• 한국과학교육학회지
• /
• 제35권5호
• /
• pp.841-856
• /
• 2015

본 연구에서는 과학 정체성 개념을 사용하여, 과학에 대한 흥미는 높지만 과학 관련 진로에 대한 포부가 낮았던 초등 4학년 학생들의 진로 포부의 변화를 설명하고자 하였다. 이를 위해 연구목적에 맞는 참여자를 선별하였고, 14명의 학생을 대상으로 2회(4학년, 5학년)의 심층면담을 실시하였다. 과학 경험에 대한 학생들의 설문조사, 교사로 부터 제공받은 자료 또한 심층면담 자료를 뒷받침하는 보조 자료로 사용하였다. 1차면담(4학년)에서 과학 관련 진로에 대한 포부가 낮았던 14명의 학생들은 2차면담(5학년)에서 다양한 변화를 보여주었는데, 6명은 지속적으로 낮은 진로 포부를, 6명은 보통의 진로 포부를, 그리고 2명은 높은 진로 포부를 보였다. 이 가운데 세 명의 초점 학생을 선정하였고, 과학 정체성 요소와 진로 포부의 관계를 깊이있게 탐색하였다. 연구 결과, 진로와 관련하여 개인마다 가치를 두는 과학 정체성 요소가 달랐으며(윤우는 타인의 평가, 태우는 자신의 흥미, 인제는 과학 능력), 이러한 요소에 따라 요소들 사이의, 그리고 요소와 과학 관련 진로 포부 사이의 상호작용은 개인마다 다른 양상을 보여주었다. 시간이 흐르면서 참여자들이 겪은 경험과 주변의 타인들과의 상호작용은 과학 정체성 요소의 변화에 영향을 주었고, 이는 요소들 사이의 상호작용을 통한 과학 관련 진로 포부의 변화로 이어졌다. 동료와의 관계에 대한 인식(나에 대한 동료의 평가와 동료에 대한 나의 평가에 대한 인식)과 과학 관련 진로에 대한 인식 또한 학생들이 자신에 대해 판단하고 과학 관련 진로에 대한 포부를 형성하는데 중요하게 영향을 미치고 있어, 이를 고려한 주변의 지원과 과학 관련 진로에 대한 안내가 필요함을 제안한다.

• 대한임상검사과학회지
• /
• 제45권2호
• /
• pp.66-72
• /
• 2013

Fine Needle Aspiration Biopsy Cytology (FNABC), which is known as the most accurate and cost-effective method for diagnosis of the thyroid nodule, may still result in indeterminate cases that are cellular paucity and show minor nuclear atypia. However, most cases are associated with suspicion of papillary thyroid carcinoma (PTC). A B-type Raf kinase (BRAF) mutation was found in about half of PTCs which is currently helping us to differentiate malignancies from benign lesions. Cases studied included 46 histological, confirmed PTC cases. FNABC 102 cell paucity and 74 atypia benign cases were previously diagnosed as suspicious of PTC using cytologic examination. These cases were analyzed for BRAF mutation by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with a new restriction enzyme. In this study, the sensitivity and specificity were calculated and, BRAF mutation was detected by means of a histological method in 23 of 46 cases of PTC and no mutation was found in 22 cases. However, one case was not detected. In using FNABC, BRAF mutation was detected in 6 of 102 cases in cell paucity and in 11 of 74 cases in the atypia. Two cases were not detected in the atypia. The sensitivity and specificity of PCR-RFLP in FNABC were 60% and 97.4% respectively. Assessment of Formalin Fixed Paraffin Embedding (FFPE) block demonstrated similarly a 51.1% positive and 48.9% negative in PTC. Evaluation of BRAF mutation revealed high specificity and low sensitivity in using FNABC method. This study suggests that BRAF mutation analysis should be useful for the clinical diagnosis of PTC in FNABC with cytological findings suspicious for PTC.

