• 한국콘텐츠학회논문지
• /
• 제12권10호
• /
• pp.1-10
• /
• 2012

과학기술 문헌의 전문용어 인식 분야는 지금까지 다양한 통계적 방법론을 사용하여 용어 인식 정확률을 향상시키기 위하여 연구되어 왔다. 하지만 기존의 연구는 단일-코어 또는 단일 머신 상에서 수행되었기 때문에, 폭발적으로 증가하는 문헌들에 대한 실시간 분석 요구를 처리할 수 없는 상황에 직면하고 있다. 본 논문에서는 전문용어를 인식하는 과정에서 병목현상이 발생하는 작업을 '후보용어 추출 과정'의 언어처리부분과 '용어 가중치 할당 과정'에서 통계정보를 취합하는 부분으로 분류하고, 각 작업을 분산병렬 처리 기반의 맵리듀스 작업을 이용하여 해결하는 전문용어 인식 방법을 구현하고 실험하였다. 실험은 확장성과 분산 병렬 처리 환경 최적화 두 가지로 수행하였고, 첫 번째 실험에서 12개의 노드를 사용하여 분산 병렬 처리하였을 때 단일 머신을 사용한 경우보다 11.27배의 처리속도 향상을 보였다. 두 번째 실험에서 1)기본 환경, 2)복수 리듀서, 3)컴바이너, 4) 2)와 3)의 조합에 대하여 수행하였고, 3)컴바이너 사용이 가장 우수한 성능을 보여 주었다. 본 논문에서 구현된 전문용어 인식 시스템은 대용량 과학기술 문헌에 대한 지식 추출 작업속도 개선에 기여하였다.

• 한국미생물생명공학회:학술대회논문집
• /
• 한국미생물생명공학회 2004년도 Annual Meeting BioExibition International Symposium
• /
• pp.60-61
• /
• 2004

Metabolic engineering is now a well established discipline, used extensively to determine and execute rational strategies of strain development to improve the performance of micro-organisms employed in industrial fermentations. The basic principle of this approach is that performance of the microbial catalyst should be adequately characterised metabolically so as to clearlyidentify the metabolic network constraints, thereby identifying the most probable targets for genetic engineering and the extent to which improvements can be realistically achieved. In order to harness correctly this potential, it is clear that the physiological analysis of each strain studied needs to be undertaken under conditions as close as possible to the physico-chemical environment in which the strain evolves within the full-scale process. Furthermore, this analysis needs to be undertaken throughoutthe entire fermentation so as to take into account the changing environment in an essentially dynamic situation in which metabolic stress is accentuated by the microbial activity itself, leading to increasingly important stress response at a metabolic level. All too often these industrial fermentation constraints are overlooked, leading to identification of targets whose validity within the industrial context is at best limited. Thus the conceptual error is linked to experimental design rather than inadequate methodology. New tools are becoming available which open up new possibilities in metabolic engineering and the characterisation of complex metabolic networks. Traditionally metabolic analysis was targeted towards pre-identified genes and their corresponding enzymatic activities within pre-selected metabolic pathways. Those pathways not included at the onset were intrinsically removed from the network giving a fundamentally localised vision of pathway functionality. New tools from genome research extend this reductive approach so as to include the global characteristics of a given biological model which can now be seen as an integrated functional unit rather than a specific sub-group of biochemical reactions, thereby facilitating the resolution of complexnetworks whose exact composition cannot be estimated at the onset. This global overview of whole cell physiology enables new targets to be identified which would classically not have been suspected previously. Of course, as with all powerful analytical tools, post-genomic technology must be used carefully so as to avoid expensive errors. This is not always the case and the data obtained need to be examined carefully to avoid embarking on the study of artefacts due to poor understanding of cell biology. These basic developments and the underlying concepts will be illustrated with examples from the author's laboratory concerning the industrial production of commodity chemicals using a number of industrially important bacteria. The different levels of possibleinvestigation and the extent to which the data can be extrapolated will be highlighted together with the extent to which realistic yield targets can be attained. Genetic engineering strategies and the performance of the resulting strains will be examined within the context of the prevailing experimental conditions encountered in the industrial fermentor. Examples used will include the production of amino acids, vitamins and polysaccharides. In each case metabolic constraints can be identified and the extent to which performance can be enhanced predicted

