• Environmental Analysis Health and Toxicology
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• v.15 no.1_2
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• pp.31-37
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• 2000

Acetanilide may be released into the environment through air and wastewater from its production and use sites and exposed to human. Acetanilide is known to produce an analgesic effect and may pose adverse effects on human health by overly exposure. According to the EUSES system, acetanilide showed a high MOS (Margin of safety) value exceeding 6$\times$10$^4$ on a regional exposure, which is safe enough for public health. Whereas the lowest MOS value in dermal exposure was estimated as 3$\times$10$^{-4}$ on a local basis (workplace), the risk could be partly counteracted by taking preventive measures such as using mask and globes and good ventilation in the work places. Acetanilide may pose a potential risk for workers by dust inhalation. For the sake of health protection in the work places, additional data should be accumulated with respect to repeated dose toxicity, reproduction toxicity and developmental toxicity, etc. It is, therefore, recommended that acetanilide should be a candidate for further work to supplement the lacking data until it is proved to be safe in the occupational health aspects.

• The Transactions of the Korea Information Processing Society
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• v.3 no.2
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• pp.283-294
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• 1996

To operate the automatic devices of manufacturing process more effectively and to solve the needs of the resource sharing, network technology is applied to the unit control devices located in common manufacturing zone and operated by connecting them. This paper introduces deign and test operation of cell system for the management of multivendor PLC by applying to wall paper process based on the manufacturing standardization of CIM. The analysis of designed multivendor PLC group is performed by selecting the parameters such as variation of data packet size and node number of PLC ladder logic program and variation by analyzing the corresponding variation values of token rotation time and waiting time for the system operation. For the method of the analysis,the equation is considering the overhead such as indicated packet service time and transmission safety margin for PLC network connection in M/G/1 queue model,and it is applied to the cell system and PLC group manage-ment for operation .Through the experiment,it is found that the realtime processing is possible with expanded and better result than the resuit obtained by Jayasumana.Browaka with PLC scan time considered,response lower limit of 10-20 msec. data packet size not more than 50 bytes.and the number of nodes less than 40.

• Korean Journal of Plant Resources
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• v.23 no.5
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• pp.399-405
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• 2010

Rosa rugosa has been used as a folk medicine with various pharmacological properties for a long time in Asia. Recently, it has been reported that the extract of fractions from different parts of Rosa rugosa have various pharmacological effects on diverse diseases including diabetes, inflammatory diseases and tumor. We investigated effects of fructus extracts of Rosa rugosa(RRF) and semen extracts of this herb(RRS) on macrophage to evaluate the possibilities as a biological response modifier. We showed increased effects on tumoricidal activity, phagocytic activity, TNF-$\alpha$ and NO production in RRF-treated groups without direct tumor cell cytotoxicity. RRS-treated groups increased direct tumor cell cytotoxicity at high dose without tumoricial activity except increasing of TNF-$\alpha$ release. These results provide further possibilities for the beneficial immunomodulating effects of RRF on immune system with relatively larger safety margin rather than RRS.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4281-4287
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• 2014

Background: Methylation of tumor suppressor genes has been investigated in all kinds of cancer. Tumor specific epigenetic alterations can be used as a molecular markers of malignancy, which can lead to better diagnosis, prognosis and therapy. Therefore, the aim of this study was to evaluate the association between gene hypermethylation and expression of fragile histidine triad (FHIT), glutathione S-transferase P1 (GSTP1) and p16 genes and various clinicopathologic characteristics in primary non-small cell lung carcinomas (NSCLC). Materials and Methods: The study included 28 primary non-small cell lung carcinomas, where an additional 28 tissue samples taken from apparently normal safety margin surrounding the tumors served as controls. Methylation-specific polymerase chain reaction (MSP) was performed to analyze the methylation status of FHIT, GSTP1 and p16 while their mRNA expression levels were measured using a real-time PCR assay with SYBR Green I. Results: The methylation frequencies of the genes tested in NSCLC specimens were 53.6% for FHIT, 25% for GSTP1, and 0% for p16, and the risk of FHIT hypermethylation increased among patients with NSCLC by 2.88, while the risk of GSTP1 hypermethylation increased by 2.33. Hypermethylation of FHIT gene showed a highly significant correlation with pathologic stage (p<0.01) and a significant correlation with smoking habit and FHIT mRNA expression level (p<0.05). In contrast, no correlation was observed between the methylation of GSTP1 or p16 and smoking habit or any other parameter investigated (p>0.05). Conclusions: Results of the present study suggest that methylation of FHIT is a useful biomarker of biologically aggressive disease in patients with NSCLC. FHIT methylation may play a role in lung cancer later metastatic stages while GSTP1 methylation may rather play a role in the early pathogenesis.