• 대한임상검사과학회지
• /
• 제46권3호
• /
• pp.99-105
• /
• 2014

Isolating total DNA from small samples using traditional methods is difficult and inefficient mainly due to loss of DNA during filtration and precipitation. With advances in molecular pathology, DNA extraction from micro-dissected cells has become essential in handling clinical samples. Genomic DNA extraction using small numbers of cells can be very important to successfully PCR amplify DNA from small biopsy specimens. We compared our experimental genomic DNA extraction method (A) with two other commercially available methods: using spin columns (B), and conventional resins (C), and determined the efficacy of DNA extraction from small numbers of cells smeared on a glass slide. Approximately 50, 100, 200, 500 and 1000 cells were isolated from fine needle aspiration biopsy (FNAB) slides aspirated from histologically proven papillary thyroid carcinoma masses. DNA was extracted using the three techniques. After measuring DNA quantity, PCR amplification was performed to detect the ${\beta}$-globin and $BRAF^{V600E}$ gene mutations. DNA extracted by method (A) showed better yield than the other methods in all cell groups. With our method, a suitable amount of genomic DNA to produce amplification was extracted from as few as 50 cells, while more than 100 to 200 cells were required when methods (B) or (C) were applied. Our genomic DNA extraction method provides high quality and improved yields for molecular analysis. It will be especially useful for paucicellular clinical samples which molecular pathologists often confront when handling fine needle aspiration cytology, exfoliative cytology and small biopsy specimens.

• Physical Therapy Rehabilitation Science
• /
• 제12권1호
• /
• pp.43-47
• /
• 2023

Objective: To present a case study of a 69-year-old woman with COVID-19 who developed neurological complications due to Extracorporeal Membrane Oxygenation (ECMO) therapy and highlight the importance of daily neurological examinations and rehabilitation in the early detection and management of ECMO-related neurological complications in an isolation ICU. Design: A case report Methods: The patient received ECMO therapy, followed by neurological monitoring and rehabilitation in an isolation ICU. Daily neurological examinations were conducted to monitor the patient's neurological symptoms. Computed tomography was performed to confirm the presence of a hematoma in the left hamstring, which was identified as the cause of the neurological complication. Ultrasound-guided aspiration was immediately performed, and sciatic neuropathy predominantly involving the peroneal division was identified after aspiration. Results: Successful recovery was made possible by the early detection of neurological complications and rehabilitation in an isolation ICU. Although electrodiagnostic tests were not performed due to limited access to the isolation ICU, the appropriate intervention time could be determined through daily neurological examinations and rehabilitation, thereby minimizing neurological sequelae. Conclusions: ECMO-related neurological complications are well known, and their recognition in the ICU can be challenging. The presented case highlights the importance of daily neurological examinations and rehabilitation in the early detection and management of ECMO-related neurological complications in an isolation ICU, which can minimize neurological sequelae.

• 한국수정란이식학회지
• /
• 제29권3호
• /
• pp.273-281
• /
• 2014

This study was carried out to establish the system of OPU derived embryo production, management of recipients as well as offspring production. OPU derived embryo production system was carried out of aspiration of immature oocytes 2 times per week, total 24 times for 3 months by an ultrasonographic guided follicular aspiration system and then produced in vitro-produced blastocysts by in vitro maturation, fertilization and culture system. This work was collected total 13,866 oocytes, average $8.2{\pm}4.5$ oocytes per session and 8,170 G1 + G2 grade oocytes, average 4.8 oocytes per session by 1,692 times session of total 71 donors for 4 years from 2010 to 2013. The rate of cleavage and blastocyst developmental competence were obtained 11,825 (85.3%) and 5,032 (36.3%) that was $7.0{\pm}3.8$ cleaved embryos and $3.0{\pm}2.5$ blastocysts per session. OPU derived embryo transfer were taken place in 2, 4, 6 and 7 local governments at 2010, 2011, 2012 and 2013 for 4 years and pregnancy rate were obtained 41.2, 43.9, 46.5 and 49.7% in each years. It means that pregnancy rate was continuously improved according of every year for 4 years. Pregnancy rate was significantly different according to individual local government in which was 62.7% in B, but 24.2% in F at 2012. Paternity identification was carried out total 26 offspring in C local government of 2012 and then confirmed 100% agreement of its analysis. In conclusion, the results obtained the possibility of mass production of elite cow embryos as well as offspring by OPU derived embryo production system, of which could be decreased the required time of genetic improvement.

