• 사상체질의학회지
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• 제32권2호
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• pp.10-21
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• 2020

Objectives Genome-wide association studies(GWAS) is a useful method to identify genetic associations for various phenotypes. The purpose of this study was to develop predictive models for Sasang constitution types using genetic factors. Methods The genotypes of the 1,999 subjects was performed using Axiom Precision Medicine Research Array (PMRA) by Life Technologies. All participants were prescribed Sasang Constitution-specific herbal remedies for the treatment, and showed improvement of original symptoms as confirmed by Korean medicine doctor. The genotypes were imputed by using the IMPUTE program. Association analysis was conducted using a logistic regression model to discover Single Nucleotide Polymorphism (SNP), adjusting for age, sex, and BMI. Results & Conclusions We developed models to predict Korean medicine constitution types using identified genectic factors and sex, age, BMI using Random Forest (RF), Support Vector Machine (SVM), and Neural Network (NN). Each maximum Area Under the Curve (AUC) of Teaeum, Soeum, Soyang is 0.894, 0.868, 0.767, respectively. Each AUC of the models increased by 6~17% more than that of models except for genetic factors. By developing the predictive models, we confirmed usefulness of genetic factors related with types. It demonstrates a mechanism for more accurate prediction through genetic factors related with type.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.107-113
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• 2011

Objectives : Sasang typology is extensively studied for the Sasang constitution diagnosis objectification with various data, for example, questionaires, reference materials, etc and analyzed with the several statistical methods. In this study, we used ROC-curve (Receiver Operating Characteristic curve) analysis to diagnose Sasang constitution, which is a kind of epidemiologic research methods and is away from traditional statistical methods. Methods : We collected personality questionnaire which consists of 15 items, from 24 oriental medical clinics. We analyzed the sensitivity and specificity using ROC curve method based on the score of personality questionnaire and also investigated classification accuracy and cut-off value of Sasang constitution. Results : The AUC (area under the ROC curve) value was 0.508 (p=.5511) for Taeeumin, 0.629 (p<.0001) for Soeumin and 0.604(p<.0001) for Soyangin, respectively. so the classification accuracy for Soeumin was highest Soeumin for over 30 points and Soyangin for below 28 points respectively. Conclusions : We suggest that Taeeumin is not classified easily in the ROC-curve analysis. We may classify Soeumin and Soyangin but the accuracy of Sasang constitutional diagnosis is still low.

• 동의신경정신과학회지
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• 제31권4호
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• pp.235-247
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• 2020

Objectives: In this study, we examine whether Sasang constitutions include all 8 attitude-function types, forming a complete paradigm from the perspective of Jungian psychological type theory. Methods: Analysis of the meanings of psychological attitudes and function of each Sasang constitution was performed, comparing them with the typological theories of C.G.Jung and John Beebe, both of whom are eminent minds in Jungian typology. Results and Conclusions: (1) Each Sasang constitution had all 8 psychological attitude-function combinations, which are diversely differentiated by type within their conscious and unconscious psyches. This is likely because attitudes and functions that develop in the conscious mind build up compensating attitudes and functions in the unconscious. (2) It seems that extroversion and introversion coexist within every Sasang constitution as psychological descriptions reported by Lee, Je ma state. The superior and inferior functions are disposed in the order of organ size in Sasang constitutions, but dominance of extroversion or introversion as defined by Jung's concepts of attitude does not seem to be determined by constitution.

• 사상체질의학회지
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• 제33권3호
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• pp.16-28
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• 2021

Introduction The Sasang Urination Defecation Inventory was developed to analyze Sasang-type specific pathophysiological clinical symptoms, and its revised Sasang Urination Inventory (SUI) illustrated its clinical usefulness in Sasang type differentiation. However, the correlation with established clinical measures for its concurrent validity were not provided yet. Methods Total of 48 healthy university students were recruited to response Urogenital Distress Inventory-6 (UDI-6) and Overactive Bladder Symptom Score (OABSS) of Western medicine along with the SUI of traditional Korean medicine. The correlation coefficients between UDI-6 and OABSS and SUI were acquired with Pearson's correlation, and Analysis of Variance (ANOVA) and Profile Analysis were used to analyze significant differences in SUI subscale profiles of each Sasang types. Results The SUI-HSS of urogenital hypersensitivity correlated positively with OABSS (r=0.442, p<0.01), and the SUI-DIS of urinary discomfort positively with UDI-6 (r=0.289, p<0.05). Interestingly, the SUI-total was correlated positively with age (r=0.326), height (r=0.318) and weight (r=0.304). The SUI-DIS for urinary discomfort of So-Yang (9.48±2.11) type was significantly (p<0.05) higher than that of Tae-Eum (7.2±2.90) type. And SUI subscale profiles of each Sasang type were significantly (Wilks' Lambda=0.792, F=2.723, p=0.034) distinctive to each other. Discussion The acceptable convergent validity of SUI was shown using established measures of urogenital symptoms. The SUI might be used as an objective traditional Korean clinical measure for Sasang type differentiation and urological patients.

