• 한국식품영양학회지
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• 제36권4호
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• pp.296-308
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• 2023

This study investigated the anti-obesity effects of Coriandrum sativum L. ethanol extracts in a high fat diet-induced obesity model (DIO). We confirmed the anti-obesity effects by analysing the expression of the related proteins, weight gain, dietary intake, dietary efficiency, blood biochemistry, histological analysis and western blot analysis. After oral administration of Coriandrum sativumL. ethanol extracts at concentrations of 250 and 500 mg/kg, a significant improvement in dietary efficiency, reduction in weight gain, triglycerides, total cholesterol and LDL-cholesterol in blood lipid was observed for 8 weeks. In addition, improvement in blood glucose and metabolism confirmed through glucose tolerance test was observed. Further, the concentration of alanine transaminase (ALT) in blood was significantly decreased, which improved the fatty liver caused by high-fat diet intake as confirmed by liver tissue analysis. This phenomenon was confirmed to decrease the expression of fat accumulation-related PPARγ and FAS protein in the liver tissue. Especially, it is believed that FAS, a liposynthetic enzyme, has a stronger inhibitory effect than PPARγ. Therefore, Coriandrum sativum L. ethanol extract is thought to improve obesity by reducing blood lipids levels, improving glucose metabolism and inhibiting synthesis of the fat that accumulates in the liver in high-fat diet-induced obesity animal models.

• 보건교육건강증진학회지
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• 제6권1호
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• pp.22-33
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• 1989

Rapid socio-cultural and economic changes in the country has brought with it changes in the society's value system. For a traditional society that is increasingly being exposed to modernization but where sex norms are still very restrictive, the adolescent sexual mores takes on added significance. Adolescents are caught between two opposing forces, the changing environment that allows for freer and liberal mores and the traditional society that cannot keep pace with the changing environment and therefore demands resistance to changes. This paper focuses on problems of adolescent sexuality in this country and considers the countermeasures for the existing problems. Amongst the problems are: (a) increasingly younger age of the adolescents who start sexual intercourse (b) non-use of contraception, (c) unwanted pregnancies, (d) increase in the number of induced abortion and (e) increase in the number of unwanted children and unmarried mothers. The Korean adolescent's sexual behavior seems to follow that of the developed countries. In other words, many western modes of life and sexual values seem to bave been copied in Korea and yet Korean adolescents lack in their knowledge of sex related matters such as reproductive physiology and contraception. Among middle and high school students, female students are reported to have less knowledge on sex than male students according to a 1988 survey by KIPH. Even among the unmarried famale factory workers, only 42.5 percent replied they know of the condom, and 25.1 percent and 23.1 percent said they had knowledge of spermicide and menstrual regulation respectively. However, 14.9 percent and 13.9 percent reported that they had a knowledge of the loop and female sterilization respectively according to the 1984 study by KIPH. Among the middle school students 0.8 percent said they had experience in sexual intercourse, while 7.3 percent of the high school students reported having had sexual intercourse. The sexual intercourse experience rate among the unmarried female factory workers is 37.8 percent. Among those female factory workers with sexual experience, 46.7 percent had more than one sex partners. Only 39.1 percent of male students and 18.9 percent of female students among those with sexual intercourse experience have used contraceptives. mostly condoms and oral pills 45.1 percent of female factory workers with sexual intercourse experience used contraceptives such as pills, condoms and rhythm methods. The pregnancy experience rate among the female factory workers who had experience in sexual intercourse is 29.5 percent, which is 11.1 percent among the total respondents. Out of the 102 pregnant female workers, 98 workers(96.1 percent) terminated their pregnancy by induced abortion and 2 workders(2 percent) in natural abortion, while 1 worker(1 percent) was in pregnancy and another 1 worker had normal birth that was subsequently sent to orphanage. In order to cope with the problem of adolescent sexuality, a drastic and strong policy measures should be taken by the government. The most effective countermeasure to the adolescent sexual problems appears to the education. The sex and population education in the school is very much in need. In addition, sex education program through mass media and at the job sit-should be promoted for a healthy development of adolescents' sexual behavior. Also, the existing national family planning program, which has focused on the married couples, should be extended to the unmarried people in its scope and contents of the program.