• 한국과학교육학회지
• /
• 제27권7호
• /
• pp.570-582
• /
• 2007

본 연구의 목적은 학생들의 과학관련 진로선택과정의 인과요인을 분석하는 것이다. 학생들의 과학관련 진로선택과정에 대한 인과관계를 구조방정식모형을 구성하여 분석하였다. 개인적 요인, 교육적 요인, 사회적 요인이 과학 진로 희망에 직접 효과를 주고 과학 진로 희망은 과학 진로 선택에 직접 영향을 준다는 연구 가설에 가장 적합한 모형에 의하면, 과학 진로 선택에 과학 진로희망이 0.95의 직접효과를 주며, 개인적 요인이 0.75, 교육적 요인이 0.46, 사회적 요인이 0.11의 간접 효과를 주며 이들 효과가 그대로 총 효과를 주는 것으로 나타났다. 과학진로희망에는 개인적 요인이 0.79의 직접효과 및 총 효과를 주며, 교육적 요인이 -0.21의 직접효과와 0.69의 간접효과를 합하여 0.48의 총 효과를 주고, 사회적 요인이 0.12의 직접효과 및 총 효과를 주는 것으로 나타났다. 한편, 교육적 요인이 사회적 요인에 0.72, 교육적 요인이 개인적 요인에 0.77의 직접 효과 및 총 효과를 주는 것으로 나타났다. 초중고 학생 및 남학생과 여학생으로 대상을 달리하여 인과 효과를 비교 분석한 결과, 학교급별로는 전체 학생들과 경향성이 같고, 각 요인들의 영향 정도만 차이가 있었으나, 성별로는 남녀 학생의 대비가 두드러졌다. 남학생은 사회적 요인의 총 효과가 가장 크고, 그 다음이 개인적 요인, 그 다음이 교육적 요인의 순서로 나타난 데 비해, 여학생은 개인적 요인의 효과가 가장 크고 나머지 두 요인의 효과는 그리 크지 않았으며, 사회적 요인은 음으로 나타났다. 이러한 대상별 분석 결과로부터 각 대상의 과학진로선택과정의 인과관계를 고려한 과학진로교육의 방향에 대한 시사점들을 논의하였다.

• Journal of Yeungnam Medical Science
• /
• 제38권1호
• /
• pp.78-82
• /
• 2021

Pancreatic metastasis from malignant phyllodes tumor (PT) of the breast is rare, and only a few cases have been reported in the literature. Here, we report a case of pancreatic metastasis from malignant PT of the breast in a 48-year-old woman. She had had three episodes of recurrence of malignant PT in her right breast. She presented with epigastric pain for 2 months. Computed tomography and magnetic resonance imaging revealed a 6 cm-sized, well-defined, heterogeneous mass with peripheral enhancement in the body of the pancreas. Endoscopic ultrasonography-guided fine-needle aspiration was performed, and the pathologic report suggested spindle cell mesenchymal neoplasm. Subsequently, surgical excision was performed, and the mass was confirmed as a metastatic malignant PT. The imaging findings are discussed and the literature is briefly reviewed in this report.