• 사상체질의학회지
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• 제36권1호
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• pp.13-30
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• 2024

Objectives This study aimed to analyze the influence of various sleep-related factors that affect sleep quality by each Sasang type. Methods A total of 400 subjects were included for this study, 108 males and 292 females. Sasang type was diagnosed using the SCAT. Then, the characteristics of each Sasang type were analyzed using HRV, DITI, and PSQI, PSS, and SDFI questionnaires. Logistic regression analysis was used to predict sleep-related factors that affect sleep disorders by Sasang types. Results This study shows that the pathophysiological characteristics for stress and digestive function of each Sasang type can differentiate sleep management through a logistic regression model including subscales of PSS and SDFI. Stress had no effect on the occurrence of sleep disturbance within only So-Eum, since the stress level is originally high in the So-Eum regardless of sleep quality. Rather, decreased appetite and poor eating habits had a significant impact on the decline in sleep quality. In addition, poor digestion and eating habits in So-Yang had a greater impact and poor digestion in Tae-Eum had a greater impact on the decline in sleep quality. Conclusion The stress and subscales of digestive function provide differentiated sleep management in So-Yang, Tae-Eum, and So-Eum types. The individualized sleep management for each Sasang type with statistically validated PSS and SDFI would be useful for sleep-related experts planning safe and effective person-centered health care as well as for Western clinicians who want to incorporate Sasang typology into their treatments as integrative medical technique in the future.

• 사상체질의학회지
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• 제32권1호
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• pp.30-38
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• 2020

Objectives The purpose of this study is to reduce the question items in Korea Sasang Constitutional Diagnostic Questionnaire (KS-15) and to assess the validity. Methods The subjects of this study were 1,553 people who had information on body shape, personality, and symptoms among the data established at the Korean Medicine Data Center. Among them, 155 people were separated into a test group to assess the validity, and the remaining 1,398 were used as training groups for model development. The reduction question items were finally confirmed through discussion by two experts. The model development went through Multinomial Logistic Regression. Results & Conclusions The Percent Correctly Predicted (PCP) in the test group was 60.00% (58.49% in men and 60.78% in women). The PCP of each constitution was 72.6% in Taeeumin, 53.3% in Soeumin, and 50% in Soyangin. The accuracy rate of KS-10 seems to be reasonable considering the ease of use of reduced time required.

• 대한한방내과학회지
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• 제30권1호
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• pp.144-152
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• 2009

Background : Ephedra (Ephedra sinica) has been widely used to treat respiratory disease in traditional medicine of East Asia for over a hundred years. Despite safety concerns raised by some, the use of ephedra in traditional medicine is documented over more than 1,800 years. It is well established that ephedra is one of the central medicines in Korean 'Seseng constitution' medicine. In Sasang constitution medicine, all humans can be divided into one of four types: Soeumin, Soyangin, Taeumin or Taeyangin, and each constitution type has their own typical characteristics. Accordingly, it is hypothesized that the adverse effects of ephedra differ depending on the Sasang constitution classification. Objectives : The aim of this study was to determine adverse effects of ephedra which is classified as a Taeumin herb, and to observe whether the response differs or not. according to Sasang constitution classification. Methods : The study design was a double-blind randomized controlled trial. The subjects were healthy adults 20 - 50 years old who agreed to participate in this study. They were allocated through randomization to either ephedra group (N=55) or placebo group (N=24). where ephedra extract (6 g of dried ephedra) and placebo with similar opaque capsules were given twice for one day. To compare the adverse events of ephedra according to Sasang constitution classification, we analyzed blood pressure (systolic and diastolic), pulse rate, the morning questionnaire, and patient's global assessment scale score for well known adverse events: palpitation, headache, sweating, tiredness, dyspepsia, and dry mouth. Results : After ingestion of ephedra, the pulse rate had a significant increase in all constitution types. The changes of diastolic pressure in Soeumin and the changes of pulse rate in Soeumin, Soyangin and Taeumin had a significant increase in the ephedra over the control group. In the ephedra group, the palpitation and dyspepsia score of the patients' global assessment scale had a significant increase in Soeumin, with palpitation and sweating score increasing in Soyangin. Others observations were insignificant results. Conclusion : The results of this study may confirm that the physical responses or adverse effects of herbs differ for each type of Sasang constitution. Future studies using other herbs will be required to ascertain the herbal drug reaction of Sasang constitutions.