• 한국수산과학회지
• /
• 제37권2호
• /
• pp.159-169
• /
• 2004

Sedimentation and depositional pattern of the fine-grained sediments in the southeastern inner shelf of Korea were studied using a very high-resolution seismic profiles and sediment data. The recent mud deposits up to 45 m thick are distributed in the inner shelf forming a nearshore belt from the eastern part of Geoje Island to off the Pohang along the coast. The sediment in this area consists of homogeneous mud with mean grain size between $8.6\;to\;5.3\phi$ and does not show any distinct variability It gradually becomes finer and well sorted northeastward along the coast. Sediments normally appear as structureless massive mud but X-radiographs show that some bioturbation and faint lamination are present. The sediments accumulate at a rate of 0.18-0.44 cm/yr and the rate coincides well with the long-term (a 1000-year scale) accumulation based on very high-resolution seismic data. Distribution of wet bulk density and velocity shows a gradual increase from the southeastern part of Ulsan to off Pohang, whereas porosity shows a reverse pattern. Correlations between velocity and porosity/mean grain size are different from other regions compared, due to the difference of sediment texture and sedimentary environment. The recent shelf deposits are seismically characterized by three distinct facies: 1) well-stratified (near the river mouth), 2) semi-transparent (eastern part of Geoje Island), and 3) transparent (off Ulsan). The results suggest that fine-grained sediment derived from rivers, forming a nearshore mud belt, have been transported northeastward by the northeastward-flowing coastal current.

• 한국수자원학회논문집
• /
• 제43권5호
• /
• pp.495-505
• /
• 2010

유역단위의 통합적 치수계획은 고려되는 단위사업의 수가 많고 그 특성도 다양하므로 이들을 조합한 최적의 대안을 수립하기가 쉽지 않다. 최적의 대안수립을 위해서는 홍수피해를 산정하는 것뿐만 아니라 감내할 수 있는 피해의 수준을 결정해야만 한다. 이에 대한 결정은 큰 틀에서 '사회적 합의'라는 방식으로 도출되지만 일차적으로는 기술적으로 가능한 범주에서 경제적 효율성 측면의 분석을 필요로 한다. 본 연구의 목적은 각 단위사업들의 조합이 경제적 효율성을 갖도록 하는 대안수립 방법을 제시하는 것이다. 이를 위해서 치수사업을 투입과 산출에 의한 경제학적 생산활동으로 정의하고 최적사업규모를 대안수립의 원칙으로 제시하였다. 본 연구는 기존에 공학적 측면에만 의존하던 대안수립 방법을 개선하여 경제적 측면에서 최적사업규모를 고려하였다는 데에 의의가 있다. 이러한 대안수립 방법은 하천중심의 소극적 치수계획을 지양하고 피해지역 중심의 유역단위 치수계획 수립으로 전환되고 있는 최근의 정부정책 방향에도 부합하며, 정책수립을 위한 효과적인 수단을 제공할 수 있을 것으로 기대된다.

• The Journal of Advanced Prosthodontics
• /
• 제6권2호
• /
• pp.71-78
• /
• 2014

PURPOSE. The objective of this study was to evaluate the clinical acceptability of all-ceramic crowns fabricated by the digital veneering method vis-$\grave{a}$-vis the traditional method. MATERIALS AND METHODS. Zirconia specimens manufactures by two different manufacturing method, conventional vs digital veneering, with three different thickness (0.3 mm, 0.5 mm, 0.7 mm) were prepared for analysis. Color measurement was performed using a spectrophotometer for the prepared specimens. The differences in shade in relation to the build-up method were calculated by quantifying ${\Delta}E^*$ (mean color difference), with the use of color difference equations representing the distance from the measured values $L^*$, $a^*$, and $b^*$, to the three-dimensional space of two colors. Two-way analysis of variance (ANOVA) combined with a Tukey multiple-range test was used to analyze the data (${\alpha}$=0.05). RESULTS. In comparing means and standard deviations of $L^*$, $a^*$*, and $b^*$ color values there was no significant difference by the manufacturing method and zirconia core thickness according to a two-way ANOVA. The color differences between two manufacturing methods were in a clinically acceptable range less than or equal to 3.7 in all the specimens. CONCLUSION. Based on the results of this study, a carefully consideration is necessary while selecting upper porcelain materials, even if it is performed on a small scale. However, because the color reproducibility of the digital veneering system was within the clinically acceptable range when comparing with conventional layering system, it was possible to estimate the possibility of successful aesthetic prostheses in the latest technology.

