• 한방비만학회지
• /
• 제15권1호
• /
• pp.1-8
• /
• 2015

Objectives: The aim of this study was to evaluate the effectiveness and safety of electroacupuncture for non-alcoholic fatty liver disease (NAFLD). Methods: A randomized, controlled pilot trial was conducted. Twenty-two participants were randomized into one of the two groups: an acupuncture group (n=11) and wait-list group (n=11). The treatment group received 8 sessions of electroacupuncture over 8 weeks. Twenty points (CV4, CV12, both LR14, GB26, ST25, ST34, ST40, ST36, SP4, SP6, LR3) were selected for needling. The control group did not receive acupuncture treatment during study period and followup were done in the 4th and 8th weeks after randomization in both groups. The primary outcome was body fat computed tomography and the secondary outcomes included blood test (aspartate aminotransferase, alanine transferase, triglyceride, total cholesterol, high density lipoproteincholesterol, low density lipoprotein-cholesterol, blood sugar test, ${\gamma}$-guanosine triphosphate) and body composition test (body mass index, weight, body fat mass, body fat rate, waist hip ratio). Safety was assessed at every visit. Results: There was no significant differences in between the experimental group and control group. There were no adverse events. Conclusions: The results suggest that In patients with NAFLD, electroacupuncture treatment did not induce worsening of liver disease and liver function, but it was no improvement symptoms of fatty liver. Study of herb medicine treatments and other acupuncture therapy of NAFLD are required later.

• 한국건축시공학회지
• /
• 제10권6호
• /
• pp.127-135
• /
• 2010

물류시설은 층고가 높고 구조가 단순하며, 투자회수를 위한 조속한 운영이 필요하기 때문에 공기단축이 절실한 특징이 있다. 이에 따라 인력 및 원가절감, 공기단축을 기대할 수 있는 PC공법의 사용은 RC조에 비해 경쟁력을 확보할 수 있다. 그러나 국내의 시공사들은 RC공법에 익숙해져 있어, PC공법에 대한 부정적 인식이 팽배하며, 새로운 공법적용에 대한 노력이 미흡한 문제점이 있다. 본 연구의 사례현장은 단위기둥의 높이가 14m로 동일한 규격의 장주(長柱)가 110본 소요되는 현장으로 RC공법을 이용할 경우 시공성, 경제성, 공사기간, 안전성등의 문제발생이 예상된다. 따라서 본 연구는 RC조로 계획된 물류창고 현장을 PC공법으로 시공하여 인력 및 원가절감, 공기단축효과를 비교분석하고, 개선효과를 제시하는데 목적을 두고 있다. 향후 본 연구의 결과물은 물류시설 시공 시공기단축, 품질 및 시공성 향상, 안전성향상, 원가절감효과를 가져올 신공법개발 연구의 기초자료로 사용될 것으로 사료된다.

• 임상간호연구
• /
• 제26권1호
• /
• pp.117-130
• /
• 2020

Purpose: This study aimed to develop a bedside nursing shift report protocol and evaluate the effect of the protocol in a tertiary hospital in South Korea. Methods: The bedside nursing handoff protocol with patient engagement was developed based on the literature review and the validation of an expert group. The effect of the protocol on clinical implication was tested in three medical-surgical units in a tertiary hospital. Outcomes were assessed by patient perception, nurse perception, and reporting time. Data collected from June to August in 2018 and analyzed with descriptive statistics and One-way ANOVA using SPSS version 25.0. Results: The bedside nursing shift report protocol with patient engagement consisted of two steps: nurse to nurse report and bedside report with patients. Nurse's perception with patient engagement was significantly increased after applying protocol (F=17.85, p<.001). Patient's perception was significantly improved in the areas of discharge plan (F=7.86, p<.001), health information privacy (F=4.46, p=.012) and identify attending nurse (F=3.19, p=.042). There were no differences in reporting time between the bedside nursing shift report and a traditional shift report (F=0.61, p=.054). Conclusion: Patient perception was significantly increased, while nurse perception was not different after applying this protocol. For the change in the perception of nurses, education may be preceded to improve nurses' competence for the bedside shift report. Furthermore, the support in enough nurse staffing should be needed for encouraging the bedside shift report. The bedside shift report may enhance patient engagement. Therefore it may improve patient safety and health outcome in clinics.