• 사상체질의학회지
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• 제22권2호
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• pp.60-69
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• 2010

1. Objectives: The purpose of this study was to analyze the serum lipid, digestive enzymes, thyroid hormone of each Sasang type groups which were classified by Sasang medicine specialist. 2. Methode: The subjects were 1084 (male:female=399:685) person with 371 of Taeeum type, 324 of Soeum type, 389 of Soyang type after the Sasang type classification. The blood samples of the 1084 subjects were to analyze the serum lipid(triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol), digestive enzymes(lipase, amylase), thyroid hormone(T3, TSH). The general linear model (SPSS 12.0) were used for the analysis. 3. Results: Taeeum type group ($133.50\pm89.84$, $189.41\pm33.11$, $107.29\pm28.66$) showed significantly higher triglyceride, total cholesterol, LDL-cholesterol than other two group. In digestive enzymes(lipase, amylase), we found significant differences in the order of Soeum>Soyang>Taeeum. Soeum type group($116.23\pm21.38$) has lower T3 than Soyang type group ($119.90\pm21.60$) with marginal significance (p=0.066). 4. Conclusions: The Results of present study showed that Taeeum type showed significantly highest in triglyceride, total cholesterol, LDL-cholesterol. Soeum type showed significantly highest in digestive enzymes. Blood sample of each Sasang type group will serve as an important evidence for further study showing that the Sasang typology has biological basis.

• Nutrition Research and Practice
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• 제14권2호
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• pp.102-108
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• 2020

BACKGROUND/OBJECTIVES: In Oriental medicine, certain foods may be beneficial or detrimental based on an individual's constitution; however, the scientific basis for this theory is insufficient. The purpose of this study was to investigate the effect of body constitution, based on the Sasang type of Korean traditional medical classification system, on the bioavailability of soy isoflavones of Cheonggukjang, a quick-fermented soybean paste. SUBJECTS/METHODS: A pilot study was conducted on 48 healthy Korean men to evaluate the bioavailability of isoflavone after ingestion of food based on constitution types classified by the Sasang typology. The participants were classified into the Taeeumin (TE; n = 15), Soyangin (SY; n = 15), and Soeumin (SE; n = 18) groups. Each participant ingested 50 g of Cheonggukjang per 60 kg body weight. Thereafter, blood was collected, and the soy isoflavone metabolites were analyzed by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Ntrikinetic analysis of individual isoflavone-derived metabolites was performed. RESULTS: Our nutrikinetic analysis identified 21 metabolites derived from isoflavones in the blood samples from 48 healthy Korean men (age range, 21-29 years). Significant differences were observed in the time to maximum concentration (T_max) and elimination half-life (t_1/2) for nine metabolites among the three groups. The T_max and t_1/2 of the nine metabolites were higher in the SE group than in the other groups. Moreover, the absorption rates, as determined by the area under the plasma-level curve (AUC) values of intact isoflavone, were 5.3 and 9.4 times higher in the TE group than in the SY and SE groups, respectively. Additionally, the highest AUC values for phase I and II metabolites were observed in the TE group. CONCLUSIONS: These findings indicate that isoflavone bioavailability, following Cheonggukjang insgestion, is high in individuals with the TE constitution, and relatively lower in those with the SE and SY constitutions.

• 대한한방소아과학회지
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• 제27권1호
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• pp.7-14
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• 2013

Objectives The goal of the present study was to elucidate the characteristics of behavior problems in Sasang typology with child patients. Methods Subjects consisted of 176 (95 boys, 81 girls) children from 36 months to 83 months were diagnosed by two clinical experts in pediatrics and Sasang medicine. There were 22 So-Yang types, 141 Tae-Eum types, and 13 So-Eum types. The behavior problems were measured with Child Behavior Checklist (CBCL) and ANOVA (analysis of variance) was used for the analysis. Results There were no significant differences between Sasang types among subject's age (F(2, 173)=.190, p=.827) and sex (${\chi}^2$(2, N=176)=1.639, p=.441) as well as their mother's age (F(2, 169)=.060, p=.942) and education level (${\chi}^2$(4, N=172)=.394, p=.983) and their father's age (F(2, 168)=1.184, p=.309) and education level (${\chi}^2$(4, N=172)=5.664, p=.226). So-Yang types ($50.14{\pm}22.35$; $17.27{\pm}8.60$) had higher scores than Tae-Eum types ($38.74{\pm}21.32$; $12.62{\pm}7.98$) in total problems and internalizing problems score of the CBCL, respectively. More specifically, So-Yang types ($5.90{\pm}2.81$; $3.77{\pm}1.90$) had significantly higher depression/anxiety and somatization subscale score than Tae-Eum types ($4.04{\pm}2.73$; $2.30{\pm}2.12$). Scores of So-Yang types were significantly higher than those of CBCL clinical group in depression/anxiety and somatization subscales. Conclusions There were significant differences between child outpatients with different Sasang types, which would be taken into consideration concerning development of Sasang type diagnosis in addition to parenting, treatment, and prevention for children.