• Molecules and Cells
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• 제40권6호
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• pp.386-392
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• 2017

Periodontal ligament stem cells (PDLSCs) are multipotent stem cells derived from periodontium and have mesenchymal stem cell (MSC)-like characteristics. Recently, the perivascular region was recognized as the developmental origin of MSCs, which suggests the in vivo angiogenic potential of PDLSCs. In this study, we investigated whether PDLSCs could be a potential source of perivascular cells, which could contribute to in vivo angiogenesis. PDLSCs exhibited typical MSC-like characteristics such as the expression pattern of surface markers (CD29, CD44, CD73, and CD105) and differentiation potentials (osteogenic and adipogenic differentiation). Moreover, PDLSCs expressed perivascular cell markers such as NG2, ${\alpha}-smooth$ muscle actin, platelet-derived growth factor receptor ${\beta}$, and CD146. We conducted an in vivo Matrigel plug assay to confirm the in vivo angiogenic potential of PDLSCs. We could not observe significant vessel-like structures with PDLSCs alone or human umbilical vein endothelial cells (HUVECs) alone at day 7 after injection. However, when PDLSCs and HUVECs were co-injected, there were vessel-like structures containing red blood cells in the lumens, which suggested that anastomosis occurred between newly formed vessels and host circulatory system. To block the $SDF-1{\alpha}$ and CXCR4 axis between PDLSCs and HUVECs, AMD3100, a CXCR4 antagonist, was added into the Matrigel plug. After day 3 and day 7 after injection, there were no significant vessel-like structures. In conclusion, we demonstrated the perivascular characteristics of PDLSCs and their contribution to in vivo angiogenesis, which might imply potential application of PDLSCs into the neovascularization of tissue engineering and vascular diseases.

• Journal of Microbiology and Biotechnology
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• 제23권8호
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• pp.1159-1166
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• 2013

Orientia tsutsugamushi, a gram-negative bacterium, causes severe acute febrile illness in humans. Despite this danger, the route of infection, infectivity, and protective mechanisms of the host's immune response to O. tsutsugamushi are unclear. Dendritic cells (DCs) are one of the most important cell types in bridging the innate and adaptive immune responses. In this study, we observed that O. tsutsugamushi infects and replicates in monocyte-derived DCs (MODCs). During infection and replication, the expressions of the cytokines IL-12 and TNF-${\alpha}$, as well as the co-stimulatory molecules CD80, CD83, CD86, and CD40, were increased in MODCs. When O. tsutsugamushi-treated MODCs were co-cultured with autologous $CD4^+$ T cells, they enhanced production of IFN-${\gamma}$, a major Th1 cytokine. Collectively, our results show that O. tsutsugamushi can replicate in MODCs and can simultaneously induce MODC maturation and increase proinflammatory cytokine levels in MODCs that subsequently activate $CD4^+$ T cells.

• 치위생과학회지
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• 제13권2호
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• pp.197-202
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• 2013

본 연구는 치위생과 학생 147명을 대상으로 체격에 따른 치열궁 크기의 관련성을 조사하고자 실시하였다. 연구를 위해 설문지 작성과 치열궁 장 폭경 계측을 위한 인상채득이 동시에 실시되었으며, 다음과 같은 결론을 얻었다. 1. 1년 이내에 구강검진 경험이 있는 경우는 74.8%, 코로 숨을 쉬는 경우는 86.4%, 교정과 발치경험이 있는 경우는 각각 18.4%, 49.7%로 조사되었다. 정제된 음식은 94.6%가 좋아한다고 응답하였으며, 단단한 음식은 52.4%가 좋아한다고 응답하였다. 2. 치열궁 크기의 관련 요인에 따른 치열궁 장 폭경은 모든 변수가 통계적으로 유의한 차이를 보이지는 못했다. 3. 체격에 따른 치열궁 장 폭경 중 통계적으로 유의한 차이를 나타낸 변수는 신장과 체중이었으며, 신장이 클수록 상악 치열궁 장경이 크게, 체중이 많이 나갈수록 하악 견치간 폭경과 상악 구치간 폭경도 큰 것으로 나타났다. 4. 체중이 많이 나갈수록 상, 하악 견치간 폭경과 상, 하악 구치간 폭경이 약한 양의 상관관계를 보였으며, 상하악 치열궁 장경과 견치간 폭경, 구치간 폭경에서는 상악 구치간폭경과 하악 구치간 폭경이 가장 높은 관련성을 보였다. 이상의 결과로 보아 체격요건 중 체중이 치열궁 형태에 영향을 주었다. 앞으로도 체격변화에 따른 치열궁의 변화를 지속적으로 조사함으로써 안정적인 교합과 구강건강을 위한 자료로 활용할 수 있도록 해야 할 것이다.