• Journal of the Korea Concrete Institute
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• v.15 no.6
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• pp.820-828
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• 2003

Recent research has indicated that the current ACI shear provision provides unconservative predictions for large slender beams and beams with low level of longitudinal reinforcement, and conservative results for deep beams. To modify some problems of ACI shear provision, ultimate shear strength equation considering size effect and arch action to compute shear strength in high-strength concrete beams without stirrups is presented in this research. Three basic equations, namely size reduction factor, rho factor, and arch action factor, are derived from crack band model of fracture mechanics, analysis of previous some shear equations for longitudinal reinforcement ratio, and concrete strut described as linear prism in strut-tie model deep beams. Constants of basic equations are determined using statistical analysis of previous shear testing data. To verify proposed shear equation for each variable, effective depth, longitudinal reinforcement ratio, concrete compressive strength and shear span-to-depth ratio, about 300 experimental data are used and proposed shear equation is compared with ACI 318-99 code, CEB-FIP Model code, Kim &Park's equation and Zsutty's equation. The proposed shear equation is not only simpler than other shear equations, it is but also shown to be economical predictions and reasonable safety margin. Hence proposed shear strength equation is expected to be applied to practical shear design.

• Journal of the Korean Society of Propulsion Engineers
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• v.15 no.2
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• pp.62-67
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• 2011

Launching tube is a kind of case to protect the guided weapons from external environments and conducted as a guide when they are fired. The guided weapons have been firmly kept at the launching tube and transferred, and would be separated at the required time when they are fired To meet the aim, it has been used explosive bolts which are reliable and efficient mechanical fastening devices having the special feature of a built-in release. The disadvantage of explosive bolt lies in that it is based on the high explosive effect of a pyrotechnic charge. When the explosive bolt is ignited, there are some bad effects; a flame, fragments and pyro-shock. Because of these bad effects there are many restriction to use bolt as joining devices to precision guided weapons. To solve these problems, the aim of the present work is to invent the ball-type separation bolt which is a pyrotechnically releasable mechanical linking device for two mechanical elements that does not suffer from such drawbacks. A standard pressure cartridge can moreover be easily integrated inside the device according to the present work and this with no modification to its structure. The present work was represented quantitatively the margin of separation safety and analysed separation mechanism in ball type separating bolt to perform the dynamic separation test.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.70-81
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• 2000

DA-5018 is a synthetic capsaicin derivative under development as a non-narcotic a analgesic ag$\varepsilon$nt. DA-50 18 showed a potent analgesic activity against acute and chronic pain m model(Tablel, 2.), but it had a narrow margin of safety. DA-5018 did not bind to opioid(${\kappa}, {\delta}, {\mu}$), NKl, CGRP receptors in vitro and its analgesic effect was not antagonized by naloxone, a and it did not develop analgesic tolerance. In addition DA-5018 had no inhibitory effects against c cyclooxygenase and 5-lipooxygenase activities. DA-5018 significantly increased the relcase of substance P from the slices of the rat spinal cord. These results suggest that DA-50 18 is not a narcotic nor aspirin-like analgesic and the release of substance P is one of analgesic mechanism of action of DA-5018. We found that DA-5018 was almost ten times more potent and was at l least IOO-times less irritable compared to capsaicin. Accordingly development of topical formula was adopted. Topical formula was desiged and screened by flux test of DA-5018 using hairless mouse skin and several formulas were selected. With these topical formulas we a assessed the analgesic efficacy and carried out the toxicity, skin irritation and pharmacokinetic studies. In streptozotocin-induced hyperalgesic rat and 50 % galactose-fed hyperalgesic rat as diabetic pain models, DA-5018 cream increased the pain thresh이ds up to 77.0% and 24.4% respectively, while Zostrix-HP(capsaicin cream) incr$\varepsilon$as cd by 65.9% and 21.0%. DA-5018 c cream showed a good analgesic effect as welI in FCA-induced arthritic rat. DA-5018 cream did not show any toxicological signs in acute and chronic toxicity test and had little skin irritation in car swclIing and scratching t$\varepsilon$st. Pharmacokinetics of DA-50 18 were studied after topical application of ${14}^C$-Iabelled or unlabelIed DA-5018 cream. Plasma and skin concentrations c except applied skin wcre below the dctection limit and after 7-day cummulative application, plasma concentrations were also below detection limit DA-50 18 may have an advantag$\varepsilon$ ov$\varepsilon$r c capsaicin and is now being developed as a topical agent for the treatment of pains. DA-50 18 cream was approved for Korean IND and is now under a Phase II clinical study for arthritic pain a after finising Phase I study. DA-50 18 was also liscensed out to Stiefel Company in America in

