• Nuclear Engineering and Technology
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• v.28 no.3
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• pp.290-298
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• 1996

Direct Containment Heating, DCH, is supposed to occur during a core melt-down accident if the primary system pressure is still high at the time of vessel breach in a Nuclear Power Plant (NPP). In this case, DCH is considered to be one of very important severe phenomena during postulated severe accident scenario because of the fast heat transfer rate to atmosphere and the sharp pressure increase in a containment. To reduce the effect of this DCH phenomena, the capture volume wes designed at Ulchin NPP units 3 and 4. But, the effect of this has not been studied extensively. This work consists of experimental and numerical analyses of the effects of capture volume in the cavity on DCH phenomena. The experimental model is a 1/30 scaled-down model of Ulchin NPP units 3 and 4. We used three types of capture volumes to investigate the effect of size. Numerical analysis using CONTAIN 1.2 is performed with the correlation for the dispersed fraction of molten corium from the cavity into the containment derived from the experimental data to examine the effect of capture volume on DCH phenomena in full scale of Ulchin NPP units 3 and 4.

• IEMEK Journal of Embedded Systems and Applications
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• v.16 no.5
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• pp.209-214
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• 2021

Panoptic segmentation, which is now widely used in computer vision such as medical image analysis, and autonomous driving, helps understanding an image with holistic view. It identifies each pixel by assigning a unique class ID, and an instance ID. Specifically, it can classify 'thing' from 'stuff', and provide pixel-wise results of semantic prediction and object detection. As a result, it can solve both semantic segmentation and instance segmentation tasks through a unified single model, producing two different contexts for two segmentation tasks. Semantic segmentation task focuses on how to obtain multi-scale features from large receptive field, without losing low-level features. On the other hand, instance segmentation task focuses on how to separate 'thing' from 'stuff' and how to produce the representation of detected objects. With the advances of both segmentation techniques, several panoptic segmentation models have been proposed. Many researchers try to solve discrepancy problems between results of two segmentation branches that can be caused on the boundary of the object. In this survey paper, we will introduce the concept of panoptic segmentation, categorize the existing method into two representative methods and explain how it is operated on two methods: top-down method and bottom-up method. Then, we will analyze the performance of various methods with experimental results.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.4
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• pp.319-324
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• 2006

Although the sera used in animal cell culture media provide the macromolecules, nutrients, hormones, and growth factors necessary to support cell growth, it could also be an obstacle to the production of recombinant proteins in animal cell culture systems used in many sectors of the biotechnology industry. For this reason, many research groups, including our laboratory, have been trying to develop serum-free media (SFM) or serum-supplemented media (SSM) for special or multi-purpose cell lines. The Chinese hamster ovary (CHO) cell, for example, is frequently used to produce proteins and is especially valuable in the large-scale production of pharmaceutically important proteins, yet information about its genome is lacking. Also, SFMs have only been evaluated by comparing growth patterns for cells grown in SFMs with those grown in SSM or by measuring the titer of the target protein obtained from cells grown in each type of medium. These are not reliable methods of obtaining the type of information needed to determine whether an SFM should be replaced with an SSM. We carried out a cDNA microarray analysis to evaluate MED-3, an SFM developed in our laboratory, as a CHO culture medium When CHO cells were cultured in MED-3 instead of an SSM, several genes associated with cell growth were down-regulated, although this change diminished over time. We found that the insulin-like growth factor (IGF) gene was representative of the proteins that were down-regulated in cells cultured in MED-3. When several key supplements - including insulin, transferrin, ethanolamine, and selenium - were removed from MED-3, the IGF expression was consistently down- regulated and cell growth decreased proportionately. Based on these results, we concluded that when an SFM is used as a culture medium, it is important to supplement it with substances that can help the cells maintain a high level of IGF expression. The data presented in this study, therefore, might provide useful information for the design and development of SFM or SSM, as well as for the design of genome-based studies of CHO cells to determine how they can be used optimally for protein production in pharmaceutical and biomedical research.

• The korean journal of orthodontics
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• v.51 no.5
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• pp.346-354
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• 2021

Objective: To compare the effectiveness of ibuprofen, acetaminophen, and chewing gum for orthodontic pain relief and to assess if chewing gum can be a non-pharmacological alternative for orthodontic pain relief. Methods: The study enrolled 106 patients of both sexes, aged ≥ 12 years, with body weight > 50 kg, and mild-to-moderate dental crowding in the upper arch. After randomization and allocation concealment, the intervention groups were either administered with ibuprofen (400 mg) or acetaminophen (500 mg) or chewed sugar-free chewing gum immediately after initial archwire placement and every 6 hours for 1 week if the pain persisted. The control group did not receive any pain relief. The pain was assessed on a 100-mm visual analog scale at rest and while biting down at T1 (2 hours), T2 (24 hours), T3 (2 days), T4 (3 days), T5 (7 days), and T6 (21 days). Statistical analyses were performed using the Kruskal-Wallis and post-hoc Mann-Whitney U tests (α = 0.05). Results: The chewing gum group experienced more pain relief than the ibuprofen group at while biting down at T3 (p = 0.04) and at rest at T4 (p < 0.001). The chewing gum group reported more pain relief than the acetaminophen and control groups while biting down at T3 (p = 0.03 and p = 0.0006, respectively) and T4 (both p < 0.001). Conclusions: Chewing gum can be a non-pharmacological alternative for orthodontic pain relief at 2 and 3 days after initial archwire placement.