• The Plant Pathology Journal
• /
• 제33권3호
• /
• pp.337-344
• /
• 2017

To develop a commercial product using the mycoparasitic fungus Simplicillium lamellicola BCP, the scale-up of conidia production from a 5-l jar to a 5,000-l pilot bioreactor, optimization of the freeze-drying of the fermentation broth, and preparation of a wettable powder-type formulation were performed. Then, its disease control efficacy was evaluated against gray mold diseases of tomato and ginseng plants in field conditions. The final conidial yields of S. lamellicola BCP were $3.3{\times}10^9conidia/ml$ for a 5-l jar, $3.5{\times}10^9conidia/ml$ for a 500-l pilot vessel, and $3.1{\times}10^9conidia/ml$ for a 5,000-l pilot bioreactor. The conidial yield in the 5,000-l pilot bioreactor was comparable to that in the 5-l jar and 500-l pilot vessel. On the other hand, the highest conidial viability of 86% was obtained by the freeze-drying method using an additive combination of lactose, trehalose, soybean meal, and glycerin. Using the freeze-dried sample, a wettable powder-type formulation (active ingredient 10%; BCP-WP10) was prepared. A conidial viability of more than 50% was maintained in BCP-WP10 until 22 weeks for storage at $40^{\circ}C$. BCP-WP10 effectively suppressed the development of gray mold disease on tomato with control efficacies of 64.7% and 82.6% at 500- and 250-fold dilutions, respectively. It also reduced the incidence of gray mold on ginseng by 65.6% and 81.3% at 500- and 250-fold dilutions, respectively. The results indicated that the new microbial fungicide BCP-WP10 can be used widely to control gray mold diseases of various crops including tomato and ginseng.

• 한국방사선학회논문지
• /
• 제5권2호
• /
• pp.51-58
• /
• 2011

본 연구는 LVEF값이 40% 미만인 환자와 정상인 환자의 심장 박동 수를 비교 분석하여 CCTA 검사 프로토콜의 최적화를 통한 양질의 영상, 환자피폭과 재 검률을 최소화시키기 위함이다. 각 심장박동수와 LVEF에 관계에서 LVEF가 40%이하가 될 때 true 100HU에 도달하는 시간이 오래 걸림을 알 수 있다. 그러므로, 40% 미만인 환자들에서 Premonitoring deay를 설정 할 때 5초정도 더 주어도 됨을 알 수 있었다. 조영제는 Scan time ${\times}$ 4cc + 30cc의 용량을 4cc/sec속도로 주입한 후 이어서 Saline은 모든 환자에게 40cc를 4cc/sec속도로 추가 주입하였으며, 40% 미만에서는 HR이 80이상을 제외하고는 큰 차이를 보이는 것 을 알 수 있다. 또한, 40% 미만에서는 조영제가 true 100HU에 도달하여 Scan을 시작 할 때 시간 차이가 커 조영제가 이미 Left ventricle에서 Wash-out 됐음을 예측 할 수 있었다. 40%이상의 LVEF와 정상 이하의 LVEF는 검사 도중 많은 차이를 가지고 있다. 낮은 LVEF 환자에게서 검사를 시작할 경우 따라서, 조영제 주입 프로토콜은 LVEF에 따라서 CCTA에 결정되어져야 한다. 그리고 우리가 낮은 LVEF에 따라 검사 실패를 감소시켜야 하기 때문에 낮은 LVEF의 경우에는 일반적 Pitch 보다 낮은 Pitch가 사용되어져야 한다.

• 한국전자통신학회논문지
• /
• 제7권2호
• /
• pp.287-293
• /
• 2012

정보처리 시스템의 프로세서가 작업 대상으로 하는 다양한 콘텐츠 정보가 온라인상에서 놀라울 정도로 확대되어진 시점은 불과 몇 년 전이다. 2000년을 실시간 공유와 같은 정보 및 자료의 홍수가 이루어진 기술기반의 해라면, 이후 2011년까지는 활용기반의 기능과 솔루션이 넘쳐나는 기간이었다. 또한 이러한 정보처리 시스템의 활용도가 높아지는 과정 속에서 2009년과 2010년에는 대규모 개인정보의 유출사건이 발생한바 있고 정보의 보호를 위한 방어와 보호를 위한 기술과 솔루션들이 지속적으로 개발, 적용되고 있다. 하지만 외부로부터의 불법접근의 문제점에서 그 범주가 확대되어 내부 사용자 또는 내부 정보처리 시스템과 클라이언트 시스템에 숨겨진 Agent 등으로 인한 피해는 날로 증가하고 있다. 따라서 본 논문에서는 내부정보에 대한 접근 제어와 관리자 및 내부 사용자의 계층별 권한설정에 대한 효율성 기반의 정보보호를 위한 연구가 필요하며, 본 연구 결과로 SOHO급 네트워크에서 대규모 네트워크에 이르기까지 실무에서 보안기법으로 활용 가능한 연구 자료를 제공코자 한다.