• Acute and Critical Care
• /
• 제33권4호
• /
• pp.246-251
• /
• 2018

Background: Target temperature management (TTM) improves neurological outcomes for comatose survivors of out-of-hospital cardiac arrest. We compared the efficacy and safety of a gel pad cooling device (GP) and a water blanket (WB) during TTM. Methods: We performed a retrospective analysis in a single hospital, wherein we measured the time to target temperature ($<34^{\circ}C$) after initiation of cooling to evaluate the effectiveness of the cooling method. The temperature farthest from $33^{\circ}C$ was selected every hour during maintenance. Generalized estimation equation analysis was used to compare the absolute temperature differences from $33^{\circ}C$ during the maintenance period. If the selected temperature was not between $32^{\circ}C$ and $34^{\circ}C$, the hour was considered a deviation from the target. We compared the deviation rates during hypothermia maintenance to evaluate the safety of the different methods. Results: A GP was used for 23 patients among of 53 patients, and a WB was used for the remaining. There was no difference in baseline temperature at the start of cooling between the two patient groups (GP, $35.7^{\circ}C$ vs. WB, $35.6^{\circ}C$; P=0.741). The time to target temperature (134.2 minutes vs. 233.4 minutes, P=0.056) was shorter in the GP patient group. Deviation from maintenance temperature (2.0% vs. 23.7%, P<0.001) occurred significantly more frequently in the WB group. The mean absolute temperature difference from $33^{\circ}C$ during the maintenance period was $0.19^{\circ}C$ (95% confidence interval [CI], $0.17^{\circ}C$ to $0.21^{\circ}C$) in the GP group and $0.76^{\circ}C$ (95% CI, $0.71^{\circ}C$ to $0.80^{\circ}C$) in the WB group. GP significantly decreased this difference by $0.59^{\circ}C$ (95% CI, $0.44^{\circ}C$ to $0.75^{\circ}C$; P<0.001). Conclusions: The GP was superior to the WB for strict temperature control during TTM.

• Journal of Korean Neurosurgical Society
• /
• 제64권6호
• /
• pp.891-900
• /
• 2021

Objective : Vertebral artery dissecting aneurysm (VADA) is a very rare subtype of intracranial aneurysms; when ruptured, it is associated with significantly high rates of morbidity and mortality. Despite several discussions and debates, the optimal treatment for VADA has not yet been established. In the last 10 years, flow diverter devices (FDD) have emerged as a challenging and new treatment method, and various clinical and radiological results have been reported about their safety and effectiveness. The aim of our study was to evaluate the clinical and radiological results with the use of FDD in the treatment of unruptured VADA. Methods : We retrospectively evaluated the data of all patients with unruptured VADA treated with FDD between January 2018 and February 2021 at our hybrid operating room. Nine patients with unruptured VADA, deemed hemodynamically unstable, were treated with FDD. Among other parameters, the technical feasibility of the procedure, procedure-related complications, angiographic results, and clinical outcomes were evaluated. Results : Successful FDD deployment was achieved in all cases, and the immediate follow-up angiography showed intra-aneurysmal contrast stasis with parent artery preservation. A temporary episode of facial numbness and palsy was noted in one patient; however, the symptoms had completely disappeared when followed up at the outpatient clinic 2 weeks after the procedure. The 3-6 months follow-up angiography (n=9) demonstrated complete/near-complete obliteration of the aneurysm in seven patients, and partial obliteration and segmental occlusion in one patient each. In the patient who achieved only partial obliteration, there was a sac 13 mm in size, and there was no change in the 1-year follow-up angiography. In the patient with segmental occlusion, the cause could not be determined. The clinical outcome was modified Rankin Scale 0 in all patients. Conclusion : Our preliminary study using FDD to treat hemodynamically unstable unruptured VADA showed that FDD is safe and effective. Our study has limitations in that the number of cases is small, and it is not a prospective study. However, we believe that the study contributes to evidence regarding the safety and effectiveness of FDD in the treatment of unruptured VADA.