• Computers and Concrete
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• v.24 no.2
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• pp.159-172
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• 2019

This paper presents an investigation into the flexural behavior of reinforced concrete (RC) beams retrofitted by ultra-high performance fiber-reinforced concrete (UHPFRC) layers. The experimental study has been conducted in two parts. In the first part, four methods of retrofitting with UHPFRC layers in both the up and down sides of the beams have been proposed and their efficiency in the bonding of the normal concrete and ultra-high performance fiber-reinforced concrete has been discussed. The results showed that using the grooving method and the pre-casted UHPFRC layers in comparison with the sandblasting method and the cast-in-place UHPFRC layers leads to increase the load carrying capacity and the energy absorption capacity and causes high bond strength between two concretes. In the second part of the experimental study, the tests have been conducted on the beams with single UHPFRC layer in the down side and in the up side, using the effective retrofitting method chosen from the first part. The results are compared with those of non-retrofitted beam and the results of the first part of experimental study. The results showed that the retrofitted beam with two UHPFRC layers in the up and down sides has the highest energy absorption and load carrying capacity. A finite element analysis was applied to prediction the flexural behavior of the composite beams. A good agreement was achieved between the finite element and experimental results. Finally, a parametric study was carried out on full-scale retrofitted beams. The results indicated that in all retrofitted beams with UHPFRC in single and two sides, increasing of the UHPFRC layer thickness causes the load carrying capacity to be increased. Also, increases of the normal concrete compressive strength improved the cracking load of the beams.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.68-72
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• 2020

Purpose: Trisomy 21, the cause of Down syndrome (DS) with various medical problems, is the most common aneuploidy during the fetal period. For diagnosis, a non-invasive screening test using maternal blood, which cannot be confirmed and invasive confirmation test with a risk of miscarriage, may be performed. The trophoblast retrieval and isolation of the cervix (TRIC) have been proposed by some researchers as an alternative to overcome the limitations of current tests. We experimented using TRIC to identify the possibility of trisomy 21 for the first time in Asia. Materials and Methods: Three cases of DS were analyzed confirmed by invasive tests (chorionic villus sampling, amniocentesis). All samples of trophoblasts immediately were immersed in phosphate-buffered saline and processed with formalin for fixation. The trophoblasts were isolated using an anti-human leukocyte antigen-G antibody coupled to magnetic nanoparticles. β-human chorionic gonadotropin (hCG)-expressing cells were considered as trophoblast cells, and the detection rate calculated. DS was confirmed by fluorescence in situ hybridization (FISH). Results: The mean trophoblast detection rate using β-hCG was 78.1%, and the detection rate using FISH was 22.2%. In all cases, the trisomy of chromosome 21 was identified. Conclusion: Trophoblast can be obtained from the five weeks of gestation and has a high detection rate, so it is noted that it can replace the current prenatal genetic test. To realize the clinical application as a prenatal genetic test, we will need additional efforts to identify trisomy 21 as well as other chromosomal abnormalities in future large-scale studies.

• Journal of Trauma and Injury
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• v.21 no.1
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• pp.53-58
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• 2008

Purpose: Skiing and snowboarding are becoming increasingly popular. Accordingly, the incidences of injuries among skiers and snowboarders are also increasing. The purpose of this study was to investigate the injury patterns of and the contributing factors to head injuries of skiers and snowboarders and to evaluate the differences in characteristics between skiing and snowboarding head injuries. Methods: One-hundred patients who visited the emergency department of Wonju Christian Hospital between January 2005 and March 2007 due to head injuries from skiing and snowboarding were enrolled. The mechanisms and the histories of the injuries were investigated by surveying the patients, and the degrees of head injuries were estimated by using brain CT and the Glasgow Coma Scale. The degrees and the characteristics of brain injuries were also analyzed and compared between skiers and snowboarders. Results: Out of 100 patients, 39 were injured by skiing, and 61 were injured by snowboarding. The mean age of the skiers was $26.7{\pm}10.0$, and that of the snowboarders was $26.7{\pm}6.2$. The percentage of male skiers was 43.6%, and that of snowboarders was 63.9%. The most frequent initial chief complaints of head-injured skiers and snowboarders were headache and mental change. The most common mechanism of injuries was a slip down. The mean Abbreviated Injury Scale Score (AIS score) of the skier group was $4.5{\pm}2.1$ and that of the snowboarder group was $5.9{\pm}5.0$ (p=0.222). The percentage of helmet users was 7.1% among skiers and 20.8% among snowboarders (p=0.346). Head injuries were composed of cerebral concussion (92.0%) and intracranial hemorrhage (8.0%). Intracranial hemorrhage was most frequently caused by falling down (62.5%). Conclusion: The most common type of head injury to skiers and snowboarders was cerebral concussion, and severe damage was usually caused by jumping and falling down. No differences in the characteristics of the head injuries existed between skiing and snowboarding injuries.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.3
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• pp.265-270
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• 2004