• 치위생과학회지
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• 제12권2호
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• pp.171-179
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• 2012

본 연구는 구강건조증과 전타액분비율과의 관련요인을 분석함으로써 건강인식도를 높이고, 삶의 질 향상 프로그램을 개발하는데 기초자료로 활용하고자 실시하였다. 2011년 1월 14일부터 2월 22일까지 경기 인천 지역에 거주하는 만 40세 이상의 성인 160명을 대상으로 설문조사와 비자극성, 자극성 전타액분비량을 측정하여 다음과 같은 결론을 얻었다. 1. 구강건조증 인식도와 전타액분비율과의 관련성을 분석한 결과 '구강건조의 완화를 위해 껌 사탕을 섭취'하는 집단에서 자극성 전타액분비율이 낮았다. 2. 중학교 졸업자와 사별(미혼) 집단에서 구강건조증을 더 많이 인식하고 있었다. 또한 중학교 졸업자는 고등학교 졸업자보다 비자극성 전타액분비율과 자극성 타액분비율이 더 낮았고, 여성은 남성보다 비자극성 전타액분비율이 낮았다. 3. 건강상태가 좋지 않으며 폐경 상태이고, 우울증 증상이 많으며, 치주질환 증상과 혀 작열감 등을 인식한 집단에서 구강건조증을 더 많이 인식하고 있었다. 또한 우울증의 증상이 많고 구취를 인식한 집단에서 비자극성 전타액분비율이 낮았다. 4. 삶의 만족도가 낮고 삶이 무의미하며 부정적 기분을 자주 인지하고, 구강건강과 관련된 삶의 질이 낮은 집단에서 구강건조증을 더 많이 인식하고 있었다. 또한 삶의 만족도가 낮고 삶이 무의미하며, 자신에 대한 만족도가 낮은 집단에서 자극성 전타액분비율이 더 낮았다. 이상의 결과로 볼 때, 전신건강과 구강건강인식도 및 삶의 질의 향상을 위하여 구강건조증과 타액분비의 저하는 조기에 예방하여야 하며, 삶의 질 향상 프로그램에 반드시 포함하여야 할 것으로 사료되었다.

• 치위생과학회지
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• 제9권5호
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• pp.513-518
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• 2009

본 연구는 청주시 소재 실업계 남자고등학교 2학년 학생 281명을 대상으로 고등학교 남학생의 흡연과 치은염과의 관련성을 알아보고자 설문조사와 구강검사를 시행한 결과 다음과 같은 결론을 얻었다. 1. 본 연구는 대상자의 흡연 경험률은 59.4였으며, 현재 흡연율은 41.3%로 나타났다. 학생들의 평균 치은염이환율은 61.5%, 그 중 흡연 경험이 있는 학생이 44.8%였다. 평균 치은염지수는 $0.20{\pm}0.27$로 그 중 흡연 경험 있는 학생이 $0.29{\pm}0.31$로 나타났다. 2. 흡연경험이 있는 경우 치은염을 가지고 있는 확률이 높았고 (p = 0.000), 음주경험이 있을수록 치은염 이환율이 높았다(p = 0.010). 3. 음주경험, 구강보건교육경험, 최근 1년 동안 치과내원 유무, 치석제거경험, 칫솔질 횟수를 통제한 다변량 분석에서 치은염 이환의 경우 비흡연군에 비해 흡연 경험군이 5.5배(p = 0.000)로 높았다. 하루 흡연량이 6개비 이상인 경우 비흡연군에 비해 8.4배(p = 0.000)로 높았다. 흡연 기간이 25개월 이상인 경우 비흡연군에 비해 13.2배(p = 0.000)로 높았다. 4. 치은염지수의 결정요인분석에서 흡연기간과 치석제거 경험이 높은 관련성을 보였고, 36.2%의 설명력을 보였다. 결론적으로 본 연구의 결과 남자고등학생들의 흡연은 치은염의 영향력을 보였다. 청소년기는 학동기에 이어 영구치의 치아우식이 계속 진행되는 연령이며 치주질환이 시작되는 시기이다. 그러므로 금연으로 구강상태를 조절할 수 있도록 동기 유발과 구강교육이 이루어지도록 청소년 구강보건 향상에 주력해야 할 것이다.