• STI Policy Review
• /
• 제6권2호
• /
• pp.54-86
• /
• 2015

The study examines the U.S. Small Business Innovation Research (SBIR) program, with a focus on the recent Reauthorization, and compares, in the political context, the U.S. and East Asian countries-Japan, Korea and Taiwan-that adopted the U.S. SBIR program. For the systematic analysis and cross-country comparison, the study employs Kingdon (2003)'s framework-his political theory and Garbage Can Model-to identify political participants and processes underlying the SBIR Reauthorization and to analyze the differences in problem, policy, and politics streams between the U.S. and East Asian countries. For the cross-country comparison, specifically, the study uses various data sources such as OECD, Global Entrepreneurship Monitor, Hofstede's Cultural Dimensions, and World Value Survey. Based on the analysis outcomes, implications of U.S. practices on East Asian countries are extracted as follows. East Asian countries tend to: Have higher entrepreneurial aspiration while lower entrepreneurial activity and attitude than the U.S.; bear higher long term orientation and uncertainty avoidance while lower individualism than the U.S.; and have greater expectations of technology development and higher confidence in political parties while participating less in political action than the U.S. Drawing on the differences, the following policy recommendations are suggested. East Asian countries should: Improve entrepreneurs' access to resources (in particular, financial resource) in order to link their high entrepreneurial aspiration to actual entrepreneurial activities; cultivate failure-tolerating culture and risk-taking entrepreneurs, for instance, by providing a second chance to SBIR-participating businesses that failed to materialize their innovative ideas; and leverage their high expectations of new technology in order to take bold actions regarding their SBIR programs, and update the programs by drawing out constructive dialogues between SBIR stakeholders.

• 한국의류학회지
• /
• 제26권9호
• /
• pp.1308-1319
• /
• 2002

The purpose of this is to analyze the aesthetics characteristics of our modern sports fashion, and thereby, discuss them in the light of the overall mentality or the 20th century, and thus, present the conditions or sports fashion design meeting modem people's divers aesthetics values and desired. Modern sports fashion sues can be categorized into futurist sports style, erotic sports style and American sheet sports style. And the 20th century mentality characterized by changes of lifestyle, identity and aspiration has influenced the aesthetic features of such sports fashion sues, which can be summed up as follows; first, the futurist sports style applies the functional items and details of active sportswear to design, while heralding a positive and hopeful message of technology and future by using the material of hi-tech functions and senses. This sports style was affected much by shift from social status, attraction and wealth to demonstration of state-of-the-art science, pursuit of functionality in terms of shapes and materials, convenience through See combinations of sportswear items or design elements. Second, the erotic sports style based on minimalism attempted to express the erotic body beauty indirectly by exposing some parts of body or using the material pressed against the body. This sports style was closely related with the changes of sexual identity such as neutral sexualism, bi-sexualism and homo-sexualism. Lastly, the American street sports style was born from black Americarns' sports and dances. This spors style pursues “youth” beyond TPO concept As mass media and commercial sports developed, the young generation copied sports stars' uniforms or fashions to share honor, wealth and youth with them. In sort, the American sheet sports style was affected much by the so-called “heroism”. Such a changed object of aspiration influenced the aesthetic characteristics of American shot sports style directly.

• Journal of Advanced Marine Engineering and Technology
• /
• 제37권8호
• /
• pp.911-917
• /
• 2013

최근 높은 출력을 요구하는 각종 산업분야에서 사용되고 있는 디젤엔진의 효율을 높이기 위해 대응출력 220HP 과급기를 장착한 디젤엔진과 자연흡기식 디젤엔진을 동일한 조건에서 동력계와 배출가스 분석기를 통해 동력특성 및 배출가스 특성을 실험한 논문이다. 자연흡기식 디젤엔진과 과급기를 장착한 디젤엔진을 실험한 결과, 저속에서의 동력특성의 차이는 적었으나 고속에서의 동력특성은 과급기를 장착한 엔진의 출력과 효율이 증가한다는 결과를 얻을 수 있다. 이와는 반대로 배출가스 특성에서는 과급기를 장착한 모델에서 $NO_X$와 $O_2$등의 배출가스가 증가되었으나 $CO_2$의 저감과 동력 특성 증가의 효율을 볼 때 배출가스의 증가치는 적다고 할 수 있다. 이와 같은 결과를 토대로 과급기가 장착된 디젤엔진이 자연흡기식 엔진 대비 효율성 면에서 경제성이 높다라고 예측된다.