Experiment study on a down scaled two-phase catalytic reactor is presented. As a preliminary step for the development of catalytic reactor, nano-particulate catalyst was prepared. Perovskite La$\_$0.8/Sr$\_$0.2/CoO$_3$is chosen and synthesized as a catalyst considering superior catalytic performance in reduction and oxidation process where oxygen is involved among the reagent. Reactor that has a scale of 2${\times}$10${\times}$25mm was made by machining of A1 block as a layered structure considering further extension to micro-machining. Hydrogen peroxide of 70wt% was adopted as reactant and was provided to the reactor loaded with 1.5 g of catalyst. Reactant flow rate was varied by precision pump with a range of 0.15cc/min to 17.2cc/min. Temperature distribution within reactor was recorded by 3 thermocouples and total amount of liquid product was measured. Temperature distribution and factors that affect temperature were observed and relation between temperature distribution and production rate was also analyzed. Relative time scale plays a significant role in the performance of the reactor. To obtain steady state operation, appropriate ratio of flow rate, catalyst mass and reactor geometry is required and furthermore to get more efficient production rate temperature distribution should be evenly distributed. The database obtained by the experiment will be used as a design parameter for micro reactor.

• Journal of The Korean Astronomical Society
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• v.48 no.4
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• pp.213-228
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• 2015

The Horizon Run 4 is a cosmological N-body simulation designed for the study of coupled evolution between galaxies and large-scale structures of the Universe, and for the test of galaxy formation models. Using 6300³ gravitating particles in a cubic box of L_box = 3150 h⁻¹Mpc, we build a dense forest of halo merger trees to trace the halo merger history with a halo mass resolution scale down to M_s = 2.7 × 10¹¹h⁻¹M_⊙. We build a set of particle and halo data, which can serve as testbeds for comparison of cosmological models and gravitational theories with observations. We find that the FoF halo mass function shows a substantial deviation from the universal form with tangible redshift evolution of amplitude and shape. At higher redshifts, the amplitude of the mass function is lower, and the functional form is shifted toward larger values of ln(1/σ). We also find that the baryonic acoustic oscillation feature in the two-point correlation function of mock galaxies becomes broader with a peak position moving to smaller scales and the peak amplitude decreasing for increasing directional cosine μ compared to the linear predictions. From the halo merger trees built from halo data at 75 redshifts, we measure the half-mass epoch of halos and find that less massive halos tend to reach half of their current mass at higher redshifts. Simulation outputs including snapshot data, past lightcone space data, and halo merger data are available at http://sdss.kias.re.kr/astro/Horizon-Run4.

• Journal of The Korean Astronomical Society
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• v.29 no.spc1
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• pp.151-154
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• 1996

We examine the observations of large-scale magnetic fields in the Universe. We begin at the largest scale with clusters of galaxies and work our way down through galaxies and finally to the Milky Way. on which we concentrate in detail. We examine the observations of the Galactic magnetic field, and their interpretation, under the philosophy that the Galactic magnetic field is like that in other spiral galaxies. We use pulsar data. diffuse Galactic synchrotron emission, and starlight polarization data to discuss the Galaxy's global magnetic configuration and the uniform ($B_u$), random ($B_r$), and total ($B_t$) components of the field strength. We find disagreement among conclusions derived from the various data sets and argue that the pulsar data are not the best indicator for large-scale Galactic field. Near the Solar circle, we find that the azimuthal average of $B_t$ is 4.2$\mu$G and we adopt $B_u\~$2.2 and $B_r\~3.6{\mu}G$. $B_t$ is higher in spiral arms, reaching $\~5.9{\mu}G$. $B_t$ is higher for smaller $R_{Gal}$, reaching $\~8.0{\mu}G$ for $R_{Gal}$ = 4.0 kpc. The pattern of field lines is not concentric circles but spirals. The inclination of the magnetic spiral may be smaller than that of the Galaxy's spiral arms if our sample, which refers primarily to the interarm region near the Sun, is representative. However, it is not inconceivable that the local field lines follow the Galaxy's spiral pattern, as is observed in external galaxies.