신종)

  • Nam, Gi Heum;Jang, Hyun-Do;Lee, Byoung-Yoon;Chung, Gyu Young
    • Korean Journal of Plant Taxonomy
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    • v.50 no.4
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    • pp.395-402
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    • 2020
  • A new species, Carex brevispicula G. H. Nam & G. Y. Chung (Cyperaceae), was found in Korea. Carex brevispicula is similar to the related species C. chungii Z. P. Wang and C. genkaiensis Ohwi in that its achenes are constricted in the middle part. However, C. brevispicula is distinguished from C. chungii as the plants, staminate, and pistillate spikes are shorter and its pistillate scales are pale green; C. brevispicula is distinguished from C. genkaiensis by its awned staminate and pistillate scales. The scientific name of this new species was based on the fact that its inflorescence is shorter than that of C. chungii. The corresponding Korean name, "Jom-mok-po-sa-cho," means that the plants of this species are smaller than the "Mok-po-sa-cho" types (C. genkaiensis). We hereby provide a description of C. brevispicula, with corresponding illustrations and photographs, a distribution map, and a key of related taxa.

A taxonomic revision of the Boehmeria spicata complex (Urticaceae) in Korea

  • JO, Hyeong Jun;KIM, Jae Young;LEE, Yuri;PARK, Se Hee;KWON, Min Ji;JEONG, Seon;CHUNG, Gyu Young
    • Korean Journal of Plant Taxonomy
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    • v.51 no.2
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    • pp.115-132
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    • 2021
  • Seven species and two varieties belonging to the genus Boehmeria Jacq. (Urticaceae) are known to be distributed in Korea. Among them, B. spicata, B. tricuspis, and B. tricuspis var. unicuspis were subjected to an external morphological study. Among the individuals believed to exhibit variations in the leaf shape, B. gracilis and B. silvestrii were newly recognized. Unlike related taxa, B. gracilis has middle leaves with an elliptic, broadly elliptic, ovate, or broadly depressed ovate shape, a regular and serrulate-dentate margin, and an unlobed and short caudate or cuspidate apex. Boehmeria silvestrii has middle leaves with 5-angled ovate, orbicular ovate or broadly ovate shapes, and 3- or 5-lobed and caudate apices. Therefore, we assigned the corresponding names 'Top-geo-buk-kko-ri' and 'Cham-geo-buk-kko-ri'. Meanwhile, the B. spicata complex (B. gracilis, B. silvestrii, B. spicata, and B. tricuspis var. unicuspis) is very closely related in terms of the morphological characters, whereas B. tricuspis exhibits no relationship. Furthermore, because the scientific name and type specimen of B. tricuspis var. unicuspis (Pul-geo-buk-kko-ri) are problematic, the correct name B. paraspicata Nakai and corresponding holotype are presented. Additionally, lectotypes of B. gracilis and B. silvestrii are newly designated here. A taxonomic treatment, descriptions, a key, photographs, type specimens, and leaf variation images of the B. spicata complex are provided in this study.

Unrecorded species of Korean invertebrates discovered through the project of 'Discovery of Korean Indigenous Species' III

  • Su-Jung Ji;Jongwoo Jung;Sa Heung Kim;Dong-Ha Ahn;Min-Seop Kim;Jeounghee Lee;Hee-Min Yang;Geon Hyuk Lee;Eunjung Nam;Taeseo Park;Anna B. Jost;Huyen T. M. Pham;Jina Park;Joohee Park;Seoyoung Keum;Ivana Karanovic;Tomislav Karanovic;Joong-Ki Park;Chuleui Jung;Gi-Sik Min
    • Journal of Species Research
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    • v.12 no.4
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    • pp.341-354
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    • 2023
  • This is the third series of catalogs reporting on Korean species discovered through the 'Discovery of Korean Indigenous Species'. This catalog includes 22 species of invertebrates, excluding insects. The catalog includes the scientific name, an abridged list of synonyms, collection sites, distribution, diagnosis, and figures for each species. Additionally, we provide the newly assigned Korean name, specimen voucher, and, if available, mitochondrial CO1 or 16S gene sequences of the species listed. All species identified and documented here will be officially listed on the 'National Species List of Korea', a database maintained by the National Institute of Biological Resources(NIBR).

Taxonomic examination of Typha angustifolia L. in Korea (한국산 애기부들에 대한 분류학적 검토)

  • Kim, Changkyun;Shin, Hyunchur;Choi, Hong-Keun
    • Korean Journal of Plant Taxonomy
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    • v.31 no.4
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    • pp.359-373
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    • 2001
  • One of Korean Typha species has been used two scientific names, T. angustifolia L. and T. angustata Bory et Chaubard without taxonomic examinations. Typha angustifolia has a longer females flowers than bracteoles and equal length of bracteoles and hairs in female flowers whereas T. angustata has equal length of female flowers and bracteoles and longer bracteloes than hairs in female flowers. In this study, the pattern of morphological variation of T. angustifolia in Korea is examined using numerical analysis to determine their taxonomical identities. Univariate analysis using morphological characters such as female flower length/bracteole length and bracteole lengh/hair length reveals that Korean T. angustifolia is composed of one group. The result of principal components analysis shows that Korean T. angustifolia is closely related to T. angustifolia distributed in Japan, Russia, and USA. Therefore, T. angustifolia L. (in Korea) is suggested as a legitimate scientific name.

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Taxonomic revision of the Artemisia sacrorum group (더위지기 및 근연분류군의 분류학적 재검토)

  • Park, Myung Soon;Nam, Bo Mi;Chung, Gyu Young
    • Korean Journal of Plant Taxonomy
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    • v.46 no.2
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    • pp.175-186
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    • 2016
  • The taxonomic status and scientific names of Artemisia gmelinii and its allied taxa have long been debated. To provide correct names and taxonomic status, A. gmelinii and its allied taxa were reviewed in this study based on morphological characters. After a comparison of original descriptions and type specimens, the names of A. freyniana f. discolor and A. freyniana f. vestita used in Korea were recognized as A. sacrorum var. sacrorum and A. sacrorum var. incana, respectively, based on the characters of the trichome on the leaf, the geographical distributions, the chromosome numbers, and the existence of a pinule connection on the exine of the pollen. A. iwayomogi, the scientific name misused as A. gmelinii, was combined and newly named A. sacrorum var. iwayomogi (Kitam.) M. S. Park & G. Y. Chung based on its morphological similarity to the A. sacrorum group. A description, illustration, and key for each of the taxa are provided here.