• Proceedings of the Korean Society of Sericultural Science Conference
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• 2002.10a
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• pp.84-84
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• 2002

No Abstract, See Full Text

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.113.2-113.2
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• 2002

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.105-105
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• 2003

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.67-67
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• 2003

• 대한생식의학회:학술대회논문집
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• 2003.12a
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• pp.115-116
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• 2003

• Steel and Composite Structures
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• v.42 no.4
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• pp.459-475
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• 2022

In this paper a model for the prediction of the ultimate axial compressive capacity of square and rectangular Concrete Filled Steel Tubes, based on an Artificial Neural Network modeling procedure is presented. The model is trained and tested using an experimental database, compiled for this reason from the literature that amounts to 1193 specimens, including long, thin-walled and high-strength ones. The proposed model was selected as the optimum from a plethora of alternatives, employing different activation functions in the context of Artificial Neural Network technique. The performance of the developed model was compared against existing methodologies from design codes and from proposals in the literature, employing several performance indices. It was found that the proposed model achieves remarkably improved predictions of the ultimate axial load.

• 대한생식의학회:학술대회논문집
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• 1999.11a
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• pp.94.1-94.1
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• 1999

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.553-561
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• 2022

Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers, including leukemia. However, small-molecule inhibitors targeting SPHK1 in CML still need to be developed. This study revealed the role of SPHK1 in CML and investigated the potential anti-leukemic activity of hirsuteine (HST), an indole alkaloid obtained from the oriental plant Uncaria rhynchophylla, in CML cells. These results suggest that SPHK1 is highly expressed in CML cells and that overexpression of SPHK1 represents poor clinical outcomes in CML patients. HST exposure led to G2/M phase arrest, cellular apoptosis, and downregulation of Cyclin B1 and CDC2 and cleavage of Caspase 3 and PARP in CML cells. HST shifted sphingolipid rheostat from sphingosine 1-phosphate (S1P) towards the ceramide coupled with a marked inhibition of SPHK1. Mechanistically, HST significantly blocked SPHK1/S1P/S1PR1 and BCR-ABL/PI3K/Akt pathways. In addition, HST can be docked with residues of SPHK1 and shifts the SPHK1 melting curve, indicating the potential protein-ligand interactions between SPHK1 and HST in both CML cells. SPHK1 overexpression impaired apoptosis and proliferation of CML cells induced by HST alone. These results suggest that HST, which may serve as a novel and specific SPHK1 inhibitor, exerts anti-leukemic activity by inhibiting the SPHK1/S1P/S1PR1 and BCR-ABL/PI3K/Akt pathways in CML cells, thus conferring HST as a promising anti-leukemic drug for CML therapy in the future.

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.17.1-17.1
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• 2008

• Journal of Microbiology and Biotechnology
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• v.34 no.7
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• pp.1376-1384
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• 2024

Viral infectious diseases have always been a threat to human survival and quality of life, impeding the stability and progress of human society. As such, researchers have persistently focused on developing highly efficient, low-toxicity antiviral drugs, whether for acute or chronic infectious diseases. This article presents a comprehensive review of the design concepts behind virus-targeted drugs, examined through the lens of antiviral drug mechanisms. The intention is to provide a reference for the development of new, virus-targeted antiviral drugs and guide their clinical usage.