• 제목/요약/키워드: sambutoxin

검색결과 3건 처리시간 0.015초

Sambutoxin이 토끼의 혈소판 응집에 미치는 영향 (Effects of Sambutoxin on the Rabbit Platelet Aggregation)

  • 홍충만;조명행
    • Toxicological Research
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    • 제14권3호
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    • pp.333-339
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    • 1998
  • Sambutoxin, a newly purified mycotoxin in Koea, caused hemorrhage in the stomach and intestine of rats. To elucidate the mechanism of hemorrhage, effects of sambutoxin on rabbit platelet aggregation were investigated. First of all, the effects of sambutoxin on the platelet aggregation response and ATP release from platelet by various appregating factors were investigated. And then the role of $Ca^{2+}$ on the platelet aggregation was investigated by flow cytometer. Finally, morphological effect of sambutoxin on platelet ultrastructure was examined by transmission electron microscope. Sambutoxin inhibited aggregation induced by ADP, collagen, thrombin, and arachidonic acid and decreased platelet activating factor-induced disaggregation time in a dose dependent manner. Sambutoxin also decreased thrombin and arachidonic acid-induced ATP release, but increased all factors induced $Ca^{2+}$ release. Sambutoxin showed severe ultrastructural changes of platelet such as appearance of disorganization debri of cellular organelle in intercellular space. Our results indicate that sambutoxin inhibitis rabbit platelet aggregation, and it may be party due to the decrease of ATP release. However, it is not clear whether the antiaggregating effect of sambutoxin is related to $Ca^{2+}$ increase.

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In vitro Cytotoxicity of Sambutoxin

  • Kim, Jin-Cheol;Park, Jeng-Bae;Kim, Gye-Won;Kim, Won-Bae;Lee, Yin-Won
    • Applied Biological Chemistry
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    • 제41권4호
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    • pp.273-274
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    • 1998
  • In vitro cytotoxicity of sambutoxin was measured by using various human and murine tumor cells and $IC_{50}$ values of sambutoxin ranged from 46.2 to 1,425.6 ng/ml.

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산수유(Cornus officinalis) 과실에서 분리한 Fusarium lateritium SSF가 생산하는 Tricyclic Pyridone계 알칼로이드 (Tricyclic Pyridone Alkaloids from Cultures of Cornus officinalis Fruits-associated Fungus, Fusarium lateritium SSF2)

  • 최현규;심상희
    • 생약학회지
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    • 제48권4호
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    • pp.268-272
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    • 2017
  • Three tricyclic pyridone alkaloids, (-)-4,6'-anhydrooxysporidinone (1), (-)-6-deoxyoxysporidinoCne (2), and (-)-sambutoxin (3) were isolated from cultures of Fusarium lateritium SSF2 derived from the fruits of Cornus officinalis. Chemical structures of the isolated compounds were determined by spectroscopic method and comparisons with reported data values. The compounds 1-3 were isolated for the first time from this fungal strain.