The Significance of SDF-1α-CXCR4 Axis in in vivo Angiogenic Ability of Human Periodontal Ligament Stem Cells |
Bae, Yoon-Kyung
(Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University)
Kim, Gee-Hye (Laboratory of Molecular Genetics, Dental Research Institute, School of Dentistry, Seoul National University) Lee, Jae Cheoun (Children's Dental Center and CDC Baby Tooth Stem Cell Bank) Seo, Byoung-Moo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) Joo, Kyeung-Min (Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University) Lee, Gene (Laboratory of Molecular Genetics, Dental Research Institute, School of Dentistry, Seoul National University) Nam, Hyun (Single Cell Network Research Center, Sungkyunkwan University School of Medicine) |
1 | Au, P., Daheron, L.M., Duda, D.G., Cohen, K.S., Tyrrell, J.A., Lanning, R.M., Fukumura, D., Scadden, D.T., and Jain, R.K. (2008). Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 111, 1302-1305. |
2 | Chen, F.M., and Jin, Y. (2010). Periodontal tissue engineering and regeneration: current approaches and expanding opportunities. Tissue Eng. Part B Rev. 16, 219-255. DOI |
3 | Corselli, M., Chen, C.W., Crisan, M., Lazzari, L., and Peault, B. (2010). Perivascular ancestors of adult multipotent stem cells. Arterioscler. Thromb. Vasc. Biol. 30, 1104-1109. DOI |
4 | Crisan, M., Yap, S., Casteilla, L., Chen, C.W., Corselli, M., Park, T.S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008). A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3, 301-313. DOI |
5 | Du, L., Yang, P., and Ge, S. (2012). Stromal cell-derived factor-1 significantly induces proliferation, migration, and collagen type I expression in a human periodontal ligament stem cell subpopulation. J. Periodontol. 83, 379-388. DOI |
6 | Gaengel, K., Genove, G., Armulik, A., and Betsholtz, C. (2009). Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb. Vasc. Biol. 29, 630-638. DOI |
7 | Gong, Q.M., Quan, J.J., Jiang, H.W., and Ling, J.Q. (2010). Regulation of the stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp cells. J. Endod. 36, 1499-1503. DOI |
8 | Huang, C., Gu, H., Yu, Q., Manukyan, M.C., Poynter, J.A., and Wang, M. (2011). Sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor SDF-1 following myocardial ischemia/reperfusion. PLoS One 6, e29246. DOI |
9 | Isner, J.M., Pieczek, A., Schainfeld, R., Blair, R., Haley, L., Asahara, T., Rosenfield, K., Razvi, S., Walsh, K., and Symes, J.F. (1996). Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348, 370-374. DOI |
10 | Isner, J.M., and Asahara, T. (1999). Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Invest. 103, 1231-1236. DOI |
11 | Ivanovski, S., Gronthos, S., Shi, S., and Bartold, P.M. (2006). Stem cells in the periodontal ligament. Oral. Dis. 12, 358-363. DOI |
12 | Iwasaki, K., Komaki, M., Yokoyama, N., Tanaka, Y., Taki, A., Kimura, Y., Takeda, M., Oda, S., Izumi, Y., and Morita, I. (2013). Periodontal ligament stem cells possess the characteristics of pericytes. J. Periodontol. 84, 1425-1433. DOI |
13 | Jaerve, A., Schira, J. and Muller, H.W. (2012). Concise review: the potential of stromal cell-derived factor 1 and its receptors to promote stem cell functions in spinal cord repair. Stem Cells Transl. Med. 1, 732-739. DOI |
14 | Jain, R.K., Au, P., Tam, J., Duda, D.G. and Fukumura, D. (2005). Engineering vascularized tissue. Nat. Biotechnol. 23, 821-823. DOI |
15 | Melero-Martin, J.M., Khan, Z.A., Picard, A., Wu, X., Paruchuri, S. and Bischoff, J. (2007). In vivo vasculogenic potential of human bloodderived endothelial progenitor cells. Blood 109, 4761-4768. DOI |
16 | Jiang, L., Zhu, Y.Q., Du, R., Gu, Y.X., Xia, L., Qin, F. and Ritchie, H.H. (2008). The expression and role of stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp. J. Endod. 34, 939-944. DOI |