• 한국식품위생안전성학회지
• /
• 제33권6호
• /
• pp.510-515
• /
• 2018

본 연구에서는 셀레늄 강화 시금치의 항산화 활성을 측정하여 무처리군와 비교하여 증가된 항산화 활성을 관찰하고자 하였다. 0.10, 0.25, 0.50, 0.75, 1.00 mg/mL의 농도를 이용하여 무처리 시금치와 셀레늄 강화 시금치의 항산화 활성을 in vitro 실험을 통해 관찰하였다. 셀레늄 함량은 무처리 시금치의 경우 $61.19{\pm}2.35mg/kg$, 셀레늄 강화시금치의 경우 $239.0{\pm}3.73mg/kg$으로 셀레늄 강화시금치에서 약 3.9배 증가되었다. DPPH radical 소거능은 무처리 시금치에 비해 셀레늄 강화 시금치가 모든 농도에서 약 11~12% 유의적으로 증가하는 경향을 보였다. ABTS radical 소거능은 0.10 mg/mL의 낮은 농도에서 무처리 시금치에 비해 셀레늄 강화시금치에서 22.9%의 높은 증가율을 나타냈으며, 셀레늄 강화 시금치의 경우 무처리 시금치에 비해 유의적으로 높은 소거 능력이 나타났다. NO radical 소거능 또한 같은 농도에서 비교했을 때 셀레늄 강화 시금치의 경우 무처리 시금치에 비해 유의적으로 높은 소거 능력을 보여주었으며, 활성 산소 종 및 유리기에 전자를 공여하는 환원력에서도 무처리 시금치에 비해 셀레늄 강화 시금치에서 더 높은 활성이 나타났다. 이러한 결과는 시금치에 함유된 여러 항산화성분과 더불어 강화 처리로 인해 증가된 셀레늄이 효과적으로 여러 활성산소종의 소거에 관여하여 항산화능의 상승효과에 관여하였다고 사료되어진다.

• 해양환경안전학회지
• /
• 제24권7호
• /
• pp.930-938
• /
• 2018

잠수함에서 발생하는 수중방사소음은 적함의 소나에 의해 피탐될 확률과 직결되며, 잠수함 저소음화 방안은 생존성 향상을 위해 필수적이다. 최신 잠수함의 경우 기계류 소음저감 및 고속/대형화가 진행됨에 따라 선체 주위에 발생하는 유동소음에 대한 관심이 높아지고 있다. 본 연구에서는 자유수면의 효과를 고려하여 잠수함 형상 주위에 발생하는 유동소음 수준을 예측할 수 있는 소음해석기법을 개발하였다. 잠수함이 자유수면 근처 운항시에 잠수함 주위 유동장의 교란에 의해 발생하는 난류유동소음과 쇄파버블에 의한 소음이 발생한다. 먼저 잠수함 주위 유동장 해석을 위해, VOF법 기반의 비압축성 이상유동(two-phase flow)해석을 수행하여 잠수함 주위 자유수면 형상과 유동장 정보를 도출하였다. 이후 난류유동소음해석을 위해 음향상사기법인 Permeable FW-H를 적용하였고, 쇄파버블 소음해석을 위해 유동해석에서 도출된 난류운동에너지 분포결과를 기반으로 쇄파버블 소음모델을 적용하였다. 최종적으로 개발된 유동소음 해석기법은 선박해양플랜트연구소(KRISO)의 대형캐비테이션터널(LCT)에서 수행된 잠수함 모형 유동소음계측 실험결과와 비교를 통해 검증을 수행하였다.