• 대한소아치과학회지
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• 제47권3호
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• pp.344-351
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• 2020

법랑질 형성부전증은 단독으로 나타나거나 다른 구강내 이상 또는 전신질환과 동반되어 나타난다. 신석회증을 동반한 법랑질 형성 부전증은 Enamel Renal Syndrome (ERS; OMIM #204690)으로 불리며, 법랑질의 심각한 저형성, 다수의 치아 맹출 장애, 치수내 석회화, 치은 증식, 신석회증을 특징으로 한다. 신석회증이란 칼슘 결정이 신장 조직 내에 침착되어 심각한 신장 합병증을 일으키게 되는 질환이다. 이 증후군은 특징적인 구강내 소견을 보이므로 신장 증상이 나타나기 전에 조기에 발견될 수 있으며, 이러한 조기발견으로 추후 심각한 신장 질환 합병증을 예방할 수 있다. 따라서 소아치과 의사는 ERS가 의심된다면 신장 평가를 위해 소아과 의사에게 의뢰하여야 하고, 또한 관련 원인 유전자 탐색을 위해 유전학자에게 의뢰를 하는 역할을 할 수 있다.

• 한국치위생학회지
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• 제7권4호
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• pp.419-431
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• 2007

The setting of dental hygiene clinics is very important to dental hygiene education, which is the place not only to educate students but also to care clients. The purpose of this study is to provide basic research material for improvement of dental hygiene care system in dental hygiene clinics by analyzing the client satisfaction. A questionnaire survey by means of self-entry method was conducted to find out satisfaction of the client, who was visited to the dental hygiene clinics in the department of dental hygiene, Yonsei University. An analysis of frequency, one way ANOVA and T-Test were performed through SPSS 12.0K program. 1. Most clients were mainly composed of students in Wonju College of Medicine. 2. The clients visited for scaling(85.8%) and oral examination(9.73%) were much than treatment(4.42%). 3. Clients aged 21 to 25 were relatively lower in satisfaction with the facilities, system, attitude than any other ages. 4. The dental hygiene students are the lowest group in satisfaction with the facility, system, attitude than medical and nursing students. 5. The clients satisfaction with dental hygiene clinics was decreased in reverse proportion to visiting frequency. 6. Most of the clients pointed out the problems of appointment system(54.0%) and fee(23.0%), which should be improved than any other operation conditions. 7. Most of the clients were not satisfied with chair time and pain during care. 8. Most clients recognized to receive the better care service than other dental offices(81.3%). Especially, they paid attention to oral health education using phase-contrast microscope. 9. Many clients were dissatisfied with facilities of the dental hygiene clinics(71.7%). The problems of appointment system(54.0%) and chair time of dental hygiene care services(63.6%) had also inconvenienced to clients. The dental hygiene clinics in school play a crucial role in dental hygiene education to foster the student to be competent as a professional dental hygienist in the future. Therefore, well-organized dental hygiene care program based on dental hygiene process is essential. It is also required to improve the environment of dental hygiene clinics including facilities, appointment system and fee etc.

• Archives of Pharmacal Research
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• 제20권6호
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• pp.555-559
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• 1997

The three different batches of an oral sustained release melatonin (MT) delivery system were prepared by aqueous-based fluid-bed coating of the sugar spheres for the evaluation of in vitro release characteristics and plasma concentration profiles in human subjects. The MT contents in 20% coated sugar spheres of three batches (B1, B2 and B3) were $3.3{\pm}0.08$, $2.4{\pm}0.1$ and $2.5{\pm}0.13$ mg per gram of coated sugar spheres, respectively. The release profiles of three different batches had a very similar fashion. However, the release profiles of three different batches had a very similar fashion. However, the release half-lives $(T_{50%})$ of MT from B1, B2 and B3 was $3.70{\pm}0.2$, $5.2{\pm}0.2$ and $4.9{\pm}0.07h$, respectively. Plasma concentration profiles of sustained release 0.2mg melatonin-loaded sugar spheres containing 10% immediate release melatonin in gelatin capsules (B1 and B2) were then evaluated in human subjects. The in vivo plasma concentration profies of the two batches (B1 and B2) were very similar each other and located between the physiological endogenous ranges. The time to reach the peak concentration $(T_max)$ was more advanced in case of B1 when compared to B2. However, there was no statistically significant difference in the maximum concentration $(C_max)$ and the area under the curve (AUC) between B1 and B2. The AUC of melatonin-loaded sugar spheres containing 10% and 20% immediate release MT in human subjects had a good linearity between dose and AUC, regardless of the fraction of immediate release MT, indicating the first order elimination process of MT within these doses. The current oral sustained release MT delivery system may be utilized to treat circadian rhythm disorders if it is proven to be more clinically useful when compared to immediate release MT.