17 | Jiang, L., Peng, W.W., Li, L.F., Yang, Y. and Zhu, Y.Q. (2012). Proliferation and multilineage potential of CXCR4-positive human dental pulp cells in vitro. J. Endod. 38, 642-647. DOI |
18 | Kim, J.H., Kim, G.H., Kim, J.W., Pyeon, H.J., Lee, J.C., Lee, G. and Nam, H. (2016). In vivo angiogenic capacity of stem cells from human exfoliated deciduous teeth with human umbilical vein endothelial Cells. Mol. Cells 39, 790-796. DOI |
19 | Lee, J.Y., Nam, H., Park, Y.J., Lee, S.J., Chung, C.P., Han, S.B., and Lee, G. (2011). The effects of platelet-rich plasma derived from human umbilical cord blood on the osteogenic differentiation of human dental stem cells. In Vitro Cell Dev. Biol. Anim. 47, 157-164. |
20 | Maeda, H., Tomokiyo, A., Fujii, S., Wada, N., and Akamine, A. (2011). Promise of periodontal ligament stem cells in regeneration of periodontium. Stem Cell Res. Ther. 2, 33. DOI |
21 | Melero-Martin, J.M., De Obaldia, M.E., Kang, S.Y., Khan, Z.A., Yuan, L., Oettgen, P., and Bischoff, J. (2008). Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ. Res. 103, 194-202. DOI |
22 | Ren, S., and Duffield, J.S. (2013). Pericytes in kidney fibrosis. Curr. Opin. Nephrol. Hypertension 22, 471-480. DOI |
23 | Mohle, R., Bautz, F., Rafii, S., Moore, M.A., Brugger, W., and Kanz, L. (1998). The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 91, 4523-4530. |
24 | Nagatomo, K., Komaki, M., Sekiya, I., Sakaguchi, Y., Noguchi, K., Oda, S., Muneta, T., and Ishikawa, I. (2006). Stem cell properties of human periodontal ligament cells. J. Periodontal. Res. 41, 303-310. DOI |
25 | Petit, I., Jin, D., and Rafii, S. (2007). The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol. 28, 299-307. DOI |
26 | Trubiani, O., Isgro, A., Zini, N., Antonucci, I., Aiuti, F., Di Primio, R., Nanci, A., Caputi, S., and Paganelli, R. (2008). Functional interleukin-7/interleukin-7Ralpha, and SDF-1alpha/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells. J. Cell Physiol. 214, 706-713. DOI |
27 | Seo, B.M., Miura, M., Gronthos, S., Bartold, P.M., Batouli, S., Brahim, J., Young, M., Robey, P.G., Wang, C.Y., and Shi, S. (2004). Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364, 149-155. DOI |
28 | Shi, S., and Gronthos, S. (2003). Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J. Bone Miner. Res. 18, 696-704. DOI |
29 | Teicher, B.A., and Fricker, S.P. (2010). CXCL12 (SDF-1)./CXCR4 pathway in cancer. Clin. Cancer Res. 16, 2927-2931. DOI |
30 | Trubiani, O., Giacoppo, S., Ballerini, P., Diomede, F., Piattelli, A., Bramanti, P., and Mazzon, E. (2016). Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res Ther. 7, 1. DOI |
31 | Wada, N., Menicanin, D., Shi, S., Bartold, P.M., and Gronthos, S. (2009). Immunomodulatory properties of human periodontal ligament stem cells. J. Cell Physiol. 219, 667-676. DOI |
32 | Wada, N., Gronthos, S., and Bartold, P.M. (2013). Immunomodulatory effects of stem cells. Periodontol. 2000 63, 198-216. DOI |
33 | Wang, K., Zhao, X., Kuang, C., Qian, D., Wang, H., Jiang, H., Deng, M., and Huang, L. (2012). Overexpression of SDF-1alpha enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway. PLoS One 7, e43922. DOI |
34 | Armulik, A., Abramsson, A., and Betsholtz, C. (2005). Endothelial/pericyte interactions. Circ. Res. 97, 512-523. DOI |
35 | Zemani, F., Silvestre, J.S., Fauvel-Lafeve, F., Bruel, A., Vilar, J., Bieche, I., Laurendeau, I., Galy-Fauroux, I., Fischer, A.M., and Boisson-Vidal, C. (2008). Ex vivo priming of endothelial progenitor cells with SDF-1 before transplantation could increase their proangiogenic potential. Arterioscler Thromb. Vasc. Biol. 28, 644-650. DOI |
36 | Zhu, W., and Liang, M. (2015). Periodontal ligament stem cells: current status, concerns, and future prospects. Stem Cells Int. 2015, 972313. |
37 | Aiuti, A., Webb, I.J., Bleul, C., Springer, T., and Gutierrez-Ramos, J.C. (1997). The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J. Exp. Med. 185, 111-120. DOI |
![]() |