• 대한한의학회지
• /
• 제40권1호
• /
• pp.124-152
• /
• 2019

Objectives: This study aimed to ascertain what should be considered in the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer" by analyzing the existing guidelines and clinical trials. Methods: The development committee searched guidelines for herbal medicinal products for colorectal cancer that have already been developed. Then, clinical trials for colorectal cancer using herbal medicine were searched. The searched trials were analyzed in terms of inclusion and exclusion of participants, intervention, comparator, outcomes and trial design. Then, we compared the results of our analysis with the regulations and guidelines of the Ministry of Food and Drug Safety in order to identify the issues we will have to consider when making the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer". Several guidelines for anti-tumor agents and clinical trials with herbal medicinal products were searched on the national institution homepage. In addition, 12 articles were searched using a combination of the following search terms: 'colorectal neoplasms', 'herbal medicine', 'Medicine, Korean traditional', 'Medicine, Chinese Traditional', 'medicine, East Asian medicine', 'medicine, Kampo', etc. Results: The characteristics of participants were various, such as people with medical histories of surgeries or recurrent cancers or who complained of chemotherapy-induced side effects. The types of interventions were also various and included decoctions, powders, intravenous fluids, intraperitoneal injections and gargles. Comparators used included placebos and conventional treatments. The outcome measurements used in the studies were quality of life, symptom score, tumor response, and survival duration, etc. Safety was evaluated by recording adverse events. Conclusions: Findings were made by reviewing existing guidelines and comparing them with clinical trials for colorectal cancer and herbal medicinal products. These results will be utilized in the development of the "Guideline for Clinical Trials with Herbal Medicinal Products for Colorectal Cancer".

• 한국재난정보학회 논문집
• /
• 제18권2호
• /
• pp.269-279
• /
• 2022

연구목적: 본 연구의 목적은 건설현장의 재해 예방을 위해 딥러닝기반의 개인보호구 검출 모델을 개발하고, 실제 건설현장에 적용하여 분석하는 것이다. 연구방법: 본 연구의 수행 방법은 실제 환경의 데이터를 구축하고, 개발된 개인보호구 검출 모델을 적용하였다. 개인보호구 검출 모델은 크게 근로자 검출 및 개인보호구 착용 분류 모델로 구성되어 있다. 근로자 검출 모델은 딥러닝 기반의 알고리즘을 실제 현장에서 획득한 데이터셋을 구축하여 학습 및 근로자를 검출하였고, 개인보호구 착용 분류 모델은 앞단에서 추출된 근로자 검출영역에서 학습된 개인보호구 검출 알고리즘을 적용하였다. 구축된 모델의 검증을 위해 건설현장 3곳에서 획득된 데이터를 통해 실험결과를 도출하였다. 연구결과: 데이터베이스 12,000장을 구축하여 정상검출 9,460장(78.8%), 오검출 1,468(12.2%), 미검출 1,072장(8.9%)으로 나타났으며 주요 원인은 영상에서의 객체 크기, 객체간 중첩(Occulusion), 객체 잘림, 그림자에 의한 오검출로 분류되었다. 결론: 개인보호구 검출모델은 현장 상황마다 다른 검출률을 확인할 수 있었고, 본 연구의 결과가 차후 현장적용을 위한 연구에 활용될 수 있을 것으로 여겨진다.

• 대한한의학방제학회지
• /
• 제30권4호
• /
• pp.241-248
• /
• 2022

Objective : The purpose of this trial is to observe the preliminary effects of Salvia plebeia (SP) extract on quality of life in patients with solid cancer. Methods : This is a prospective, open-label, single-arm, and single-dose clinical trial. Twenty participants who have been diagnosed with solid cancer between the ages of 20 and 65 will be included. All participants will be administered SP granules for 12 weeks. Data will be collected at 4, 8, and 12 weeks after enrollment. The primary outcome is quality of life, using the Korean version of the Functional Assessment Cancer Therapy-General questionnaire. Secondary outcomes include tumor markers in blood tests for each cancer type, soluble programmed death-ligand 1, the percentage of natural killer cells among lymphocytes, ratio of T-helper and T-suppressor cells, ratio of total T, T-helper, T-suppressor, and B cells in lymphocytes, level of C-reactive protein, and tumor size via radiology examination. Safety will be assessed by clinical laboratory tests and monitoring of adverse events. Discussion : This study aims to observe the effects of an oral administration of SP preparations in patients with solid cancer on changes in quality of life and an improvement in immune function. It is expected to provide objective evidence of the effect and safety of SP for patients with solid cancer. Trial registration: KCT0007315 (Clinical Research Information Service)