• Journal of Pharmaceutical Investigation
• /
• 제25권3호
• /
• pp.249-264
• /
• 1995

Although liposome has many advantages as a pharmaceutical dosage form, its application in the industrial field has been limited because of some problems such as preparation method, reproducibility, scale-up, stability and sterilization etc. Liposomes prepared by microemulsification method had defined size, narrow size distribution, reproducibility and high entrapment efficiency. For enhancing the stability, the dry form of liposome was recommended. These types of liposome are proliposome and freeze-dried liposome. The liposome must have some properties for preparing of freeze-dried liposome; small size $(50{\sim}200\;nm)$, narrow size distribution and cryoprotectant. In this experiment, the liposomes containing 5-Fluorouracil(5-FU) and its prodrug(pentyl-5-FU-1-acetate; PFA, hexyl-5-FU-1-acetate; HFA) were made with soybean phosphatidylcholine, cholesterol, stearylamine(SA) and dicetyl phosphate(DCP) employing hydration method or microemulsification method using $Microfluidizer^{TM}$. Both or liposome types were MLV and MEL. After preparation, freeze drying and rehydration were performed. In the process of freezing, trehalose(Tr) was added as a cryoprotectant. Their evaluation methods were as follows; entrapment efficiency, mean particle size and size distribution, dissolution test, retain of entrapment efficiency and turbidity after freeze-drying. The results are summarized as belows. The entrapment efficiency of 5-FU was dependent on total lipid concentration and cholesterol content but that of PFA and HFA was decreased when cholesterol was added. When DCP and SA were added, entrapment efficiency was decreased. As the partition coefficient of drug was increased, entrapment efficiency was increased. Under the same condition, entrapment efficiency of MEL is similar to that of MLV. The mean particle size and size distribution of MEL were smaller than those of MLV. Dissolution rates of drug from both liposome types were comparatively similar. Dissolution rates of drugs with serum and liver homogenate were faster than without these material. After preparation of liposome, free drug was removed efficiency by Dowex 50W-X4. When liposome was freeze-dried and then rehydrated in the presence of Tr, characteristics of liposome were maintained well in MEL than MLV. Tr Was used successfully as a cryoprotectant in the process of freeze drying and the optimal ratio of Tr:Lipid was 4:1(g/g).

• Nuclear Engineering and Technology
• /
• 제46권4호
• /
• pp.547-556
• /
• 2014

Korea expects a shortage in storage capacity for spent fuels at reactor sites. Therefore, a need for more metal and/or concrete casks for storage systems is anticipated for either the reactor site or away from the reactor for interim storage. For the purpose of interim storage and transportation, a dual purpose metal cask that can load 21 spent fuel assemblies is being developed by Korea Radioactive Waste Management Corporation (KRMC) in Korea. At first the gamma and neutron flux for the design basis fuel were determined assuming in-core environment (the temperature, pressure, etc. of the moderator, boron, cladding, $UO_2$ pellets) in which the design basis fuel is loaded, as input data. The evaluation simulated burnup up to 45,000 MWD/MTU and decay during ten years of cooling using the SAS2H/OGIGEN-S module of the SCALE5.1 system. The results from the source term evaluation were used as input data for the final shielding evaluation utilizing the MCNP Code, which yielded the effective dose rate. The design of the cask is based on the safety requirements for normal storage conditions under 10 CFR Part 72. A radiation shielding analysis of the metal storage cask optimized for loading 21 design basis fuels was performed for two cases; one for a single cask and the other for a $2{\times}10$ cask array. For the single cask, dose rates at the external surface of the metal cask, 1m and 2m away from the cask surface, were evaluated. For the $2{\times}10$ cask array, dose rates at the center point of the array and at the center of the casks' height were evaluated. The results of the shielding analysis for the single cask show that dose rates were considerably higher at the lower side (from the bottom of the cask to the bottom of the neutron shielding) of the cask, at over 2mSv/hr at the external surface of the cask. However, this is not considered to be a significant issue since additional shielding will be installed at the storage facility. The shielding analysis results for the $2{\times}10$ cask array showed exponential decrease with distance off the sources. The controlled area boundary was calculated to be approximately 280m from the array, with a dose rate of 25mrem/yr. Actual dose rates within the controlled area boundary will be lower than 25mrem/yr, due to the decay of radioactivity of spent fuel in storage.