• Journal of the Korean Geotechnical Society
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• v.31 no.10
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• pp.5-16
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• 2015

Considering the conversion of the Korea Construction Standards to Limit State Design (LSD), we analyzed the resistance bias factor for pullout resistance, as a part of the development of the Load and Resistance Factor Design (LRFD) for soil nailing; very few studies have been conducted on soil nailing. In order to reflect the local characteristics of soil nailing, such as the design and construction level, we collected statistics on pullout tests conducted on slopes and excavation construction sites around the country. In this study a database was built based on the geotechnical properties, soil nailing specifications, and pullout test results. The resistance bias factors are calculated to determine the resistance factor of the pullout resistance for gravity and pressurized grouting method, which are the most commonly used methods in Korea; moreover, we have relatively sufficient data on these methods. We found the resistance bias factors to be 1.144 and 1.325, which are relatively conservative values for predicting the actual ultimate pullout resistance. It showed that our designs are safer than those found in a research case in the United States (NCHRP Report); however, there was an uncertainty, $COV_R$, of 0.27-0.43 in the pullout resistance, which is relatively high. In addition, the pressurized grouting method has a greater margin of safety than the gravity grouting method, and the actual ultimate pullout resistance determined using the pressurized grouting method has low uncertainty.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.3
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• pp.1095-1104
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• 2013

The number of vehicles registered in Korea is rapidly increasing and will reach 18.26 million as of June 2011. The rapid increase of large-size passenger cars and RVs among this number is causing damage to other vehicles when parked in currently installed parking lots, increased civil complaints from the damage, and inconveniences to people trying to pass through parking lots as well. In particular, the car-stoppers indiscriminately installed at the parking lots are also causing accidents and adding to parking problems, causing economic losses. Accordingly, there should be new regulations for the amount of parking space per vehicle and for locations to install the car-stoppers. The research has first reviewed the distribution ratio of vehicle models from home and abroad for the width and length of the vehicles by each model, parking space per vehicle where the car-stoppers are installed and examples of changes in distribution ratio. In addition, the amount of parking space per vehicle was calculated with consideration for various specifications by each car model. As a result, margin width of full sized car is decreased by 18~21mm on the existing width. This is judged decreases accident of parking lot, because length of the front of car is not deviate parking Space Section. In conclusion, presented improvement ideas for parking plans with enhanced convenience and safety from the aspect of the drivers. Parking lot relevant businesses will also be maximized in terms of cost and efficiency when the criteria for the structure of parking lots and their installation is established and the improved parking plan is applied in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.6949-6958
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• 2015

Radio based train control system performs train safe interval control by receiving in realtime the position information of trains driving in the control area of the wayside system and providing onboard system in each train with updated movement authority. The performance of the train control system is evaluated to calculate the minimum operation headway, which reflects the operation characteristics and the characteristics of the train as well as the interval control performance of the train control system. In this paper, we propose the operation headway calculation for radio based train control system and a new train interval control algorithm to improve the operation headway. The proposed headway calculation defines line headway and station headway by the estimation the safety margin distance reflecting the performance of the train control system. Furthermore the proposed Enhanced Train Interval Control(ETIC) algorithm defines a new movement authority including both distance and speed, and improves the train operation headway by using braking distance occurring inevitably in the preceding train. The proposed operation headway calculation is simulated with Korean Radio-based Train Control System(KRTCS) and the simulated result is compared to improved train interval control algorithm. According to the simulated results, the proposed operation headway calculation can be used as performance indicator for radio based train control system, and the improved train control algorithm can improve the line and station headway of the conventional radio based train control system.